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| 1 | PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production显示文摘由象严重急性呼吸症候群(SARS ) 那样的 coronaviruses 的感染 coronavirus (SCoV ) 和老鼠肝炎病毒 A59 (MHV-A59 ) 导致很小的类型我干扰素(IFN ) 生产由招待细胞,它为与 SARS 联系的快速的病毒的生长和严重 immunopathology 潜在地负责。然而,为在感染 coronaviruses 的房间的低 IFN 生产的分子的机制仍然保持不清楚。这里,我们提供证据象 Papain 一样朊酶领域 2 (PLP2 ) , nonstructural 蛋白质的一个催化领域 3 (nsp3 ) MHV-A59,能绑在 IRF3,引起它的 deubiquitination 并且阻止它的原子 translocation。作为后果, PLP2 的合作表示强烈禁止 CARDIF- ,调停 TBK1 、调停 IRF3 的 IFN 记者活动。另外,我们显示出那野类型的 PLP2 然而并非缺乏 deubiquitinase 的变异的 PLP2 (称) 活动能减少感应的 IFN 并且在感染 VSV 的房间支持病毒的生长。因此,我们的学习揭开了一病毒称它 coronaviruses 可以使用逃离主人天生的抗病毒的回答。 | Dahai Zheng Gang Chen Beichu Guo Genhong Cheng Hong Tang | 2008 | Cell Research2008，18，11： | 20 |
| 2 | 空气质量模型及参数选用导则显示文摘本研究是为了在大气污染物浓度估算中提供一个可以接受的技术分析的共同尺度,将所需用的空气质量模式分为三个等级。第一级模式作为在制定大气环境管理的法规和政策时主要应用的模式。第二、三级模式作为研究级模式。本文详细介绍了第一级模式的主要应用原则,简要介绍了第二、三级模式。 | Lin Hong(Chinese Research Academy of Environmental Sciences, Beijing 100012)Sang Jianguo(Beijing University,Beijing 100871)Xu Dahai et al.(The Research Academy of Meteorology, Beijing 100086) | 1993 | 环境科学研究1993，6，4： | 18 |
| 3 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 4 | The single nucleotide polymorphisms of the chicken myostatin gene are associated with skeletal muscle and adipose growth显示文摘Myostatin, a new member of the TGF-β superfamily, is predominantly expressed in skeletal muscle cells and functions as a negative regulator of skeletal muscle growth in animals. Recently, we have reported three single nucleotide polymorphisms (SNPs) in the chicken myostatin gene. Herein, we investigate the association of those SNPs with the production traits in a F2 chicken line derived from Broilers crossing to Silky with the least square analysis. The results show that the BB and AA genotypes are strongly associated with abdominal fat weight (AFW), abdominal fat percentage (AFP), and birth weight (BW) (P < 0.05). Breast muscle percentage (BMP) of the AA type is higher than that of the AB type. The breast muscle weight and breast muscle percentages of F2 individuals have significant difference between CC and DD genotypes (P < 0.05). Breast muscle weight (BMW) of EF birds is higher than that of EE birds (P < 0.05). In this report, we present the first genetic evidence to show that chicken myostatin not only plays an important role in controlling skeletal muscle growth and differentiation, but also may be involved in regulation of adipose growth in chicken. | GU Zhiliang, ZHU Dahai, LI Ming, LI Hui, DENG Xuemei & WU ChangxinMolecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin 150001, China College of Animal Science & Technology, Northeast Agricultural University, Harbin 150030, China National Laboratories for Agribiotechnology, China Agricultural University, Beijing 100094, China College of Animal Science & Technology, China Agricultural University, Beijing 100094, China Department of Life Science and Technology, Changshu Institute of Technology, Changshu 215500, China Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Peking Union Medical College, Beijing 100005, China | 2004 | Science China(Life Sciences)2004，47，1： | 9 |
| 5 | Atmospheric environmental capacity and urban atmospheric load in China's Mainland显示文摘Daily and annual average atmospheric environmental capacity coefficient(A-value) sequences for China's Mainland are calculated from hourly data recorded at 378 ground stations over 1975–2014. A-values at different recurrence intervals are calculated by fitting the sequences to Pearson type III distribution curves. Based on these A-values and source-sink balance(reference concentration 100 μg m^(-3)), atmospheric environmental capacities at the recurrence intervals are calculated for all of China's Mainland and each provincial administrative region. The climate average atmospheric environmental capacity reference value for the entire mainland is 2.169×10~7 t yr^(-1). An urban atmospheric load index is defined for analyses of the impact of population density on the urban atmospheric environment. Analyses suggest that this index is also useful for differentiating whether air quality changes are attributable to varying meteorological conditions or variations of artificial emission rate.Equations guiding the control of unorganized emission sources are derived for preventing air quality deterioration during urban expansion and population concentration. | XU DaHai WANG Yu ZHU Rong | 2018 | Science China Earth Sciences2018，61，1： | 7 |
