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| 1 | The preparation and characterization of folate-conjugated human serum albumin magnetic cisplatin nanoparticles显示文摘Objective:Nanoparticles are becoming an important method of targeted drug delivery.To evaluate the importance of folate-conjugated human serum albumin(HSA)magnetic nanoparticles(Folate-CDDP/HSA MNP),we prepared drug-loaded Folate-CDDP/HSA MNPs and characterized their features.Methods:First, folate was conjugated with HSA under the effect of a condensing agent,and the conjugating rate was evaluated by a colorimetric method using 2,4,6-trinitrobenzene sulfonic acid.Second,under N 2 gas,Fe 3 O 4 magnetic nanomaterials were prepared and characterized by using transmission electron microscopy(TEM),SEM-EDS and X-ray diffraction(XRD).Finally,Folate-CDDP/HSA MNP was prepared by using a solvent evaporation technique. TEM was used to observe particle morphology.The particle size and distribution of the prepared complexes were determined by a Laser particle size analyzer.Drug loading volume and drug release were investigated by a high performance liquid chromatography method(HPLC)in vitro.Results:We successfully prepared folate-conjugated HSA and its conjugating rate was 27.26μg/mg.Under TEM,Fe 3 O 4 magnetic nanoparticles were highly electron density and had an even size distribution in the range of 10-20 nm.It was confirmed by SEM-EDS and XRD that Fe 3 O 4 magnetic nanoparticles had been successfully prepared.Under TEM,drug-loaded magnetic nanoparticles were observed,which had a round shape,similar uniform size and smooth surface.Their average size was 79 nm which was determined by laser scattering,and they exhibited magnetic responsiveness.Encapsulation efficiency was 89.75%and effective drug loading was calculated to be 15.25%.The release results in vitro showed that the half release time(t1/ 2 )of cisplatin in cisplatin Solution and Folate-CDDP/HSA MNP was 65 min and 24 h respectively, which indicated that microspheres had an obvious effect of sustained-release.Conclusion:Folate-CDDP/HSA MNPs were prepared successfully.The preparation process and related characteristics data provided a foundation for further study,including the mechanism of the nanoparticles distribution in vivo and their intake by tumor cells. | Daozhen Chen Qiusha Tang Wenqun Xue Jingying Xiang Li Zhang Xinru Wang | 2010 | The Journal of Biomedical Research2010，24，1： | 13 |
| 2 | RO_(x) Budgets and O_(3) Formation during Summertime at Xianghe Suburban Site in the North China Plain显示文摘Photochemical smog characterized by high concentrations of ozone(O_(3)) is a serious air pollution issue in the North China Plain(NCP)region,especially in summer and autumn.For this study,measurements of O_(3),nitrogen oxides(NO_(x)),volatile organic compounds(VOCs),carbon monoxide(CO),nitrous acid(HONO),and a number of key physical parameters were taken at a suburban site,Xianghe,in the NCP region during the summer of 2018 in order to better understand the photochemical processes leading to O_(3)formation and find an optimal way to control O_(3)pollution.Here,the radical chemistry and O_(3)photochemical budget based on measurement data from 1−23 July using a chemical box model is investigated.The daytime(0600−1800 LST)average production rate of the primary radicals referred to as RO_(x)(OH+HO2+RO2)is 3.9 ppbv h−1.HONO photolysis is the largest primary RO_(x)source(41%).Reaction of NO2+OH is the largest contributor to radical termination(41%),followed by reactions of RO2+NO2(26%).The average diurnal maximum O_(3)production and loss rates are 32.9 ppbv h−1 and 4.3 ppbv h−1,respectively.Sensitivity tests without the HONO constraint lead to decreases in daytime average primary RO_(x)production by 55%and O_(3)photochemical production by 42%,highlighting the importance of accurate HONO measurements when quantifying the RO_(x)budget and O_(3)photochemical production.Considering heterogeneous reactions of trace gases and radicals on aerosols,aerosol uptake of HO2 contributes 11%to RO_(x)sink,and the daytime average O_(3)photochemical production decreases by 14%.The O_(3)-NO_(x)-VOCs sensitivity shows that the O_(3)production at Xianghe during the investigation period is mainly controlled by VOCs. | Min XUE Jianzhong MA Guiqian TANG Shengrui TONG Bo HU Xinran ZHANG Xinru LI Yuesi WANG | 2021 | Advances in Atmospheric Sciences2021，38，7： | 2 |
| 3 | Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics显示文摘Effective cancer treatment puts high demands for cancer theranostics.For cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent.Briefly,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable nanoagent.The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT bioimaging.The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo.And the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side effects.Both of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely biodegradable.Overall,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. | Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang Zhouyi Guo Jun Wu | 2021 | Bioactive Materials2021，6，3： | 1 |
