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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | Synchrotron radiation X-ray powder diffraction techniques applied in hydrogen storage materials--A review显示文摘Synchrotron radiation is an advanced collimated light source with high intensity. It has particular advantages in structural characterization of materials on the atomic or molecular scale. Synchrotron radiation X-ray powder diffraction(SR-XRPD) has been successfully exploited to various areas of hydrogen storage materials. In the paper, we will give a brief introduction on hydrogen storage materials, X-ray powder diffraction(XRPD), and synchrotron radiation light source. The applications of ex situ and in situ time-resolved SR-XRPD in hydrogen storage materials, are reviewed in detail. Future trends and proposals in the applications of the advanced XRPD techniques in hydrogen storage materials are also discussed. | Honghui Cheng Chen Lu Jingjing Liu Yongke Yan Xingbo Han Huiming Jin Yu Wang Yi Liu Changle Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 5 |
| 3 | Effect of inverted T arrangement on AC pollution flashover characteristics of insulator strings显示文摘The arrangement of insulator strings has an effect on its pollution flashover characteristics.A new arrangement of insulator strings,inverted T-type arrangement,is proposed in this study.The electric field distribution is simulated and the pollution flashover characteristics are tested in an artificial climate chamber.The test results indicate that the inverted T-type arrangement can greatly improve the flashover voltage of polluted insulator strings,the‘7+2’inverted T-type arrangement can increase the flashover voltage of each insulator by 8.5%on average,and the‘3+3’inverted T-type arrangement can increase the flashover voltage of each insulator by 13.4%.The discharge process is different from that of the normal suspension string when the insulator string is inverted T-shaped,i.e.a local arc is produced at the low voltage end of the insulator string and develops downward along the suspension part.While as for the horizontal tension string parts,it is difficult to generate arc during discharge development. | Xingliang Jiang Xiaodong Ren Han Wang Xingbo Han Conglai Bi Zhiyu Li Ledong Hou | 2019 | High Voltage2019，4，2： | 2 |
| 4 | Influence of pollution chemical components on AC flashover performance of various types of insulators显示文摘The pollution on insulators is composed of various chemical components,which threaten the stability of external insulation.However,the existing insulation designs have not taken this issue into consideration.This work aimed to study the influence of pollution chemical components on flashover performance of insulators with various materials.Flashover tests of porcelain,glass and silicone rubber insulators polluted by eight types of common contaminants were conducted.Based on the test data,the influence of chemical components and their solubility on equivalent salt deposit density(ESDD)and insulator flashover performance were analysed;and the electrical properties of different types of insulators were compared.Results show that the ESDD contribution rate changes with chemical components.The dissolution characteristic has a significant influence on the measurement of ESDD;slightly soluble contaminants need to be considered separately.The corresponding insulator flashover gradient for ions can be summarised as Cl^(−) | Zhongyi Yang Xingliang Jiang Xingbo Han Zhijin Zhang Jianlin Hu | 2019 | High Voltage2019，4，2： | 2 |
| 5 | Tracing PRX1+cells during molar formation and periodontal ligament reconstruction显示文摘Neural crest-derived mesenchymal stem cells(MSCs)are known to play an essential function during tooth and skeletal development.PRX1+cells constitute an important MSC subtype that is implicated in osteogenesis.However,their potential function in tooth development and regeneration remains elusive.In the present study,we first assessed the cell fate of PRX1+cells during molar development and periodontal ligament(PDL)formation in mice.Furthermore,single-cell RNA sequencing analysis was performed to study the distribution of PRX1+cells in PDL cells.The behavior of PRX1+cells during PDL reconstruction was investigated using an allogeneic transplanted tooth model.Although PRX1+cells are spatial specific and can differentiate into almost all types of mesenchymal cells in first molars,their distribution in third molars is highly limited.The PDL formation is associated with a high number of PRX1+cells;during transplanted teeth PDL reconstruction,PRX1+cells from the recipient alveolar bone participate in angiogenesis as pericytes.Overall,PRX1+cells are a key subtype of dental MSCs involved in the formation of mouse molar and PDL and participate in angiogenesis as pericytes during PDL reconstruction after tooth transplantation. | Xuyan Gong Han Zhang Xiaoqiao Xu Yunpeng Ding Xingbo Yang Zhiyang Cheng Dike Tao Congjiao Hu Yaozu Xiang Yao Sun | 2022 | International Journal of Oral Science2022，14，1： | 2 |
