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| 1 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 2 | Petrogenesis of the Xihuashan Granite in Southern Jiangxi Province,South China:Constraints from Zircon U-Pb Geochronology,Geochemistry and Nd Isotopes显示文摘Mesozoic granitic intrusions are widely distributed in the Nanling region,South China.Yanshanian granites are closely connected with the formation of tungsten deposits.The Xihuashan granite is a typical representative of tungsten-bearing granite.The Xihuashan granite consists mainly of medium-grained porphyritic biotite granite,medium-grained biotite granite and fine-grained two-mica granite,which correspond to LA-ICP-MS zircon U-Pb ages of 155.5±0.4 Ma,153.0±0.6 Ma and 152.8±0.9 Ma,respectively.Rocks from the Xihuashan mining area displays high SiO2(73.85% to 76.49%) and Na2O+K2O contents(8.09% to 9.43%),belonging to high-K calc-alkaline series.They are metaluminous to weakly peraluminous with A/CNK values ranging from 0.96 to 1.06.All granites in this study area are rich in Rb,Th,U and Pb,and depleted in Ba,Sr,P,Ti,Nb and Eu,especially depleted in medium-grained biotite granite and fine-grained two-mica granite.The medium-grained porphyritic biotite granites usually have high LREE concentrations,whereas medium-grained biotite granite and fine-grained two-mica granite displays high HREE contents.Our geochemical data reveal that the studied rocks are highly fractionated I-type granite.The magma underwent strong magma differentiation with decreasing temperature and increasing oxygen fugacity,which may explain the formation of three types of distinct granites.Variations of Rb,Sr and Ba concentrations in different type granites were controlled by fractional crystallization of biotite and feldspar.Fractional crystallization of monazite,allanite and apatite resulted in LREE changes in granite,and formation of garnet mainly caused HREE changes.Granites from the Xihuashan mining area have relatively high εNd(t) values(-9.77 to -11.46),indicating that they were probably generated by partial melting of underlying Proterozoic metasedimentary rocks with minor addition of juvenile crust or mantle-derived magmas. | YANG Jiehua PENG Jiantang ZHAO Junhong FU Yazhou YANG Chen HONG Yinglong | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 17 |
| 3 | Preoperative diagnosis and operative effect of intracranial aneurysm with three-dimensional computed tomography angiography显示文摘BACKGROUND: Digital subtraction angiography (DSA) is always regarded as the golden standard for diagnosis of intracranial aneurysm; however, the procedure is complex, traumatic, expensive and easy to induce vascular complication. Three-dimensional computed tomography angiography (3D-CTA) can make up deficiencies of DSA; therefore, it is used in clinical therapy wider and wider. OBJECTIVE: To evaluate the clinical effect of 3D-CTA on disruption and hemorrhage of intracranial aneurysm pre- and post-operation and compare with the effect of DSA.DESIGN: Auto-control contrast observation.SETTING: Department of Neurosurgery, Shengjing Hospital of China Medical University.PARTICIPANTS: A number of 106 patients with disruption and hemorrhage of intracranial aneurysm were selected from the Department of Neurosurgery, Shengjing Hospital of China Medical University from January 2003 to April 2006. All patients were diagnosed with cranial operation and consent. There were 47 males and 59 females aged from 3-76 years with the mean age of (47±13) years. Among them, 82 patients had extensive subarachnoid hemorrhage (SAH), 7 had hemorrhage at longitudinal fissure, and 17 had hemorrhage at ambiens cisterna and lateral fissure. Moreover, intraventricular hematocele was accompanied on 13 patients and hematom on 9 patients. METHODS: ① 3D-CTA examination: Siemens SOMATOM Sensation 64 CT was used in this study. The thickness was 1 mm and interval of reconstruction was 0.8 mm. Localizing section was plainly scanned as the standard of canthus line. Scan ranged from 30 mm below sella to 50 mm above sella. Non-ion contrast medium of Omnipaque 350 (concentration of iodine was 350 g/L) was inserted into anterior vein of elbow with 18G trochar retained with high-pressured injectoc pum. The speed was 4.5 mL/s and the total volume was 80-100 mL with the means of 90 mL. Scan started at 10-20 s after injection of contrast medium. Original image was dealt with Leonardo workstation and retreated with Syngo software. Volume rendering and maximum intensity projection were used to reconstructed images. ② All 106 patients suffered from occlusion of aneurysm clamp. Before operation, 3D-CTA was undertaken and DSA was followed. After operation, patients were rechecked with 3D-CTA. MAIN OUTCOME MEASURES: Comparisons between 3D-CTA and DSA.RESULTS: All 106 patients were involved in the final analysis. ① Examination of 3D-CTA and DSA: Among 118 patients with aneurysm, 110 were checked with 3D-CTA and the detected rate was 93.2% (110/118). Among other 8 cases, 3 were negative and checked again with DSA; 1 had pericallosal aneurysm, 1 ophthalmic aneurysm, and 1 anterior choroidal artery of aneurysm. 