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| 1 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020,63,10: | 6 |
| 2 | Structural characterization and comparative analysis of the chloroplast genome of Ginkgo biloba and other gymnosperms显示文摘Ginkgo biloba is a famous living“fossil”and has played an important role in the evolution of the Plant Kingdom.Here,the complete chloroplast genome of G.biloba was sequenced and analysed.The chloroplast genome was 156,990 bp long and predicted to encode 134 genes including 85 protein-coding genes,41 tRNA genes and 8 rRNA genes.The chloroplast genome has a typical quadripartite structure with a pair of inverted repeat regions(IRa and IRb,17,732 bp),a large(LSC,99,259 bp)and small single(SSC,22,267 bp)copy region.After an extensive comparison to previously published gymnosperm plastomes,the gene content and organisation of G.biloba showed high divergence,although part was relatively conserved.The two typical IR regions in the G.biloba chloroplast genome were relatively shorter because it the ycf2 gene.In addition,it was obvious that the IR regions and gene loss were responsible for changes in chloroplast genome size and structure stability,which influenced plastome evolution in different gymnosperms.Phylogenetic analysis revealed that G.biloba is sister to cycads rather than to gnetophytes,cupressophytes,and Pinaceae.Overall,the study showed that the genomic characteristics of G.biloba would be of great help in the further research on the taxonomy,species identification and evolutionary history of gymnosperms,especially for their position in plant systematics and evolution. | Xiaoming Yang Tingting Zhou Xiya Su Guibin Wang Xuhui Zhang Qirong Guo Fuliang Cao | 2021 | Journal of Forestry Research2021,32,2: | 2 |
| 3 | Design Method of Curved-bar Refining Plates for Disc Refiner显示文摘Straight-and curved-bar refining plates are two important types of plates commonly used in disc refiners in the papermaking industry.Theoretically,the curved-bar refining plate has a relatively uniform bar interaction angle,which indicates uniform refining effects.The bar angle of the curved bar was proposed and two typical curved-bar plates,the three-stage radial curved-bar plate and isometric curved-bar plate,were designed in this paper.The arc equations of the curved-bar center line and curved-bar edges were established and finally,the specific edge load(SEL)of the curved-bar plate was derived.The determination of bar parameters was discussed,which provides a theoretical basis for the design of curved-bar plates. | Huan Liu JiXian Dong XiYa Guo RuiFan Yang Hui Jing XiaoJun Jiang | 2019 | Paper And Biomaterials2019,4,1: | 2 |
| 4 | Vacancy manipulating of molybdenum carbide MXenes to enhance Faraday reaction for high performance lithium-ion batteries显示文摘“Intrinsic”strategies for manipulating the local electronic structure and coordination environment of defect-regulated materials can optimize electrochemical storage performance.Nevertheless,the structure–activity relationship between defects and charge storage is ambiguous,which may be revealed by constructing highly ordered vacancy structures.Herein,we demonstrate molybdenum carbide MXene nanosheets with customized in-plane chemical ordered vacancies(Mo_(1.33)CT_(x)),by utilizing selective etching strategies.Synchrotron-based X-ray characterizations reveal that Mo atoms in Mo1.33CTx show increased average valence of+4.44 compared with the control Mo_(2)CT_(x).Benefited from the introduced atomic active sites and high valence of Mo,Mo_(1.33)CT_(x)achieves an outstanding capacity of 603 mAh·g^(−1)at 0.2 A·g^(−1),superior to most original MXenes.Li+storage kinetics analysis and density functional theory(DFT)simulations show that this optimized performance ensues from the more charge compensation during charge–discharge process,which enhances Faraday reaction compared with pure Mo_(2)CT_(x).This vacancy manipulation provides an efficient way to realize MXene’s potential as promising electrodes. | Xin Guo Changda Wang Wenjie Wang Quan Zhou Wenjie Xu Pengjun Zhang Shiqiang Wei Yuyang Cao Kefu Zhu Zhanfeng Liu Xiya Yang Yixiu Wang Xiaojun Wu Li Song Shuangming Chen Xiaosong Liu | 2022 | Nano Research Energy2022,1,3: | 2 |
