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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Hydrothermal Synthesized Co-Ni3S2 Ultrathin Nanosheets for Efficient and Enhanced Overall Water Splitting显示文摘We used the one-step hydrothennal controlled synthesis method for Co-Ni3S2 ultrathin nanosheets grown directly on nickel foam(NF).The as-synthesized Co-Ni3S2/NF showed eiilianced activities in the hydrogen evolution reaction(HER),oxygen evolution reaction(OER)and better overall water splitting(OWS)efficiency than the iin-doped Ni3S2/NF.the voltage of Co-Ni3S2/NF for OWS was only 1.58 V at the current density of 10 niA/cm^2 and with long time(>30 h)current output during the current-density(i-t)test.The good i-t pertonnance was also observed in both HER and OER processes.Additionally,the Co-Ni3S2/NF showed a large current density(>1A/cm^2)for both HER and OER.Wlien the current densities reached 100 and 1000 mA/cm^2,the required overpotentials tor Co-Ni3S2/NF were 0.35 and 0.75 V for OER and 0.30 and 0.85 V for HER.Therefore,after introducing Co,the activity of Ni3S2-based material was strongly enhanced. | JIAN Juan YUAN Long LI He LIU Huanhuan ZHANG Xinghui SUN Xuejiao YUAN Hongming FENG Shouhua | 2019 | Chemical Research in Chinese Universities2019，35，2： | 2 |
| 3 | MicroRNA-181b regulates NF-[kappa]B-mediated vascular inflammation显示文摘 | Sun Xinghui Icli Basak Wara Akm Khyrul Belkin Nathan He Shaolin Kobzik Lester Hunninghake Gary M Vera Miguel Pinilla Blackwell Timothy S Baron Rebecca M Feinberg Mark W | 2012 | EN2012，，： | 1 |
| 4 | Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats显示文摘 | Yang Xu Jingye Wang Xinghui Song Ruili Wei Fangping He Guoping Peng Benyan Luo | 2016 | Brain Research Bulletin2016，，： | 1 |
| 5 | Computerized design and simula- tion of meshing of modified double circular - arc helical gears by tooth end relief with helix显示文摘 | Zhang He Hua Lin Han Xinghui | 2009 | Mechanism and Machine Theory2009，45，1： | 1 |
| 6 | Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys显示文摘Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating neural progenitor cells into the diverse types of mature functional spinal cord neurons in vivo is challenging. In this study, engineered human embryonic spinal cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing human neural progenitor cells (hscNPCs) to differentiate into various types of dorsal and ventral neuronal cells on collagen scaffold in vitro. Transplantation of DV-SC into complete SCI models in rats and monkeys showed better therapeutic effects than undifferentiated hscNPCs, including pronounced cell survival and maturation. DV-SC formed a targeted connection with the host’s ascending and descending axons, partially restored interrupted neural circuits, and improved motor evoked potentials and the hindlimb function of animals with SCI. This suggests that the transplantation of pre-differentiated hscNPCs with spinal cord dorsal and ventral neuronal characteristics could be a promising strategy for SCI repair. | Bai Xu Dingyang Liu Weiyuan Liu Ge Long Wenbin Liu Yayu Wu Xinghui He Yeyu Shen Peipei Jiang Man Yin Yongheng Fan He Shen Liyang Shi Qi Zhang Weiwei Xue Chen Jin Zhenni Chen Bing Chen Jiayin Li Yali Hu Xing Li Zhifeng Xiao Yannan Zhao Jianwu Dai | 2023 | Bioactive Materials2023，，9： | 0 |
| 7 | Bipolar electrocoagulation on functional cortex(BCFC)for intractable epilepsy involving eloquent cortex:a review显示文摘Twenty percent to forty percent of patients with epilepsy are medically refractory.For these patients,epilepsy surgeries such as resecting the epileptogenic focus may provide an alternative option.However,when the epileptogenic focus is located in the eloquent cortex,the resection of epileptogenic focus may lead to unacceptable functional deficits.Bipolar electrocoagulation on functional cortex(BCFC)is a surgical technique that holds the same principles with multiple subpial transections(MST)and aims to benefit patients with epilepsy whose epileptogenic zone is located in the eloquent cortex.It uses thermal injury to interrupt the horizontal fibers in the cortex while mechanical injury is used in MST.Here,we reviewed the rationale,surgical procedure,laboratory research,and clinical application of BCFC.We also discussed the ongoing challenges of BCFC. | Xinghui He Guoming Luan | 2018 | Journal of Translational Neuroscience2018，3，1： | 0 |
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