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| 1 | The initial attempt to reveal the emission processes of both mechanoluminescence and room temperature phosphorescence with the aid of circular dichroism in solid state显示文摘A phenothiazine derivative PtzChol containing non-conjugated chiral cholesterol group was designed and synthesized. By analyzing the single crystal structure of PtzChol carefully, coupled with the circular dichroism(CD) signals before and after grinding, it was found that the introduction of cholesterol produced a positive effect on the production of chiral space group, on mechanoluminescence(ML) and room temperature phosphorescence(RTP), and throughout the entire light-emitting process, the CD signal could well reflect the changes of molecular arrangement. | Yu Tian Xuekang Yang Yanbin Gong Yunsheng Wang Manman Fang Jie Yang Zhiyong Tang Zhen Li | 2021 | Science China Chemistry2021，64，3： | 2 |
| 2 | Osteosarcoma cell proliferation and migration are partly regulated by redox-activated NHE-1显示文摘Background:Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.OS is associated with locally aggressive growth and high metastatic potential.The mechanisms that underlie these processes are currently elusive.Reactive oxygen species(ROS)and Na+/H+exchanger 1(NHE1)have been suggested to regulate proliferation and migration of tumor cells.However,the relationship between NHE1 and ROS in OS proliferation and migration has not been investigated before.Aim:To investigate the role of NHE1 and ROS in the proliferation and migration of OS.Methods:ROS levels and NHE1 expression were studied in cultured human OS cells and human OS xenografts in nude mice.In vitro,OS cells were treated with different doses of tert-butyl hydroperoxide(tBHP),a ROS inducer,and cariporide,an NHE1 inhibitor,to study the effect on cell proliferation and migration.In vivo,nude mice bearing OS cells were administrated with NHE1 inhibitor or antioxidant and the tumor weights were measured.Results:This study reported for the first time that the expression of NHE1 and intracellular ROS level were both increased in OS tissues and cells.Exposure of OS cell to ROS derived from tBHP was able to accelerate cell proliferation and migration and also up-regulate NHE1 protein expression.Moreover,tBHP significantly increased intracellular pH(pHi),decreased extracellular pH(pHe)and induced upregulation of ERK,MMP2,and MMP9.Lowering of ROS levels with the anti-oxidant DMTU or inhibiting NHE1 activity via cariporide abolished the stimulatory effect of tBHP.However,there cariporide did not affect intracellular ROS levels.In vivo study we further confirmed that cariporide could inhibit tumor growth in the nude mouse xenografts of OS cells.Conclusions:The data demonstrate that up-regulation of NHE1 was induced by low concentrations of ROS contributes to the regulation of tumor proliferation and invasion of OS.Relevance for patients:There is potential application for cariporide as an effective antitumor agent during the development of human osteosarcoma.In addition,redox modulation on proton transport may represent a novel target of osteosarcoma prevention,and open a new avenues for future research. | Hua Bai Guojing Chen Congwen Fang Xuekang Yang Sixun Yu Chunxu Hai | 2015 | Journal of Clinical & Translational Research2015，1，3： | 2 |
| 3 | The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species显示文摘Background:Acute lung injury(ALI)is a common complication following severe burns.The underlying mechanisms of ALI are incompletely understood;thus,available treatments are not sufficient to repair the lung tissue after ALI.Methods:To investigate the relationship between the Notch pathway and burn-induced lung injury,we established a rat burn injury model by scalding and verified lung injury via lung injury evaluations,including hematoxylin and eosin(H&E)staining,lung injury scoring,bronchoalveolar lavage fluid and wet/dry ratio analyses,myeloperoxidase immunohistochemical staining and reac-tive oxygen species(ROS)accumulation analysis.To explore whether burn injury affects Notch1 expression,we detected the expression of Notch1 and Hes1 after burn injury.Then,we extracted pulmonary microvascular endothelial cells(PMVECs)and conducted Notch pathway inhibition and activation experiments,via aγ-secretase inhibitor(GSI)and OP9-DLL1 coculture,respectively,to verify the regulatory effect of the Notch pathway on ROS accumulation and apoptosis in burn-serum-stimulated PMVECs.To investigate the regulatory effect of the Notch pathway on ROS accumulation,we detected the expression of oxidative-stress-related molecules such as superoxide dismutase,nicotinamide adenine dinucleotide phosphate(NADPH)oxidase(NOX)2,NOX4 and cleaved caspase-3.NOX4-specific small interfering RNA(siRNA)and the inhibitor GKT137831 were used to verify the regulatory effect of the Notch pathway on ROS via NOX4.Results:We successfully established a burn model and revealed that lung injury,excessive ROS accumulation and an inflammatory response occurred.Notch1 detection showed that the expression of Notch1 was significantly