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| 1 | Knockdown of CD146 reduces the migration and proliferation of human endothelial cells显示文摘我们的以前的学习证明了那个 CD146 分子是脉管的内皮细胞层上的一个简历标记,它涉及 angiogenesis 和肿瘤生长。然而机制在后面不是清楚的。这里,我们第一次用 CD146 siRNA 开发了一个新奇 CD146 封锁系统在 endothelial 房间上学习它的功能。我们的数据证明 CD146 siRNA 明确地在 mRNA 和蛋白质层次上堵住了 CD146 的表达式,导致 HUVEC 增长,粘附和移植的重要抑制。这些结果证明 CD146 在脉管的 endothelial 房间活动和 angiogenesis 起一个关键作用,并且 CD146 siRNA 能为 anti-angiogenesis 治疗被用作一个新禁止者。 | Yanyong Kang Fengcai Wang Jing Feng Dongling Yang Xu Yang Xiyun Yan | 2006 | Cell Research2006，16，3： | 33 |
| 2 | Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma显示文摘Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma (NPC). Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STAT. The constitutive activation of these signaling cascades explains LMP1’s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle: the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. | Hui Zheng Lili Li Duosha Hu Xiyun Deng Ya Cao | 2007 | Cellular & Molecular Immunology2007，4，3： | 34 |
| 3 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 4 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 5 | Photodegradation of fluoroquinolone antibiotic gatifloxacin in aqueous solutions显示文摘Fluoroquinolone antibiotics (FQs) are frequently detected as emerging pollutants in aqueous environments.In this study,kinetics,influencing factors and mechanisms on the photodegradation of gatifloxacin,a representative FQ,were investigated.The photodegradation follows the pseudo-first-order kinetics.Gatifloxacin photodegrades with a quantum yield of (5.94 ± 0.95) × 10 3 in pure water and undergoes direct photolysis as well as self-sensitized photodegradation.The FQ photodegrades slower in freshwater and seawater than in pure water,which is attributed to the integrative effects of pH and the aqueous dissolved matter (e.g.,humic acids and NO 3-) on the photodegradation.A toxicity test using Vibrio fischeri revealed the formation of hazardous photoproducts. | GE LinKe CHEN JingWen ZHANG SiYu CAI XiYun WANG Zhuang WANG ChunLing | 2010 | Chinese Science Bulletin2010，55，15： | 17 |
| 6 | Nanozymes: an emerging field bridging nanotechnology and biology显示文摘Enzymes are biological catalysts that can convert substrates into products in biochemical reactions.In 1926,the first enzyme,urease,was determined to be a protein by James B.Sumner who won the Nobel Prize in 1946.Since then,enzymes have been considered to be proteins,which allows them to achieve their high catalytic activity with high specific activity under mild conditions.However,in general,the enzyme activity of proteins is lost after exposure to extremes of p H and high temperature,and proteins are also susceptible to digestion by proteases in the environment,which dramatically hinders their practical applications | Lizeng Gao Xiyun Yan | 2016 | Science China(Life Sciences)2016，59，4： | 17 |
| 7 | Effect of Mach number on transonic flow past a circular cylinder显示文摘The effect of Mach number on transonic flow past a circular cylinder is investigated numerically for the free-stream Mach number M∞ from 0.85 to 0.98 and the Reynolds number 2×105 based on the diameter of the cylinder. The work provides an insight into several salient features, including unsteady and quasi-steady flow state, formation of local supersonic zone, and evolution of turbulent shear layer. Results show that there exist two flow states dependent of a critical Mach number Mcr around 0.9. One is an unsteady flow state characterized by moving shock waves interacting with the turbulent flow in the near region of the cylinder for M∞Mcr, suppressing vortex shedding from the cylin-der. Some