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| 1 | Prognostic significance of neutrophil to lymphocyte ratio in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization显示文摘 | Xu Xinsen Chen Wei Zhang Lingqiang Miao Runchen Zhou Yanyan Wan Yong Dong Yafeng Liu Chang | 2014 | Chinese Medical Journal2014，，24： | 10 |
| 2 | Exploring the diagnosis markers for gallbladder cancer based on clinical data显示文摘一会儿,没有有效标记是可得到的便于胆囊癌症(GBC ) 诊断。这研究试图为 GBC 诊断探索可得到的标记。144 GBC 和 116 个胆石病病人的临床的数据回顾地被考察。逻辑回归分析被执行评估 GBC 风险因素。操作特征(巨鸟) 曲线的接收装置被用来估计风险因素的诊断价值。由比较 GBC 和胆石病病人的特征,下列因素展出了统计差别:年龄,性,胆石,全部的 bilirubin (TB ) ,碱的磷酸酶(高山) , aspartate aminotransferase (著名计算机生产厂商) ,丙氨酸 aminotransferase (中高音) ,血小板计数(PLT ) , CA125 (carcinoembryonic 抗原 125 ) ,和 CA199 (糖类抗原 199 ) 。逻辑回归分析显示了那年龄[机会比率(或) , 1.032;95%confidence 间隔(95% CI ) , 1.004 ~ 1.061;P = 0.024 ] ,性(或, 0.346;95% CI, 0.167 ~ 0.716;P = 0.004 ) ,胆石(或, 0.027;95% CI, 0.007 ~ 0.095;P < 0.001 ) ,高山(或, 1.003;95% CI, 1.000 ~ 1.006;P = 0.032 ) , TB (或, 1.004;95% CI, 1.000 ~ 1.009;P = 0.042 ) ,并且 CA125 (或, 1.007;95% CI, 1.002 ~ 1.013;P = 0.011 ) 是为 GBC 的独立风险因素。根据巨鸟曲线, CA125 [在曲线(AUC ) 下面的区域, 0.720 ] ,高山(AUC, 0.713 ) , TB (AUC, 0.636 ) ,并且年龄(AUC, 0.573 ) 是珍贵诊断标记。基于独立风险因素,另外, GBC 诊断模型被建立。年龄, TB,高山,和 CA125 能被用作 GBC 的辅助诊断因素。当包括地考虑各种各样的风险因素时,诊断模型为 GBC 诊断提供一个量的工具。 | Lingqiang Zhang Runchen Miao Xiude Zhang Wei Chen Yanyan Zhou Ruitao Wang Ruiyao Zhang Qing Pang Xinsen Xu Chang Liu | 2015 | Frontiers of Medicine2015，9，3： | 4 |
| 3 | p53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers显示文摘The DNA damage response helps to maintain genome integrity,suppress tumorigenesis,and mediate the effects of radiotherapy and chemotherapy.Our previous studies have shown that Smad1 is upregulated and activated by Atm in DNA damage response,which can further bind to p53 and promote p53 stabilization.Herewe report another aspect of the interplay between p53 and Smad1.Comparison of rectal tumor against paired paraneoplastic specimens and analysis of>500 colorectal tumors revealed that Smad1 was upregulated in tumor samples,which was attributable to p53 defects.Using MEFs as a model,we found that knockdown of the elevated Smad1 in p532/2 MEFs promoted cell proliferation,E1A/Ras-induced cell transformation,and tumorigenesis.Mechanistic studies suggest that elevated Smad1 and momentary activation inhibit cell proliferation by upregulating p57Kip2 and enhancing Atm–Chk2 activation.Surprisingly,elevated Smad1 appears to have a negative effect on chemotherapy,as colorectal tumors,primary cancer cells,and cell lines with Smad1 knockdown all showed an increase in chemosensitivity,which could be attributable to elevated p57Kip2.These findings underscore the significance of Smad1–p53 interaction in tumor suppression and reveal an unexpected role for Smad1 in chemoresistance of colorectal cancers. | Xinsen Ruan Qiao Zuo Hao Jia Jenny Chau Jinlin Lin Junping Ao Xuechun Xia Huijuan Liu Samy LHabib Chuangang Fu Baojie Li | 2015 | Journal of Molecular Cell Biology2015，7，2： | 2 |
