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| 1 | An Insect Imaging System to Automate Rice Light-Trap Pest Identification显示文摘Identification and counting of rice light-trap pests are important to monitor rice pest population dynamics and make pest forecast. Identification and counting of rice light-trap pests manually is time-consuming, and leads to fatigue and an increase in the error rate. A rice light-trap insect imaging system is developed to automate rice pest identification. This system can capture the top and bottom images of each insect by two cameras to obtain more image features. A method is proposed for removing the background by color difference of two images with pests and non-pests. 156 features including color, shape and texture features of each pest are extracted into an support vector machine (SVM) classifier with radial basis kernel function. The seven-fold cross-validation is used to improve the accurate rate of pest identification. Four species of Lepidoptera rice pests are tested and achieved 97.5% average accurate rate. | YAO Qing LV Jun LIU Qing-jie DIAO Guang-qiang YANG Bao-jun CHEN Hong-ming TANGJian | 2012 | Journal of Integrative Agriculture2012，11，6： | 21 |
| 2 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 3 | Effects of Temperature and Moisture on Soil Organic Matter Decomposition Along Elevation Gradients on the Changbai Mountains, Northeast China显示文摘Decomposition of soil organic matter(SOM) is of importance for CO_2 exchange between soil and atmosphere and soil temperature and moisture are considered as two important factors controlling SOM decomposition. In this study, soil samples were collected at 5 elevations ranging from 753 to 2 357 m on the Changbai Mountains in Northeast China, and incubated under different temperatures(5, 10, 15, 20, 25, and 30?C) and soil moisture levels(30%, 60%, and 90% of saturated soil moisture) to investigate the effects of both on SOM decomposition and its temperature sensitivity at different elevations. The results showed that incubation temperature(F = 1 425.10, P < 0.001), soil moisture(F = 1 327.65, P < 0.001), and elevation(F = 1 937.54, P < 0.001) all had significant influences on the decomposition rate of SOM. The significant effect of the interaction of incubation temperature and soil moisture on the SOM decomposition rate was observed at all the 5 sampling elevations(P < 0.001). A two-factor model that used temperature and moisture as variables fitted the SOM decomposition rate well(P < 0.001) and could explain 80%–93% of the variation of SOM decomposition rate at the 5 elevations. Temperature sensitivity of SOM decomposition, expressed as the change of SOM decomposition rate in response to a 10?C increase in temperature(Q_(10)), was significantly different among the different elevations(P < 0.01), but no apparent trend with elevation was discernible. In addition, soil moisture and incubation temperature both had great impacts on the Q_(10) value(P < 0.01), which increased significantly with increasing soil moisture or incubation temperature. Furthermore, the SOM decomposition rate was significantly related to soil total Gram-positive bacteria(R^2= 0.33, P < 0.01) and total Gram-negative bacteria(R^2= 0.58, P < 0.001). These findings highlight the importance of soil moisture to SOM decomposition and its Q_(10) value,which needs to be emphasized under warming climate scenarios. | WANG Dan HE Nianpeng WANG Qing LV Yuliang WANG Qiufeng XU Zhiwei ZHU Jianxing | 2016 | Pedosphere2016，26，3： | 12 |