flow behaviors in the unsteady and quasi-steady flow states are revealed. From time evolu-tion of flow structures, local supersonic zones are identified in the wake and generated by two typical processes, i.e. reverse flow behind the cylinder and shed vortices in the near wake. The convective Mach number Mc of turbulent shear layers shed from the cylinder is identified nearly as Mc<1 in the unsteady flow regime and Mc>1 in the quasi-steady flow regime, resulting in different evolutions of the shear layers. | XU ChangYue CHEN LiWei LU XiYun | 2009 | Chinese Science Bulletin2009，54，11： | 15 |
| 8 | Nanozymes: created by learning from nature显示文摘Nanozymes,a type of nanomaterials with enzyme-like activity,have shown great potential to replace natural enzymes in many fields such as biochemical detection,environmental management and disease treatment.However,the catalytic efficiency and substrate specificity of nanozymes still need improvement.To further optimize the enzymatic properties of nanozymes,recent studies have introduced the structural characteristics of natural enzymes into the rational design of nanozymes,either by employing small molecules to mimic the cofactors of natural enzymes to boost nanozymes’catalytic potential,or by simulating the active center of natural enzymes to construct the nanostructure of nanozymes.This review introduces the commonly used bio-inspired strategies to create nanozymes,aiming at clarifying the current progress and bottlenecks.Advances and challenges focusing on the research of bio-inspired nanozymes are outlined to provide ideas for the de novo design of ideal nanozymes. | Ruofei Zhang Kelong Fan Xiyun Yan | 2020 | Science China(Life Sciences)2020，63，8： | 13 |
| 9 | Porous Pt/Ag nanoparticles with excellent multifunctional enzyme mimic activities and antibacterial effects显示文摘提高基于磅的 nanocatalysts 的活动还大意义是为氧减小反应(ORR ) 的挑战。在这个工作,一系列多孔的 Pt/Ag nanoparticles (NP ) 从常规磅 x Ag 100x (x = 25, 50, 75 ) 由一个灵巧、节俭的 dealloying 过程的 octahedra。在与 ORR 有关的多重酶模仿活动的显著改进为 dealloyed 磅 50 Ag 50(D 磅 50 Ag 50) NP。这效果能被归因于结果充满磅的表面结构,增加的表面区域,和在 D 磅 50 Ag 50 NP。而且, D 磅 50 Ag 50 NP 在二个模型细菌(克否定的 Escherichia coli 和克积极的葡萄球菌 aureus ) 上施加了优秀抗菌剂效果。现在的工作为各种各样的有希望的应用在在高质量的 nanoalloys 和他们的新奇催化性质的可控制的合成之间的关系的探索代表重要进展,包括催化剂,生物传感器,和 biomedicine。 | Shuangfei Cai Xinghang Jia Qiusen Han Xiyun Yan Rong Yang Chen Wang | 2017 | Nano Research2017，10，6： | 10 |
| 10 | DYNAMIC VARIATIONS OF WATER QUALITY IN TAIHU LAKE AND MULTIVARIATE ANALYSIS OF ITS INFLUENTIAL FACTORS显示文摘Dynamic variation of water quality in Meiliang Bay and part of West Taihu Lake has been analysed based on data from 1991 to 1992. Principal Component Analysis is used to reveal the mutual relationships of various factors. It is shown that there existis an obvious spatial and temporal variation in the main factors of water quality. Annual values of TP, CON, TN, Chl-a and conductivity decrease evidently from inner Meiliang Bay to the outer from north to south. TP and TN fluctuate seasonally with much higher value in winter. This is particularly true for the mouth of Liangxi River. In addition, the Chl-1 has a synchronous variation with water temperature, although being lagged a little, and closely relates to TP and TN. Finally, the results from Principal Component Analysis show that TP, TN, SS (or SD), water temperature and Chl-a are the most influential factors to water qualuty in this area, and both suspensions and algae can contribute to transparency to Taihu Lake. | Cai Qiming Gao Xiyun Chen Yuwei Ma Shengwei Nanjing Institute of Geography and Limnology, CAS, Nanjing 210008 People’s Republic of ChinaMartin Dokulil Institute of Limnology, Austria | 1997 | Journal of Geographical Sciences1997，7，3： | 9 |