| 6 | Calibration method of phase distortions for cross polarization channel of instantaneous polarization radar system显示文摘A novel polarimetric calibration method for new target property measurement radar system is presented.Its application in the real radar system is also discussed.The analysis indicates that instantaneous polarization radar(IPR) has inherent cross-polarization measurement error.The proposed method can effectively eliminate this error,and thus enhance the polarization scattering matrix(PSM) measurement precision.The phase error caused by digital receiver's direct IF sampling and mixing of two orthogonal polarization channels can be removed.Consequently,the inherent error of target polarization scattering measurement of the instantaneous polarization radar system is well revised.It has good reference value for further ploarimetric calibration and high practical application prospect. | Huanyao Dai Yuliang Chang Dahai Dai Yongzhen Li XuesongWang | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 7 |
| 7 | RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer显示文摘由 E3 ubiquitin ligases 的蛋白质 ubiquitination 在癌症开发起一个重要作用。在这研究,我们提供 RING-finger-containing 蛋白质 RNF13 是 ER/Golgi 联系膜的 E3 ubiquitin ligase,它的戒指手指领域为 ubiquitin ligase 活动被要求的试验性的证据。胰腺的 ductal 腺癌(PDAC ) 和从 72 个病人的 paracancerous 正常纸巾的 Immunohistochemical 分析在 30 件肿瘤样品记录了 RNF13 在表示上(41.7% , 30/72 ) ,并且它的表示显著地与组织学的分级被联系(P = 0.024 ) 。另外, RNF13 在癌症前期的损害被检测:在长期的胰腺炎(CP ) 和胰腺的 intraepithelial 瘤形成(PanIN ) 的管状的建筑群(79.3% , 23/29 并且 62.8% , 22/35,分别地) 。而且,染色的 RNF13 显著地与 Tenascin-C 表示被相关(P = 0.004 ) 在 PDAC 样品,进一步在癌症支持 RNF13 的角色前进。在胰腺的 MiaPaca-2 癌症房间的野类型然而并非戒指域异种 RNF13 的在表示上由矩阵 metalloproteinase-9 增加了侵略潜力和 gelatinolytic 活动。一起拿,这些调查结果表明 RNF13 是涉及胰腺的 carcinogenesis 的新奇 E3 ubiquitin ligase;由 RNF13 的蛋白质的调停 ubiquitin 的修正可以参予胰腺的癌症开发。 | Qiang Zhang Yunxiao Meng Lei Zhang Jie Chen Dahai Zhu | 2009 | Cell Research2009，19，3： | 6 |
| 8 | Enhanced orange emission by doping CeB_6 in CaAlSiN_3:Ce^(3+) phosphor for application in white LEDs显示文摘A series of CeB6-doped and CeO_2-doped Ca_(1-x)SiAlN_3:xCe3+(denoted as CASN:Ce3+@CeB6 and CASN:Ce3+@CeO_2, respectively) were synthesized by alloy-nitridation method under high-purity nitrogen atmosphere. The morphologies, crystal phases, and luminescence properties were investigated in detail.With an increase in the concentration of CeB_6, the unit cell volume of CASN:Ce3+@CeB_6 slightly increases due to the substitution between ions, which leads to a change of micro structure around Ce3+. CASN:Ce3+@CeB6 efficiently emits yellow-orange light with a maximum emission intensity at around 550 nm for the content x of 0.01(being in comparable situation, CASN:Ce3+@CeO_2 is x = 0.04) when excited at460 nm. Compared with CASN:Ce3+@CeO_2, the red emission component of Ce3+ in CASN:Ce3+@CeB6 is much stronger. This is ascribed to energy transfer of intra-Ce3+(within one Ce3+ ion) and inter-Ce3+(between Ce3+ and Ce3+ ions). In addition, the replacements of N3-(0.132 nm for CN = 4) and O^(2-)(0.124 nm for CN = 4) by B^(2-)(0.140 nm for CN = 4), which can lead to a marked expansion of the host lattice and a decrease of the oxidation of samples, are also responsible for the increase of red emission component. Furthermore, CASN:Ce3+@CeB_6 phosphor has an excellent thermal stability because of the partial substitution of Ce-O(Ce-N) bonds by more covalent Ce-B. As a result, the outstanding luminescent properties of CASN:Ce3+@CeB6 phosphor make it practical to use in the single phosphor-coated high-color-rendering power white LED. | Wenjie Wu Kefu Chao Wenquan Liu Lesi Wei Dahai Hu Taiyang Wang O. Tegus | 2018 | Journal of Rare Earths2018，36，12： | 6 |
