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| 1 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 2 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 3 | MHD and kinetic analysis of flow bursts in the Earth's plasma sheet显示文摘In an attempt to study the flow bursts in the Earth’s plasma sheet we select an event that took place on August 7,2004 in the expansion phase of a substorm,using data from the geomagnetic index,solar wind data,plasma and magnetic field observations from C1 Cluster satellite(the Cluster mission has 4 satellites)and from Double Star TC-1 satellite.In MHD approach,TC-1 firstly observed the tailward flow,then the earthward,and finally the flow alternated in two directions.C1 firstly observed the earthward plasma flow,and then the tailward plasma flow.Before flow bursts are observed by TC-1 and C1,there are disturbances in local entropy with their tailward local entropy larger than those of the earthward.The kinetic features of the plasma flow observed by C1 are similar to those in MHD.However,kinetic characteristics of the plasma flow observed by TC-1 are far more than the description in MHD.The inadequacy mainly exists in two cases:(i)the firstly enhanced tailward flows given in MHD are found without significant increase of the energetic tailward flux;(ii)the almost stagnant flow in MHD is composed of the enhanced energetic ion flux in both earthward and tailward directions.The earthward flow burst observed by TC-1 might be multiple overshoots and rebounds.The earthward flow burst observed by C1 might be simply rebounded in the near-Earth.The pulsation observed by C1 is earlier than that observed by TC-1 with the former intensity less than that of the latter.After the energetic ion flux in the tailward direction is significantly enhanced,the power spectrum intensity of the ULF wave commences to increase obviously,which may suggest that the stream instability is closely correlated with ULF pulsations. | MA YuDuan CAO JinBin FU HuiShan REME H. DANDOURAS I. YANG JunYing WANG ZhiQiang TAO Dan YANG Jian | 2014 | Science China(Technological Sciences)2014，57，1： | 7 |
| 4 | Reversible 3D optical data storage and information encryption in photo-modulated transparent glass medium显示文摘Transparent glass has been identified as a vital medium for three-dimensional(3D)optical information storage and multi-level encryption.However,it has remained a challenge for directly writing 3D patterning inside a transparent glass using semiconductor blue laser instead of high-cost femtosecond laser.Here,we demonstrate that rare earth ions doped transparent glass can be used as 3D optical information storage and data encryption medium based on their reversible transmittance and photoluminescence manipulation.The color of tungsten phosphate glass doped with rare earth ions change reversibly from light yellow to blue upon alternating 473 nm laser illumination and temperature stimulation,resulting in the reversible luminescence modulation.The information data could be repeatedly written and erased in arbitrary 3D space of transparent glass,not only showing the ability of the excellent reproducibility and storage capacity,but also opening opportunities in information security.The present work expands the application fields of luminescent glass,and it is conducive to develop a novel 3D data storage and information encryption media. | Zhen Hu Xiongjian Huang Zhengwen Yang Jianbei Qiu Zhiguo Song Junying Zhang Guoping Dong | 2021 | Light(Science & Applications)2021，10，8： | 6 |
| 5 | The mid-high latitude whistler mode chorus waves observed around substorm onsets显示文摘Using the data of LFEW/TC-2, we studied the dawn side chorus around substorm onsets during a strong geomagnetic storm in November 2004. During this storm, LFEW/TC-2 observed 14 dawnside chorus events. Nine of them were associated with substorms and occurred within 40 min around the substorm onsets. The fre-quencies of waves have a very good correlation with the half equatorial electron cyclotron frequencies. Chorus can be excited in the region near magnetic equato-rial plane and then propagate to the mid and high latitudes. When the wave fre-quencies reach the local lower hybrid frequencies, chorus can be reflected due to the lower hybrid resonance. The time delay between the chorus and its echo is about 28 min. Previous observations show that the chorus can propagate at most to the magnetic latitudes of 40°. LFEW/ TC-2 found for the first time that the chorus in space could propagate to the magnetic latitude of 70°. Since most of the previous chorus observations are made close to the magnetic equatorial plane, our results are important for the studies of excitation and propagation of whistler mode wave, and relevant relativistic electron acceleration in the magnetosphere. | YANG JunYing CAO JinBin YAN ChunXiao LI LiuYuan MA YuDuan | 2008 | Science China(Technological Sciences)2008，51，10： | 6 |