| 11 | CD146 is essential for PDGFRβ-induced pericyte recruitment显示文摘 | Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan | 2018 | Protein & Cell2018，9，8： | 9 |
| 12 | Nanozymes Inspired by Natural Enzymes显示文摘CONSPECTUS:Nanozymes,nanomaterials with enzyme-like activities with high structural stability,adjustable catalytic activity,functional diversity,recyclability,and feasibility in large-scale preparation,have become a hot spot in the field of artificial enzymes in recent years and are expected to become potential surrogates and competitors for natural enzymes in practical applications.With the development of in-depth research and a wide range of application requirements,creating nanozymes with catalytic performance comparable to or even surpassing that of natural enzymes has been the key research topic in this field.Most of the nanozymes reported in the past were obtained based on random synthesis and screening,for which the catalytic efficiency is far inferior to that of natural enzymes.Natural enzymes that have evolved over hundreds of millions of years have developed a lot of high-efficiency catalysis know-how hidden in their structural features.To create highly active nanozymes,we assumed that there is a general structure−activity relationship between nanozymes and natural enzymes and proposed the nanozyme optimization strategy by grafting the catalytic principles of natural enzymes into the rational design of nanozymes.On the basis of this bioinspired strategy,a series of nanozymes that exhibit similar catalytic activities that are closer to or even beyond those of natural enzymes have been successfully synthesized.By now,rationally designed high-activity bioinspired nanozymes have become a hot topic in the current research on nanozymes.In this Account,we focus on recent representative research progress in the systemic design and construction of bioinspired nanozymes and are devoted to introducing strategic concepts in the bioinspired optimization of nanozymes.We show that the de novo design of nanozymes by simulating the amino acid microenvironment and using metal-free architecture and the coordination structure of metal active sites in natural enzymes is an effective strategy for significantly improving the catalytic performance of nanozymes.A future perspective of the challenges and countermeasures of bioinspired nanozymes is proposed on the basis of these achievements.We hope that the biologically inspired perception will arouse widespread interest in fundamental research and practical applications as well as provide inspiration for the rational design of nanozymes. | Ruofei Zhang Xiyun Yan Kelong Fan | 2021 | Accounts of Materials Research2021，2，7： | 8 |
| 13 | Nanozymes: an emerging field bridging nanotechnology and enzymology显示文摘Nanozyme,a class of nanomaterials with intrinsic enzymelike properties,is a new concept which has been included in the Encyclopedia of China and the textbook of enzyme engineering.Since the first evidence published in 2007(Gao et al.,2007),great progress has been achieved in the study of nanozyme from new concept,new material to its new application,and it becomes an emerging field bridging nanotechnology and biology(Gao and Yan,2016). | Xiangqin Meng Kelong Fan Xiyun Yan | 2019 | Science China(Life Sciences)2019，62，11： | 8 |
| 14 | FXYD6: a novel therapeutic target toward hepatocellular carcinoma显示文摘FXYD6, FXYD 领域包含离子运输管理者 6,被报导了影响 Na 的活动 < 啜 class= “ a-plus-plus ” >+/K+-ATPase 并且与心理疾病被联系。这里,我们证明 FXYD6 在 hepatocellular 癌(HCC ) 是起来调整的并且提高 HCC 房间的迁居和增长。FXYD6 的起来规定不仅断然随 Na 的增加相关 < 啜 class= “ a-plus-plus ” >+/K 有它发信号的下游的 Src 英皇家空军之阶级最低之兵的激活的 +-ATPase 而且坐标小径。更重要地,显著地由它的功能的抗体堵住 FXYD6 在老鼠禁止 xenografted HCC 肿瘤的生长潜力,显示 FXYD6 代表向 HCC 的一个潜在的治疗学的目标。总的来说,我们的结果在 HCC 前进建立 FXYD6 的一个关键角色并且建议指向 FXYD6 的治疗能向 HCC 病人有益于临床的治疗。 | Qian Gao Xiongfei Chen Hongxia Duan Zhaoqing Wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan | 2014 | Protein & Cell2014，5，7： | 7 |