increased after burn injury.In PMVECs challenged with burn serum,ROS and cell death were elevated.Moreover,when the Notch pathway was suppressed by GSI,ROS and cell apoptosis levels were significantly increased.Conversely,these parameters were reduced when the Notch pathway was activated by OP9-DLL1.Mechanistically,the inhibition of NOX4 by siRNA and GKT137831 showed that the Notch pathway reduced ROS production and cell apoptosis by downregulating the expression of NOX4 in PMVECs.Conclusions:The Notch pathway reduced ROS production and apoptosis by downregulating the expression of NOX4 in burn-stimulated PMVECs.The Notch-NOX4 pathway may be a novel therapeutic target to treat burn-induced ALI. | Weixia Cai Kuo Shen Peng Ji Yanhui Jia Shichao Han Wanfu Zhang Xiaolong Hu Xuekang Yang Juntao Han Dahai Hu | 2022 | Burns & Trauma2022，10，1： | 2 |
| 4 | Mitochondrial fission factor promotes cisplatin resistance in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and one of the leading causes of cancer-related death worldwide.Chemotherapeutic agents/regimens such as cisplatin(DDP)are frequently used for advanced HCC treatment.However,drug resistance remains a major hindrance and the underline mechanisms are not fully understood.In this study,we investigated the expression pattern and function of mitochondrial fission factor(Mff)in cisplatin-resistant HCC.We found that Mff is highly expressed in cisplatin-resistant HCC tissues and cell lines.Knockdown of Mff suppresses cell proliferation and promotes cell apoptosis of HCC/DDP cells.In addition,knockdown of Mff sensitizes Huh-7/DDP cells to cisplatin treatment,inhibits cell proliferation,migration and invasion,and enhances cell apoptosis.Confocal imaging showed that knockdown of Mff inhibits the mitochondrial fission and downregulates the expression of GTPase dynamin-related protein 1(Drp1)in cisplatin-resistant Huh-7/DDP cells.Moreover,xenograft tumor model revealed that knockdown of Mff sensitizes Huh-7/DDP xenograft tumor to cisplatin treatment in vivo.In summary,our findings suggest that Mff regulates mitochondrial Drp1 expression and promotes cisplatin resistance in HCC,which provides a potential therapeutic target for the treatment of cisplatin-resistant HCC. | Xiaoliang Li Quanlin Wu Fujun Ma Xinxin Zhang Lei Cai Xuekang Yang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 1 |
| 5 | Ultimate stress of unbonded partially prestressed concrete beams 显示文摘 | Du Gongchen Tao Xuekang | 1985 | PCI Journal1985，30，6： | 1 |
| 6 | Frequency response of distributed fiber-optic vibration sensor based on nonbalanced Mach-Zehnder interferometer显示文摘 | Wei Pu Shan Xuekang Sun Xiaohan | 2013 | Optical Fiber Technology2013，19，1： | 1 |
| 7 | Adoptive transfer of metabolically reprogrammed macrophages for atherosclerosis treatment in diabetic ApoE^(-/-) mice显示文摘Atherosclerosis is characterized by inflammation in the arterial wall,which is known to be exacerbated by diabetes.Therapeutic repression of inflammation is a promising strategy for treating atherosclerosis.In this study,we showed that diabetes aggravated atherosclerosis in apolipoproteinE knockout(ApoE^(-/-))mice,in which increased expression of long-chain acyl-CoA synthetase 1(Acsl1)in macrophages played an important role.Knockdown of Acsl1 in macrophages(Mφ^(shAcsl1))reprogrammed macrophages to an anti-inflammatory phenotype,especially under hyperglycemic conditions.Injection of Mφ^(shAcsl1) reprogrammed macrophages into streptozotocin(STZ)-induced diabetic ApoE^(-/-) mice(ApoE^(-/-)+STZ)alleviated inflammation locally in the plaque,liver and spleen.Consistent with the reduction in inflammation,plaques became smaller and more stable after the adoptive transfer of reprogrammed macrophages.Taken together,our findings indicate that increased Acsl1 expression in macrophages play a key role in aggravated atherosclerosis of diabetic mice,possibly by promoting inflammation.Adoptive transfer of Acsl1 silenced macrophages may serve as a potential therapeutic strategy for atherosclerosis. | Tingting Wang Yan Dong Li Yao Fan Lu Chenxi Wen Zhuo Wan Li Fan Zhelong Li Te Bu Mengying Wei Xuekang Yang Yi Zhang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 8 | Proper- ties of ZnO thin film on A120,, substrate prepared by pulsed laser deposition under different substrate tempera- ture显示文摘 | Wang Yunfei Chen Xuekang Wang Lanxi | 2011 | Physics Procedia2011，18，： | 1 |
| 9 | Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats显示文摘 | Xuekang Yang Hua Bai Weixia Cai Jun Li Qin Zhou Yunchuan Wang Juntao Han Xiongxiang Zhu Maolong Dong Dahai Hu | 2013 | Chemico-Biological Interactions2013，，3： | 1 |
| 10 | The practice and effect of analysis of task driven teaching method to elementary information technology of teaching显示文摘 | Xu Xuekang | 2012 | Equipment of China Teaching technology2012，，13： | 1 |
