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54篇 您的检索式:作者名="Weiwei Xue"
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1Characteristics of Settings and Etiologic Agents of Foodborne Disease Outbreaks—China,2020显示文摘Introduction:Foodborne diseases are a growing public health problem and have caused a large burden of disease in China.This study analyzed epidemiological characteristics of foodborne diseases in China in 2020 to provide a scientific basis for prevention and control measures.Methods:Data were collected from 30 of 31 provincial-level administrative divisions(PLADs)in the mainland of China,excluding Xizang(Tibet)Autonomous Region,via the National Foodborne Disease Outbreaks Surveillance System・The number and proportion of outbreaks,illnesses,hospitalizations,deaths by setting,pathogen-food category pairs and etiology were calculated.Results:In 2020,7,073 foodborne disease outbreaks were reported,resulting in 37,454 illnesses and 143 deaths.Among the identified pathogens,microbial pathogens were the most common confirmed etiology,accounting for 41.7%of illnesses.Poisonous mushrooms caused the largest proportion of outbreaks(58.0%)and deaths(57.6%).For venues where foodborne disease outbreaks occur,household had the highest number of outbreaks(4,140)and deaths(128),and catering service locations caused the largest proportion of illnesses(59.9%).Outbreaks occurring between June and September accounted for 62.8%of total outbreaks.Conclusions:Foodborne disease outbreaks mainly occurred in households・Microbial pathogens remained the top cause of outbreak-associated illnesses.Poisonous mushrooms were ranked the top cause of deaths in private homes in China.The supervision and management of food safety and health education should be strengthened to reduce the burden of foodborne diseases・Publicity should be increased to reduce the incidence of mushroom poisonings in families,and supervision and management of food should be strengthened to reduce microbial contamination.Hongqiu Li Weiwei Li Yue Dai Yuyan Jiang Junhua Liang Santao Wang Maoqiang Zhuang Zheng Huang Lizi Xu Bo Xue Jikai Liu Haihong Han Sara M.Pires Ping Fu Yunchang Guo 2021China CDC weekly2021,3,42:14
2De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai 2014Cell Research2014,24,11:13
3Testicular defense systems: immune privilege and innate immunity显示文摘因为它显著有免疫力的特权和有效本地天生的免疫的性质,哺乳动物的睾丸拥有特殊免疫学的环境。阴囊的有免疫力的特权保护产生免疫性的细菌房间免受全身的有免疫力的攻击的伤害,并且本地天生的免疫在阻止阴囊的微生物引起的感染是重要的。本地阴囊的有免疫力的动态平衡的故障可以导致睾丸炎,男不孕的一个 etiological 因素。位于阴囊的有免疫力的特权下面的机制很长时间被调查了。增加的证据两个都显示出那本地抑制免疫力的周围和全身的有免疫力的忍耐涉及维持阴囊的有免疫力的特权地位。位于阴囊的天生的免疫下面的机制基于模式识别的调查正在出现在阴囊的房间的调停受体的天生的有免疫力的反应。这评论总结我们阴囊的防卫机制的当前的理解并且鉴别应得的话题推进调查。Shutao Zhao Weiwei Zhu Shepu Xue Daishu Han 2014Cellular & Molecular Immunology2014,11,5:10
4Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize显示文摘Genic male sterility(GMS)is critical for heterosis utilization and hybrid seed production.Although GMS mutants and genes have been studied extensively in plants,it has remained unclear whether chloroplast-associated photosynthetic and metabolic activities are involved in the regulation of anther development.In this study,we characterized the function of ZmMs33/ZmGPAT6,which encodes a member of the glycerol-3-phosphate acyltransferase(GPAT)family that catalyzes the first step of the glycerolipid synthetic pathway.We found that normal structure and function of endothecium(En)chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are crucial for maize anther development.ZmMs33 is expressed mainly in the tapetum at early anther developmental stages and critical for cell proliferation and expansion at late stages.Chloroplasts in En cells of wild-type anthers function as starch storage sites before stage 10 but as photosynthetic factories since stage 10 to enable starch metabolism and carbohydrate supply.Loss of ZmMs33 function inhibits the biosynthesis of glycolipids and phospholipids,which are major components of En chloroplast membranes,and