| 4 | Comparative study on flow and heat transfer characteristics of sinusoidal and zigzag channel printed circuit heat exchangers显示文摘Printed circuit heat exchangers(PCHEs)are promising candidates for recuperators in supercritical CO2 Brayton cycles.A comparative study is given in this paper on the flow and heat transfer characteristics of PCHEs with sinusoidal and zigzag channels.With mass flow rates of 0.6–1.8 kg/h and the bend angles of 15°–30°,the thermal-hydraulic performance of the PCHEs is discussed.Results show that the sinusoidal channel is superior to the zigzag channel in its comprehensive performance.Larger bend angles result in greater reductions in pressure drop if sinusoidal channels are used instead of zigzag channels and a maximum of 48.4%reduction can be obtained in the considered working conditions.Meanwhile,the inlet sections should be carefully optimized since these sections account for up to 31%and 17%of the total pressure drop in the sinusoidal and zigzag channels,respectively.The corner shape of the zigzag channel can be specially designed to further reduce the pressure drop.The nonuniform density and heat flux distributions in both channels are found to be related to the periodic changes of flow directions and the centrifugal forces should not be ignored when optimizing the sinusoidal and zigzag channels. | WEN Zhe-Xi LV Yi-Gao LI Qing | 2020 | Science China(Technological Sciences)2020，63，4： | 11 |
| 5 | Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis显示文摘AIM To investigate the impact of cigarette smoking on the recurrence rate and recurrence-free survival in patients with hyperlipidemic acute pancreatitis(HLAP).METHODS A total of 863 patients were admitted to our hospital for acute pancreatitis(AP) from January 2013 to March2016, of whom 88 diagnosed with HLAP were enrolled in this retrospective study. Demographic data, medical history, previous episodes of pancreatitis, consumption of alcohol and cigarettes, as well as biochemical and hematological data were carefully recorded for univariate and multivariate analyses. During followup, the information on current smoking status and recurrent AP was gathered. Recurrence-free survival(RFS) was calculated using the Kaplan-Meier method, and the differences between groups were compared using the log-rank test.RESULTS No significant differences were observed between the three groups in age or medical history of hyperlipidemia, fatty liver, diabetes mellitus, hypertension, or AP. The current smokers had a remarkably higher recurrence rate and a greater incidence of repeated episodes of AP(50.0% and 77.8%, respectively) than non-smokers(9.8% and 39.0%), and these two percentages were reduced to 9.1% and 36.4% for patients who gave up smoking. The median follow-up time was 13.5 mo and HLAP recurred after hospital discharge in 23(26.1%) patients. Multivariate analysis identified current smoking(HR = 6.3, P = 0.020) as an independent risk factor contributing to HLAP recurrence. Current smokers had significantly worse RFS than non-smokers(23 mo vs 42 mo), but no significant difference was documented between ex-smokers(34 mo) and non-smokers. The RFS was not significantly different between light and heavy smokers.CONCLUSION Smoking is associated with worse RFS and an increased rate of HLAP recurrence. Continued smoking correlates with a compromised survival and smoking cessation should be recommended. | Jun-Xi Xiang Liang-Shuo Hu Peng Liu Bo-Yan Tian Qing Su Yi-Chun Ji Xu-Feng Zhang Xue-Min Liu Zheng Wu Yi Lv | 2017 | World Journal of Gastroenterology2017，23，47： | 11 |
| 6 | Facile production of ultrathin graphitic carbon nitride nanoplatelets for efficient visible-light water splitting显示文摘Ultrathin graphitic 碳氮化物 nanoplatelets (UGCNP ) 被一种灵巧的方式经由一条有效、 eco 友好的球 milling 途径综合。获得的 UGCNP 在厚度是在尺寸和 0.350.7 nm 的 26 nm,与在体积 graphitic 碳氮化物的上的改进特定的表面区域。光化学的实验证明 UGCNP 在切开的可见光的水里是高度活跃的,与 1,365 摩尔的氢进化率 ?? ? 洠条敮楳瑯敨浲吗? | Qing Han Fei Zhao Chuangang Hu Lingxiao Lv Zhipan Zhang Nan Chen Liangti Qu | 2015 | Nano Research2015，8，5： | 11 |
