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| 1 | Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy显示文摘The prevalence of skin cancer is rising along with the rapid population aging in recent years.Traditional therapies,such as surgical treatment,radiotherapy,chemotherapy,photodynamic therapy,and immunotherapy,may accompany serious side effects,limiting their clinical benefits.According to the biological characteristics of skin cancer,we have already established two kinds of synergetic systems of photothermal therapy(microneedle)and chemotherapy,containing gold nanorods(GNR).Although the microneedle system exhibited great potential for skin cancer treatment,the system could be still improved further.So,we designed a near-infrared lightresponsive 5-fluorouracil(5-Fu)and indocyanine green(ICG)loaded monomethoxy-poly(ethylene glycol)-polycaprolactone(MPEG-PCL)nanoparticle(5-Fu-ICG-MPEG-PCL),and then 5-Fu-ICG-MPEG-PCL was integrated with a hyaluronic acid dissolvable microneedle system(HA MN)to get 5-Fu-ICG-MPEG-PCL loaded HA MN for treating skin cancers,including human epidermoid cancer and melanoma.In this system,hyaluronic acid,the microneedle carrier,possesses good skin penetration ability and is approved by FDA as a pharmaceutical adjuvant;5-Fu is recommended by FDA for skin cancer treatment;ICG,a photothermal agent,possesses a strong photothermal ability and is approved by FDA for its use in the human body.We hypothesized that 5-Fu-ICG-MPEG-PCL could be delivered by the dissolvable microneedle through the skin,and the release behavior of the drug in the nanoparticle could be controlled by near-infrared light for achieving a single-dose cure of skin cancer,improving the cure rate of skin cancer and providing a new idea and possibility for the clinical treatment of skin cancer. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2020 | Bioactive Materials2020，5，3： | 17 |
| 2 | A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS_1 in Arabidopsis显示文摘DNA methylation is typically regarded as a repressive epigenetic marker for gene expression.Genome-wide DNA methylation patterns in plants are dynamically regulated by the opposing activities of DNA methylation and demethylation reactions. In Arabidopsis, a DNA methylation monitoring sequence(MEMS) in the promoter of the DNA demethylase gene ROS_1 functions as a methylstat that senses these opposing activities and regulates genome DNA methylation levels by adjusting ROS_1 expression. How DNA methylation in the MEMS region promotes ROS_1 expression is not known. Here, we show that several Su(var)3-9 homologs(SUVHs) can sense DNA methylation levels at the MEMS region and function redundantly to promote ROS_1 expression. The SUVHs bind to the MEMS region, and the extent of binding is correlated with the methylation level of the MEMS.Mutations in the SUVHs lead to decreased ROS_1 expression, causing DNA hypermethylation at more than 1,000 genomic regions. Thus, the SUVHs function to mediate the activation of gene transcription by DNA methylation. | Xinlong Xiao Jieqiong Zhang Tao Li Xing Fu Viswanathan Satheesh Qingfeng Niu Zhaobo Lang Jian-Kang Zhu Mingguang Lei | 2019 | Journal of Integrative Plant Biology2019，61，2： | 11 |
| 3 | A fast and accurate initial alignment method for strapdown inertial navigation system on stationary base显示文摘In this work,a fast an d accurate stationary alignment method for strapdown inertial navigation system (SINS) is proposed.It h as been demonstrated that the stationary alignment o f SINS can be improved by employing the multipositio n technique,but the alignment time of the azimuth error is relatively longer.Over here,the two-posi tion alignment principle is presented.On the basis of this SINS error model,a fast estimation algorithm of the azimuth error for the initial a lignment of SINS on stationary base is derived f ully from the horizontal velocity outputs and the output rates,and the novel azimuth error estimatio n algorithm is used for the two-position alignment. Consequently,the speed and accuracy of the SINS’ s initial alignment is enhanced greatly.The computer simulation results illustrate the efficiency of this alignment method. | Xinlong WANG Gongxun SHEN | 2005 | 控制理论与应用(英文版)2005，3，2： | 11 |