disrupts the development and function of En chloroplasts,resulting in the formation of abnormal En chloroplasts containing numerous starch granules.Further analyses reveal that starch synthesis during the day and starch degradation at night are greatly suppressed in the mutant anthers,leading to carbon starvation and low energy status,as evidenced by low trehalose-6-phosphate content and a reduced ATP/AMP ratio.The energy sensor and inducer of autophagy,SnRK1,was activated to induce early and excessive autophagy,premature PCD,and metabolic reprogramming in tapetal cells,finally arresting the elongation and development of mutant anthers.Taken together,our results not only show that ZmMs33 is required for normal structure and function of En chloroplasts but also reveal that starch metabolism and photosynthetic activities of En chloroplasts at different developmental stages are essential for normal anther development.These findings provide novel insights for understanding how lipid biosynthesis in the tapetum,the structure and function of En chloroplasts,and energy and substance metabolism are coordinated to maintain maize anther development.Taotao Zhu Ziwen Li Xueli An Yan Long Xiaofeng Xue Ke Xie Biao Ma Danfeng Zhang Yijian Guan Canfang Niu Zhenying Dong Quancan Hou Lina Zhao Suowei Wu Jinping Li Weiwei Jin Xiangyuan Wan 2020Molecular Plant2020,13,11:9
5Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China:a decision analysis and implications for practice显示文摘Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.Methods: A decision tree model with three scenarios(low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort(100,000 smokers aged45-80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality(primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables.Results: Among the 100,000 subjects, there were 448,541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively(17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, lowdose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths(relative numbers) with low-dose CT screening in the worst and optimal cases were16(5.4%) and 288(40.2%) over no screening, respectively.Conclusions: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China.However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed.Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang 2017Chinese Journal of Cancer2017,36,8:9
6The Low Energy X-ray telescope (LE) onboard the Insight-HXMT astronomy satellite显示文摘The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical area of 384 cm^2 and an energy band from 0.7 to 13 ke V. In order to evaluate the particle induced X-ray background and the cosmic X-ray background simultaneously, LE adopts collimators to define four types of Field Of Views(FOVs), i.e., 1.6°×6°, 4°×6°, 50°-60°×2°-6 oand the blocked ones which block the X-ray by an aluminum cover. LE is constituted of three detector boxes(LEDs) and an electric control box(LEB) and achieves a good energy resolution of 140 e V@5.9 ke V, an excellent time resolution of 0.98 ms, as well as an extremely low pileup(<1%@18000 cts/s). Detailed performance tests and calibration on the ground have been performed,including energy-channel relation, energy response, detection efficiency and time response.Yong Chen WeiWei Cui Wei Li Juan Wang YuPeng Xu FangJun Lul YuSa Wang TianXiang Chen DaWei Han Wei Hu Yi Zhang Jia Huo YanJi Yang MaoShun Li Bo Lu ZiLiang Zhang TiPei Li ShuangNan Zhang ShaoLin Xiong Shu Zhang RongFeng Xue XiaoFan Zhao Yue Zhu YuXuan Zhu HongWei Liu YiJung Yang Fan Zhang 2020Science China(Physics,Mechanics & Astronomy)2020,63,4:8