| 11 | Y(sl(2)) Algebra Application in Extended Hydrogen Atom and Monopole Models显示文摘We present the extended hydrogen atom and monopole-hydrogen atom theory through generalizing the usual hydrogen atom model and with a monopole model respectively, in which Y (sl(2) ) algebras are realized. We derive the Hamiltonians of the two models based on the Y(sl(2) ) and the generalized Pauli equation. The energy spectra of the systems are also given in terms of Yangian algebra and quantum mechanics. | TIANLi-Jun ZHANGHong-Biao JINShuo XUEKang | 2004 | Communications in Theoretical Physics2004，41，5： | 1 |
| 12 | A Realization of Yangian and Its Applications to the Bi—spin System in an External Magnetic Field显示文摘Yangian Y(sl(2)) is realized in the bi-spin system coupled with a time-dependent external magnetic field. It is shown that Y(sl(2)) generators can describe the transitions between the 'spin triplet' and the 'spin singlet' that evolve with time. Furthermore, new transition operators between the states with Berry phase factor and those between the states of nuclear magnetic resonance are presented. | JINShuo XUEKang 等 | 2003 | Communications in Theoretical Physics2003，39，1： | 1 |
| 13 | Laser nitriding of titanium alloy in the atmosphere environment显示文摘 | Chen Xuekang Wu Gan Wang Rui | 2007 | Surface and Coatings Technology2007，201，911： | 1 |
| 14 | Induced circularly polarized luminescence of perovskite nanocrystals by self-assembly chiral gel显示文摘Perovskites nanocrystals(NCs)with circularly polarized light(CPL)activity have drawn much attention due to the fascinating photoelectric properties of perovskite NCs as well as the abundant applications of CPL in three-dimensional(3D)displays,nonlinear optics,spintronics devices,CPL lasers,and so on.Herein,bio-inspired by life,we designed and synthesized a simple amphiphilic molecule which could self-assemble into chiral gel with helix chirality in non-polar solvents.Through co-assembly of the CsPbX3 NCs with the chiral gel,CPL at the first excitation band of CsPbX3 NCs is induced in the whole visible spectrum with a maximum glum of 8.2×10−3.The induced CPL arises from the selective CPL-absorption of the CsPbX3 NCs’luminesce by the chiral gel,which provides a facile and practical approach to induce CPL in perovskite NCs and other nanocrystals. | Rui Cao Xuekang Yang Yong Wang Yin Xiao | 2023 | Nano Research2023，16，1： | 1 |
| 15 | Ultimate stress of unbonded par- tially prestressed concrete beams 显示文摘 | Du Gongchen Tao Xuekang | 1985 | PCI Journal1985，30，6： | 1 |
| 16 | Ultimate stress of unbonded partially prestressed concrete beams 显示文摘 | Du Gongchen and Tao Xuekang | 1985 | PCI Journal1985，30，6： | 1 |
| 17 | Ultimate stress of unbonded ten-dons in partially prestressed concrete beanas 显示文摘 | Du Gongchen Tao Xuekang | 1985 | PCI Journal1985，30，6： | 1 |
| 18 | Contents of Heavy Metals in Typical Aquatic Products from a Market in Binzhou显示文摘To evaluate the levels of heavy metal pollution and risks in consumption of aquatic products from a market in Binzhou,the contents of Cu,Zn,Cd,Cr and Pb in the edible part of eight aquatic species such as Ctenopharyngodon idellus were determined by inductively coupled plasma mass spectrometry.The results show that the levels of the five elements differed among different species of aquatic products.The ability of bivalves to accumulate heavy metals was significantly higher than that of fish.Compared with relevant food hygiene standards,there was a certain excess of Cr in Ruditapes philippinarum and Penaeus vannamei.The results of human exposure risk assessment show that the THQ values of the heavy metals in the eight aquatic species were all less than 1,indicating that the consumption of these aquatic products had no potential non-carcinogenic risks. | Xuekang ZHANG Zaiwang ZHANG Zhuang REN Linlin ZHAO Hui YU Shenqiang ZHAI | 2019 | Asian Agricultural Research2019，11，11： | 0 |
| 19 | Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice显示文摘Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate traumatic brain injury in mice by intrape ritoneal injection of erythro poietin for 3 consecutive days.RNA sequencing detected a total of 4065 differentially expressed RNAs,including 1059 mRNAs,92 microRNAs,799 long non-coding RNAs,and 2115circular RNAs.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses revealed that the coding and non-coding RNAs that were differentially expressed after traumatic brain injury and treatment with erythropoietin play roles in the axon guidance pathway,Wnt pathway,and MAPK pathway.Constructing competing endogenous RNA networks showed that regulatory relationship between the differentially expressed non-coding RNAs and mRNAs.Because the axon guidance pathway was repeatedly enriched,the expression of Wnt5a and Ephb6,key factors in the axonal guidance pathway,was assessed.Ephb6 expression decreased and Wnt5a expression increased after traumatic brain injury,and these effects were reversed by treatment with erythro poietin.These findings suggest that erythro poietin can promote recove ry of nerve function after traumatic brain injury through the axon guidance pathway. | Weilin Tan Jun Ma Jiayuanyuan Fu Biying Wu Ziyu Zhu Xuekang Huang Mengran Du Chenrui Wu Ehab Balawi Qiang Zhou Jie Zhang Zhengbu Liao | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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