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| 1 | Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。 | Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang | 2016 | Cell Research2016，26，9： | 138 |
| 2 | Mitochondria-mediated apoptosis in mammals显示文摘调停线粒体的 caspase 激活小径是 mitochondrial 描绘的一条主要 apoptotic 小径外部膜 permeabilization (MOMP ) 和进细胞质到的细胞色素 c 的随后的版本激活 caspases。MOMP 被蛋白质的 Bcl-2 家庭调整。这条小径不仅在正常开发,组织动态平衡的维护和免疫系统的规定,而且在象有免疫力的混乱, neurodegeneration 和癌症那样的人的疾病起重要作用。在过去的十年,这条小径和规章的机制的分子的基础包括地被学习了,然而,很多新证据显示从线粒体的那个细胞色素 c 版本总是不导致激活能也有的不可逆的房间死亡,和那 caspase 非死亡功能。因此,许多未解决的问题和新挑战正在尚待。而且,涉及癌症开发的这条小径的机能障碍是明显的,并且作为治疗学的策略指向小径广泛地被探索了,但是指向的治疗的功效仍然在开发中。在这评论,我们将讨论调停线粒体的 apoptosis 小径和它的生理的角色和治疗学的含意。 | Shunbin Xiong Tianyang Mu Guowen Wang Xuejun Jiang | 2014 | Protein & Cell2014，5，10： | 31 |
| 3 | Nerve Growth Factor Prevents the Apoptosis-associated Increase in Acetylcholinesterase Activity after Hydrogen Peroxide Treatment by Activating Akt显示文摘Acetylcholinesterase (疼痛) 被认为玩结果显示出的重要角色 duringapoptosis.Our 那 H_2O_2 导致了疼痛活动,功能的标记 inapoptosis,象 neuronal 一样 PC 12 房间的增加。谷胱甘肽,涉及细胞的氧化还原作用动态平衡,禁止了疼痛活动的增加,建议在这个过程的那个反应的氧种类(ROS ) 千盐湖钥匙角色。进一步的调查证明疼痛的举起在 Akt,从进 cytosol 的线粒体的细胞色素 c 的版本,和 caspase 家庭成员的激活的降级以后被观察。神经生长因素(NGF ) 什么时候是在场的,与 Akt 水平,疼痛的举起,细胞色素 c 散开,以及 apoptosis 的维护,显著地在对待 H_2O_2 的 PC12 细胞被稀释。然而, wortmannin, PI3K/Aktpathway 的一个禁止者,加速了 apoptosis 并且增加了疼痛活动。过去表示 ofconstitutively 激活 Akt,它是 NGF receptorTrkA,推迟的 mitochondrial 倒塌和疼痛活动的禁止的举起的一个下游的发信号元素。因此, NGF preventedapoptosis 和由激活 Akt 小径并且稳定线粒体的功能的疼痛活动的举起。 | Hua JIANG~(1,3) Jingya ZHANG~(1,3) Hui ZHU~(1,3) Hong LI~2 and Xuejun ZHANG~1 ~1Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shangha Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ~2DEFEMA,Faculté de Medecine et de Pharmacie,University of Rouen,Rouen 76821,France ~3Graduate school of the Chinese Academy of Sciences,Beijing 100080,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 9 |
| 4 | PTEN: a default gate-keeping tumor suppressor with a versatile tail显示文摘肿瘤 suppressor PTEN 包括房间增长,生长,移植,和死亡控制许多生物过程。作为一位主人细胞的管理者, PTEN 本身也受到商讨规定保证它的合适的功能。在 PTEN 规定的缺点在 carcinogenesis 上有深刻影响。在这评论,我们简短有关 PTEN 规定讨论最近的进展并且如此的知识怎么便于我们的理解和 PTEN 的进一步的探索生物学。PTEN 的 carboxyl 尾巴,看起来与 posttranslational 规定的多重类型被联系,将在详细审查下面。进一步,当 p53 需要被激活压制 tumorigenesis (一个休眠看门人) 时, PTEN 和 p53 的比较分析建议, PTEN 可能是对癌症开发的一个组成的监视者,这样一个缺省看门人。 | Xinjiang Wang Xuejun Jiang | 2008 | Cell Research2008，18，8： | 7 |
| 5 | Weighted Multi-sensor Data Level Fusion Method of Vibration Signal Based on Correlation Function显示文摘As the differences of sensor's precision and some random factors are difficult to control,the actual measurement signals are far from the target signals that affect the reliability and precision of rotating machinery fault diagnosis.The traditional signal processing methods,such as classical inference and weighted averaging algorithm usually lack dynamic adaptability that is easy for trends to cause the faults to be misjudged or left out.To enhance the measuring veracity and precision of vibration signal in rotary machine multi-sensor vibration signal fault diagnosis,a novel data level fusion approach is presented on the basis of correlation function analysis to fast determine the weighted value of multi-sensor vibration signals.The approach doesn't require knowing the prior information about sensors,and the weighted value of sensors can be confirmed depending on the correlation measure of real-time data tested in the data level fusion process.It gives greater weighted value to the greater correlation measure of sensor signals,and vice versa.The approach can effectively suppress large errors and even can still fuse data in the case of sensor failures because it takes full advantage of sensor's own-information to determine the weighted value.Moreover,it has good performance of anti-jamming due to the