7Preparation of an anti-diethylstilbestrol monoclonal antibody and development of an indirect competitive ELISA to detect diethylstilbestrol in biological samples显示文摘Based on the preparation of an anti-diethylstilbestrol(DES) monoclonal antibody,a simple and convenient indirect competitive enzyme-linked immunosorbent assay(ELISA) method for DES detection has been developed.The monoclonal antibody demonstrated high sensitivity to DES with an IC50 value of 275 pg mL-1 and detection limit(LOD) of 90 pg mL-1.The specificity of the assay was studied by measuring cross-reactivity of the antibody with structurally related compounds of ethinyl estradiol(<7%),estrone(<0.1%),estriol(<0.1%),and diethylstilbestrol benzoate(<0.1%).Chicken,fish,shrimp,urine and bile spiked with different concentration of DES were detected by the developed method,and the recovery rates were greater than 79.5%.Intra-and inter-assay variations were about 6%.This method exhibited high stability with a coefficient of variation less than 10% in buffer and in real samples.The LODs in fish/shrimp,liver,feed and urine spiked with DES were 600,600,4800 and 600 pg mL-1,respectively.These results confirmed that the antibody to DES was successfully produced and could be used to establish ELISA methods for DES detection in food producing animals.LI WeiHua MENG Meng HE FangYang WAN YuPing XUE HuYin LIU Wei YIN WeiWei XU Jing FENG CaiWei WANG ShanLiang LU Xiao LIU JinTing XI RiMo 2011Chinese Science Bulletin2011,56,8:4
8Effects of modified Wenjing decoction on microcirculation in reproductive organs in rats with symptom patterns of cold coagulation and blood stasis显示文摘OBJECTIVE: To investigate the relationship between symptom patterns of cold coagulation and blood stasis(CCBS) and microcirculation disturbance. In addition, we determined the efficacy of modified Wenjing decoction(WJD) for the treatment of CCBS.METHODS: CCBS was induced in rats with an icewater bath treatment. The ovarian function, microvascular and circulatory status of reproductive organs, and function of local microvascular endothelial cells(VECs) and vascular smooth muscle cells(VSMCs) were evaluated.RESULTS: Ovarian dysfunction was observed in the rats with CCBS. It was characterized by the presence of an estrous cycle disorder and a decrease in reproductive hormone levels. Microvascular circulation disorders were associated with an imbalance in vasoconstriction, relaxation substances, nitric oxide, abnormal blood flow in whole blood, and decreased blood flow in the auricle and uterus. VECs were damaged, and VSMCs contracted and proliferated in ovarian and uterine tissues.CONCLUSION: Our findings suggest that the dysfunctional reproductive organs observed in gynecological CCBS may be closely related to the microcirculation disturbance of local tissues, microvascular contraction, and vascular remodeling. Modified WJD can be used to treat CCBS by improving microcirculation in reproductive organs.Wang Di Cheng Xiumei Fang Huimin Ren Yanqing Li Xinhua Ren Weiwei Xue Bing Yang Cairui 2020Journal of Traditional Chinese Medicine2020,40,2:4
9An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization显示文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions.Mingkui LI Shaoqing ZHANG Lixin WU Xiaopei LIN Ping CHANG Gohkan DANABASOGLU Zhiqiang WEI Xiaolin YU Huiqin HU Xiaohui MA Weiwei MA Haoran ZHAO Dongning JIA Xin LIU Kai MAO Youwei MA Yingjing JIANG Xue WANG Guangliang LIU Yuhu CHEN 2020Advances in Atmospheric Sciences2020,37,9:4
10中国城市人群低剂量计算机断层扫描筛查肺癌的死亡率结果:决策分析和实践意义显示文摘背景与目的不同低剂量计算机断层扫描(computed tomography,CT)筛查肺癌试验得出的死亡率结果不一致。本研究旨在评价中国城市CT筛查是否能够降低肺癌死亡率,并探讨影响筛查效果的因素。方法建立了3种场景(低剂量CT筛查、胸部X线筛查和无筛查)的决策树模型来比较模拟的中国城市人群(100,000例年龄45–80岁的吸烟者)的筛查结果。从国家登记和流行病学调查中获得了参与者特征数据并估算了肺癌患病比例。根据文献调研选择了低剂量CT和胸部X线筛查的灵敏度和特异度等其他树变量。计算了3种筛查方法间肺癌死亡率(主要结局)、误诊和误诊导致死亡的差异。通过敏感性分析找出了与筛查结果相关的因素,并确定了在变量可能范围内的最差和最优筛查效果。结果 100,000例研究对象中,低剂量CT、胸部X线和无筛查场景分别有448例、541例和591例肺癌死亡(低剂量CT筛查比胸部X线筛查死亡人数减少17.2%,比无筛查减少24.2%)。100,000例研究对象中,2种筛查场景的代价分别为9387例和2497例误诊及7例和2例误诊导致的死亡。低剂量CT筛查比无筛查的死亡数降低,影响最大的因素是筛查人群的肺癌患病比例、低剂量CT的灵敏度和低剂量CT检出肺癌中早期癌的比例。综合了所有可能性,低剂量CT筛查肺癌的死亡人数(相对数)在最坏和最好情况下分别比无筛查降低了16例(5.4%)和288例(40.2%)。结论就死亡率结局而言,我们的研究结果支持在中国城市人群中进行低剂量CT筛查。然而,急需策略来减少误诊和优化纳入标准等重要筛查条件。Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang 2018癌症2018,37,8:3