| 4 | New normalized LMS adaptive filter with a variable regularization factor显示文摘A new normalized least mean square(NLMS) adaptive filter is first derived from a cost function, which incorporates the conventional one of the NLMS with a minimum-disturbance(MD)constraint. A variable regularization factor(RF) is then employed to control the contribution made by the MD constraint in the cost function. Analysis results show that the RF can be taken as a combination of the step size and regularization parameter in the conventional NLMS. This implies that these parameters can be jointly controlled by simply tuning the RF as the proposed algorithm does. It also demonstrates that the RF can accelerate the convergence rate of the proposed algorithm and its optimal value can be obtained by minimizing the squared noise-free posteriori error. A method for automatically determining the value of the RF is also presented, which is free of any prior knowledge of the noise. While simulation results verify the analytical ones, it is also illustrated that the performance of the proposed algorithm is superior to the state-of-art ones in both the steady-state misalignment and the convergence rate. A novel algorithm is proposed to solve some problems. Simulation results show the effectiveness of the proposed algorithm. | LI Zhoufan LI Dan XU Xinlong ZHANG Jianqiu | 2019 | Journal of Systems Engineering and Electronics2019，30，2： | 9 |
| 5 | DEGREE OF APPROXIMATION ASSOCIATED WITH SOME ELLIPTIC OPERATORS AND ITS APPLICATIONS显示文摘The Jackson-type estimates by using some elliptic operators will be achieved. These results will be used to characterize the regularity of some elliptic operators by means of the approximation degree and the saturation class of the multivariate Bernstein operators as well. | Xinlong Zhou(University of Duisburg, Germany) | 1995 | Analysis in Theory and Applications1995，11，2： | 8 |
| 6 | One-step synthesis of basic magnesium sulfate whiskers by atmospheric pressure reflux显示文摘 | Xinlong Ma Guoqing Ning Chuanlei Qi Jinsen Gao | 2016 | Particuology2016，14，1： | 7 |
| 7 | Mechanism and kinetics study on removal of Iron from phosphoric acid by cation exchange resin显示文摘Iron element is one of the main impurities in wet-process phosphoric acid and it has a significant impact on the subsequent phosphorus chemical products. This paper studied the feasibility of using Sinco-430 cation exchange resin for iron removal from phosphoric acid. The specific surface area and the total exchange capacity of resin were 8.91 m2·g-1 and 5.18 mmol·g-1, respectively. The sorption mechanism was determined by FTIR and XPS and the results indicated that iron was combined with-SO3 H in resin. The removal process was studied as a function of temperature, H3 PO4 content and mass ratio between resin and solution. The unit mass of resin to remove iron was 0.058 g·g-1 resin when the operating parameters were T = 50 ℃, H3 PO4 content = 27.61 wt%and S/L = 0.1, respectively. Kinetics study demonstrated that pseudo-second-order reaction model fits this study best and the calculated activation energy of overall reaction is 29.10 kJ·mol-1. The overall reaction process was mainly controlled by pore diffusion. | Xinke Leng Yanjun Zhong Dehua Xu Xinlong Wang Lin Yang | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 7 |
| 8 | Preparation of SiO_2/TiO_2 Janus particles by electrostatic assembly,hydrolysis and calcination显示文摘This paper describes a novel chemical method for preparing SiO_2/TiO_2 Janus particles.First,polystyrene(PSt)/SiO_2 particles with a raspberry-like structure are prepared by electrostatic assembly.The influences of the reaction time of sulfonation and the treatment times of polyelectrolyte solutions(PDADMAC,PSS)on PSt and SiO_2 are investigated with respect to the surface charge density of the particles.SiO_2/TiO_2 Janus particles are then obtained by hydrolysis of butyl titanate on the surface of PSt/SiO_2 particles followed by a calcination process.Particle size analyzer,Zeta potential instrument,FTIR,TEM and SEM are used to characterize the particle size,the amount of charge on the surface of PSt and SiO_2 particles and the compositions and morphologies of PSt/SiO_2,SiO_2/TiO_2 and PSt/SiO_2/TiO_2.The diameters of the PSt,SiO_2,PSt/SiO_2 and SiO_2/TiO_2 particles are 2.0 μm,303 nm,2.7 μm and 330nm,respectively. | Baoliang Zhang Qiuyu Zhang Hepeng Zhang Xinlong Fan Dezhong Yin Xiangjie Li Wei Li | 2013 | Particuology2013，11，5： | 6 |