| 4 | Association between telomere length and survival in cancer patients: a meta-analysis and review of literature显示文摘在 telomere 长度和癌症幸存之间的关系广泛地被学习了。获得更深的卓见,我们考察了出版研究。29 研究的一个总数在外部血评估了 telomere 长度;22 研究在肿瘤织物评估了 telomere 长度。首先,在外设,血学习,为有弄短的 telomere 长度,为死亡的联合危险比率(HR ) 和肿瘤前进的稳固的肿瘤病人是 1.21 (95%CI, 1.10-1.32 ) 并且 1.71 (95%CI, 1.37-2.13 ) 分别地。同时,在血液学,恶意,为死亡的联合 HR 和肿瘤前进是 2.83 (95%CI, 2.14-3.74 ) 并且 2.65 (95%CI, 2.18-3.22 ) 分别地。第二在使用肿瘤织物的研究,为有弄短的 telomeres 的病人,为死亡和肿瘤前进的联合 HR 是 1.26 (95%CI, 0.95-1.66 ) 并且 1.65 (95%CI, 1.26-2.15 ) 分别地。在计算肿瘤织物的 telomere 长度比率到邻近的正常 mucosa 的研究,为有更低的 telomere 长度比率的病人,联合 HR 是 0.66 (95%CI, 0.53-0.83 ) 并且 0.74 (95%CI, 0.41-1.32 ) 为死亡和肿瘤前进分别地。可能为癌症病人在结论,在外部血的弄短的 telomere 和肿瘤织物显示差的幸存。由计算肿瘤织物的 telomere 长度比率到邻近的正常 mucosa,然而,更低的比率可能显示更好的幸存。 | Xinsen Xu Kai Qu Qing Pang Zhixin Wang Yanyan Zhou Chang Liu | 2016 | Frontiers of Medicine2016，10，2： | 2 |
| 5 | Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a German experience显示文摘(ICU ) 特别护理联合起来在极其有病的病人的康复是重要的。在过去的十年,在 ICU 接受了好攻击的治疗的许多病人在多重中心开发了 sclerosing 胆管炎。在极其有病的病人(SC-CIP ) 的 Sclerosing 胆管炎是一个相对新的问题。调查 SC-CIP 的原因,临床的表明,治疗,和预后,我们从 2001 ~ 2012 在 PubMed,高空绳索,和 Elsevier 的数据库寻找了出版案例。数据用一种标准形式被提取并且回顾地分析了。与 64 个男人和 24 个女人一起,盖住 88 个病人的 12 合格研究在这分析被注册。吝啬的年龄是 49.8 年。所有从重病病人恢复了,例如损伤,感染,灼伤,和主要手术。高迫使积极结束吐气的压力(偷看,在 12.8 厘米 H2O 的山峰水平) 为所有病人被利用,与 36.3 d 的平均持续时间。另外, vasopressor 代理人在近似 60%of SC-CIP 被管理。cholestasis 的快速的增加和在 intrahepatic 胆汁管的不规则的苛评在下列月内被观察。与 17.9 个月的平均后续经期,差的结果在 54 个病人被观察,包括 34 死亡。在结论,胆汁的树的 ischemic 损害,可以被偷看或 vasopressor 管理影响,影响 cholangiopathic 过程。作为第二等的 sclerosing 胆管炎的一种最新发现的类型, SC-CIP 是在 ICU 的病人的严重进步复杂并发症并且应该被临床医生小心地监视。 | Ting Lin Kai Qu Xinsen Xu Min Tian Jie Gao Chun Zhang Ying Di Yuelang Zhang Chang Liu | 2014 | Frontiers of Medicine2014，8，1： | 2 |
| 6 | Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma显示文摘 | Kai Qu Xinsen Xu Chang Liu Qifei Wu Jichao Wei Fandi Meng Lei Zhou Zhixin Wang Lei Lei Peijun Liu | 2012 | Cancer Letters2012，，： | 2 |
| 7 | Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma显示文摘因为这个过程涉及肿瘤抑制并且被许多化学疗法的代理人导致了,加速的老朽是重要的。基于铂的化学疗法的代理人 cisplatin 显示大量 antitumor 活动。然而,在 hepatocellular 癌(HCC ) 的导致 cisplatin 的加速的老朽的分子的机制仍然保持不清楚。在现在的学习,生长 HepG2 和 SMMC-7721 细胞上的 cisplatin 的禁止的效果被 3-(4,5-dimethylthiazol-2-yl ) 检测 -2,5-diphenyltetrazolium 溴化物试金。细胞的老朽然后被牛乳糖试金估计。包括 p53, p21,和 p16,老朽相关的因素被量的反向的抄写聚合酶链反应评估。反应的氧种类(ROS ) 被流动 cytometry 分析。我们的结果表明 cisplatin 在一个剂量依赖者和时间依赖者举止减少了 HepG2 和 SMMC-7721 房间的增长。在 cisplatintreated hepatoma 房间观察的衰老的显型依赖于 p53 和 p21 激活然而并非在 p16 激活上。而且, cisplatininduced 加速了取决于的老朽细胞内部的 ROS 产生。ROS scavenger N-acetyl-L-cysteine 显著地也压制了 HepG2 和 SMMC-7721 房间的导致 cisplatin 的老朽。在结论,我们的结果揭示了在细胞内部的 ROS 产生和导致 cisplatin 的加速的老朽之间的一个功能的连接,并且这个连接可以被用作 HCC 的一个潜在的目标。 | Kai Qu Ting Lin Zhixin Wang Sinan Liu Hulin Chang Xinsen Xu Fandi Meng Lei Zhou Jichao Wei Minghui Tai Yafeng Dong Chang Liu | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 8 | Assessment of liver volume variation to evaluate liver function显示文摘In order to assess the value of liver volumetry in cirrhosis and acute liver failure(ALF)patients,we explored the correlation between hepatic volume and severity of the hepatic diseases.The clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collected.Computed tomography-derived liver volume(CTLV)and body surface area(BSA)of normal controls were calculated to get a regression formula for standard liver volume(SLV)and BSA.Then CTLV and SLV of all patients were calculated and grouped by Child-Turcotte-Pugh classification for cirrhosis patients and assigned according to prognosis of ALF patients for further comparison.It turned out that the mean liver volume of the control group was 1058±337 cm^(3).SLV was correlated with BSA according to the regression