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| 1 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 2 | Comprehensive profiling and natural variation of flavonoids in rice显示文摘Flavonoids constitute a major group of plant phenolic compounds.While extensively studied in Arabidopsis,profiling and naturally occurring variation of these compounds in rice(Oryza sativa),the monocot model plant,are less reported.Using a collection of rice germplasm,comprehensive profiling and natural variation of flavonoids were presented in this report.Application of a widely targeted metabolomics method facilitated the simultaneous identification and quantification of more than 90 flavonoids using liquid chromatography tandem mass spectrometry(LC-MS/MS).Comparing flavonoid contents in various tissues during different developmental stages revealed tissue-specific accumulation of most flavonoids.Further investigation indicated that flavone mono-C-glycosides,malonylated flavonoid O-hexosides,and some flavonoid O-glycosides accumulated at significantly higher levels in indica than in japonica,while the opposite was observed for aromatic acylated flavone C-hexosyl-O-hexosides.In contrast to the highly differential accumulation between the two subspecies,relatively small variations within subspecies were detected for most flavonoids.Besides,an association analysis between flavonoid accumulation and its biosynthetic gene sequence polymorphisms disclosed that natural variation of flavonoids was probably caused by sequence polymorphisms in the coding region of flavonoid biosynthetic genes.Our work paves the way for future dissection of biosynthesis and regulation of flavonoid pathway in rice. | Xuekui Dong Wei Chen Wensheng Wang Hongyan Zhang Xianqing Liu Jie Luo | 2014 | Journal of Integrative Plant Biology2014，56，9： | 8 |
| 3 | Weighted average consensus problem in networks of agents with diverse time-delays显示文摘This paper studies the weighted average consensus problem for networks of agents with fixed directed asymmetric unbalance information exchange topology. We suppose that the classical distributed consensus protocol is destroyed by diverse time-delays which include communication time-delay and self time-delay. Based on the generalized Nyquist stability criterion and the Gerschgorin disk theorem, some sufficient conditions for the consensus of multi-agent systems are obtained. And we give the expression of the weighted average consensus value for our consensus protocol. Finally, numerical examples are presented to illustrate the theoretical results. | Wenhui Liu Feiqi Deng Jiarong Liang Xuekui Yan | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 4 |
| 4 | A complex structure of arrestin-2 bound to a G protein-coupled receptor显示文摘Arrestins comprise a family of signal regulators of G-protein-coupled receptors(GPCRs),which include arrestins 1 to 4.While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin,arrestins 2 and 3(Arr2 and Arr3)areβ-arrestins known to regulate many nonvisual GPCRs.The dynamic and promiscuous coupling of Arr2 to nonvisual GPCRs has posed technical challenges to tackle the basis of arrestin binding to GPCRs.Here we report the structure of Arr2 in complex with neurotensin receptor 1(NTSR1),which reveals an overall assembly that is strikingly different from the visual arrestin–rhodopsin complex by a 90°rotation of Arr2 relative to the receptor.In this new configuration,intracellular loop 3(ICL3)and transmembrane helix 6(TM6)of the receptor are oriented toward the N-terminal domain of the arrestin,making it possible for GPCRs that lack the C-terminal tail to couple Arr2 through their ICL3.Molecular dynamics simulation and crosslinking data further support the assembly of the Arr2‒NTSR1 complex.Sequence analysis and homology modeling suggest that the Arr2‒NTSR1 complex structure may provide an alternative template for modeling arrestin–GPCR interactions. | Wanchao Yin Zhihai Li Mingliang Jin Yu-Ling Yin Parker Wde Waal Kuntal Pal Yanting Yin Xiang Gao Yuanzheng He Jing Gao Xiaoxi Wang Yan Zhang Hu Zhou Karsten Melcher Yi Jiang Yao Cong X.Edward Zhou Xuekui Yu H.Eric Xu | 2019 | Cell Research2019，29，12： | 4 |