| 6 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 7 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 8 | Folate-chitosan-gemcitabine core-shell nanoparticles targeted to pancreatic cancer显示文摘Objective:Human pancreatic cancer is one of the most common clinical malignancies.The effect of comprehensive treatment based on surgery is general.The effects of chemotherapy were not obvious mainly because of lack of targeting and chemoresistance in pancreatic cancer.This study aimed to investigate the effects of folate receptor(FR)-mediated gemcitabine FA-Chi-Gem nanoparticles with a core-shell structure by electrostatic spray on pancreatic cancer.Methods:In this study,the levels of expression of FR in six human pancreatic cancer cell lines were studied by immunohistochemical analysis.The uptake rate of isothiocyanate-labeled FA-Chi nanoparticles in FR high expression cell line COLO357 was assessed by fluorescence microscope and the inhibition rate of FAChi-Gem nanoparticles on COLO357 cells was evaluated by MTT assay.Moreover,the biodistribution of PEG-FA-ICGDER02-Chi in the orthotopic pancreatic tumor model was observed using near-infrared imaging and the human pancreatic cancer orthotopic xenografts were treated with different nanoparticles and normal saline control.Results:The expression of FR in COLO357 was the highest among the six pancreatic cancer cell lines.The FR mainly distributed on cell membrane and fewer in the cytoplasm in pancreatic cancer.Moreover,the absorption rate of the FA-Chi-Gem nanoparticles was more than the Chi nanoparticles without FA modified.The proliferation of COLO357 was significantly inhibited by FA-Chi-Gem nanoparticles.The PEG-FAICGDER02-Chi nanoparticles were enriched in tumor tissue in human pancreatic cancer xenografts,while non-targeted nanoparticles were mainly in normal liver tissue.PEG-FA-Gem-Chi significantly inhibited the growth of human pancreatic cancer xenografts(PEG-FA-Gem-Chi vs.Gem,t=22.950,P=0.000).Conclusions:PEG-FA-FITC-Chi nanoparticles might be an effective targeted drug for treating human FR-positive pancreatic cancer. | Jiahua Zhou Junying Wang Qian Xu Shi Xu Jin Wen Zeqian Yu Detong Yang | 2013 | Chinese Journal of Cancer Research2013，25，5： | 5 |
| 9 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 10 | The m6A methylation regulates gonadal sex differentiation in chicken embryo显示文摘Background:As a ubiquitous reversible epigenetic RNA modification,N6-methyladenosine(m6A)plays crucial regulatory roles in multiple biological pathways.However,its functional mechanisms in sex determination and differentiation during gonadal development of chicken embryos are not clear.Therefore,we established a transcriptome-wide m6A map in the female and male chicken left gonads of embryonic day 7(E7)by methylated RNA immunoprecipitation sequencing(MeRIP-seq)to offer insight into the landscape of m6A methylation and investigate the post-transcriptional modification underlying gonadal differentiation.Results:The chicken embryonic gonadal transcriptome was extensively methylated.We found 15,191 and 16,111 m6A peaks in the female and male left gonads,respectively,which were mainly enriched in the coding sequence(CDS)and stop codon.Among these m6A peaks,we identified that 1013 and 751 were hypermethylated in females and males,respectively.These differential peaks covered 281 and 327 genes,such as BMP2,SMAD2,SOX9 and CYP19A1,which were primarily associated with development,morphogenesis and sex differentiation by functional enrichment.Further analysis revealed that the m6A methylation level was positively correlated with gene expression abundance.Furthermore,we found that YTHDC2 could regulate the expression of sex-related genes,especially HEMGN and SOX9,in male mesonephros/gonad mingle cells,which was verified by in vitro experiments,suggesting a regulatory role of m6A methylation in chicken gonad differentiation.Conclusions:This work provided a comprehensive m6A methylation profile of chicken embryonic gonads and revealed YTHDC2 as a key regulator responsible for sex differentiation.Our results contribute to a better understanding of epigenetic factors involved in chicken sex determination and differentiation and to promoting the future development of sex manipulation in poultry industry. | Jianbo Li Xiuan Zhang Xiqiong Wang Congjiao Sun Jiangxia Zheng Junying Li Guoqiang Yi Ning Yang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 4 |