formula.The hepatic volume of cirrhosis patients in Child A,B level was not reduced,but in Child C level it was significantly reduced with the lowest liver volume index(CTLV/SLV).Likewise,in the death group of ALF patients,the volume index was significantly lower than that of the survival group.Based on volumetric study,we proposed an ROC(receiver operating characteristic)analysis to predict the prognosis of ALF patients that CTLV/SLV<83.9% indicates a poor prognosis.In conclusion,the CTLV/SLV ratio,which reflects liver volume variations,correlates well with the liver function and progression of cirrhosis and ALF.It is also a very useful marker for predicting the prognosis of ALF. | Cong Tong Xinsen Xu Chang Liu Tianzheng Zhang Kai Qu | 2012 | Frontiers of Medicine2012，6，4： | 1 |
| 9 | Pomegranate micro/nano hierarchical plasma structure for superior microwave absorption显示文摘Inspired by the pomegranate natural artful structure,pomegranate micro/nano hierarchical plasma configuration of Fe/Fe3C@graphitized carbon(FFC/pCL)was constructed based on the green sol-gel method and in-situ chemical vapor deposition(CVD)synthesis protocol.Pomegranate-like FFC/pCL successfully overcame the agglomeration phenomenon of magnetic nanoparticles with each seed of the pomegranate consisting of Fe/Fe_(3)C as cores and graphitized carbon layers as shells.The high-density arrangement of magnetic nanoparticles and the design of pomegranate-like heterostructures lead to enhanced plasmon resonance.Thus,the pomegranate-like FFC/pCL achieved a great electromagnetic wave(EMW)absorbing performance of 6.12 GHz wide band absorption at a low mass adding of only 16.7 wt.%.Such excellent EMW performance can be attributed to its unique pomegranate hierarchical plasma configuration with separated nanoscale iron cores,surface porous texture,and good carbon conductive network.This investigation provides a new paradigm for the development of magnetic/carbon based EMW absorbing materials by taking advantage of pomegranate hierarchical plasma configuration. | Chunyan Ding Tao Wu Xinsen Hu Chengshuai Shao Zhipeng Xu Hui Fu Songsong Wu Guangwu Wen Xiaoxiao Huang | 2022 | Nano Research2022，15，10： | 1 |
| 10 | Estimation of Probability of Damage Detection in Offshore Structural Inspection显示文摘- To characterize the uncertainty and fuzziness in offshore structural inspection, probability of detection (POD) must be determined. This paper presents the expressions for the POD of four different damage forms mainly existing in offshore structures. The fuzzy-set theory is applied to estimate human errors through the definition of inspection quality. Expressions of inspection quality are achieved. To verify the validity and correctness of the expressions, the data from an offshore platform field inspection of evaluation results of human errors affecting inspection quality are used to estimate the parameters of the POD. The results show that the present models can provide basis for further study of ofTshore structural inspection reliability. | Song Ruxin and Lu Xinsen Postdoctor, Dept. of Naval Arch, and Ocean Engng. Shanghai Jiao Tong University, Shanghai 20030 . Professor, Dept. of Naval Arch, and Ocean Engng. shanghai Jiao Tong University, Shanghai 20030 | 1996 | China Ocean Engineering1996，11，3： | 1 |