| 5 | Tri-functionalized TiOxCl4-2x accessory layer to boost efficiency of hole-free, all-inorganic perovskite solar cells显示文摘Tin dioxide(SnO2) is generally regarded as a promising electron-transporting layer(ETL) for state-of-theart perovskite solar cells(PSCs), however, the ubiquitous oxygen-vacancy-related defects at SnO2 surface and the large energy difference between conduction band of SnO2 and perovskite layer undoubtedly cause severe charge carrier recombination, resulting in sluggish charge extraction efficiency and non-negligible open-circuit voltage(Voc) loss. Herein, a chlorine-containing TiOxCl4-2x accessory layer is fabricated by immersing SnO2 layer into the TiCl4 aqueous solution to passivate the surface oxygen-vacancy-related defects of SnO2 layer and to set an intermediate energy level at ETL/perovskite interface in all-inorganic cesium lead tri-bromine(CsPbBr3) PSCs. Furthermore, the TiOxCl4-2x layer also improves the infiltration of SnO2 layer surface toward perovskite precursor for high-quality perovskite film. Finally, the hole-free, allinorganic CsPbBr3PSC with a structure of FTO/SnO2/TiOxCl4-2x/Cs0.91Rb0.09PbBr3/carbon achieves a champion efficiency of 10.44% with a Vocas high as 1.629 V in comparison to 8.31% for control device. Moreover, the optimized solar cell presents good stability in 80% humidity in air. | Qingwei Zhou Jialong Duan Yudi Wang Xiya Yang Qunwei Tang | 2020 | Journal of Energy Chemistry2020,29,11: | 1 |
| 6 | Reducing defect of inorganic perovskite film by sulphur-containing Lewis base for robust photodetectors显示文摘Sluggish charge transfer in perovskite film induced by inherent defects such as uncoordinated Pb2+undoubtedly hinders the rapid response of self-powered photovoltaic-typed detector.Based on interaction between Lewis acids and bases,herein,we employ thiourea molecule as a multifunctional Lewis base to significantly improve the quality of all-inorganic CsPbIBr2 perovskite film.After careful characterizations,the quality of perovskite film has been well regulated.Arising from the reduced defect and the reinforced the interfacial charge extraction owing to the strong interaction between uncoordinated Pb2+ions and the-C=S groups in thiourea and the formation of hydrogen bond at perovskite/TiO_(2) interface,an enhanced responsivity of 0.335 A W-1 and specific detectivity of 3.92×10^(12) Jones has been achieved for the self-powered,carbon-electrode based photodetector,which is comparable to the state-of-theart device based on CsPbIBr2 film.More importantly,the device free of encapsulation remains 82.8%of initial performance after storage over 56 days in ambient atmosphere,promoting the practical deployment of perovskite products. | Jian Du Jialong Duan Xiya Yang Qingwei Zhou Yanyan Duan Tingting Zhang Qunwei Tang | 2021 | Journal of Energy Chemistry2021,30,10: | 1 |
| 7 | Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia显示文摘Aberrant self-renewal of leukemia initiation cells(LICs)drives aggressive acute myeloid leukemia(AML).Here,we report that UHRF1,an epigenetic regulator that recruits DNMT1 to methylate DNA,is highly expressed in AML and predicts poor prognosis.UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs.Mechanistically,UHRF1 directly interacts with Sin3A-associated protein 30(SAP30)through two critical amino acids,G572 and F573 in its SRA domain,to repress gene expression.Depletion of UHRF1 or SAP30 derepresses an important target gene,MXD4,which encodes a MYC antagonist,and leads to suppression of leukemogenesis.Further knockdown of MXD4 can rescue the leukemogenesis by activating the MYC pathway.Lastly,we identified a UHRF1 inhibitor,UF146,and demonstrated its significant therapeutic efficacy in the myeloid leukemia PDX model.Taken together,our study reveals the mechanisms for altered epigenetic programs in AML and provides a promising targeted therapeutic strategy against AML. | Cheng-Long Hu Bing-Yi Chen Zijuan Li Tianbiao Yang Chun-Hui Xu Ruirui Yang Peng-Cheng Yu Jingyao Zhao Ting Liu Na Liu Bin Shan Qunling Zhang Junhong Song Ming-Yue Fei Li-Juan Zong Jia-Ying Zhang Ji-Chuan Wu Shu-Bei Chen Yong Wang Binhe Chang Dan Hou Ping Liu Yilun Jiang Xiya Li Xinchi Chen Chu-Han Deng Yi-Yi Ren Roujia Wang Jiacheng Jin Kai Xue Ying Zhang Meirong Du Jun Shi Ling-Yun Wu Chun-Kang Chang Shuhong Shen Zhu Chen Sai-Juan Chen Xiaolong Liu Xiao-Jian Sun Mingyue Zheng Lan Wang | 2022 | Cell Research2022,32,12: | 1 |