| 11 | In-flight observations of electromagnetic interferences emitted by satellite显示文摘Using the data from STAFF/TC-1, this paper for the first time analyzes the electromagnetic interferences of Chinese scientific satellite. The electromagnetic interference of satellite exists mainly below 30 Hz, but can extend to 190 Hz with an obviously decreasing power spectral density. The electromagnetic interferences at frequencies below 190 Hz have good correlation with the solar aspect angle. The electromagnetic interferences at frequencies between 190 and 830 Hz have also correlation with solar as-pect angle. However, the electromagnetic interferences at frequencies above 830 Hz have no correlation with the solar aspect angle. The correlation coefficient between solar aspect angel and electromagnetic interferences is around 0.90. The larger the solar aspect angle, the stronger the satellite electromagnetic interference. When the solar aspect angle increases from 90.6° to 93.6°, the electromagnetic interferences at frequencies <10 Hz increase by 8 times and those at frequencies 190―830 Hz increase by 60%. This close association of electromagnetic interferences with the solar aspect angle indicates that the solar aspect angle is the main factor to determine the electromagnetic interferences. The electromagnetic interferences of satellite in sunlight are larger than those in eclipse. The electro-magnetic interference produced by solar panel occupies about 87% in the low frequency band (<100 Hz) and 94% in the high frequency band (>100 Hz) of the total electromagnetic interference produced by satellite. These in flight observations of electromagnetic radiation of satellites will be very helpful to the designs of future satellites of space sciences or earthquake sciences. | CAO JinBin YANG JunYing YUAN ShiGan SHEN XuHui LIU YuanMo YAN ChunXiao LI WenZhen CHEN Tao | 2009 | Science China(Technological Sciences)2009，52，7： | 4 |
| 12 | Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly显示文摘Error-free cell division depends on the accurate assembly of the spindle midzone from dynamic spindle microtubules to ensure chromatid segregation during metaphase-anaphase transition.However,the mechanism underlying the key transition from the mitotic spindle to central spindle before anaphase onset remains elusive.Given the prevalence of chromosome instability phenotype in gastric tumorigenesis,we developed a strategy to model context-dependent cell division using a combination of light sheet microscope and 3D gastric organoids.Light sheet microscopic image analyses of 3D organoids showed that CENP-E inhibited cells undergoing aberrant metaphase-anaphase transition and exhibiting chromosome segregation errors during mitosis.Highresolution real-time imaging analyses of 2D cell culture revealed that CENP-E inhibited cells undergoing central spindle splitting and chromosome instability phenotype.Using biotinylated syntelin as an affinity matrix,we found that CENP-E forms a complex with PRC1 in mitotic cells.Chemical inhibition of CENP-E in metaphase by syntelin prevented accurate central spindle assembly by perturbing temporal assembly of PRC1 to the midzone.Thus,CENP-E-mediated PRC1 assembly to the central spindle constitutes a temporal switch to organize dynamic kinetochore microtubules into stable midzone arrays.These findings reveal a previously uncharacterized role of CENP-E in temporal control of central spindle assembly.Since CENP-E is absent from yeast,we reasoned that metazoans evolved an elaborate central spindle organization machinery to ensure accurate sister chromatid segregation during anaphase and cytokinesis. | Xu Liu Leilei Xu Junying Li Phil Y.Yao Wanjuan Wang Hazrat Ismail Haowei Wang Bryce Liao Zhihong Yang Tarsha Ward Ke Ruan Jianchun Zhang Quan Wu Ping He Xia Ding Dongmei Wang Chuanhai Fu Zhen Dou Feng Yan Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，8： | 3 |
| 13 | HLS bunch current measurement system显示文摘Bunch current is an important parameter for studying the injection fill-pattern in the storage ring and the instability threshold of the bunch, and the bunch current monitor also is an indispensable tool for the top-up injection. A bunch current measurement (BCM) system has been developed to meet the needs of the upgrade project of Hefei Light Source (HLS). This paper presents the layout of the BCM system. The system based on a high-speed digital oscilloscope can be used to measure the bunch current and synchronous phase shift. To obtain the absolute value of bunch-by-bunch current, the calibration coefficient is measured and analyzed. Error analysis shows that the RMS of bunch current is less than 0.01 mA when bunch current is about 5 mA, which can meet project requirement. | YANG YongLiang MA TianJi SUN BaoGen LU Ping WANG JiGang ZOU JunYing TANG LeiLei | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 14 | Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study显示文摘OBJECTIVE: To determine the clinical efficacy and safety of Liangxue Jiedu decoction(LJD) for the treatment of progressive psoriasis vulgaris and to provide the basis for the development of a standardized treatment protocol for psoriasis vulgaris.METHODS: In this multicenter, randomized, controlled study, patients with blood-heat type psoriasis were randomly assigned to receive either Chinese herbal medicine(LJD;treatment group) or Western Medicine(cetirizine hydrochloride, vitamin C, and vitamin B complex;control group). Psoriasis Area and Severity Index(PASI) scores were calculated in addition to the number of patients who achieved ≥ 50% or ≥ 75% improvement in PASI score from baseline. The change in symptoms of Chinese medicine(color of rash, burning sensation,itchiness, severity of irritation, and anger) was evaluated and safety was assessed as adverse events and laboratory analysis. t test, independent sample non-parametric test and χ2 test were used to analyze the results.RESULTS: A total of 238 participants were included in the study [treatment group, n = 122(PP analysis117);control group, n = 116(PP analysis 104)]. LJD treatment was associated with a significant improvement in skin lesions and symptoms com-pared with Western Medicine treatment. At the end of the 8-week treatment period, 23.77%(PP analysis 24.79%) of patients in the treatment group had achieved PASI75 and 57.38%(PP analysis 58.97%)had achieved PASI50;the corresponding figures in the control group were 9.48%(9.62%) and 25.00%(25.00%), respectively. The between-group differences were statistically significant(P < 0.05).CONCLUSION: Treatment of psoriasis vulgaris of the blood-heat type using LJD was associated with significantly better outcomes compared with those achieved using standard Western Medicine. | Sun Liyun Li Tiantian Zhou Dongmei Yang Xiumin Tian Jing Zhao Junying Xu Wei He Yanling Liu Fang Tong Chunguan Chu Xiaoling Dai Ling Zhu Wei Xu Xuying Wang Ping | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 3 |
| 15 | Detrimental effects of excessive fatty acid secretion on female sperm storage in chickens显示文摘Background:Female sperm storage(FSS),the maintenance of sperm inside the female reproductive tract for an extended period of time,is pervasive among organisms with internal fertilization.Because FSS enables asynchronous mating and fertilization,it could be extremely important to reproduction.However,the physiological mechanisms underlying prolonged preservation and maintenance are poorly understood.Here,we used chicken,a typical oviparous animal,to determine the mechanisms ensuring sperm functionality in sperm storage tubules(SSTs).Results:We performed an insemination experiment on over two thousand hens at two periods,and found that the FSS capabilities varied widely among individuals.Except for the differences in the SST density between the two groups with distinct FSS abilities,we quantitatively profiled small-molecule metabolites derived from SST cells,and identified 28 metabolites with differential expression.In particular,high levels of lipids,fatty acids and lipid peroxidation product were observed in hens with low FSS capability.Pathway analysis showed that these differential metabolites were significantly enriched in the biosynthesis of unsaturated fatty acids.Moreover,we detected the total antioxidant capacity and lipid peroxidation level of SSTs,and found that chickens with a lower FSS ability had a significantly higher content of lipid peroxidation end-product,which was 2.4-fold greater than chickens with a higher FSS capability,and no significant difference was found in the total antioxidant capacity between these two groups.Conclusions:Our findings reveal that the long-term storage of sperm and the maintenance of their function in the female reproductive tract require an adequate microenvironment.The superabundance of fatty acids secreted by SST cells had detrimental effects on sperm storage in the female reproductive tract.Lipid peroxidation produces toxic biological substances that may cause irreversible damage to resident spermatozoa,resulting in short-term sperm retention and decreased fertility.Our findings provide new avenues for studying sperm storage and sustaining fertility. | Chaoliang Wen Chunning Mai Bin Wang Junying Li Congjiao Sun Ning Yang | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 2 |
| 16 | Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection显示文摘Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation. | Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang | 2018 | Science Bulletin2018，63，14： | 2 |