| 4 | Clinical practice guideline for body composition assessment based on upper abdominal magnetic resonance images annotated using artificial intelligence显示文摘Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed. | Han Lv Mengyi Li Zhenchang Wang Dawei Yang Hui Xu Juan Li Yang Liu Di Cao Yawen Liu Xinru Wu He Jin Peng Zhang Liqin Zhao Rixing Bai Yunlong Yue Bin Li Nengwei Zhang Mingzhu Zou Jinghai Song Weibin Yu Pin Zhang Weijun Tang Qiyuan Yao Liheng Liu Hui Yang Zhenghan Yang Zhongtao Zhang National Clinical Research Center for Digestive Diseases in Beijing Friendship Hospital,Capital Medical University Beijing Quality Control and Improvement Center of Medical Imaging National Health Commission Capacity Building and Continuing Education Center,Chinese College of Metabolic and Bariatric Surgeons Beijing Quality Control and Improvement Center of Metabolic and Bariatric Surgery | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 5 | CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity显示文摘Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation.Mechanisms underlying antipsychotics cardiotoxicity remain largely unknown.Herein we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics cardiotoxicity.Pyroptosis-based small-molecule compound screen identified cannabinoid receptor 1(CB1R)as an upstream regulator of the NLRP3 inflammasome.Mechanistically,antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm,where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177–209,rendering stabilization of the inflammasome.Knockout of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and cardiotoxicity.Multi-organ-based investigation revealed no additional toxicity of newer CB1R antagonists.In authentic human cases,the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced cardiotoxicity.These results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and smallmolecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics. | Liliang Li Pan Gao Xinru Tang Zheng Liu Mengying Cao Ruoyu Luo Xiaoqing Li Jing Wang Xinyi Lin Chao Peng Zhihong Li Jianhua Zhang Xian Zhang Zhonglian Cao Yunzeng Zou Li Jin | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 6 | Metal-organic frameworks-derived metal phosphides for electrochemistry application显示文摘Metal-organic frameworks(MOFs)with high porosity and variable structure have attracted extensive attention in the field of electrochemistry,but their poor conductivity and stability have limited their development.Materials derived from MOFs can maintain the structural diversity and porosity characteristics of MOFs while improving their electrical conductivity and stability.Metal phosphides play an important role in electrochemistry because they possess rich active sites,unique physicochemical properties,and a porous structure.Published results show that MOF-derived metal-phosphides materials have great promise in the field of electrochemistry due to their controllable structure,high specific surface area,high stability and excellent electrical conductivity.MOF-derived metal-phosphides with significant electrochemical properties can be obtained by simply,economical and scalable synthetic methods.This work reviews the application of MOF-derived metal phosphides in electrochemistry.Specifically,the synthesis methodology and morphological characterization of MOFs derived metal-phosphides and their application in electrochemistry are described.Based on recent scientific advances,we discuss the challenges and opportunities for future research on MOF-derived metal-phosphides materials. | Xinru Tang Nan Li Huan Pang | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 7 | Time-series surface water reconstruction method(TSWR)based on spatial distance relationship of multi-stage water boundaries显示文摘Spatiotemporal continuity of surface water datasets widely known for its significance in the surface water dynamic monitoring and assessments,are faced with drawbacks like cloud influence,which hinders the direct extraction of data from time-series remote sensing images.This study proposes a Time-series Surface Water Reconstruction method(TSWR).The initial stage of this method involves the effective use of remote sensing images to automatically construct multi-stage surface water boundaries based on Google Earth Engine(GEE).Then,we reconstructed regions the reconstruction of regions with missing water pixels using the distance relationship between the multi-stage water boundaries in previous and later periods.When applied to 10 large rivers around the world,this method yielded an overall accuracy of 98%for water extraction,an