| 8 | Two-dimensional conjugated N-rich covalent organic frameworks for superior sodium storage显示文摘Sodium-ion batteries(SIBs) are considered as a promising next-generation energy storage system. To achieve the large-scale application of SIBs, it is crucial to develop cost-effective anode materials with high Na-ion storage capacity. Herein twodimensional(2D) conjugated covalent organic frameworks(c COFs) with N-rich phthalocyanine(Pc) units fused via benzene moieties(named MPc-2D-c COFs) were explored as the SIBs anode materials. Electrochemical tests reveal their high reversible capacities of 538 and 342 m A h g^(-1) at 50 and 1000 m A g^(-1), respectively, good rate performance, and excellent stability,comparable to the state-of-the-art anode materials of SIBs, indicating their outstanding Na-ion storage performance. Ex situ Xray photoelectron and Fourier transform infrared spectroscopies together with theoretical calculations disclose the N atoms at the pore channels and conjugated pyrrole moieties of MPc-2D-c COFs provide abundant Na-ion storage sites. This, in cooperation with the enhanced electrical conductivity owing to the 2D conjugated structure, contributes to the outstanding Na-ion storage capacity of MPc-2D-c COFs. The present result is surely helpful for developing high-performance and cost-effective COFs as electroactive materials for SIBs. | Xiya Yang Yucheng Jin Baoqiu Yu Lei Gong Wenbo Liu Xiaolin Liu Xin Chen Kang Wang Jianzhuang Jiang | 2022 | Science China Chemistry2022,65,7: | 0 |
| 9 | Stretchable alkenamides terminated Ti_(3)C_(2)T_(x)MXenes to release strain for lattice-stable mixed-halide perovskite solar cells with suppressed halide segregation显示文摘Bandgap-tunable mixed-halide perovskite materials have attracted considerable interest because of their indispensability as top counterparts in tandem solar cells.However,the soft and disordered lattice always suffers from severe phase segregation under illumination,which is particularly susceptible to residual lattice strain.Herein,we report a strain regulation strategy by using alkenamides terminated Ti_(3)C_(2)T_(x)MXenes as an additive into perovskite precursor.Apart from the role of a template for grain growth to obtain high-quality films,the stretchable alkyl chain promotes lattice shrinkage or expansion to form an elastic grain boundary to eliminate the spatially distributed stain and shut down ion migration channels.As a result,the all-inorganic perovskite solar cells based on CsPbIBr_(2)and CsPbI_(2)Br halides achieve prolonged device stability under harsh conditions and the best power conversion efficiencies up to 11.06%and 14.30%,respectively. | Xuemei Yao Jialong Duan Yuanyuan Zhao Junshuai Zhang Qiyao Guo Qiaoyu Zhang Xiya Yang Yanyan Duan Peizhi Yang Qunwei Tang | 2023 | Carbon Energy2023,5,12: | 0 |
| 10 | Fe-doped Co_(3)O_(4) nanowire strutted 3D pinewood-derived carbon: A highly selective electrocatalyst for ammonia production via nitrate reduction显示文摘Nitrate(NO_(3)^(-)),a nitrogen-containing pollutant,is prevalent in aqueous solutions,contributing to a range of environmental and health-related issues.The electrocatalytic reduction of NO_(3)^(-)holds promise as a sustainable approach to both eliminating NO_(3)^(-)and generating valuable ammonia(NH_(3)).Nevertheless,the reduction reaction of NO_(3)^(-)(NO_(3)^(-)RR),involving 8-electron transfer process,is intricate,necessitating highly efficient electrocatalysts to facilitate the conversion of NO_(3)^(-)to NH_(3).In this study,Fe-doped Co_(3)O_(4) nanowire strutted three-dimensional(3D)pinewood-derived carbon(Fe-Co_(3)O_(4)/PC)is proposed as a high-efficiency NO_(3)^(-)RR electrocatalyst for NH_(3) production.Operating within 0.1 M NaOH containing NO_(3)^(-),Fe-Co_(3)O_(4)/PC demonstrates exceptional performance,obtain an impressively large NH_(3) yield of 0.55 mmol·h^(-1)·cm^(-2) and an exceptionally high Faradaic efficiency of 96.5%at-0.5 V,superior to its Co_(3)O_(4)/PC counterpart(0.2 mmol·h^(-1)·cm^(-2),73.3%).Furthermore,the study delves into the reaction mechanism of Fe-Co_(3)O_(4) for NO_(3)^(-)RR through theoretical calculations. | Xuwei Liu Chaozhen Liu Xun He Zhengwei Cai Kai Dong Jun Li Xiaoya Fan Ting Xie Xiya Yang Yonglan Luo Dongdong Zheng Shengjun Sun Sulaiman Alfaifi Feng Gong Xuping Sun | 2024 | Nano Research2024,17,4: | 0 |