11Effective Antarctic krill oil extraction using switchable hydrophilicity solvents显示文摘Antarctic krill has been widely studied because of its abundant biomass,rich nutritional value,and great production potential.Notably,krill oil(KO)is rich in phospholipids(PLs),polyunsaturated fatty acids(PUFAs),and astaxanthin.A method based on a green switchable hydrophilicity solvent N,7V-dimethyIcyclohexylamine(DMCHA),which can reversibly change from oil soluble to water soluble in the presence of CO2 was used to extract KO from frozen Antarctic krill as it consumes less energy than traditional methods.We showed that DMCHA destroyed the surface structure of Antarctic krill and accelerated the dissolution of KO.In addition,this method enabled the PL extraction to reach up to 80.2%of total PLs,among which PC accounted for the highest proportion,up to 90.91%in PL.In fact,the astaxanthin extraction reached up to 81.44%of total astaxanthin while the fatty acid(FA)extraction up to 84.35%.The KO extracted through DMCHA was rich in PUFA,up to 47.74%,and the content of EPA+DHA reached 42.16%of total FA content.Furthermore,the amount of residual solvent in the lipid phase was just 0.23%of the DMCHA used for the extraction and the recovery rate of solvent was up to 93.2%.Our results demonstrated the high efficiency of oil extraction and the environmental friendliness of this method.Weiwei Sun Wencan Hua Bowen Shi Changhu Xue Xiaoming Jiang 2020Marine Life Science & Technology2020,2,1:3
12Anaerobic biodegradation,physical and structural properties of normal and high-amylose maize starch films显示文摘Biodegradable plastics have attracted considerable attention in recent years due to their biodegradability,biocompatibility and non-toxicity.In this study,normal maize starch(containing 25%amylose)and high-amylose maize starch(containing 80%amylose)were served as model materials to prepare starch/polyvinyl alcohol(PVA)blends.To comprehensively study the effects of amylose contents on the film performances,the mechanical properties,water resistance and anaerobic biodegradability of the two films were examined.Moreover,the processes of anaerobic degradation were investigated by evolutions of biogas production,pH in reactors and the changes of film structures and compositions.The results indicated that amylose content played an important role in the microstructures of starch film as well as mechanical properties and water resistance,whereas it had no significant influence on anaerobic biodegradability of the films.Nonetheless,the structure of high-amylose maize starch/PVA film was more suitable and beneficial to the anaerobic biodegradation than that of the normal maize starch/PVA film,because it could effectively avoid accumulation of volatile fatty acids,which contributed to the stable biogas production,short fermentation period and non-souring in the reactor.Liu Weiwei Xue Juan Cheng Beijiu Zhu Suwen Ma Qing Ma Huan 2016International Journal of Agricultural and Biological Engineering2016,9,5:3
13Pt/Mo2C heteronanosheets for superior hydrogen evolution reaction显示文摘One of the most primary challenges to achieve large-scale hydrogen generation from water electrolysis is the sluggish kinetics and noble metal dependence of cathodic hydrogen evolution reaction(HER).By considering the excellent water dissociation catalytic activity of Mo2C, abundant Pt/Mo2C interfaces were facilely engineered via galvanic replacement(gr) by using Mo/Mo2C nanosheets as self-sacrificed templates to alter the alkaline HER mechanism on Pt based catalyst. The rational designed interface-rich gr-Pt/Mo2C catalyst exhibited excellent activity with the overpotential to drive 10 mA/cm2 current density decreased by 18.5 mV compared with the commercial Pt/C catalyst. 34.3 mV/dec Tafel slope confirms the Volmer-Tafel HER route on gr-Pt/Mo2C in alkaline condition. Platinum utilization is calculated to be improved by 9.7 times by considered the low Pt loading in the gr-Pt/Mo2C catalyst. With its satisfied stability, the scalable gr-Pt/Mo2C catalyst shows promising application potential in industrial electrolysis systems.Zhao Liu Jing Li Shiji Xue Shunfa Zhou Konggang Qu Ying Li Weiwei Cai 2020Journal of Energy Chemistry2020,29,8:2