correlation measures between noise and effective signals are usually small.Through the simulation of typical signal collected from multi-sensors,the comparative analysis of dynamic adaptability and fault tolerance between the proposed approach and traditional weighted averaging approach is taken.Finally,the rotor dynamics and integrated fault simulator is taken as an example to verify the feasibility and advantages of the proposed approach,it is shown that the multi-sensor data level fusion based on correlation function weighted approach is better than the traditional weighted average approach with respect to fusion precision and dynamic adaptability.Meantime,the approach is adaptable and easy to use,can be applied to other areas of vibration measurement. | BIN Guangfu JIANG Zhinong LI Xuejun DHILLON B S | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 7 |
| 6 | Industrial and Agricultural Effects on Water Environment and Its Optimization in Heavily Polluted Area in Taihu Lake Basin, China显示文摘The deteriorating water quality in the Taihu Lake Basin has attracted widespread attention for many years, and is correlated with a sharp increase in the quantity of pollutant discharge such as agricultural fertilizers and industrial wastewater. In this study, several factors were selected for evaluating and regionalizing the water environmental capacity by ArcGIS spatial analysis, including geomorphologic characteristics, water quality goals, water body accessibility, water-dilution channels, and current water quality. Then, the spatial optimization of agriculture and industry was adjusted through overlay analysis, based on the balance between industrial space and water environmental capacity. The results show that the water environmental capacity gradually decreases from the west to the east, in contrast, the pollution caused by industrial and agricultural clustering is distributes along Taihu Lake, Gehu Lake and urban districts. The analysis of the agricultural space focuses on optimizing key protected areas of the Taihu Lake Basin, and the shores of Gehu Lake, optimally adjusting the second protected areas of the Taihu Lake Basin, and generally adjusting the urban areas of Changzhou and Wuxi cities. The analysis of industrial space focuses on optimizing the downtowns of Changzhou and Wuxi cities, optimally adjusting key protected areas and second protected areas of the Taihu Lake Basin, and generally adjusting the south and southwest of Gehu Lake. Lastly, some schemes of industrial and agricultural layouts and policies for the direction of industrial and agricultural development were proposed, reflecting a correlation between industry and agriculture and the water environment. | ZHAO Haixia YOU Bensheng DUAN Xuejun Stewart BECKY JIANG Xiaowei | 2013 | Chinese Geographical Science2013，23，2： | 7 |
| 7 | Quantitative analysis of the ribbon synapse number of cochlear inner hair cells in C57BL/6J mice using the three-dimensional modeling method显示文摘In mammals,the ribbon synapses of cochlear inner hair cells are a synaptic structure of the first sensory nerve in the pathway of acoustical signal transmission to the acoustic center,and it is directly involved in voice coding and neurotransmitter release. It is difficult to quantitatively analyze the ribbon synaptic number only using an electron microscope,because the ribbon synaptic number is relatively limited and their location is deep. In this study,the specific presynaptic structure-RIBEYE,and non-specific postsynaptic structure-GluR 2 & 3 in C57BL/6J mouse basilar membrane samples were treated by immunofluorescent labeling. Serial section was performed on the samples using a laser scanning confocal microscope,and then the serial sections were used to build three-dimensional models using 3DS MAX software. Each