| 11 | Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma显示文摘 | Kai Qu Xinsen Xu Chang Liu Qifei Wu Jichao Wei Fandi Meng Lei Zhou Zhixin Wang Lei Lei Peijun Liu | 2012 | Cancer Letters2012，，： | 1 |
| 12 | 显示文摘 | XINSen(辛森) GVOYu-Guo(郭玉国) WANLi-Jun(万立骏) | | ZhonggtaKexue Huaxue0，，： | 1 |
| 13 | Femoral mechanical performance of precocial and altricial birds:a simulation study显示文摘Background:As the major load-bearing structures,bones exhibit various properties related to mechanical perfor-mance to adapt to different locomotor intensities.The habits and ontogenetic changes of locomotion in animals can,thus,be explored by assessing skeletal mechanical performance.Methods:In this study,we investigated the growing femoral mechanical performance in an ontogenetic series of Cabot’s Tragopans(Tragopan caboti)and Pigeons(Columba livia domestica).Micro-computed tomography-based finite element analysis was conducted to evaluate the stress,strain,and strain energy density(SED)of femora under axial and radial loading.Results:Femora deflected medio-laterally and dorso-ventrally under axial and radial loading,respectively.Femora deformed and tensed more severely under radial loading than axial loading.In adult individuals,Cabot’s Tragopans had lower strain and SED than pigeons.During ontogeny,the strain and SED of pigeons decreased sharply,while Cabot’s Tragopans showed moderately change.The structural properties of hatchling pigeons are more robust than those of hatchling Cabot’s Tragopans.Conclusions:Limb postures have dominant effect on skeletal deformation.The erect posture is preferred by large mammals and birds to achieve a high safety factor of bones during locomotion.Adult Cabot’s Tragopans have stronger femora than pigeons,reflecting a better bone adaption to the terrestrial locomotion of the studied pheas-ant species.Changes in strain and SED during growth reflect the marked difference in locomotor ability between precocial and altricial hatchlings.The femora of hatchling Cabot’s Tragopans were built with better energy efficiency than deformation resistance,enabling optimized mechanical performance.In contrast,although weak in mechani-cal function at the time of hatching,pigeon femora were suggested to be established with a more mature structural design as a prerequisite for rapid growth.These results will be helpful for studies regarding developmental patterns of fossil avian species. | Xinsen Wei Zihui Zhang | 2021 | Avian Research2021，12，2： | 1 |
| 14 | Hepatitis B Does Not Explain Male-biased Sex Ratios in China显示文摘 | Emily Oster Gang Chen Xinsen Yu Wenyao Lin | 2010 | Economics Letters2010，107，2： | 1 |
| 15 | Model-based assessment of muscle forces and strain distribution in the femur of Cabot’s Tragopans(Tragopan caboti)显示文摘The hindlimbs play a crucial role in bird locomotion,making the biomechanical properties of the musculoskeletal system in these limbs a focal point for researchers studying avian behaviour.However,a comprehensive analysis of the mechanical performance within the long bones of hindlimbs during locomotion remains lacking.In the present study,the strain and deformation of the femur of Cabot’s Tragopans(Tragopan caboti)were estimated.We employed inverse simulation to calculate the force and moment of femoral muscles during mid-stance terrestrial locomotion and conducted finite element analysis to calculate femoral strain.Results showed that