14Changes in Growth, Carbon and Nitrogen Enzyme Activity and mRNA Accumulation in the Halophilic Microalga Dunaliella viridis in Response to NaCl Stress显示文摘Many species of microalga Dunaliella exhibit a remarkable tolerance to salinity and are therefore ideal for probing the effects of salinity. In this work, we assessed the effects of NaCl stress on the growth, activity and m RNA level of carbon and nitrogen metabolism enzymes of D. viridis. The alga could grow over a salinity range of 0.44 mol L^(-1) to 3.00 mol L^(-1) NaCl, but the most rapid growth was observed at 1.00 mol L^(-1) NaCl, followed by 2.00 mol L^(-1) NaCl. Paralleling these growth patterns, the highest initial and total Rubisco activities were detected in the presence of 1.00 mol L^(-1) NaCl, decreasing to 37.33% and 26.39% of those values, respectively, in the presence of 3.00 mol L^(-1) Na Cl, respectively. However, the highest extracellular carbonic anhydrase(CA) activity was measured in the presence of 2.00 mol L^(-1) NaCl, followed by 1.00 mol L^(-1) NaCl. Different from the two carbon enzymes, nitrate reductase(NR) activity showed a slight change under different NaCl concentrations. At the transcriptional level, the m RNAs of Rubisco large subunit(rbcL), and small subunit(rbc S), attained their highest abundances in the presence of 1.00 and 2.00 mol L^(-1)NaCl, respectively. The CA mRNA accumulation was induced from 0.44 mol L^(-1) to 3.00 mol L^(-1) NaCl, but the NR m RNA showed the decreasing tendency with the increasing salinity. In conclusion, the growth and carbon fixation enzyme of Rubisco displayed similar tendency in response to NaCl stress, CA was proved be salt-inducible within a certain salinity range and NR showed the least effect by NaCl in D. viridis.WANG Dongmei WANG Weiwei XU Nianjun SUN Xue 2016Journal of Ocean University of China2016,15,6:1
15Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro显示文摘WeiWei Lin Xue Chen XiaoDong Wang Jie Liu XiaoSong Gu 2008In Vitro Cellular & Developmental Biology - Animal (-)2008,,1:1
16Profile inference on partially linear varying-coefficient errors-in-variables models under restricted condition 显示文摘ZHANG Weiwei LI Gaorong XUE Liugen 2011Computational Statistics & Data Analysis2011,55,:1
17Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer显示文摘Chemokine-like factor super family(CKLFSF)is a gene family reported in 2003.In humans,the family is composed of nine members,namely chemokine-like factor(CKLF)and CKLF-like MARVEL transmembrane domain-containing member 1-8(CMTM1-8)[1].Genes in the CMTM family have different spliceosomes,which code for MAL-related proteins for vesicle trafficking and membrane link domain(MARVEL).Studies have shown that molecules containing this domain play important physiological and pathological roles in protein transport[2].Hui Xue Bin Qiu Hao Wang Ping Jiang Weiwei Zhang Lixiang Xue Junjie Wang 2022Acta Biochimica et Biophysica Sinica2022,54,8:1
18Synthesis, Biological Activity Evaluation and Molecular Modeling Study on the New Isoconessimine Derivatives as Acetylcholinesterase Inhibitors显示文摘新 isoconessimine 衍生物从 conessine (1 ) 被综合并且作为 acetylcholinesterase (疼痛) 评估了禁止者。衍生物经由二反应步, N-demethylation 和亲核的替换被准备。所有比 conessine (1 ) 综合衍生物展出了更潜在的 anti-acetylcholinesterase 活动(IC50=16 ???? 作吗??Guofei Jin Zhongduo Yang Weiwei Xue Jie Sheng Yin Shi Xiaojun Yao 2013Chinese Journal of Chemistry2013,31,9:1
19Experimental investigation of the stimulated Brillouin scattering fiber optic gyros显示文摘Yan Fengping Wu Jianbo Xue Weiwei 2004SPIE2004,5279,:1
20Profile inference on partially linear varying-coefficient errors-in-variables models under restricted condition显示文摘Weiwei Zhang Gaorong Li Liugen Xue 2011Computational Statistics and Data Analysis2011,,11:1
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