| 11 | Comparison of leaf morphological,anatomical,and photosynthetic responses to drought stress among eight apple rootstocks显示文摘The drought resistance of eight commonly used apple rootstocks under natural drought conditions was examined to provide clues for the selection,promotion,and utilization of drought-resistant apple rootstocks.The ultrastructural differences and physiological and biochemical characteristics of the leaves of eight apple rootstocks under drought stress were observed.The index changes were used to rank drought resistance by the membership function method comprehensively.The results showed that the leaf thickness,palisade tissue thickness,sponge tissue thickness,net photosynthetic rate,and chlorophyll content were significantly higher in‘Fupingqiuzi'than those of other rootstocks at various stress conditions.The leaf water content and water use efficiency of'Qingzhen 1'were significantly higher than those of other rootstocks under different stress conditions.The root vigor of‘B.9'was significantly higher than that of other rootstocks.The results of membership function analysis showed that the drought resistance of different rootstocks was in the order:‘Fupingqiuzi'>‘Qingzhen 1'>‘B.9'>‘MM.111'>‘GM256'>‘MM.106'>‘M.26'>‘M.9-Nic29'.‘Fupingqiuzi'had the strongest drought resistance,and‘Qingzhen 1'and‘B.9'were also relatively droughtresistant.These rootstocks can be used as raw materials for drought-resistant apple rootstock breeding and are propagated and utilized in arid areas. | Pengpeng Sun Muhammad Mobeen Tahir Xian Lu Zhimin Liu Xiaoyun Zhang Xiya Zuo Yun Shao Xiangyun Xiao Na An Chao Wang Dong Zhang Weiwei Yang | 2022 | Fruit Research2022,2,1: | 0 |
| 12 | Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients显示文摘Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of mortality.Therefore,it is critical to identify novel biomarkers for the prognostic assessment of BRCA.Methods:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases.PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western blotting.Single sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell infiltration.Finally,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA curves.The application of the nomogram was further validated in an immunotherapy cohort.Results:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA cohort.Furthermore,PLK1 expression level,age and stage were identified as independent prognostic factors of BRCA.While the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low patients.We also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA patients.In addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive performance.Conclusions:PLK1 expression and immune cell infiltration can predict post-immunotherapy prognosis of BRCA patients. | JUAN SHEN WEIYU ZHANG QINQIN JIN FUYU GONG HEPING ZHANG HONGLIANG XU JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG SHUGUANG ZHOU | 2024 | Oncology Research2024,32,2: | 0 |
| 13 | Platinum-Iridium Alloy Films Prepared by MOCVD显示文摘Platinum-Iridium alloy films were prepared by MOCVD on Mo substrate using metal-acetylacetonate precursors. Effects of deposition conditions on composition, microstructure and mechanical properties were determined. In these experimental conditions, the purities of films are high and more than 99.0%. The films are homogeneous and monophase solid solution of Pt and Ir. Weight percentage of platinum are much higher than iridium in the alloy. Lattice constant of the alloy changes with the platinum composition. Iridium composition showing an up-down-up trend at the precursor temperature of 190~230℃ and the deposition temperature at 400~ 550℃. The hardness of Pt-Ir alloys prepared by MOCVD is three times more than the alloys prepared by casting. | WEI Yan CHEN Li CAI Hongzhong ZHENG Xu YANG Xiya HU Changyi | 2012 | 贵金属2012,33,A01: | 0 |
| 14 | Interface regulation of Cu_(2)Se via Cu–Se–C bonding for superior lithium-ion batteries显示文摘Transition metal selenides have aroused great attention in recent years due to their high theoretical capacity.However,the huge volume fluctuation generated by conversion reaction during the charge/discharge process results in the significant electrochemical performance reduction.Herein,the carbon-regulated copper(I)selenide(Cu_(2)Se@C)is designed to significantly promote the interface stability and ion diffusion for selenide electrodes.The systematic X-ray spectroscopies characterizations and density functional theory(DFT)simulations reveal that the Cu–Se–C bonding forming on the surface of Cu2Se not only improves the electronic conductivity of Cu_(2)Se@C but also retards the volume change during electrochemical cycling,playing a pivotal role in interface regulation.Consequently,the storage kinetics of Cu_(2)Se@C is mainly controlled by the capacitance process diverting from the ion diffusion-controlled process of Cu2Se.When employed this distinctive Cu_(2)Se@C as anode active material in Li coin cell configuration,the ultrahigh specific capacity of 810.3 mA·h·g^(−1)at 0.1 A·g^(−1)and the capacity retention of 83%after 1,500 cycles at 5 A·g^(−1)is achieved,implying the best Cu-based Li^(+)-storage capacity reported so far.This strategy of heterojunction combined with chemical bonding regulation opens up a potential way for the development of advanced electrodes for battery storage systems. | Kefu Zhu Shiqiang Wei Quan Zhou Shuangming Chen Yunxiang Lin Pengjun Zhang Yuyang Cao Changda Wang Yixiu Wang Yujian Xia Dengfeng Cao Zeinab Mohamed Xin Guo Xiya Yang Xiaojun Wu Li Song | 2023 | Nano Research2023,16,2: | 0 |