3D-CTA results of other 5 cases were suspicious, and then, they were regarded as having aneurysm with DSA. Before operation, correlation among site, body, neck of aneurysm and peripheral anatomic structure were shown sufficiently. After operation, 82 patients were rechecked with 3D-CTA, which was complete occlusion, precise, unobvious constriction, emphraxis or remains as compared with 3D-CTA those pre-operation. ② Characteristics of 3D-CTA: With multiple vessels and angles, 3D-CTA observed the relationship between aneurysm neck and carried artery and showed thrombosis in cavity of aneurysm, calcification of aneurysm wall and peripheral structure of vessel at the same time. However, DSA could not detect the reactions mentioned above. It could delete image of cranium, simulate image of operative route, eliminate artifact induced by metal, but not distinguish blood stream direction. Meanwhile, posterior communicating artery was always poor during circle of Willis artery showing. CONCLUSION: ① 3D-CTA is characterized by simple operation and non-invasive showing vascular stereo structure and correlation. Therefore, it is significant for diagnosis and designing plan of operative approach and focal location pre-operation and evaluating effect post-operation. ② 3D-CTA does not completely replace DSA on the diagnosis of intracranial aneurysm. | Xuxin Zhang Junhong Guan Duo Chen Yongjie Yang Xiangtai Wei | 2006 | Neural Regeneration Research2006，1，4： | 11 |
| 4 | Biological soil crust distribution in Artemisia ordosica communities along a grazing pressure gradient in Mu Us Sandy Land, Northern China显示文摘This study investigated the distribution pattern of biological soil crust (BSC) in Artemisia ordosica communities in Mu Us Sandy Land. Three experimental sites were selected according to grazing pressure gradient. In each experimental site, the total vegetation cover, A. ordosica cover, BSC cover, litter-fall cover, BSC degree of fragmentation, BSC thickness and soil properties were investigated in both fixed and semi-fixed sand dunes and simultaneously analyzed in the laboratory. The results showed that at the same grazing pressure, BSC cover and composition were significantly affected by the fixation degree of sand dunes. In addition, BSC cover in the fixed sand dunes was 83.74% on average, whereas it is proportionally dominated by 28% mosses, 21% lichens, and 51% algae. Meanwhile, BSC cover in the semi-fixed sand dunes was 23.54% on average, which is proportionally dominated by 6.3% mosses, 2.5% lichens, and 91.2% algae. Fine sand, organic matter, and total nitrogen (N) contents in the fixed sand dunes were all significantly higher than those in the semi-fixed sand dunes. Litter-fall cover decreased along the grazing pressure gradient, whereas BSC fragmentation degree increased. Fine sand content decreased along with the increase of grazing pressure, whereas medium sand content increased in both fixed and semi-fixed dunes. The organic matter and total N contents in the no grazing site were significantly higher than those in light and normal grazing sites. However, there were no significant differences between the light and normal grazing sites. In addition, there were also no significant differences in BSC thickness between the light and normal grazing sites in the fixed sand dunes. However, a significant decrease was observed in both BSC cover and thickness in the normal grazing site. The BSC in the semi-fixed dunes was more sensitive to disturbance. | JunHong ZHANG Bo WU YongHua LI WenBin YANG YaKai LEI HaiYan HAN Ji HE | 2013 | Journal of Arid Land2013，5，2： | 10 |
| 5 | Effect of calcining temperature and time on the characteristics of Sb-doped SnO_2 nanoparticles synthesized by the sol-gel method显示文摘Spherical Sb-doped SnO2 (ATO) nanoparticles were synthesized by the sol-gel route, employing SnCl4·5H2O and SbCl3 as precursors in an ethanol solution. The influences of the calcining temperature and calcining time on the crystallite size, crystallinity, lattice parameters, lattice distortion ratio and the resistivity of the ATO nanoparticles were synthetically investigated. The results suggested that the ATO nanoparticles were crystallized in a tetragonal cassiterite structure of SnO2 with a highly (110)- plane-preferred orientation. The calcining temperature had a dominating effect on the crystallite size, crystallinity, lattice distortion ratios and resistivity of the ATO. As the calcining temperature increased, the average crystallite size increased, the crystallinity was promoted accompanied by a decrease in the lattice distortion ratio and a corresponding decrease in the resistivity of the ATO. X-ray diffraction (XRD) and Fourier transform infrared spectrophotometer (FTIR) analysis revealed that Sb ions could not entirely supplant the Sn ions in the SnO2 lattice for a calcining time of less than 0.5 h, even at a calcining temper- ature of 1000°C. The ATO nanoparticles calcined at 1000°C for 3.0h possessed the lowest resistivity of 10.18Ωcm. | Xiaohua Zhong Baoping Yang Xiaoliang Zhang Junhong Jia Gewen Yi | 2012 | Particuology2012，10，3： | 8 |