| 9 | Research on instantaneous polarization radar system and external experiment显示文摘Instantaneous polarization radar can obtain radar target polarization scattering matrix (PSM) by using single pulse echo.The system overcomes the defects of inter-pulse interval polarization measurement radar and accurately measures the PSM of the moving target.Thus the capabilities of detection,anti-jamming and target identification can be improved.The present paper reports the first international self-developed instantaneous polarization radar experimental system and,by using this system,the measurement experiments of target polarization characteristics are conducted.The results show that the performance of target instantaneous polarization measurement by different waveforms is good.The basic and common problems in polarization scattering feature extraction and recognition domain are solved. | WANG XueSong LI YongZhen DAI HuanYao CHANG YuLiang DAI DaHai MA Liang LIU Yong | 2010 | Chinese Science Bulletin2010，55，15： | 5 |
| 10 | Composition Operators on a Banach Space of Analytic Functions | Cao Guangfu (Department of Mathematics,Sichuan University,Chengdu 610064,China)N.Elias (6611 Tauglewood Court 3B,Hammond,IN46323)P.Ghatage (Department of Mathematics,Cleveland State University,Cleveland,OH44115)Yu Dahai (Department of Mathematics,Sichuan University,Chengdu 610064,China) | 1998 | Acta Mathematica Sinica,English Series1998，14，2： | 4 |
| 11 | Application of Principal Component Analysis(PCA)to the Evaluation and Screening of Multiactivity Fungi显示文摘Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs. | YANG Zonglin SHI Yaqi LI Pinglin PAN Kanghong LI Guoqiang LI Xianguo YAO Shuo ZHANG Dahai | 2022 | Journal of Ocean University of China2022，21，3： | 4 |
| 12 | miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice显示文摘骨胳的肌肉质量和动态平衡大部分在出生后的肌肉开发和新生期间取决于成年肌肉干细胞(卫星房间) 。我们最近证明 miR-378 的全球 overexpression 显著地在老鼠减少了骨胳的肌肉质量。在当前的学习,我们使用了 miR-378 转基因(Tg ) 估计的老鼠在里面 vivo 骨胳的肌肉生长和新生上的 miR-378 的功能的效果。骨胳的肌肉纸巾的代表性的分析证明 myofibers 的数字和尺寸比在野类型的老鼠在 miR-378 Tg 老鼠是显著地更低的。在 miR-378 Tg 老鼠的稀释导致 cardiotoxin 的肌肉新生被发现与推迟的卫星房间激活和区别被联系。机械学地, miR-378 被发现直接在 vitro 并且在 vivo 在肌肉房间指向 Igf1r。这些 miR-378 Tg 老鼠可以为在人在联系肌肉的疾病调查骨胳的肌肉的生理、病理学的角色提供一个模型,特别地在 sarcopenia。 | Ping Zeng Wanhong Han Changyin Li Hu Li Dahai Zhu Yong Zhang Xiaohong Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 13 | Protecting healthcare personnel from 2019-nCoV infection risks:lessons and suggestions显示文摘The outbreak of a novel coronavirus disease(COVID-19,caused by the 2019-nCoV infection)in December 2019 is one of the most severe public health emergencies since the founding of People’s Republic of China in 1949.Healthcare personnel(HCP)nationwide are facing heavy workloads and high risk of infection,especially those who care for patients in Hubei Province.Sadly,as of February 20,2020,over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide,with nearly 90%of them from Hubei Province.Based on literature search and interviews with some HCP working at Wuhan,capital city of Hubei,we have summarized some of the effective measures taken to reduce infection among HCP,and also made suggestions for improving occupational safety during an infectious disease outbreak.The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world. | Zhiruo Zhang Shelan Liu Mi Xiang Shijian Li Dahai Zhao Chaolin Huang Saijuan Chen | 2020 | Frontiers of Medicine2020，14，2： | 4 |
| 14 | Biological identity of nanomaterials:Opportunities and challenges显示文摘The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and therapy.Many novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or tissues.However,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in vivo.Many efforts have been paid to studying the interactions and mechanisms of NPs and cells.Unless deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological systems.In this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are summarized.By understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed. | DENG Jun YU DaHai GAO ChangYou | 2013 | Science China Chemistry2013，56，11： | 3 |
| 15 | Changes in hospital admissions and inpatient tariff associated with a Diabetes Integrated Care Initiative: Preliminary findings (与糖尿病综合护理计划相关的住院以及住院费用的变化:初步调查结果)显示文摘 | David Simmons Dahai Yu Helmut Wenzel | 2014 | Journal of Diabetes2014，，1： | 3 |