during mid-stance,the femur experiences combined deformation primarily characterized by torsion,bending,and compression.It emphasises the importance of considering the influence of varying loads on bone adaptation when investigating bone form-function relationships.Muscles were found to play a significant role in offsetting joint loads on the femur,subsequently reducing the deformation and overall strain on the bone.This reduction enhances femoral safety during locomotion,allowing birds to meet mechanical demands while maintaining a lightweight bone structure.Notably,the M.iliotrochantericus caudalis significantly reduces torsional deformation of the proximal femur,protecting the vulnerable femoral neck from high fracture risk induced by rotation load.Given that the femur torsion during terrestrial locomotion in birds is associated with changes in hindlimb posture due to their adaptation to flight,the characteristics of M.iliotrochantericus caudalis may provide insight into the locomotor evolution of theropods and the origin of avian flight. | Xinsen Wei Zihui Zhang | 2023 | Avian Research2023，14，4： | 0 |
| 16 | Boosting Kernel Search Optimizer with Slime Mould Foraging Behavior for Combined Economic Emission Dispatch Problems显示文摘Reducing pollutant emissions from electricity production in the power system positively impacts the control of greenhouse gas emissions.Boosting kernel search optimizer(BKSO)is introduced in this research to solve the combined economic emission dispatch(CEED)problem.Inspired by the foraging behavior in the slime mould algorithm(SMA),the kernel matrix of the kernel search optimizer(KSO)is intensified.The proposed BKSO is superior to the standard KSO in terms of exploitation ability,robustness,and convergence rate.The CEC2013 test function is used to assess the improved KSO's performance and compared to 11 well-known optimization algorithms.BKSO performs better in statistical results and convergence curves.At the same time,BKSO achieves better fuel costs and fewer pollution emissions by testing with four real CEED cases,and the Pareto solution obtained is also better than other MAs.Based on the experimental results,BKSO has better performance than other comparable MAs and can provide more economical,robust,and cleaner solutions to CEED problems. | Ruyi Dong Lixun Sun Long Ma Ali Asghar Heidari Xinsen Zhou Huiling Chen | 2023 | Journal of Bionic Engineering2023，20，6： | 0 |
| 17 | The Darner显示文摘NOWADAYS,are there any city dwellers wearing patched clothes?No!Now,people have enough food and clothing.Clothes,if used or outmoded,will be discarded without hesitation.However,they are reluctant to throw away some clothes,such as fancy woolen suits,handembroidered cheongsams,and old unlined upper garments,skirts,trousers,and gowns that have commemorative significance.If holes are burned in them or they are torn,or have some wormholes,their owners will have them mended or restored by a darner. | NIE XINSEN | 2023 | China Today2023，72，6： | 0 |
| 18 | Peptide tyrosine-tyrosine combined with its receptors exhibits an anti-cancer potential in pancreatic cancer MiaPaCa-2 cell显示文摘 | Li Hongxia Wang Zhixin Dong Lei Jiang Jiong Xu Xinsen Zhou Lei Wan Yong | 2014 | Chinese Medical Journal2014，，24： | 0 |