| 7 | Establishment and Preliminary Application of a Rapid Fluorescent Focus Inhibition Test (RFFIT) for Rabies Virus显示文摘The World Health Organization (WHO) standard assay for determining levels of the rabies virus neutralization antibody (RVNA) is the rapid fluorescent focus inhibition test (RFFIT), which is used to evaluate the immunity effect after vaccination against rabies. For RFFIT, CVS-11 was used as the challenge virus, BSR cells as the adapted cells, and WHO rabies immunoglobulin (WHO STD) as the reference serum in this study. With reference to WHO and Pasteur RFFIT procedures, a micro-RFFIT procedure adapted to our laboratory was produced, and its specificity and reproducibility were tested. We tested levels of RVNA in human serum samples after immunization with different human rabies vaccines (domestic purified Vero cell rabies vaccine (PVRV) and imported purified chick embryo cell vaccine (PCECV)) using different regimens (Zagreb regimen and Essen regimen). We analyzed the levels of RVNA, and compared the immune efficacy of domestic PVRV and imported PCECV using different immunization regimens. The results showed that the immune efficacy of domestic PVRV using the Zagreb regimen was as good as that of the imported PCECV, but virus antibodies were generated more rapidly with the Zagreb regimen than with the Essen regimen. The RFFIT procedure established in our laboratory will enhance the comprehensive detection ability of institutions involved in rabies surveillance in China. | Pengcheng Yu Xinjun Lv Xinxin Shen Qing Tang Guodong Liang | 2013 | Virologica Sinica2013，28，4： | 11 |
| 8 | Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction显示文摘 | Xiaoxiao Zhang Li Yuan Linli Qiu Yali Yang Qing Lv Lin Li Jing Wang Lin He Li Zhang Xinfang Wang Mingxing Xie Xu Yu Jin | 2016 | Frontiers of Medicine2016，10，4： | 10 |
| 9 | The efficacy and safety of cilostazol as an alternative to aspirin in Chinese patients with aspirin intolerance after coronary stent implantation: a combined clinical study and computational system pharmacology analysis显示文摘有阿司匹林和 clopidogrel 的双 antiplatelet 治疗(DAT ) 是标准政体完成快速的血小板抑制并且阻止 thrombotic 事件。当前,很少信息都不关于在有过敏症或不耐的病人的其他的 antiplatelet 治疗是可得到的到阿司匹林。尽管 cilostazol 已经是在在中国的临床的实践的阿司匹林的一种普通选择,它的功效和安全尚待坚定。我们回顾地分析了经历了主要经皮的冠的干预(一种总线标准) 的 613 个中国病人。在他们之中, 405 个病人收到了标准 DAT (加 clopidogrel 的阿司匹林) , 205 个病人与不耐被识别到阿司匹林并且收到了其他的 DAT (加 clopidogrel 的 cilostazol ) 。在他们的基线的二个组之间没有重要差别临床的特征。学习的主要结果在 12 月后续期间包括了主要不利心脏的事件(权标) 和流血事件。权标端点在与 cilostazol (4.9%) 并且在与阿司匹林(8.3%) 对待的 408 个病人中的 34 个对待的 205 个病人中的 10 个被到达。没有统计上重要的差别在在二个组之间的权标被观察。然而,在 cilostazol 组的病人比的有更少的狭窄在阿司匹林的病人组织了(1.5% 对 4.9% , P=0.035 ) 。为事件放血的出现趋于在 cilostazol 组更低(0.49% 对 2.7% , P=0.063 ) 。这些临床的观察进一步用网络系统药理学分析被分析,并且结果与临床的观察和现出症状之前的潜的数据报告一致。我们断定在有经历冠的 stent 培植的阿司匹林不耐的中国病人,有 cilostazol 的 clopidogrel 的联合可以是标准 DAT 政体的一种有效、安全的选择。 | Ying XUE Zhi-wei FENG Xiao-ye LI Zi-heng HU Qing XU Zi WANG Jia-hui CHENG Hong-tao SHI Qi-bing WANG Hong-yi WU Xiang-Qun XIE Qian-zhou LV | 2018 | Acta Pharmacologica Sinica2018，39，2： | 8 |
| 10 | Effects of cotton straw amendment on soil fertility and microbial communities显示文摘 | Wuren HUANG Zhihui BAI Daniel HOEFEL Qing HU Xin LV Guoqiang ZHUANG Shengjun XU Hongyan QI Hongxun ZHANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 8 |