| 6 | Effects of Tourmaline Particles on Structure and Properties of Polypropylene Filtration Melt-Blown Nonwoven Electrets显示文摘 | BIN YU JIAN HAN XIANGBING HE GUOPING XU XINGBO DING | 2012 | Journal of Macromolecular Science, Part B2012，，： | 1 |
| 7 | On the Stability of Homoclinic and Heteroclinic Cycles 显示文摘 | Han Maoan Hu Shouchuan Liu Xingbo | 2005 | Nonlinear Analysis2005，53，： | 1 |
| 8 | The top cited articles on glioma stem cells in Web of Science显示文摘BACKGROUND: Glioma is the most common intracranial tumor and has a poor patient prognosis. The presence of brain tumor stem cells was gradually being understood and recognized, which might be beneficial for the treatment of glioma. OBJECTIVE: To use bibliometric indexes to track study focuses on glioma stem cell, and to investigate the relationships among geographic origin, impact factors, and highly cited articles indexed in Web of Science. METHODS: A list of citation classics for glioma stem cells was generated by searching the database of Web of Science-Expanded using the terms 'glioma stem cell' or 'glioma, stem cell'' or 'brain tumor stem cell'. The top 63 cited research articles which were cited more than 100 times were retrieved by reading the abstract or full text if needed. Each eligible article was reviewed for basic information on subject categories, country of origin, journals, authors, and source of journals. Inclusive criteria: (1) articles in the field of glioma stem cells which was cited more than 100 times; (2) fundamental research on humans or animals, clinical trials and case reports; (3) research article; (4) year of publication: 1899-2012; and (5) citation database: Science Citation Index-Expanded. Exclusive criteria: (1) articles needing to be manually searched or accessed only by telephone; (2) unpublished articles; and (3) reviews, conference proceedings, as well as corrected papers. RESULTS: Of 2 040 articles published, the 63 top-cited articles were published between 1992 and 2010. The number of citations ranged from 100 to 1 754, with a mean of 280 citations per article. These citation classics came from nineteen countries, of which 46 articles came from the United States. Duke University and University of California, San Francisco led the list of classics with seven papers each. The 63 top-cited articles were published in 28 journals, predominantly Cancer Research and Cancer Cell, followed by Cell Stem Cell and Nature. CONCLUSION: Our bibliometric analysis provides a historical perspective on the progress of glioma stem cell research. Articles originating from outstanding institutions of the United States and published in high-impact journals are most likely to be cited. | Fuxin Yi Jun Ma Weimin Ni Rui Chang Wenda Liu Xiubin Han Dongxiao Pan Xingbo Liu Jianwu Qiu | 2013 | Neural Regeneration Research2013，8，15： | 0 |
| 9 | Malicious Code Detection Model Based on Behavior Association显示文摘Malicious applications can be introduced to attack users and services so as to gain financial rewards,individuals’sensitive information,company and government intellectual property,and to gain remote control of systems.However,traditional methods of malicious code detection,such as signature detection,behavior detection,virtual machine detection,and heuristic detection,have various weaknesses which make them unreliable.This paper presents the existing technologies of malicious code detection and a malicious code detection model is proposed based on behavior association.The behavior points of malicious code are first extracted through API monitoring technology and integrated into the behavior;then a relation between behaviors is established according to data dependence.Next,a behavior association model is built up and a discrimination method is put forth using pushdown automation.Finally,the exact malicious code is taken as a sample to carry out an experiment on the behavior’s capture,association,and discrimination,thus proving that the theoretical model is viable. | Lansheng Han Mengxiao Qian Xingbo Xu Cai Fu Hamza Kwisaba | 2014 | Tsinghua Science and Technology2014，19，5： | 0 |
| 10 | Improvement in hydrogen storage performance of Mg by mechanical grinding with molten salt etching Ti_(3)C_(2)Cl_(x)显示文摘Mg-based materials are currently a hot research topic as hydrogen storage materials due to their considerable theoretical hydrogen storage capacity.However,the kinetic performance of hydrogen absorption and desorption of Mg is too slow and requires high temperature,which seriously hinders the application of this material.MXene is a new type of two-dimensional material with significant role in improving thermodynamics and kinetics.In this experiment,a two-dimensional layered MXene containing Cl functional group was prepared by molten salt etching using the Ti-containing MAX phase as the raw material.Then different ratios of Ti_(3)C_(2)Cl_(x) were uniformly dispersed onto the surface of Mg by high energy ball