| 9 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 10 | 抗高血压药与骨质疏松症显示文摘骨质疏松症和高血压有共同的发病高危因素和病理生理机制,多见于老年人群。对于患者个体而言,二者往往同时存在。因此在进行抗高血压治疗的同时,有必要考虑抗高血压药物对骨密度和脆性骨折发生的影响。目前文献证实,除了袢利尿剂对骨量有负性作用外,噻嗪类利尿剂、血管紧张素转化酶抑制剂(ACEI)和血管紧张素II受体阻滞剂(ARB)、β受体阻滞剂和钙离子通道阻滞剂似乎都有一定骨保护作用,可增加骨密度和强度,降低骨质疏松骨折的发生几率。但尚需要双盲随机对照的临床试验和更多基础实验室证据支持骨质疏松症和高血压的相关性及抗高血压药物缓解骨丢失的作用。 | 王烨明 MA Xinlong | 2016 | 中国骨质疏松杂志2016，22，9： | 6 |
| 11 | Biomechanical properties of acellular sciatic nerves treated with a modified chemical method显示文摘Nerve grafts are able to adapt to surrounding biomechanical environments if the nerve graft itself exhibits appropriate biomechanical properties (load, elastic modulus, etc.). The present study was designed to determine the differences in biomechanical properties between fresh and chemically acellularized sciatic nerve grafts. Two different chemical methods were used to establish acellular nerve grafts. The nerve was chemically extracted in the Sondell method with a combination of Triton X-100 (nonionic detergent) and sodium deoxycholate (anionic detergent), and in the modified method with a combination of Triton X-200 (anionic detergent), sulfobetaine-10 (SB-10, amphoteric detergents), and sulfobetaine-16 (SB-16, amphoteric detergents). Following acellularization, hematoxylin-eosin staining and scanning electron microscopy demonstrated that the effect of acellularization via the modified method was similar to the traditional Sondell method. However, effects of demyelination and nerve fiber tube integrity were superior to the traditional Sondell method. Biomechanical testing showed that peripheral nerve graft treated using the chemical method resulted in decreased biomechanical properties (ultimate load, ultimate stress, ultimate strain, and mechanical work to fracture) compared with fresh nerves, but the differences had no statistical significance (P > 0.05). These results demonstrated no significant effect on biomechanical properties of nerves treated using the chemical method. In conclusion, nerve grafts treated via the modified method removed Schwann cells, preserved neural structures, and ensured biomechanical properties of the nerve graft, which could be more appropriate for implantation studies. | Xinlong Ma Zhao Yang Xiaolei Sun Jianxiong Ma Xiulan Li Zhenzhen Yuan Yang Zhang Honggang Guo | 2011 | Neural Regeneration Research2011，6，4： | 6 |
| 12 | Adhesion Characteristics of a Novel Synthetic Polydimethylsiloxane for Bionic Adhesive Pads显示文摘 | Qingsong He Min Yu Yang Li Xinlong Chen Hao Zhang Ling Gong Zhendong Dai | 2014 | Journal of Bionic Engineering2014，11，3： | 6 |
| 13 | Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction显示文摘The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER. | Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 14 | Analysis of structural components of decellularized scaffolds in renal fibrosis显示文摘Chronic kidney disease has been recognized as a major public health problem worldwide and renal fibrosis is a common pathological process occurring in chronic renal failure.It is very promising to find the strategies to slow or even prevent the progression of fibrosis.This study focused on whether renal fibrosis decellularized scaffolds has the potential to be a model of cellular mechanisms of tissue fibrosis or donors for tissue engineering.In order to evaluate the feasibility of decellularized scaffolds derived from pathological kidneys,histology,proteomics and ELISA will be used to analysis the changes in the structure and main components of fibrotic tissue.The fibrosis model in this paper was induced by adenine-fed and the results showed that the structure of fibrotic scaffold was changed and some protein were up-regulated or down-regulated,but the cytokines associated with renal regeneration after injury were remained.In cell experiments,endothelial progenitor cells proliferated well,which proved that the fibrotic scaffolds have non-cytotoxic.All these conclusions indicate that the renal fibrosis decellularized scaffolds model has the ability to study fibrosis mechanism and the potential to be engineering donors as well as normal scaffolds. | Rui Zhang Junqun Jiang Yaling Yu Fangfang Wang Niuniu Gao Yingjie Zhou Xinlong Wan Zhibin Wang Peng Wei Jin Mei | 2021 | Bioactive Materials2021，6，7： | 5 |