| 11 | Simultaneous determination of four active components in Alisma orientale (Sam.) Juz. by HPLC–DAD using a single reference standard显示文摘A rapid, simple and practical high-performance liquid chromatography method coupled with diode array detector(HPLC–DAD) was developed to evaluate the quality of Alisma orientale(Sam.) Juz.through a simultaneous determination of four major active triterpenes using a single standard to determine the multi-components(SSDMCs). Alisol B 23-acetate was selected as the reference compound for calculating the relative response factors. All calibration curves showed good linearity(R240.9998) within test ranges. RSDs for intra- and inter-day of four analytes were less than 3.6% and 2.3%; the overall recovery was 92.1–110.2%(SSDMC). The proposed method was successfully applied to quantify the four components in 20 samples from different localities in China. Moreover, significant variations were demonstrated in the content of these compounds. In addition, hierarchical clustering analysis(HCA) and principal components analysis(PCA) were performed to differentiate and classify the samples based on the contents of Alisol C 23-acetate, Alisol A, Alisol A 24-acetate and Alisol B 23-acetate. This simple,rapid, low-cost and reliable HPLC–DAD method using SSDMC is suitable for routine quantitative analysis and quality control of A. orientale(Sam.) Juz. | Yao-Wen Zhang Qing Li Chun-Xiao Lv Xiu-Jia Liu Xiao-Hui Chen Kai-Shun Bi | 2015 | Journal of Pharmaceutical Analysis2015，5，2： | 8 |
| 12 | Developmental expression of Cyclin H and Cdk7 in zebrafish: the essential role of Cyclin H during early embryo development显示文摘Cyclin 依赖的 kinase (Cdk7 ) 7 是激活 metazoanCdk kinase (CAK ) 的催化子单元。Cdk7 的激活与一个规章的子单元要求它的协会, Cyclin H。尽管 Cdk7/Cyclin H 建筑群在几种在 RNA 的规定被含有,他们在斑马鱼的 orthologs 的精确功能充分没被阐明。在这研究,我们从斑马鱼胞胚胚胎孤立编码人的 Cyclin H 和 Cdk7 的 theorthologs 的二 cDNAs,并且在 zebrafishembryogenesis 检验了 Cdk7/Cyclin H 的角色。顺序分析证明斑马鱼 Cyclin H 和 Cdk7 cDNAs 与 65% 和 86% 身份编码蛋白质到各自的人的 orthologs。RT-PCR 并且在他们在建议的成年的鱼的未受精卵,胚胎和机关的表示的 situhybridization 分析整个山那 Cyclin H 和 Cdk7 消息是装载的似母亲。我们的数据也证明他们的抄本在整个开发被检测。抄本被发现在开发的早阶段期间无所不在并且变得的 Cyclin H 的分发限制了为前面的神经试管,大脑,眼睛,生到 5 天的纸巾,肝和心授精以后。Cyclin H 的 adominant 否定的形式的表示在早胚胎推迟了 zygotic 抄写的发作,导致在授精以后、导致的 5 个小时的 apoptosis 在通常展出 Cyclin H 的高水平的纸巾切断缺点表示。这些结果含有在 transcriptional 机械的规定的 Cyclin H 在中间的胞胚期间转移并且建议它是在早斑马鱼的必要基因幼虫的开发。 | Qing Yun Liu Zhi Li Wu Wen Jian Lv Yuan Chang Yan Yi Ping Li | 2007 | Cell Research2007，17，2： | 7 |
| 13 | In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus显示文摘As D-amino acids play important roles in the physiological metabolism of bacteria,combination of D-amino acids with antibiotics may provide synergistic antibacterial activity. The aim of the study was to evaluate in vitro and in vivo activity of D-serine alone and in combination withβ-lactams against methicillin-resistant Staphylococcus aureus(MRSA) strains, and to explore the possible sensitization mechanisms. The activity of D-serine, β-lactams alone and in combinations was evaluated both in vitro by standard MICs, time–kill curves and checkerboard assays, and in vivo by murine systemic infection model as well as neutropenic thigh infection model. An in vitro synergistic effect was demonstrated with the combination of D-serine and β-lactams against MRSA standard and clinical strains.Importantly, the combinations enhanced the therapeutic efficacy in the animal models as compared toβ-lactam alone groups. Initial mechanism study suggested possible revision of D-alanine-D-alanine residue to D-alanine-D-serine in peptidoglycan by adding of D-alanine in the medium, which may cause decreased affinity to PBPs during transpeptidation. In conclusion, D-serine had synergistic activity in combination with β-lactams against MRSA strains both in vitro and in vivo. Considering the relatively good safety of D-serine alone or in combination with β-lactams, D-serine is worth following up as new anti-MRSA infection strategies. | Qing Wang Yuemeng Lv Jing Pang Xue Li Xi Lu Xiukun Wang Xinxin Hu Tongying Nie Xinyi Yang Yan Q.Xiong Jiandong Jiang Congran Li Xuefu You | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 6 |