fluorescein color pair indicates one synapse,so the number of ribbon synapses of inner hair cells is obtained. The spatial distribution and the number of ribbon synapses of cochlear inner hair cells were clearly shown in this experiment,and the mean number of ribbon synapses per inner hair cell was 16.10±1.03. Our results have demonstrated the number of ribbon synapses is accurately calculated by double immunofluorescent labeling to presynaptic and postsynaptic structures,serial sections obtained using a laser scanning confocal microscope,and three-dimensional modeling obtained using 3DS MAX software. The method above is feasible and has important significance for further exploring the mechanism of sensorineural deafness. | LIU Ke,LI ShuNa & JIANG XueJun Department of Otolaryngology,the First Affiliated Hospital,China Medical University,Shenyang 110001,China | 2009 | Science China(Life Sciences)2009，52，9： | 5 |
| 8 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 9 | A Novel Resource Allocation Algorithm based on Downlink and Uplink Decouple Access Scheme in Heterogeneous Networks显示文摘Traditional cellular network requires that a user equipment(UE) should associate to the same base station(BS) in both the downlink(DL) and the uplink(UL). Based on dual connectivity(DC) introduced in LTE-Advanced R12, DL/UL decouple access scheme has been proposed, which is especially suitable for heterogeneous networks(Het Nets). This paper is the pioneer to take the DL/UL decouple access scheme into consideration and develop a novel resource allocation algorithm in a two-tier Het Net to improve the total system throughput in the UL and ease the load imbalance between macro base stations(MBSs) and pico base stations(PBSs). A model is formulated as a nonlinear integer programming, and the proposed algorithm is a sub-optimal algorithm based on the graph theory. First, an undirected and weighted interference graph is obtained. Next, the users are grouped to let users with large mutual interferences to be assigned to different clusters. Then, the users in different clusters are allocated to different resource blocks(RBs) by using the Hungarian algorithm. Simulation results show that the proposed algorithm can provide great promotions for both the total system throughput and the average cell edge user throughput and successfully ease the load imbalance between MBSs and PBSs. | Laiwei Jiang Xuejun Sha Xuanli Wu Naitong Zhang | 2016 | China Communications2016，13，6： | 4 |
| 10 | Wavy PtCu alloy nanowire networks with abundant surface defects enhanced oxygen reduction reaction显示文摘Bimetalic platinum-copper(Pt-Cu)alloy nanowires have emerged as a novel class of fuel cell electrocatalysts for oxygen reduction reaction(ORR)due to their intrinsic high catalytic activity and durability,but preparing such electrocatalysts with clean surface via facile method is still a challenge.Herein,PtCu alloy with nanowire networks(NWNs)structure is obtained by a simple modified polyol method accompanied with a salt-mediated self-assembly process in a water/ethylene glycol(EG)mixing media.The formation mechanism of PtCu NWNs including the morphological evolution and the relevant experimental parameters has been investigated systematically.We propose that a micro-interface in H2O-EG media formed with the assistance of disodium dihydrogen pyrophosphate(Na2H2P2O7)and its unique nature of coordinating with Pt^2+ or Cu^2+ play critical roles in the formation of NWNs.When tested as ORR catalyst,the PtCuNWNs/C exhibits much higher activity and durability than that of PtNWNs/C and commercial PtC,even exceeding the target of DOE in 2020.The excellent performance of PtCuNWNs/C could be attributed to the unique structure of NWNs with 2.4 nm ultrathin wavy nanowires and plentiful surface defects and the modified electronic effect caused by alloying with Cu atoms. | Dahui Fang Lei Wan Qike Jiang Hongjie Zhang Xuejun Tang Xiaoping Qin Zhigang Shao Zidong Wei | 2019 | Nano Research2019，12，11： | 4 |