| 15 | Multistage analysis method for detection of effective herb prescription from clinical data显示文摘为特定的疾病条件或特别的耐心的组决定有效繁体中文药(TCM ) 治疗是因为复杂个性化的表明,在真实世界的病人和在临床的背景规定的个性化的联合治疗要求调查的一个困难的问题。在这研究,集成倾向大小写匹配的一个多级式的分析方法,复杂网络分析,和植物给了丰富分析被建议为特别疾病识别有效植物药方(例如,失眠) 。首先,匹配的倾向大小写被使用匹配临床的盒子。然后,核心网络抽取和植物集合丰富被联合检测核心有效植物药方。基于有效性的相互的信息被用来检测强壮的 herbsymptom 关系。这个方法在一个 TCM 临床的数据集合上被使用, 955 个病人从设计得好的观察研究收集了。结果与更高的有效性率揭示了那组植物药方(76.9% 对 42.8% 为匹配的样品;94.2% 对 84.9% 为所有样品) 与原版相比,药方被发现。有症状表明的特别的耐心的组也被识别帮助调查有效植物药方的指示。 | Kuo Yang Runshun Zhang Liyun He Yubing Li Wenwen Liu Changhe Yu Yanhong Zhang Xinlong Li Yan Liu Weiming Xu Xuezhong Zhou Baoyan Liu | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 16 | CHARACTERIZATION OF COVERGENT SUBDIVISION SCHEMES显示文摘Subdivision schemes provide important techniques for the fast generationof curves and surfaces.A recusive refinement of a given control polygonwill lead in the limit to a desired visually smooth object.These methodsplay also an important role in wavelet analysis.In this paper,we use arather simple way to characterize the convergence of subdivision schemesfor multivariate cases.The results will be used to investigate the regularityof the solutions for dilation equations. | Zhou Xinlong (University of Duisburg,Germang) | 1998 | Analysis in Theory and Applications1998，14，3： | 4 |
| 17 | Broadband terahertz wave generation from an epsilon-near-zero material显示文摘Broadband light sources emitting in the terahertz spectral range are highly desired for applications such as noninvasive imaging and spectroscopy.Conventionally,THz pulses are generated by optical rectification in bulk nonlinear crystals with millimetre thickness,with the bandwidth limited by the phase-matching condition.Here we demonstrate broadband THz emission via surface optical rectification from a simple,commercially available 19nmthick indium tin oxide(ITO)thin film.We show an enhancement of the generated THz signal when the pump laser is tuned around the epsilon-near-zero(ENZ)region of ITO due to the pump laser field enhancement associated with the ENZ effect.The bandwidth of the THz signal generated from the ITO film can be over 3 THz,unrestricted by the phasematching condition.This work offers a new possibility for broadband THz generation in a subwavelength thin film made of an ENZ material,with emerging physics not found in existing nonlinear crystals. | Wenhe Jia Meng Liu Yongchang Lu Xi Feng Qingwei Wang Xueqian Zhang Yibo Ni Futai Hu Mali Gong Xinlong Xu Yuanyuan Huang Weili Zhang Yuanmu Yang Jiaguang Han | 2021 | Light(Science & Applications)2021，10，1： | 4 |
| 18 | Relationship Between Soil and Water Conservation Practices and Soil Conditions in Low Mountain and Hilly Region of Northeast China显示文摘The soil and water conservation practices of ecological restoration(ER),fish scale pit(FP),furrow and ridge tillage across the slope(FR),shrub strips(SS),and vegetation-covered ridge(VR)are characteristic of the Jixing small watershed of the low mountain and hilly region of Jilin Province,Northeast China.This study aims to elucidate the effects of soil and water conservation practices on soil conditions after the short-term implementation of practices.Soil samples were collected from five soil and water conservation sites(ER,FP,FR,SS,and VR)and two controls(BL and CT)to investigate their properties.To evaluate the influence of soil and water conservation practices on soil quality,an integrated quantitative index,soil quality index(QI),was developed to compare the soil quality under the different soil and water conservation practices.The results show that not all soil and water conservation practices can improve the soil conditions and not all soil properties,especially soil organic carbon(SOC),can be recovered under soil and water conservation practice in short-term.Moreover,the QI in the five soil and water conservation practices and two controls was in the following order:ER>VR>BL>FR>CT>SS>FP.ER exhibited a higher soil quality value on a slope scale.In the low mountain and hilly region of Northeast China,ER is a better choice than the conversion of farmlands to planted grasslands and woodlands early in the soil and water conservation program. | ZHANG Yubin CAO Ning XU Xiaohong ZHANG Feng YAN Fei ZHANG Xinsheng TANG Xinlong | 2014 | Chinese Geographical Science2014，24，2： | 4 |