| 17 | Development and application of the new BPM system data processing program at Hefei light source显示文摘A data processing program has been applied for the new beam position monitor (BPM) system of the storage ring at Hefei Light Source (HLS). The new BPM system in the upgrade project will be equipped with Libera Brilliance BPM processors to replace the old Bergoz MX-BPM processors. The embedded Linux system on Libera has completed some important work, including instrument status check,data acquisition, position calculation, EPICS IOC data release,and so on. A new EPICS record type has been developed to recalculate the beam position with log-ratio method. The property of the new position data was analyzed in the time and frequency domain. The results show that the rms value of beam position measurement resolution can be up to submicron. Preliminary studies have been carried out on the measurement of the tune and the beam lifetime with this new BPM system. | MA Tianji YANG Yongliang SUN Baogen ZOU Junying LU Ping ZHOU Zeran XU Hongliang | 2012 | Nuclear Science and Techniques2012，23，5： | 2 |
| 18 | Case study of small scale polytropic index in the central plasma sheet显示文摘This paper studies the effective polytropic index in the central plasma sheet(CPS) by using the method of Kartalev et al.(2006), which adopts the denoising technique of Haar wavelet to identify the homogeneous MHD Bernoulli integral(MBI) and has been frequently used to study the polytropic relation in the solar wind. We chose the quiet CPS crossing by Cluster C1 during the interval 08:51:00–09:19:00 UT on 03 August 2001. In the central plasma sheet, thermal pressure energy per unit mass is the most important part in MBI, and kinetic energy of fluid motion and electromagnetic energy per unit mass are less important. In the MBI, there are many peaks, which correspond to isothermal or near isothermal processes. The interval lengths of homogenous MBI regions are generally less than 1 min. The polytropic indexes are calculated by linearly fitting the data of lnp and lnn within a 16 s window, which is shifted forward by 8 s step length. Those polytropic indexes with |R|≥0.8(R is the correlation coefficient between lnp and lnn) and p-value≤0.1 in the homogeneous regions are almost all in the range of [0, 1]. The mean and median effective polytropic indexes with high R and low p-value in homogeneous regions are 0.34 and 0.32 respectively, which are much different from the polytropic index obtained by traditional method(?trad=?0.15). This result indicates that the CPS is not uniform even during quiet time and the blanket applications of polytropic law to plasma sheet may return misleading value of polytropic index. The polytropic indexes in homogeneous regions with a high correlation coefficient basically have good regression significance and are thus credible. These results are very important to understand the energy transport in magnetotail in the MHD frame. | PANG XueXia CAO JinBin LIU WenLong MA YuDuan LU HaoYu YANG JunYing LI LiuYuan LIU Xu WANG Jing WANG TieYan YU Jiang | 2015 | Science China Earth Sciences2015，58，11： | 2 |
| 19 | Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity显示文摘Triple-negative breast cancer(TNBC)is the most challenging subtype of breast cancer.Various endeavor has been made to explore the molecular biology basis of TNBC.Herein,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in TNBC.KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor prognosis.In functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and invasiveness.RNA-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further experiments.CXCL8 depletion inhibited the tumorigenesis and progression of TNBC.Additionally,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in vivo.Furthermore,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of cells.Moreover,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 protein.Taken together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and progression.KTN1 may be a potential molecular target for the development of TNBC treatment. | Lin Gao Shanze Chen Malin Hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang Hsien-Da Huang Xiang Gao Chang Zou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 20 | A cumulant-based parameter estimation algorithm for near-field sources显示文摘高效地使用数组孔并且避免配对计算的复杂参数,这篇论文为本地化近地的狭窄的乐队来源建议一个新基于 cumulant 的算法。第一,算法建议一个对称的一致线性数组(ULA ) ,并且由使用适当地选传感器产量的一些的第四顺序的 cumulants 构造三个 cumulant 矩阵;第二,它不同于分析在数据或潜水艇空格领域建模的常规平行 fctor (PARAFAC ) ,用三个矩阵,和 analyzies 在第四顺序的 cumulant 域形成一个三路的数组(TWA ) 它的低等级的分解的唯一;第三,它联合经由低等级分解从矩阵估计频率,方向到达(DOA ) ,和每近地的来源的范围, TWA 模拟结果,,介绍了验证我们的建议方法的表演。 | Liang Junli Yang Shuyuan Zhang Junying | 2007 | Progress in Natural Science:Materials International2007，17，8： | 2 |
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