| 15 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 16 | Measurements and analysis of force and moment of caudal fin model in C-start显示文摘与不同形状和不同秋千持续时间对鱼的尾的鳍模型起作用的不稳定的水动力学力量和时刻试验性地被测量模仿鱼 C 开始。模型的运动被旋转描绘模型到在旅行时间 Tu 并且回到在在它的根轴附近的回来时间 Td 的起始的位置的一个最大的偏转角度。研究证明尾鳍的戏在鱼 C 开始的一个重要角色并且与不同形状和不同秋千持续时间尾鳍产生不同力量和时刻。另外,与不同形状对模型起作用的水动力学力量和时刻能被 2 nd 和 3 区域的 rd 时刻分别地。与不同秋千持续时间对模型起作用的力量和时刻,而是到 Td 的 Tu 的一样的比率能也被放大。 | ZHAO Liang JING Jun LU Xiyun YIN Xiezhen | 2006 | Progress in Natural Science:Materials International2006，16，8： | 5 |
| 17 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 18 | Carbon-based nanozymes for biomedical applications显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility,high cost,and impossible mass production.Over the past decade,a broad variety of nanomaterials have been found to mimic the enzyme-like activity by engineering the active centers of natural enzymes or developing multivalent elements within nanostructures.Carbon nanomaterials with well-defined electronic and geometric structures have served as favorable surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural enzymes.In particular,by combining the unique electronic,optical,thermal,and mechanical properties,carbon nanomaterials-based nanozymes can offer a variety of multifunctional platforms for biomedical applications.In this review,we will introduce the enzymatic characteristics and recent advances of carbon nanozymes,and summarize their significant applications in biomedicine. | Hui Ding Bing Hu Bin Zhang Han Zhang Xiyun Yan Guohui Nie Minmin Liang | 2021 | Nano Research2021，14，3： | 4 |
| 19 | Numerical investigation on the aerodynamics of a simplified high-speed train under crosswinds显示文摘The yaw effect of the side flow around a high-speed train is studied by means of large eddy simulation at two typical yaw angles of φ = 30° and 60°, respectively. Both the mean and fluctuating values of lift force and side force coefficients increase obviously as the yaw angle increases. The spectral analysis indicates that the time-dependent aerodynamic forces are dominated by several energetic frequencies and the frequency range is broadened to a higher extent for the large yaw angle. To have a better understanding of the train aerodynamic behaviors, the dedicate three-dimensional vortical structures are analyzed for the flow at the two yaw angles. Moreover, the time-averaged flow patterns, turbulent statistics and the surface forces are also studied on sectional planes along the train. | Yueqing Zhuang Xiyun Lu | 2015 | Theoretical & Applied Mechanics Letters2015，5，5： | 4 |
| 20 | CD146:a potential therapeutic target For systemic sclerosis显示文摘Dear Editor, Systemic sclerosis (scleroderma,SSc)is a chronic disease of connective tissues,and is clinically characterized by persistent fibrosis in the skin as well as in a variety of organs (Katsumoto et al.,2011).The pathogenesis of SSc is com- plex and involves vasculopathy,autoimmunity and fibrosis. The hallmarks of late-stage SSc are the excessive secretion and accumulation of extracellular matrix (ECM)by aberrantly activated fibroblasts (myofibroblasts)in the skin and internal organs (Bhattacharyya et al.,2012). | Lingling Zhang Yongting Luo Xiao Teng Zhenzhen Wu Mengtao Li Dong Xu Qian Wang Fei Wang Jing Feng Xiaofeng Zeng Xiyun Yan | 2018 | Protein & Cell2018，9，12： | 4 |
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