| 15 | Hydrothermal synthesis of polyimide-linked covalent organic frameworks towards ultrafast and stable cathodic sodium storage显示文摘Redox-active organic materials are capturing growing attention as cathode materials for sustainable alkaline metal ion batteries.However,the storage of Na+in most organic materials-based cathodes is plagued by low capacity and unsatisfying rate performance due to their low active site densities and limited exposed active sites.Herein,two polyimide-linked covalent organic frameworks(COFs),namely HATN-PD-COF and HATN-TAB-COF,were fabricated from hydrothermal synthesis with redoxactive triphenylene-2,3,6,7,10,11-hexacarboxylic acid and aromatic amines as starting materials.Powder X-ray diffraction and electron microscopy analysis indicate the high crystalline nature of these COFs with AA stacking configuration and orderly mesoporous tunnel.N_(2) sorption measurement discloses the permanent porosity of these two COFs with a Brunauer-EmmettTeller surface area of 1,065-1,200 m^(2)g^(-1)and a large pore size of 2.0-3.1 nm.Galvanostatic intermittent titration technique and density functional theory calculations reveal the facile Na+ion diffusion along the mesoporous tunnel of these COFs with a small energy barrier of 0.13-0.40 e V.In particular,the as-prepared COFs based-cathodes show ultrafast and stable Na+storage associated with their conjugated electronic structure,highly ordered mesoporous tunnel,robust structure,and redox-active C=N/C=O-rich framework as exemplified by the high reversible capacity of 210 m A h g^(-1)at 200 m A g^(-1),record-high rate performance(195 m A h g^(-1)at a high current density of 10,000 m A g^(-1))among organic electrodes and the capacity retention of nearly 91%at 10,000 m A g^(-1)after 7,000 cycles for HATN-PD-COF. | Xiya Yang Lei Gong Zhixin Liu Qianjun Zhi Baoqiu Yu Xin Chen Kang Wang Xiaofeng Li Dongdong Qi Jianzhuang Jiang | 2024 | Science China Chemistry2024,67,4: | 0 |
| 16 | Covalent organic frameworks with imine proton acceptors for efficient photocatalytic H_(2) production显示文摘Covalent organic frameworks (COFs) are promising crystalline materials for the light-driven hydrogen evolution reaction (HER) due to their tunable chemical structures and energy band gaps.However,deeply understanding corresponding mechanism is still challenging due to the multiple components and complicated electron transfer and reduction paths involved in photocatalytic HER.Here,the photocatalytic HER investigation has been reported based on three COFs catalysts,1–3,which are prepared by benzo[1,2-b:3,4-b’:5,6-b’]trithiophene-2,5,8-trialdehyde to react with C3symmetric triamines including tris(4-aminophenyl)amine,1,3,5-tris(4-aminophenyl)benzene,and (1,3,5-tris-(4-aminophenyl)triazine,respectively.As the isostructural hexagonal honeycomb-type COF of 2 and 3 reported previously,the crystal structure of 1 has been carefully correlated through the powder X-ray diffraction study with the help of theoretical simulations.1 shows highly porous framework with Brunauer-Emmett-Teller surface area of1249 m^(2)/g.Moreover,the introduction of ascorbic acid into the photocatalytic system of COFs achieves the hydrogen evolution rate of 3.75,12.16 and 20.2 mmol g^(–1)h^(–1) for 1–3,respectively.The important role of ascorbic acid in photocatalysis of HER is disclosed to protonate the imine linkages of these COFs,leading to the obvious absorbance red-shift and the improved charge separation efficiency together with reduced resistance in contrast to pristine materials according to the spectroscopic and electronic characterizations.These innovations of chemical and physical properties for these COFs are responsible for their excellent photocatalytic performance.These results elucidate that tiny modifications of COFs structures is able to greatly tune their band structures as well as catalytic properties,therefore providing an available approach for optimizing COFs functionalities. | Xiaolin Liu Xiya Yang Xu Ding Hailong Wang Wei Cao Yucheng Jin Baoqiu Yu Jianzhuang Jiang | 2023 | Chinese Chemical Letters2023,34,10: | 0 |