| 6 | Fatigue Crack Growth Rate of Ti-6Al-4V Considering the Effects of Fracture Toughness and Crack Closure显示文摘Fatigue fracture is one of the main failure modes of Ti-6A1-4V alloy,fracture toughness and crack closure have strong effects on the fatigue crack growth(FCG)rate of Ti-6A1-4V alloy.The FCG rate of Ti-6A1-4V is investigated by using experimental and analytical methods.The effects of stress ratio,crack closure and fracture toughness on the FCG rate are studied and discussed.A modified prediction model of the FCG rate is proposed,and the relationship between the fracture toughness and the stress intensity factor(SIF)range is redefined by introducing a correcting coefficient.Notched plate fatigue tests(including the fracture toughness test and the FCG rate test)are conducted to investigate the influence of affecting factors on the FCG rate.Comparisons between the predicted results of the proposed model,the Paris model,the Walker model,the Sadananda model,and the experimental data show that the proposed model gives the best agreement with the test data particularly in the near-threshold region and the Paris region,and the corresponding calculated fatigue life is also accurate in the same regions.By considering the effects of fracture toughness and crack closure,the novel FCG rate prediction model not only improves the estimating accuracy,but also extends the adaptability of the FCG rate prediction model in engineering. | ZHANG Junhong YANG Shuo LIN Jiewei | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 5 |
| 7 | ^(226)Ra evidence for the ecosystem shift over the past 40 years in the North Pacific Subtropical Gyre显示文摘Surface seawater was collected for ^(226)Ra measurement in the North Pacific Subtropical Gyre from July to October, 1999 and October to December, 2003. Combined with the historical data reported for this sea area, a declined trend of surface ^(226)Ra concentrations was observed since 1960s, indicating the ecosystem shift in response to global warming. On one side, the enhanced stratification of the upper water column resulting from global warming reduced the ^(226)Ra input from the depth, on the other, the temporal increase of biological production resulting from the climate-related ecosystem structure change strengthened the ^(226)Ra removal from the surface ocean. Both the physical and biological processes resulted in the decrease of surface ^(226)Ra concentrations in the North Pacific Subtropical Gyre. The temporal trend of surface ^(226)Ra concentrations was consistent with the trends of chlorophyll a, silicate, phosphate and primary production previously reported. This study provided ^(226)Ra evidence for the ecosystem shift under global change. | YANG JunHong CHEN Min QIU YuSheng LI YanPing MA Qiang LUE E ZHANG Run HUANG YiPu | 2007 | Chinese Science Bulletin2007，52，6： | 5 |
| 8 | Effects of three needling manipulations of the right-side Zusanli(ST 36) on brain using functional magnetic resonance imaging显示文摘OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with needles.METHODS: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture manipulations.RESULTS: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left caudate.Twirling activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifting-thrusting were the strongest, especially in the limbic system,followed by twirling plus lifting-thrusting; twirling alone was the weakest.CONCLUSION: Three methods of needling manipulations similarly activated areas associated with the somatosensory system, vision, cognition, and emotional regulation. This may have significant implications for acupuncture in clinical practice. | Lu Fengyan Gao Junhong Wang Yuanyuan Dai Qiufu Bao Yan Hong Yang Zhang Guolei Xin Juanjuan Zhao Yuxue Wu Shuyang Chen Yuanyuan Li Xiaojiao Fang Jiliang Yu Xiaochun | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 5 |