| 11 | Preparation of one-dimensional nanostructured ZnO显示文摘Rod-like ZnO particles were synthesized via a sol-gel method by adding ethylene diamine(EDA) to the reaction system of Zn(Ac)2·2H2O and H2C2O4·2H2O.The crystal phase and morphology of the products were characterized by XRD(X-ray powder diffractometer) and TEM(transmission electron microscope).Rod-like ZnO belongs to the hexagonal Wurtzite system,with diameters and lengths of about 20-200 nm and 0.2-1.5 m,respectively.Experimental results showed that the morphology of nano-ZnO can be controlled by modulating the quantities of EDA added into the reaction system and that EDA plays an important role in the formation of rod-like ZnO particles.The growth mechanism of the rod-like nanoZnO was briefly discussed.The proposed facile,reproducible,effective and low-cost synthesis promises future large-scale preparation of nanostructured ZnO for application in nanotechnology. | Xiuping Jiang Youzhi Liu Yanyang Gao Xuejun Zhang Lihong Shi | 2010 | Particuology2010，8，4： | 4 |
| 12 | A new checkpoint against ferroptosis显示文摘By taking different approaches,two research groups made the same discovery that a CoQ oxidoreductase(renamed as ferroptosis suppressor protein-1,or FSP1)can inhibit ferroptosis,a form of cell death driven by iron-dependent phospholipid peroxidation.As FSP1 is expressed in various cancers and can halt ferroptosis even in the absence of glutathione peroxidase 4(GPX4),which was previously considered indispensable for ferroptosis surveillance,the potential of FSP1 as a new cancer therapeutic target should be explored. | Deguang Liang Liang Deng Xuejun Jiang | 2020 | Cell Research2020，30，1： | 4 |
| 13 | A monotone finite volume method for time fractional Fokker-Planck equations显示文摘We develop a monotone ?nite volume method for the time fractional Fokker-Planck equations and theoretically prove its unconditional stability. We show that the convergence rate of this method is of order 1 in the space and if the space grid becomes suffciently ?ne, the convergence rate can be improved to order 2.Numerical results are given to support our theoretical ?ndings. One characteristic of our method is that it has monotone property such that it keeps the nonnegativity of some physical variables such as density, concentration,etc. | Yingjun Jiang Xuejun Xu | 2019 | Science China Mathematics2019，62，4： | 3 |
| 14 | Incidence of Macrosomia in Rural Areas—Henan Province,China,2013–2017显示文摘Introduction:Macrosomia has short-term and long-term adverse health effects and is thus an important public health concern.Recent decades have witnessed increasing incidence of macrosomia in many countries.Methods:The present study used a large population-based birth cohort study to depict incidence of macrosomia among live births in rural areas of Henan Province of China from 2013 to 2017.Results:Among the 1,262,916 births,82,353 were cases of macrosomia.The overall incidence of all types of macrosomia,of macrosomia with birth weight<4,500 g,and of macrosomia with birth weight≥4,500 g were 6.52%,5.30%,and 1.22%,respectively.From 2013 to 2017,the incidence of macrosomia decreased by 31.3%from 7.96%in 2013 to 5.47%in 2017(X^(2)_(trend)=946.96,P_(trend)<0.001).Male infants and infants≥42 gestational weeks had significantly higher incidence of macrosomia than that of female infants and infants<42 gestational weeks(P<0.001).Conclusion:Gestational weight control through nutrition management and physical activities during pregnancy are needed to reduce incidence of macrosomia. | Shiqi Lin Jian Chai Jiajia Li Xuejun Shang Lijun Pei Lifang Jiang Junxi Zhang Panpan Sun Wei Dong Yuhong Wang Dezhuan Zhou | 2021 | China CDC weekly2021，3，37： | 3 |