| 19 | Reconstruction of the Hindlimb Locomotion of Confuciusornis (Aves) and Its Implication for the Origin of Avian Flight显示文摘As one of the most basal avian clades,the Confuciusornithids are ideal in revealing the early evolution of avianflight.Birds’hindlimbs are functionally diverse and contain a wealth of information about their behavior.The hindlimb of Confuciusornis,however,has only been studied in detail in terms of functional morphology,and quantitative studies that directly assess locomotor ability are relatively lacking.This has led to certain controver-sies on the behavior of Confuciusornis.This paper reviews the debates over the life habits and take-off ability of Confuciusornis,which are closely related to their hindlimb function.Several methodologies adopted engineering techniques,including the geometrical analysis of long bones,physiological reconstruction of muscles,kinematic and kinetic characteristics estimating,and appendage locomotor mechanism analysis,are recommended for esti-mating the hindlimb functions of Confuciusornis.Considering that the fossil bones are fragile,irregular in shape,and usually deformed,it is appropriate to apply computer numerical simulation techniques to such studies.A sufficient functional quantitative study will help clarify early bird locomotor behavior,which will provide clues and evidence for further exploration of the origin of birdflight and early bird movement. | Xinsen Wei Ying Guo Yan Zhao | 2023 | Molecular & Cellular Biomechanics2023，20，2： | 0 |
| 20 | Epidemiological study of a von Hippel-Lindau family in northwest China显示文摘von Hippel-Lindau(VHL)disease is a rare,inherited neoplastic disease characterized by hemangioblastomas(HBL)of the central nervous system(CNS),retinal angiomas,renal cell carcinomas(RCC),pancreatic endocrine tumors(PETs),pheochromocytomas,paragangliomas,and visceral cysts.We encountered a large VHL family in northwest China and conducted a systematic screening of the family members based on their epidemiological and clinical characteristics.A self-designed questionnaire was used to collect the general sociodemographic and health information of the family members.For the preliminary family screening,physical examination and abdomen B ultrasonography were performed.The suspected patients were subjected to cranial computerized tomography and fundus examination.The clinical data of the patients with confirmed VHL disease were collected from hospital records.A total of 63 lineal descendants in six generations were observed in the family(generations O,A,B,C,D,E),including 9 dead suspected cases(6 males,3 females)and 10 living cases(2 males,8 females).Among the 10 living cases,4,2,1,3,4,8,and 2 manifested HBLs of the CNS,PETs,RCC,pancreatic cysts,renal cysts,pheochromocytomas(4 hemi and 4 bilateral),and paragangliomas,respectively.Data showed that the morbidity of VHL disease in generation C was lower than that in generation B,but the age of onset was younger.This study is the first to report VHL disease in northwest China and VHL-associated PET cases in Chinese.Therefore,follow-up checkups of the family should be focused on younger generations.Proper family screening protocols should be followed for the treatment of patients with VHL disease. | Jingyao Zhang Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Lei Zhou Xinsen Xu Chang Liu | 2013 | Frontiers of Medicine2013，7，3： | 0 |
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