| 9 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 10 | Preparation and properties of novel PIPD fibers显示文摘Poly[2, 6-diimidazo (4,5-b:4’,5’-e) pyridinylene-1,4(2,5-dihydroxy) phenylen] (PIPD) was synthesized and the obtained PIPD/ PPA dope was directly spun into fibers via a dry-jet wet-spinning process for the first time. The obtained polymers were mainly characterized by ATR-FTIR and dynamic contact angle analysis. FTIR spectrum of the PIPD fibers indicates that the product was consistent with the target product. The contact angle measurements show that the wetting process of water on PIPD fibers is apparently faster than that on PBO fibers. The axial compression bending test indicates that PIPD fibers showed larger compressive strength compared with that of PBO fibers under the same axial compressive load. Meanwhile, the TGA test results indicate that the PIPD fibers have excellent thermal stability. | ZHANG Tao JIN JunHong YANG ShengLin LI Guang JIANG JianMing | 2010 | Chinese Science Bulletin2010，55，36： | 5 |
| 11 | Introduction of fluorin into PBO polymer chains:Toward higher thermal stability and lower dielectric constant显示文摘A series of novel fluorinated benzoxazole polymers (6FPBO's) with high thermal stability and low dielectric constant were synthesized by copolymerization of 1,3-diamino-4, 6-dihydroxybenzene dihy-drochloride (DAR), 1,4-benzenedicarboxylic acid (PTA) and various amount of 4'4- (hexafluoroisopro-pylidene) bis (benzoic acid) (BIS-B-AF) in the medium of polyphosphoric acid (PPA). 6FPBO fibers were then obtained via dry-jet wet-spinning technique and characterized by means of Fourier transform infrared (FTIR) spectra, thermogravimetric analysis (TGA), single fiber tensile testing machine and scanning electron microscopy (SEM). FTIR spectrum of 6FPBO fibers indicated that the fluorine groups had been incorporated into PBO molecular chains successfully. TGA curves revealed that 6FPBO fibers possessed high thermal stability just as pure PBO fibers. Moreover, dielectric constant spectrum of 6FPBO exhibited that the polymers had low dielectric constant, especially in the range of high- frequency. | ZHANG Tao HU DaYong JIN JunHong YANG ShengLin LI Guang JIANG JianMing | 2009 | Science China(Technological Sciences)2009，52，1： | 4 |
| 12 | Reliability analysis of aero-engine blades considering nonlinear strength degeneration显示文摘To comprehensively consider the effects of strength degeneration and failure correlation, an improved stress-strength interference (SSI) model is proposed to analyze the reliability of aeroengine blades with the fatigue failure mode. Two types of TC4 alloy experiments are conducted for the study on the damage accumulation law. All the parameters in the nonlinear damage model are obtained by the tension-compression fatigue tests, and the accuracy of the nonlinear damage model is verified by the damage tests. The strength degeneration model is put forward on the basis of the Chaboche nonlinear damage theory and the Griffith fracture criterion, and determined by measuring the fatigue toughness during the tests. From the comparison of two kinds of degeneration models based on the Miner's linear law and the nonlinear damage model respectively, the nonlinear model has a significant advantage on prediction accuracy especially in the later period of life. A time-dependent SSI reliability model is established. By computing the stress distribution using the finite element (FE) technique, the reliability of a single blade during the whole service life is obtained. Considering the failure correlation of components, a modified reliability model of aero-engine blades with common cause failure (CCF) is presented. It shows a closer and more reasonable process with the actual working condition. The improved reliability model is illustrated to be applied to aero-engine blades well, and the approach purposed in this paper is suitable for any actual machinery component of aero-engine rotor systems. | Lin Jiewei Zhang Junhong Yang Shuo Bi Fengrong | 2013 | Chinese Journal of Aeronautics2013，26，3： | 4 |
| 13 | Influence of particle composition on thorium scavenging in the marginal China seas显示文摘Thorium-234 and particle composition (organic matter, biogenic silica, carbonate and lithogenic component) were examined in the East China Sea (ECS) and the northern South China Sea (NSCS) in order to constrain the particle types scavenging thorium isotopes. Good positive correlations be-tween particulate organic matter (POM) or carbonate and thorium-234 in suspended particulate matter (SPM) indicates that POM and carbonate are efficient to scavenge thorium-234. No relation-ship between biogenic silica and thorium-234 suggests that geochemical behavior of thorium-234 may be not influenced by biogenic silica. A simple model was used to evaluate the affinity of thorium-234 to different particle components. The results show that POM is the most efficient scavenger for thorium-234 in the ECS and the NSCS, followed by carbonate. The authors’ re-sults lend support to the utility of thorium-234 as a proxy of POC and carbonate in the upper layer. However, the strong dependence of thorium scavenging on particle composition challenges thorium-230 as a constant flux proxy. | YANG Weifeng CHEN Min CAO Jianping QIU Yusheng ZHANG Run MA Qiang TONG Jinlu YANG Junhong YANG Zhi LUE E | 2009 | Acta Oceanologica Sinica2009，28，2： | 4 |
