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| 1 | Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation显示文摘Upon the osteoporotic condition,sluggish osteogenesis,excessive bone resorption,and chronic inflammation make the osseointegration of bioinert titanium(Ti)implants with surrounding bone tissues difficult,often lead to prosthesis loosening,bone collapse,and implant failure.In this study,we firstly designed clickable mussel-inspired peptides(DOPA-N3)and grafted them onto the surfaces of Ti materials through robust catechol-TiO2 coordinative interactions.Then,two dibenzylcyclooctyne(DBCO)-capped bioactive peptides RGD and BMP-2 bioactive domain(BMP-2)were clicked onto the DOPA-N3-coated Ti material surfaces via bio-orthogonal reaction.We characterized the surface morphology and biocompatibility of the Ti substrates and optimized the osteogenic capacity of Ti surfaces through adjusting the ideal ratios of BMP-2/RGD at 3:1.In vitro,the dual-functionalized Ti substrates exhibited excellent promotion on adhesion and osteogenesis of mesenchymal stem cells(MSCs),and conspicuous immunopolarization-regulation to shift macrophages to alternative(M2)phenotypes and inhibit inflammation,as well as enhancement of osseointegration and mechanical stability in osteoporotic rats.In summary,our biomimetic surface modification strategy by bio-orthogonal reaction provided a convenient and feasible method to resolve the bioinertia and clinical complications of Ti-based implants,which was conducive to the long-term success of Ti implants,especially in the osteoporotic or inflammatory conditions. | Jie Sun Yingkang Huang Huan Zhao Junjie Niu Xuwei Ling Can Zhu Lin Wang Huilin Yang Zhilu Yang Guoqing Pan Qin Shi | 2022 | Bioactive Materials2022，7，3： | 0 |
| 2 | Detection and targeted control of regional stress field for coal burst prevention显示文摘As coal burst normally occurs in the area of high stress concentration,it is of significance to study the features of regional stress field in coal mines.Primitive stress field,mining-induced stress field and their coupling effect are investigated through the methods of theoretical analysis,field measurement,numerical simulation and wave velocity CT inversion,and the relationship among regional stress field,high-energy seismic events and coal bursts are analyzed.Investigation of the 3#mining district in Xingcun coal mine shows that:(1)Though stress concentration changes in the mining process,several special areas witnesses stress concentration in the whole mining process,such as the rise pillar area,several syncline axis areas and large fault areas;(2)Coal burst occurrence and high-energy seismic events have a close relationship with regional stress field.Coal bursts and high-energy seismic events tend to occur in areas of stable stress concentration,such as the rise area,several syncline axis areas and large fault areas.Targeted control of stress field for coal burst prevention is developed based on stress field detection.The process of targeted control of stress field for coal burst prevention is:detection of regional stress field based mainly on wave velocity CT,identification of stress concentration,implementation of destress measures to control the identified stress concentration.This method of stress field control was applied to LW3306 working face in Xingcun coal mine and coal burst hazards were effectively controlled in LW3306. | Linming Dou Zhenyu Sun Xuwei Li Quan Liu Siyuan Gong Chao Wang | 2023 | Geohazard Mechanics2023，1，1： | 0 |