| 5 | Cryo-EM structure of human heptameric Pannexin 1 channel显示文摘Dear Editor,Cellular communication is crucial during basic development and in the maintenance of homeostasis in adult organisms,and such communication involves the connexin and pannexin(PANX)families of large-pore channels.The PANX family was identified in 20001 and consists of PANX1,PANX2,and PANX3.2 Among the three subtypes,the most studied is PANX1 because of its potential effects on multiple physiological and pathological functions,3 including microbial infection,cancer progression,ischemia,and neurological disorders.Very recently,we also identified mutations in PANX1 causing familial female infertility characterized by oocyte death.4 PANX1 is a major ATP release and nucleotide permeation channel,which is N-glycosylated and forms three species,GLYO,GLY1,and GLY2.5 Cleavage of the C-terminus by Caspase 3/7 activates the channel and causes the release of ATP and UTP,which functions as a 'find-me'signal during apoptosis. | Ronggui Qu Lili Dong Jilin Zhang Xuekui Y u Lei Wang Shujia Zhu | 2020 | Cell Research2020，30，5： | 4 |
| 6 | Antioxidant and antihyperlipidemic activities of polysaccharides from sea cucumber Apostichopus japonicus显示文摘 | Xin Liu Zhenliang Sun Miansong Zhang Xiumei Meng Xuekui Xia Wenpeng Yuan Feng Xue Changheng Liu | 2012 | Carbohydrate Polymers2012，，4： | 3 |
| 7 | 肘内静脉放血治疗急性单纯性胃炎显示文摘笔者近年来,在临床上采用肘内静脉放血的方法,治疗急性单纯性胃炎取得了满意疗效,现报道如下. | WANG Xuekui 王磊 王燕敏 | 2005 | 中医外治杂志2005，14，2： | 3 |
| 8 | Synthesis of crosslinked starch-graft-polyacrylamide- co -sodium xanthate and its performances in wastewater treatment显示文摘 | Qing Chang Xuekui Hao Lili Duan | 2008 | Journal of Hazardous Materials2008，，2： | 2 |
| 9 | Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection显示文摘Antigen detection provides particularly valuable information for medical diagnoses;however,the current detection methods are less sensitive and accurate than nucleic acid analysis.The combination of CRISPR/Cas12a and aptamers provides a new detection paradigm,but sensitive sensing and stable amplification in antigen detection remain challenging.Here,we present a PCR-free multiple trigger dsDNA tandem-based signal amplification strategy and a de novo designed dual aptamer synergistic sensing strategy.Integration of these two strategies endowed the CRISPR/Cas12a and aptamer-based method with ultra-sensitive,fast,and stable antigen detection.In a demonstration of this method,the limit of detection was at the single virus level(0.17 fM,approximately two copies/μL)in SARS-CoV-2 antigen nucleocapsid protein analysis of saliva or serum samples.The entire procedure required only 20 min.Given our system’s simplicity and modular setup,we believe that it could be adapted reasonably easily for general applications in CRISPR/Cas12a-aptamer-based detection. | Xiangxiang Zhao Zhengduo Wang Bowen Yang Zilong Li Yaojun Tong Yuhai Bi Zhenghong Li Xuekui Xia Xiangyin Chen Lixin Zhang Weishan Wang Gao-Yi Tan | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 1 |