| 14 | AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease显示文摘Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin(AVP) in the brain of patients with Alzheimer’s disease(AD). AVP(4-8), different from its precursor AVP, plays memory enhancement roles in the CNS without peripheral side-effects. However, it is not clear whether AVP(4-8) can improve cognitive behaviors and synaptic plasticity in the APP/PS1 mouse model of AD. Here, we investigated for the first time the neuroprotective effects of AVP(4-8) on memory behaviors and in vivo long-term potentiation(LTP) in APP/PS1-AD mice.The results showed that:(1) APP/PS1-AD mice had lower spontaneous alternation in the Y-maze than wild-type(WT) mice, and this was significantly reversed by AVP(4-8);(2) the prolonged escape latency of APP/PS1-AD mice in the Morris water maze was significantly decreased by AVP(4-8), and the decreased swimming time in target quadrant recovered significantly after AVP(4-8) treatment;(3) in vivo hippocampal LTP induced by high-frequency stimulation had a significant deficit in the AD mice, and this was partly rescued by AVP(4-8);(4) AVP(4-8)significantly up-regulated the expression levels of postsynaptic density 95(PSD95) and nerve growth factor(NGF)in the hippocampus of AD mice. These results reveal the beneficial effects of AVP(4-8) in APP/PS1-AD mice,showing that the intranasal administration of AVP(4-8)effectively improved the working memory and long-term spatial memory of APP/PS1-AD mice, which may be associated with the elevation of PSD95 and NGF levels in the brain and the maintenance of hippocampal synaptic plasticity. | Xiumin Zhang Fang Zhao Chenfang Wang Jun Zhang Yu Bai Fang Zhou Zhaojun Wang Meina Wu Wei Yang Junhong Guo Jinshun Qi | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 15 | Phyllotaxis-inspired nanosieves with multiplexed orbital angular momentum显示文摘Nanophotonic platforms such as metasurfaces,achieving arbitrary phase profiles within ultrathin thickness,emerge as miniaturized,ultracompact and kaleidoscopic optical vortex generators.However,it is often required to segment or interleave independent sub-array metasurfaces to multiplex optical vortices in a single nano-device,which in turn affects the device’s compactness and channel capacity.Here,inspired by phyllotaxis patterns in pine cones and sunflowers,we theoretically prove and experimentally report that multiple optical vortices can be produced in a single compact phyllotaxis nanosieve,both in free space and on a chip,where one meta-atom may contribute to many vortices simultaneously.The time-resolved dynamics of on-chip interference wavefronts between multiple plasmonic vortices was revealed by ultrafast time-resolved photoemission electron microscopy.Our nature-inspired optical vortex generator would facilitate various vortex-related optical applications,including structured wavefront shaping,free-space and plasmonic vortices,and high-capacity information metaphotonics. | Zhongwei Jin David Janoschka Junhong Deng Lin Ge Pascal Dreher Bettina Frank Guangwei Hu Jincheng Ni Yuanjie Yang Jing Li Changyuan Yu Dangyuan Lei Guixin Li Shumin Xiao Shengtao Mei Harald Giessen Frank Meyer zu Heringdorf Cheng-Wei Qiu | 2021 | eLight2021，1，1： | 3 |
| 16 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 17 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 18 | Effect of coagulation temperature on structures and properties of poly(p-phenylene benzobisoxazole) (DHPBO) fibers during dry-jet wet-spinning process显示文摘The effect of coagulation temperature on the morphology, microstructures and mechanical properties of dihydroxy poly(p-phenylene benzobisoxazole) (DHPBO) fibers was investigated during dry-jet wet- spinning process, in which the coagulation bath concentration and drawn ratio were kept as 10 wt% of PPA in water and 1.7, respectively. The structures and mechanical properties of the as-spun DHPBO fibers were characterized by FTIR, XRD, SEM, and single fiber tensile testing. The results indicated that in PPA/H2O coagulation system, when the coagulation temperature was 25℃, highly crystallized DHPBO as-spun fibers possessing fine crystallites, circular and smooth morphology, and excellent mechanical properties could be achieved. | Tao Zhang JunHong Jin DaYong Hu ShengLin Yang Guang Li JianMing Jiang | 2009 | Science China(Technological Sciences)2009，52，4： | 2 |