milling.The samples were characterized by hydrogen absorption and desorption kinetics,SEM,XRD,XPS,and DSC to investigate the effect of Ti_(3)C_(2)Cl_(x) on the hydrogen absorption and desorption performance of Mg.The onset hydrogen absorption temperature can be reduced to room temperature and the hydrogen release temperature is reduced by 200℃ by doping Ti_(3)C_(2)Cl_(x).And there is also 5.4wt%hydrogen storage in the isothermal hydrogen absorption test at 400℃.The results of DSC demonstrate that the Ea of Mg+15wt%Ti_(3)C_(2)Cl_(x) was reduced by 12.6%compared to pristine Mg.TheΔH is almost invariable.The results of XPS show that the presence of multivalent Ti promotes electron transfer and thus improves the conversion between Mg^(2+)/Mg and H^(−)/H.This study provides a guideline for further improving the hydrogen absorption and desorption performance of Mg-based hydrogen storage materials. | Shuaicheng Hu Lijun Lv Guo Yang Wei Liu Hong Miao Honghui Cheng Xingbo Han Zifeng Lin | 2023 | Progress in Natural Science:Materials International2023，33，2： | 0 |
| 11 | Mechanism and preventive measures of slurry leakage at shield tail brushes under abnormal shutdown condition—A case study显示文摘Based on an underwater shield tunnel project,this study introduces the phenomenon of abnormal shutdown and the measures designed to mitigate problems in construction.On the strength of the analysis of the slurry leakage causes during re-tunneling,the mech-anism of slurry leakage induced by jack retraction was studied,and treatment measures of leakage at shield tail brushes were elaborated upon.The results show that the sudden change of stratum leads to an abnormal shutdown,and a sharp increase in the slurry pressure at the shield cut location leads to the slurry penetrating the gap between the outer wall of the shield shell and the soil,increasing the risk of instantaneous breakdown at shield tail brushes.The radial displacement of the outer wall of the segments caused by retractions of three jacks and a single jack along the circumferential direction distinctly shows three regions and four regions,respectively.The radial shrink-age of the outer wall of the segments at the jack retraction position decreases the tightness between the shield tail brushes and the outer wall of the segments.The expansion of the outer wall of the segments at the surrounding position,especially at the lower position,increases the slurry level to the radial shrinkage position of the segments,which increases the risk of slurry leakage.Furthermore,when the shield machine faces an abnormal shutdown,re-tunneling,and assembly of segments,the jack can be gradually retracted from top to bottom.The slurry leakage degree can be observed when retracting,and the corresponding measures can be taken for timely plugging.According to the leakage degree,it can be determined whether to replace the shield tail brushes to reduce the risk of large-scale leakage accidents. | Fei Ye Haolan Feng Xingbo Han Xiaoming Liang Haidong Sun Wenjun Zhang Xiaoyong Cao | 2023 | Underground Space2023，，1： | 0 |
| 12 | Hydrogen storage performance of LaNi_(3.95)Al_(0.75)Co_(0.3) alloy with different preparation methods显示文摘Rare-earth AB5-type La–Ni–Al hydrogen storage alloys are widely studied due to their extensive application potentials in hydrogen isotope storage,hydrogen isotope isolation and hydrogen compressors,etc.Good hydriding/dehydriding kinetics,easily activation,high reversibility are important factors for their practical application.However,their overall hydrogen storage performance,especially plateau pressure and hydrogen absorption/desorption durability need to be further optimized.In this study,the microstructures and the hydrogen storage properties of as-cast,annealed,and melt-spun LaNi_(3.95)Al_(0.75)Co_(0.3) alloys were investigated.The experimental results of XRD and SEM showed that all alloys contained a pure CaCu5 type hexagonal structure LaNi_(4)Al phase.The cell volume increased in an order of annealed>melt-spun>as-cast,resulting in a lower hydrogen absorption/desorption plateau pressure and a more stable hydride phase.The hydrogen storage capacity of three alloys was almost the same.The slope factor of the annealed and melt-spun alloys is smaller than the as-cast alloy,indicating that heat-treatment process can make the alloys more uniform.For the cycle stability of the alloys,the hydrogen absorption rate of the annealed alloy and melt-spun alloy was much faster than that of the as-cast alloy after 500 cycles.The melt-spun alloy showed high pulverization resistance during hydrogen absorption/desorption,and exhibited an excellent cycling retention of 99%after 500 cycles,suggesting that melt-spinning process can enhance the cycle stability and improve the cycle life of the alloy. | Lijun Lv Jian Lin Guo Yang Zhaowei Ma Linhua Xu Xiujie He Xingbo Han Wei Liu | 2022 | Progress in Natural Science:Materials International2022，32，2： | 0 |
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