| 10 | Semen Analysis and Fecundity Association Among Women with Polycystic Ovary Syndrome Experiencing Ovulatory Dysfunction Treated by Ovulation Induction显示文摘In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,motile count,progressive motile count,and morphology,are unclear for women with polycystic ovary syndrome(PCOS).A secondary analysis was conducted based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatory disorder between 2011 and 2016 in China.A total of 1000 women received ovulation induction(acupuncture and clomiphene).We randomized the women with PCOS in 27 hospitals in China who received one of four interventions(acupuncture plus clomiphene,sham acupuncture plus clomiphene,acupuncture plus placebo,or sham acupuncture plus placebo).Semen analysis was performed for every male partner according to the World Health Organization(WHO)criteria.The outcomes included conception,clinical pregnancy,and live birth.Logistic regression was used to evaluate the predictive value of semen analysis among ovulatory women for conception,clinical pregnancy,and live birth.Among the 1000 couples,the number of couples who attained ovulation,conception,clinical pregnancy,and live birth were 780,320,235,and 205,respectively.Semen volume and motility were applied and used as prediction parameters for conception(area under the curve(AUC)of 0.62(95%confidence interval(CI),0.55–0.69)),clinical pregnancy(AUC of 0.67(95%CI:0.61–0.73)),and live birth(AUC of 0.57(95%CI:0.50–0.64)).No poor calibration was shown for these models in Hosmer–Lemeshow tests.The predictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatory dysfunction is limited. | Jingshu Gao Yu Wang Mubai Li Mengyi Zhu Xuekui Liu Hongli Ma Yijuan Cao Lu Li Xinming Yang Xiaoke Wu | 2021 | Engineering2021，7，11： | 1 |
| 11 | Reaction mechanism and influence factors analysis for calcium sulfide generation in the process of phosphogypsum decomposition显示文摘 | Liping Ma Xuekui Niu Juan Hou Shaocong Zheng Wenjuan Xu | 2011 | Thermochimica Acta2011，，1： | 1 |
| 12 | Reaction mecha- nism and influence factors analysis for calcium sulfide generation in the process of phosphogypsum dccompo-sition 显示文摘 | MA Liping NIU Xuekui HOU Juan | 2011 | Thermochimica Acta2011，526，： | 1 |
| 13 | Reductive decomposition of phosphogypsum with high-sulfur-concentration coal to SO 2 in an inert atmosphere显示文摘 | Shaocong Zheng Ping Ning Liping Ma Xuekui Niu Wei Zhang Yuhang Chen | 2011 | Chemical Engineering Research and Design2011，，12： | 1 |
| 14 | Using a linear stapler for pharyngeal closure in total laryngectomy显示文摘 | Xinrui Zhang Zhimin Liu Quan Li Xuekui Liu Hao Li Weiwei Liu Qiuli Li Zhuming Guo Zongyuan Zeng | 2013 | European Archives of Oto-Rhino-Laryngology2013，，4： | 1 |
| 15 | Reaction mechanism and influence factors analysis for calcium sulfide generation in the process of phosphogypsum decomposition 显示文摘 | Ma Liping Niu Xuekui Hoa Juan | 2011 | Thermochimica Acta2011，526，： | 1 |
| 16 | Synthesis of crosslinked starch- graft-polyacrylamide-co-sodium xanthate and its performances in wastewater treatment 显示文摘 | Chang Qing Hao Xuekui Duan Lili | 2008 | Journal of Hazardous Materials2008，159，213： | 1 |
| 17 | Synergetically acting new flocculants on the basis of starch-graft-poly (acrylamide)-co-sodium xanthate 显示文摘 | Hao Xuekui Chang Qing Duan Lili | 2007 | Starch2007，59，6： | 1 |
| 18 | Synthesis,characterization, and properties of polymeric flocculant with the function of trapping heavy metal ions 显示文摘 | Hao Xuekui Chang Qing Li Xiaohong | 2009 | Journal of Applied Polymer Science2009，112，1： | 1 |
| 19 | Fault detection and isolation of systems with slowly varying parameters-simulation with a simplified aircraft turbo engine model显示文摘 | Wu Xuekui Campion G | 2004 | Mechanical Systems and Signal Processing2004，18，： | 1 |
| 20 | Reaction mechanism and influence factors analysis for calcium sulfide generation in the process of phosphogypsum decomposition显示文摘 | MA Liping NIU Xuekui HOU Juan | 2011 | Thermochemica Acta2011，526，12： | 1 |
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