| 14 | Assessment of an Evapotranspiration Deficit Drought Index in Relation to Impacts on Ecosystems显示文摘Ecosystems have increasingly been subject to the challenge of heavy drought under global warming. To quantitatively evaluate the impacts of drought on ecosystems, it is necessary to develop a drought index that can sensitively depict the response of vegetation to drought evolution at a biological time scale. For the ability of direct connection between climate and ecosystem by deficit of evapotranspiration, in the present study, a drought index was defined based on standardized evapotranspiration deficit (SEDI), according to the difference between actual and potential evapotranspiration, to meet the need for highlighting drought impacts on ecological processes. Comparisons with traditional indices show that SEDI can reasonably detect droughts and climatic dry and wet transitions, especially at a monthly time scale, and can also regenerate long-term trends. Moreover, SEDI can more sensitively capture the biological changes of ecosystems in response to the dynamics of drought intensity, compared with the indices of precipitation and temperature. SEDI is more practical than the precipitation and temperature indices to highlight signals of biological effects in climate droughts. Hence, it has potential for use in assessments of climate change and its impact on ecosystems. | Xia ZHANG Mingxing LI Zhuguo MA Qing YANG Meixia LV Robin Clark | 2019 | Advances in Atmospheric Sciences2019，36，11： | 6 |
| 15 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 16 | miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro显示文摘Metastasis is a multistep process involving modification of morphology to suit migration, reduction of tumor cell adhesion to the extracellular matrix, increase of cell mobility, tumor cell resistance to anoikis, and other steps. MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to repress numerous target genes in a coordinated manner, thereby enabling their intervention at multiple steps of the invasion-metastasis cascade. In this study, we identified a microRNA exemplifying these attributes, miR-124, whose expression was reduced in aggressive MDA-MB-231 and SK-3rd breast cancer cells. Down-regulation of miR-124 expression in highly aggressive breast cancer cells contributed in part to DNA hypermethylation around the promoters of the three genes encoding miR-124. Ectopic expression of miR-124 in MDA-MB-231 cells suppressed metastasis-related traits including formation of spindle-like morphology, migratory capacity, adhesion to fibronectin, and anoikis. These findings indicate that miR-124 suppresses multiple steps of metastasis by diverse mechanisms in breast cancer cells and suggest a potential application of miR-124 in breast cancer treatment. | Xiao-Bin Lv Yu Jiao Yanwei Qing Haiyan Hu Xiuying Cui Tianxin Lin Erwei Song Fengyan Yu | 2011 | Chinese Journal of Cancer2011，30，12： | 6 |
| 17 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 18 | Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1显示文摘Oxidative stress-related cartilage degeneration, synovitis, and joint pain play vital roles in the progress of osteoarthritis (OA). Anti-oxidative stress agents not only prevent structural damage progression but also relieve OA-related pain. In this study, we investigated the therapeutic effect of methylene blue (MB), a classical and important anti-oxidant with strong neural affinity. Experimental OA was established in rats by radial transection of medial collateral ligament and medial meniscus (MCLT + MMT) of the right knee joint. The OA rats received intra-articular injection of MB (1 mg/kg) every week starting one week after surgery. We showed that MB administration exerted significant cartilage protection, synovitis inhibition as well as pain relief in OA rats. In human chondrocytes and fibroblast-like synoviocytes, MB significantly attenuated tert-butyl hydroperoxide (TBHP)-induced inflammatory response and oxidative stress. We demonstrated that these effects of MB resulted from dual targets of important antioxidant enzymes, Nrf2 and PRDX1, which also mutually reinforcing and participated in an interaction. Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons;MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1. Taken together, these results suggest that MB ameliorates oxidative stress via Nrf2/PRDX1 regulation to prevent progression and relieve pain of OA. | Jia-wei Li Rong-liang Wang Jia Xu Kuo-yang Sun Hui-ming Jiang Zi-ying Sun Zhong-yang Lv Xing-quan Xu Rui Wu Hu Guo Qing Jiang Dong-quan Shi | 2022 | Acta Pharmacologica Sinica2022，43，2： | 5 |
| 19 | Elevated Resting Heart Rate is Associated with Dyslipidemia in Middle-aged and Elderly Chinese显示文摘Objective To study the relationship between resting heart rate and blood lipid level.Methods A total of 9 415 subjects aged≥40 years were included in the present study.Their resting heart rate was monitored and their serum levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.Results The subjects were divided into group A with their resting heart rate<70 beats/min,group B with their resting heart rate=70-79 beats/min,group C with their resting heart rate=80-89 beats/min,and group D with their resting heart rate≥90 beats/min.High TG,TC,and LDL-C were presented across the resting heart rate(Ptrend<0.01).Multiple logistic regression analysis revealed that the risk of high TG and TC was higher in subjects with their resting heart rate≥90 beats/min than in those with their resting heart rate<70 beats/min(OR=1.42;95%CI:1.16-1.74 and OR=1.33;95%CI:1.09-1.64,respectively).Conclusion Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects. | SUN Ji Chao HUANG Xiao Lin DENG Xin Ru LV Xiao Fei LU Jie Li CHEN Yu Hong BI Yu Fang WANG Wei Qing XU Min NING Guang | 2014 | Biomedical and Environmental Sciences2014，27，8： | 5 |
| 20 | Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling显示文摘Glioblastoma(GBM)is a prevalent and highly lethal form of glioma,with rapid tumor progression and frequent recurrence.Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche,but their function in mediating chemoresistance has not been fully explored.Herein,we uncovered that pericytes potentiate DNA damage repair(DDR)in GBM cells residing in the perivascular niche,which induces temozolomide(TMZ)chemoresistance.We found that increased pericyte proportion correlates with accelerated tumor recurrence and worse prognosis.Genetic depletion of pericytes in GBM xenografts enhances TMZ-induced cytotoxicity and prolongs survival of tumor-bearing mice.Mechanistically,C-C motif chemokine ligand 5(CCL5)secreted by pericytes activates C-C motif chemokine receptor 5(CCR5)on GBM cells to enable DNA-dependent protein kinase catalytic subunit(DNA-PKcs)-mediated DDR upon TMZ treatment.Disrupting CCL5-CCR5 paracrine signaling through the brain-penetrable CCR5 antagonist maraviroc(MVC)potently inhibits pericyte-promoted DDR and effectively improves the chemotherapeutic efficacy of TMZ.GBM patient-derived xenografts with high CCL5 expression benefit from combined treatment with TMZ and MVC.Our study reveals the role of pericytes as an extrinsic stimulator potentiating DDR signaling in GBM cells and suggests that targeting CCL5-CCR5 signaling could be an effective therapeutic strategy to improve chemotherapeutic efficacy against GBM. | Xiao-Ning Zhang Kai-Di Yang Cong Chen Zhi-Cheng He Qiang-Hu Wang Hua Feng Sheng-Qing Lv Yan Wang Min Mao Qing Liu Yao-Yao Tan Wen-Ying Wang Tian-Ran Li Lin-Rong Che Zhong-Yi Qin Ling-Xiang Wu Min Luo Chun-Hua Luo Yu-Qi Liu Wen Yin Chao Wang Hai-Tao Guo Qing-Rui Li Bin Wang Wei Chen Shuang Wang Yu Shi Xiu-Wu Bian Yi-Fang Ping | 2021 | Cell Research2021，31，10： | 5 |
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