RMSE of 0.41 km2.Furthermore,time-series reconstruction tests conducted in 2020 on the Lancang and Danube rivers revealed a significant improvement in the image availability.These findings demonstrated that this method could not only be used to accurately reconstruct the surface water distribution missing water images,but also to depict a more pronounced time variation characteristic.The successful application of this method on GEE demonstrates its importance for use on large scales or in global studies. | Mingyang Li Shanlong Lu Cong Du Yong Wang Chun Fang Xinru Li Hailong Tang Muhammad Hasan Ali Baig Harrison Odion Ikhumhen | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 8 | Three-dimensional Co_(2)V_(2)O_(7)·nH_(2)O superstructures assembled by nanosheets for electrochemical energy storage显示文摘Hierarchical superstructures assembled by nanosheets can effectively prevent aggregation of nanosheets and improve performance in energy storage.Therefore,we proposed a facile hydrothermal method to obtain three-dimensional(3D)superstructure assembled by nanosheets.We found that the ratio of Co^(2+)/HMTA affected the morphology of the samples,and the 3D hierarchical structures of are obtained while the ratio of Co^(2+)/HMTA is 12:25.The hierarchical structures with sufficient interior space preserves the original sheet-like dimensional components and results in sufficient active sites and efficient mass diffusion.Hence,the 3D Co_(2)V_(2)O_(7)·nH_(2)O hierarchical structure exhibits good rate capability and high stability while as electrode materials.Meanwhile,when power density is 745.13 W/kg,the assembled CVO-2//AC shows an energy density of 47.7 Wh/kg.The work displays a facile method for fabrication of 3D superstructure assembled by 2D nanosheets that can be applied in energy storage. | Nan Li Xiaowen Guo Xinru Tang Yichen Xing Huan Pang | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 9 | Effects of Different Chinese Hickory Husk Returning Modes on Soil Nutrition and Microbial Community in Acid Forest Soil显示文摘Chinese hickory(Carya cathayensis Sarg.)is an important economic forest in Southeastern China.A large amount of hickory husk waste is generated every year but with a low proportion of returning.Meanwhile,intensive management has resulted in soil degradation of Chinese hickory plantations.This study aims to investigate the effects of three Chinese hickory husk returning modes on soil amendment,including soil acidity,soil nutrition,and microbial community.The field experiment carried out four treatments:control(CK),hickory husk mulching(HM),hickory husk biochar(BC),and hickory husk organic fertilizer(OF).The phospholipid fatty acid(PLFA)biomarker method was employed to determine the soil microbial community.After one year of treatment,the results showed that:(i)HM and BC significantly increased soil pH by 0.33 and 1.71 units,respectively;(ii)HM,BC and OF treatments significantly increased the soil organic carbon,alkaline nitrogen,available phosphorous,and available potassium.The OF treatment demonstrated the most significant improvement in the soil nutrient;(iii)The soil microbial biomass significantly increased in the HM,BC and OF treatments,and all microbial groups showed an increasing trend.HM treatment increased the fungal/bacterial ratio(F/B).The OF treatment significantly decreased the Shannon-Wiener diversity(H’)and evenness index(J)of the microbial community(P<0.05).Considering the treatments effects,costs,and ease of operation,our recommended returning modes of Chinese hickory husk are mulching and organic fertilizer produced by composting with manure. | Qian Liu Sayikal Duyxanale Yongqian Tang Xinyu Shen Yuanlai Zhao Xinru Ma Shuai Shao Chenfei Liang | 2023 | Phyton-International Journal of Experimental Botany2023，92，3： | 0 |
| 10 | CASP8 promoter polymorphism,mRNA expression and risk of prostate cancer among Chinese men显示文摘Caspase-8 (CASP8) plays a key role in apoptosis.We examined by genotyping whether the-652 six-nucleotide insertion-deletion (6N ins/del) polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancerfree controls.Additionally,23 prostate cancer tissues were analyzed for CASP8 mRNA expression.We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio (OR)=0.68;95% confidence interval (CI)=0.51-0.92] and del/del genotype (OR=0.34;95% CI=0.19-0.63) compared with the ins/ins genotype.The 6N del allele was associated dose-dependently with decreased prostate cancer risk (P trend=0.001).RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ins genotype (P=0.024).These findings suggested that the CASP8-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men. | Guangbo Fu Jialin Tang Meilin Wang Chao Qin Fu Yan Qi Ding Changjun Yn Xinru Wang Zhengdong Zhang | 2011 | The Journal of Biomedical Research2011，25，2： | 0 |
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