| 16 | Enhanced metastasis in RNF13 knockout mice s mediated by a reduction in GM-CSF levels显示文摘 | He Cheng Aodi Wang Jiao Meng Yong Zhang Dahai Zhu | 2015 | Protein & Cell2015，6，10： | 3 |
| 17 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 18 | Research progress in artificial upwelling and its potential environmental effects显示文摘Artificial upwelling, as a geoengineering tool, has received worldwide attention because it may actualize ocean fertilization in a sustainable way, which could potentially alleviate the pressures on the fish stocks and human-driven climate change in the ocean. We reviewed the current knowledge on the development of an artificial upwelling system and its potential environmental effects. Special attention was given to the research progress on the air-lift concept artificial upwelling by Zhejiang University. The research on artificial upwelling over the past few decades has generated a range of devices that have been successfully applied in the field for months. Based on field experiments and the associated modeling results, part of them reported positive effects on increasing primary production and enhancing CO2 sequestration. However, as a significant disturbance to the environment, especially for large-scale applications, the uncertainties related to the potential effects on ecosystem remain unsolved. Zhejiang University has overcome the technical challenges in designing and fabricating a robust and high efficiency artificial upwelling device which has been examined in two field experiments in Qiandao Lake and one sea trial in the East China Sea. It was investigated that cold and hypoxic deep ocean water(DOW) could be uplifted to the euphotic layer, which could potentially change the nutrient distribution and adjust the N/P ratio. Both simulation and field experiments results confirmed that utilizing self-powered energy to inject compressed air to uplift DOW was a valid and efficient method. Therefore, further field-based research on artificial upwelling, especially for long-term field research is required to test the scientific hypothesis. | PAN YiWen FAN Wei ZHANG DaHai CHEN JiaWang HUANG HaoCai LIU ShuXia JIANG ZongPei DI YaNan TONG MengMeng CHEN Ying | 2016 | Science China Earth Sciences2016，59，2： | 3 |
| 19 | A new coordinated backup protection scheme for distribution network containing distributed generation显示文摘This paper proposes a new backup protection scheme,named coordinated backup protection(CBP)scheme,for distribution networks containing distributed generation.The proposed protection scheme takes into account the issues faced by traditional backup protection,such as difficulty in setting parameters and complex cooperation,and considers the features of distribution networks,such as changeable power flow because of high penetration of distributed generation sources and insufficient measuring quantities.The CBP scheme includes two aspects:coordinated substation protection and regional master substation protection,who also work as nearby backup protection and remote backup protection respectively.The two protections support each other by local information coordination and regional information sharing,in order to improve the reliability of fault identification.The configuration principles and performances of the proposed backup protection scheme are addressed in the paper.Different fault conditions in the IEEE 14-node system have been used to illustrate and verify the feasibility of the CBP scheme. | Jinghan He Lin Liu Fanfan Ding Changcheng Li Dahai Zhang | 2017 | Protection and Control of Modern Power Systems2017，2，1： | 3 |
| 20 | Comparative assessment of SAS and DES turbulence modeling for massively separated flows显示文摘经过在雷纳兹数字\的圆形的柱体的流动的数字研究( 1.4 \times 10 ^{ 5 }\)并且在攻击\的角度的 NACA0021 机翼( 60 ^{ \circ }\)被规模适应的模拟( SAS )执行了并且分开旋涡模拟( DES ),与存在比较试验性的数据。Egorov 和 Menter 开发的模型的新版本被估计,并且 SAS 模拟的优点和劣势详细被分析以后为工业申请提供指导。而且,在分开的区域的规模适应的特征的机制被讨论,它在以前的分析是阴暗的。它被结束那:吝啬的流动性质令人满意地为 SAS 模拟同意试验性的结果,尽管第二份订单的预言狂暴的统计在近醒来区域只是合理的。SAS 模型能在再通行水泡生产狂暴的动能的更大的大小,并且,因而,一个更小的再通行区域和在再通行区域外面的吝啬的速度的更快速的恢复与一样的格子决定比 DES 来临。流的旋涡比与 DES 途径与 SAS 模型一起是稍微不太不规则的,可能由于在粗糙的网孔的条件下面的 SAS 模拟的更高的驱散。 | Weilin Zheng Chao Yan Hongkang Liu Dahai Luo | 2016 | Acta Mechanica Sinica2016，32，1： | 3 |
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