| 3 | Ecosystem changes revealed by land cover in the three-river headwaters region of Qinghai,China(1990–2015)显示文摘The Three-River Headwaters Region(TRHR) of Qinghai Province, in the Tibetan Plateau of China, is the main source of the Yangtze, Yellow, and Lancang rivers, and is very significant to the security of freshwater resources for China and southeastern Asia. It is a critical ecological region of China for its ecological functions, and has been changed or even degraded in recent decades owing to climate change and human pressure. To effectively protect and restore the degraded ecosystems, the Chinese government initiated a series of ecological conservation projects in TRHR. It is essential to quantitatively assess ecosystem changes and their relationship to driving factors for indepth understanding of long-term changes of ecosystems and effects of ecological restoration policies and offer practical insights for ecological restoration. Here, land cover data has been interpreted with the series data of Landsat during 1990–2015. The patterns of different ecosystems and their developing process have been derived from land cover change. The results show that ecosystem types in TRHR include forest, grassland, cropland,wetland, artificial surface and barren land, accounting for 4.51%, 70.80%, 0.15%, 9.47%, 0.16% and 14.90%,respectively. Barren land converted to wetland was the significant ecosystem change from 1990 to 2015. Increases in temperature and precipitation and implementation of ecological rehabilitation helped maintain relatively stable ecosystem patterns. It is necessary to continue ecological projects to improve and/or maintain the ecosystems in TRHR because there is still a risk of land degradation under increasing climate change and human activity. | XuWei Sun Sen Li XiaoHui Zhai XiaoXu Wei ChangZhen Yan | 2023 | Research in Cold and Arid Regions2023，15，2： | 0 |
| 4 | Fe-doped Co_(3)O_(4) nanowire strutted 3D pinewood-derived carbon: A highly selective electrocatalyst for ammonia production via nitrate reduction显示文摘Nitrate(NO_(3)^(-)),a nitrogen-containing pollutant,is prevalent in aqueous solutions,contributing to a range of environmental and health-related issues.The electrocatalytic reduction of NO_(3)^(-)holds promise as a sustainable approach to both eliminating NO_(3)^(-)and generating valuable ammonia(NH_(3)).Nevertheless,the reduction reaction of NO_(3)^(-)(NO_(3)^(-)RR),involving 8-electron transfer process,is intricate,necessitating highly efficient electrocatalysts to facilitate the conversion of NO_(3)^(-)to NH_(3).In this study,Fe-doped Co_(3)O_(4) nanowire strutted three-dimensional(3D)pinewood-derived carbon(Fe-Co_(3)O_(4)/PC)is proposed as a high-efficiency NO_(3)^(-)RR electrocatalyst for NH_(3) production.Operating within 0.1 M NaOH containing NO_(3)^(-),Fe-Co_(3)O_(4)/PC demonstrates exceptional performance,obtain an impressively large NH_(3) yield of 0.55 mmol·h^(-1)·cm^(-2) and an exceptionally high Faradaic efficiency of 96.5%at-0.5 V,superior to its Co_(3)O_(4)/PC counterpart(0.2 mmol·h^(-1)·cm^(-2),73.3%).Furthermore,the study delves into the reaction mechanism of Fe-Co_(3)O_(4) for NO_(3)^(-)RR through theoretical calculations. | Xuwei Liu Chaozhen Liu Xun He Zhengwei Cai Kai Dong Jun Li Xiaoya Fan Ting Xie Xiya Yang Yonglan Luo Dongdong Zheng Shengjun Sun Sulaiman Alfaifi Feng Gong Xuping Sun | 2024 | Nano Research2024，17，4： | 0 |
| 5 | A GSH-depleted platinum(Ⅳ) prodrug triggers ferroptotic cell death in breast cancer显示文摘Cisplatin is the first-line drug for treatment of various solid tumors including breast cancer due to the broad anti-tumor spectrum and strong anti-tumor effect.However,serious side effects and long-term medication of reduced sensitivity by high GSH in tumor cells have severely restricted its further clinical application.Herein,a GSH-depleted Pt(Ⅳ)prodrug(Platin B)based on cisplatin and 4-carboxylphenylboronic acid pinacol ester was prepared to solve the problems.As an excellent GSH scavenger,4-carboxylphenylboronic acid pinacol ester could be activated by intracellular redox reactions to release quinone methide,thereby amplifying oxidative stress and leading to breast cancer ferroptosis therapy.Interestingly,the consumption of GSH can also reduce cisplatin inactivation,enhance the sensitivity of tumor cells to cisplatin and efficiently induce apoptosis/ferroptosis.This work highlights the use of GSH scavenger for triggering ferroptotic cell death in breast cancer. | Dachuan Qi Lei Xing Lijun Shen Wenshuang Sun Cheng Cai Chunhua Xue Xuwei Song Hua Yu Hulin Jiang Chengjun Li Qingri Jin Zhiqi Zhang | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
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