| 19 | Sensitivity of P300 auditory event-related potentials for assessing cognitive impairment in elderly type 2 diabetic patients显示文摘BACKGROUND:In previous studies, cognitive function in elderly type 2 diabetic patients was evaluated by psychometric tests. These studies have confirmed that P300 event-related potential is an objective way of assessing cognitive function. OBJECTIVE: To analyze the objectivity of P300 for assessment of cognitive function in elderly type 2 diabetic patients. DESIGN, TIME AND SETTING: This case-control experiment was performed at the Department of Endocrinology of the Fourth Affiliated Hospital, Guangxi Medical University from January 2004 to December 2006. PARTICIPANTS: Seventy-two patients (38 males and 34 females) with type 2 diabetes mellitus were enrolled in this study. The patients were divided according to those with diabetes alone (diabetes alone group) (n=38) and those with diabetes and cerebral ischemia (diabetes and cerebral ischemia group) (n=34). A further 31 healthy individuals (16 males and 15 females), who received health examinations over the same period, were included as normal controls (normal control group). METHODS: All subjects were assessed by Mini-Mental State Examination (MMSE). Abnormalities in cognitive functions were identified by analyzing the auditory P300 event-related potentials. MAIN OUTCOME MEASURES: Auditory event-related potentials and MMSE scores. Multiple linear regression analysis was conducted using the 'enter method' with the 72 elderly patients with type 2 diabetes mellitus. P3 latency, P3 amplitude and N2 latency served as dependent variables. Age, sex, education, course of the disease, glycosylated hemoglobin, and ischemic brain damage were used as independent variables. RESULTS: No significant difference in scores of MMSE was detected between the diabetes alone and normal control groups (P > 0.05). MMSE score was significantly lower in the diabetes and cerebral ischemia group (P < 0.01) than in the normal control group. N2 and P3 latencies of auditory event-related potential were significantly longer, and P3 amplitude was significantly lower in the diabetes alone and diabetes and cerebral ischemia groups (P < 0.01) than in the normal control group. N2 and P3 latencies were significantly longer in the diabetes and cerebral ischemia group than in the diabetes alone group (P < 0.01), but amplitude was not significantly different. N2 and P3 latencies were negatively correlated with MMSE score in elderly type 2 diabetic patients (r=–0.421, –0.604; both P < 0.01). P3 amplitude was positively related to the score of MMSE (r =0.517; P < 0.01). P3 latency was positively associated with age, course of disease, glycosylated hemoglobin and ischemic brain damage in elderly type 2 diabetic patients (t=2.186 to 3.490; all P < 0.05). P3 amplitude was negatively correlated with age, course of disease and glycosylated hemoglobin (t=–2.220, –2.491, and –2.024, respectively; all P < 0.05). N2 latency was positively correlated with age, course of disease and ischemic brain damage (t=2.946, 2.511, and 2.331, respectively; P < 0.05). CONCLUSION: The course of disease, glycosylated hemoglobin and ischemic brain damage are key influential factors for cognitive impairment in elderly type 2 diabetic patients. The P300 event-related potential is a sensitive index for objective assessment of cognitive impairment in elderly diabetic patients. | Hong Yang Junhong She Xianfu Lu Rihong Peng | 2008 | Neural Regeneration Research2008，3，8： | 2 |
| 20 | Gasdermins:pore-forming activities and beyond显示文摘Gasdermins(GSDMs)belong to a protein superfamily that is found only in vertebrates and consists of GSDMA,GSDMB,GSDMC,GSDMD,DFNA5(a.k.a.GSDME)and DFNB59(a.k.a.Pejvakin(PJVK))in humans.Except for DFNB59,all members of the GSDM superfamily contain a conserved twodomain structure(N-terminal and C-terminal domains)and share an autoinhibitory mechanism.When the N-terminal domain of these GSDMs is released,it possesses pore-forming activity that causes inflammatory death associated with the loss of cell membrane integrity and release of inflammatory mediators.It has also been found that spontaneous mutations occurring in the genes of GSDMs have been associated with the development of certain autoimmune disorders,as well as cancers.Here,we review the current knowledge of the expression profile and regulation of GSDMs and the important roles of this protein family in inflammatory cell death,tumorigenesis and other related diseases. | Zengzhang Zheng Wanyan Deng Xiwen Lou Yang Bai Junhong Wang Huasong Zeng Sitang Gong Xing Liu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
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