| 19 | Efficient CO_2 capture on low-cost silica gel modified by polyethyleneimine显示文摘In this work,a series of polyethyleneimine(PEI) functionalized commercial silica gel were prepared by wet impregnation method and used as CO 2 sorbent.The as-prepared sorbents were characterized by N 2 adsorption,FT-IR and SEM techniques.CO 2 capture was tested in a fixed bed reactor using a simulated flue gas containing 15.1% CO 2 in a temperature range of 25-100 C.The effects of sorption temperature and amine content on CO 2 uptake of the adsorbents were investigated.The silica gel with a 30 wt% PEI loading manifested the largest CO 2 uptake of 93.4 mg CO 2 /g adsorbent(equal to 311.3 mg CO 2 /g PEI) among the tested sorbents under the conditions of 15.1%(v/v) CO 2 in N 2 at 75 C and atmospheric pressure.Moreover,it was rather low-cost.In addition,the PEI-impregnated silica gel exhibited stable adsorption-desorption behavior during 5 consecutive test cycles.These results suggest that the PEI-impregnated silica gel is a promising and cost-effective sorbent for CO 2 capture from flue gas and other stationary sources with low CO 2 concentration. | Ke Wang Hongyan Shang Lin Li Xinlong Yan Zifeng Yan Chenguang Liu Qingfang Zha | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 4 |
| 20 | Expression,structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep(Ovis aries)显示文摘Background:JUNO and IZUMO1 are the first receptor-ligand protein pairs discovered to be essential for spermoocyte fusion;their interaction is indispensable for fertilization.Methods:PCR was used to clone the full-length DNA sequence of the Juno gene in sheep.The single nucleotide polymorphism(SNP)loci of Juno were genotyped by Sequenom MassARRAY®.PCR combined with rapid amplification of cDNA Ends were used to clone the full-length cDNA sequence of Juno and Izumo1.Reverse transcriptase-PCR(RT-PCR)and real time-quantitative-PCR(RT-qPCR)were used to analyze the genes’expression in tissues of sheep,and single cell RNA-seq was used to analyze the genes’expression in oocytes,granulosa cells and follicular theca of polytocous and monotocous Small Tail Han ewes.Bioinformatics was used to analyze advanced structure and phylogeny of JUNO and IZUMO1 proteins.Results:The full-length DNA sequence of the Juno gene in sheep was cloned and nine SNPs were screened.We found a significant association between the g.848253 C>A locus of Juno and litter size of Small Tail Han sheep(P<0.05).The full-length cDNA sequence of Juno and Izumo1 genes from Small Tail Han sheep were obtained.We found a new segment of the Izumo1 CDS consisting of 35 bp,and we confirmed the Izumo1 gene has 9 exons,not 8.RT-qPCR showed that Juno and Izumo1 genes were highly expressed in ovarian and testicular tissues,respectively(P<0.01).Single cell RNA-seq showed Juno was specifically expressed in oocytes,but not in granulosa cells or follicular theca,while Izumo1 displayed little to no expression in all three cell types.There was no difference in expression of the Juno gene in oocyte and ovarian tissue in sheep with different litter sizes,indicating expression of Juno is not related to litter size traits.Bioinformatic analysis revealed the g.848253 C>A locus of Juno results in a nonconservative missense point mutation leading to a change from Phe to Leu at position 219 in the amino acid sequence.Conclusions:For the first time,this study systematically analyzed the expression,structure and function of Juno and Izumo1 genes and their encoded proteins in Small Tail Han sheep,providing the basis for future studies of the regulatory mechanisms of Juno and Izumo1 genes. | Wenping Hu Xinlong Dong Zhilong Tian Zhuangbiao Zhang Jishun Tang Benmeng Liang Qiuyue Liu Mingxing Chu | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 3 |
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