| 15 | Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor γ显示文摘Peroxisome 激活 proliferator 的受体(PPAR ) 属于 ligand 依赖的抄写因素的原子荷尔蒙受体总科。最近的结果证明了 PPAR 纬的收缩筋例如 troglitazone (TGZ ) ,能禁止房间增长并且支持独立于 PPAR 纬的房间区别。在现在的学习,我们提供 TGZ 可以直接绑在 EGFR 并且触发它发信号和 PPAR 纬的成为主观独立人士的证据。详细研究表明有 TGZ 的延长孵化有效地稀释了由指向受体到 endo-lysosomal 降级机械发信号的 EGFR。尽管细胞外的调整信号的发信号 kinase 小径被 TGZ 短暂地在 EGFR overexpressing 癌症细胞激活,导致 EGF 的 Akt phosphorylation 的抑制很可能说明了 TGZ 在 pharmacologically 可完成的集中引起的肿瘤细胞的生长拘捕。因此,我们提供了显示 TGZ 由支持 EGFR 降级和 attenuating Akt phosphorylation 禁止房间增长的证据的一根新线。 | Xiaoqi Li Xuanming Yang Youli Xu Xuejun Jiang Xin Li Fajun Nan Hong Tang | 2009 | Cell Research2009，19，6： | 2 |
| 16 | State feedback stabilization of stochastic nonlinear time-delay systems:a dynamic gain method显示文摘Dear editor,During the past few decades,a significant amount of attention has been focused on deterministic time-delay systems.These studies are based on all types of growth conditions on nonlinear functions.In a recent study[1],Zhang et al.obtained particularly good results using a dynamic gain method with wide practical use[2],and proved that restrictive growth conditions are unnecessary and can be removed in the case ot state teedback control. | Mengmeng JIANG Xuejun XIE | 2021 | Science China(Information Sciences)2021，64，1： | 2 |
| 17 | Pairwise distance-based heteroscedasticity test for regressions显示文摘In this study,we propose nonparametric testing for heteroscedasticity in nonlinear regression models based on pairwise distances between points in a sample.The test statistic can be formulated such that Ustatistic theory can be applied to it.Although the limiting null distribution of the statistic is complicated,we can derive a computationally feasible bootstrap approximation for such a distribution;the validity of the introduced bootstrap algorithm is proven.The test can detect any local alternatives that are different from the null at a nearly optimal rate in hypothesis testing.The convergence rate of this test statistic does not depend on the dimension of the covariates,which significantly alleviates the impact of dimensionality.We provide three simulation studies and a real-data example to evaluate the performance of the test and demonstrate its applications. | Xu Guo Xuejun Jiang Shumei Zhang Lixing Zhu | 2020 | Science China Mathematics2020，63，12： | 2 |
| 18 | Toll-like receptor 5 agonist CBLB502 induces radioprotective effects in vitro显示文摘从沙门氏菌 flagellin 导出的 CBLB502 是像使用费的受体的新奇收缩筋 5 (TLR5 ) 。CBLB502 能与低毒性和 immunogenicity 在整个身体的照耀期间从官方补给、造血的症候群在老鼠和首领上施加高避免受辐射影响的功效,这被显示出。然而,没有有效系统被用来在 vitro 对照耀和相关机制调查 CBLB502 的保护的效果。在这研究,我们在组成地表示人的 TLR5 和 NF-B-dependent 酶的 HEK293-N-T 房间调查了 CBLB502 的避免受辐射影响的性质。HEK293-N-T 房间在 60 公司 -- 光线照耀。在照耀以后,房间生存能力是即时的由使用即时房间分析系统为 4 是天。我们发现 CBLB502 能够高效地维持照耀的 HEK293-N-T 房间的幸存率。然后, apoptotic 房间死亡和房间周期被流动 cytometry 检测。结果证明那个 CBLB502 预告的处理能减少 apoptosis 并且以一种剂量依赖者方式从 G2 阶段拘捕支持照耀的 HEK293-N-T 房间的恢复。我们的数据显示 CBLB502 经由 anti-apoptosis 在 vitro 有直接避免受辐射影响的效果并且支持房间周期恢复。这里开发的方法能是一在 vitro 有效屏蔽象 CBLB502 一样的另外的 TLR5 目标 radioprotectants 的系统。 | Tong Shi Liqin Li Guochao Zhou Chen Wang Xuejun Chen Ruihua Zhang Jianfu Xu Xiaojing Lu Hui Jiang Jisheng Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 2 |
| 19 | Responses of acid/alkaline phosphatase, lysozyme, and catalase activities and lipid peroxidation to mercury exposure during the embryonic development of goldfish Carassius auratus显示文摘 | Xianghui Kong Shuping Wang Hongxia Jiang Guoxing Nie Xuejun Li | 2012 | Aquatic Toxicology2012，，： | 1 |
| 20 | Synthesis and characterization of fluoropolymer modified polyacrylate in emulsion polymerization显示文摘 | Cui Xuejun Jiang Wenyong | 2006 | Journal of Applied Polymer Science2006，99，： | 1 |
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