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| 1 | The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice显示文摘G-protein signaling and ubiquitin-dependent degradation are both involved in grain development in rice,but how these pathways are coordinated in regulating this process is unknown.Here,we show that Chang Li Geng 1(CLG1),which encodes an E3 ligase,regulates grain size by targeting the Gγprotein GS3,a negative regulator of grain length,for degradation.Overexpression of CLG1 led to increased grain length,while overexpression of mutated CLG1 with changes in three conserved amino acids decreased grain length.We found that CLG1 physically interacts with and ubiquitinats GS3which is subsequently degraded through the endosome degradation pathway,leading to increased grain size.Furthermore,we identified a critical SNP in the exon 3 of CLG1 that is significantly associated with grain size variation in a core collection of cultivated rice.This SNP results in an amino acid substitution from Arg to Ser at position 163 of CLG1 that enhances the E3 ligase activity of CLG1 and thus increases rice grain size.Both the expression level of CLG1 and the SNP CLG1163S may be useful variations for manipulating grain size in rice. | Wensi Yang Kun Wu Bo Wang Huanhuan Liu Siyi Guo Xiaoyu Guo Wei Luo Shengyuan Sun Yidan Ouyang Xiangdong Fu Kang Chong Qifa Zhang Yunyuan Xu | 2021 | Molecular Plant2021，14，10： | 6 |
| 2 | Artificial Selection in Domestication and Breeding Prevents Speciation in Rice显示文摘Speciation has long been regarded as an irreversible process once the reproductive barriers had been established.However,unlike in natural populations,artificial selection might either accelerate or prevent speciation processes in domesticated species.Asian cultivated rice is a target crop for both domestication and artificial breeding;it contains two subspecies of indica and japonica,which usually produce sterile inter-subspecific hybrids due to reproductive barriers.In this study,we constructed the evolutionary trajectory of a reproductive isolation system S5,which regulates fertility in indica-japonica hybrids via three adjacent genes,based on the data of 606 accessions including two cultivated and 11 wild rice species.Although hybrid sterility haplotypes at S5 lead to establishment of a killer-protector reproductive barrier,origin of wide-compatibility haplotypes by complex hybridization and recombination provides an opposing force to reproductive isolation and thus prevents speciation during domestication.Analysis in a diallel set of 209 crosses involving 21 parents showed that the wide-compatibility genotypes largely rescued fertility of indica-japonica hybrids,indicating that the wide-compatibility gene would enable gene flow to maintain species coherence.This counteracting system indicates that combined effects of natural evolution and artificial selection may result in reversible processes of speciation in rice,which may also have implications for genetic improvement of rice. | Jiaming Mi Guangwei Li Conghao Xu Jiangyi Yang Huihui Yu Gongwei Wang Xianghua Li Jinghua Xiao Huazhi Song Qifa Zhang Yidan Ouyang | 2020 | Molecular Plant2020，13，4： | 6 |
| 3 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 4 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 5 | Relationships of differential gene expression in leaves with heterosis and heterozygosity in a rice diallel cross显示文摘 | L. Z. Xiong G. P. Yang C. G. Xu Qifa Zhang M. A. Saghai Maroof | 1998 | Molecular Breeding1998，，2： | 1 |
| 6 | Molecular marker heterozygosity and hybrid performance in indica and japonica rice显示文摘 | Qifa Zhang Z. Q. Zhou G. P. Yang C. G. Xu K. D. Liu M. A. Saghai Maroof | 1996 | Theoretical and Applied Genetics1996，，8： | 1 |
| 7 | Comparative analysis of microsatellite DNA polymorphism in landraces and cultivars of rice显示文摘 | G. P. Yang M. A. Saghai Maroof C. G. Xu Qifa Zhang R. M. Biyashev | 1994 | MGG Molecular & General Genetics1994，，2： | 1 |
| 8 | Short-term cascaded hydroelectric system scheduling based on chaotic particle swarm optimization using improved logistic map 显示文摘 | HE Yaoyao YANG Shanlin XU Qifa | 2013 | Com- munications in Nonlinear Science and Numerical Simula- tion2013，18，7： | 1 |
| 9 | A novel cha- otic differential evolution algorithm for short-term cascaded hydroelectric system scheduling 显示文摘 | HE Yaoyao XU Qifa YANG Shanlin | 2014 | International Journal of Electrical Power & Energy Systems2014，61，： | 1 |
| 10 | Targeting xa13, a recessive gene for bacterial blight resistance in rice显示文摘 | Zhaohui Chu Binying Fu Hong Yang Caiguo Xu Zhikang Li A. Sanchez Y. J. Park J. L. Bennetzen Qifa Zhang Shiping Wang | 2006 | Theoretical and Applied Genetics2006，，3： | 1 |
| 11 | Comparative analysis of microsatellite DNA polymorphism in landraces and cultivars of rice显示文摘 | G. P. Yang M. A. Saghai Maroof C. G. Xu Qifa Zhang R. M. Biyashev | 1994 | MGG Molecular & General Genetics1994，，2： | 1 |
| 12 | Electrophoretic Carbon Nanotube Field Emission Layer for Plasma Display Panels显示文摘A carbon-nanotube(CNT) electrophoretic deposition(EPD) process has been developed to prepare a field emission layer in plasma display panels(PDP) for discharge voltage reduction. The CNT layer as a source of discharge priming electrons has been fabricated on the PDP front panel. The balling grinding,mix-acid treatment and EPD parameters have been investigated in order to obtain good uniformity and excellent field emission capability of CNT layer, in order to meet the specifications of CNTs in PDP cell. The measured turn-on field was around 1.1 V/μm in the field emission testing while the minimum sustaining voltage was decreased by 30~40 V with the use of CNT layer in the discharge testing. | Qifa Liu Zhuoqing Yang Yan Wang Guifu Ding | 2012 | Nano-Micro Letters2012，4，4： | 1 |
| 13 | Comparative analysis of microsatellite DNA polymorphism in landraces and cultivars of rice显示文摘 | G. P. Yang M. A. Saghai Maroof C. G. Xu Qifa Zhang R. M. Biyashev | 1994 | MGG Molecular & General Genetics1994，，2： | 1 |
| 14 | A Killer-Protector System Regulates Both Hybrid Sterility and Segregation Distortion in Rice显示文摘 | Jiangyi Yang Xiaobo Zhao Ke Cheng Hongyi Du Yidan Ouyang Jiongjiong Chen Shuqing Qiu Jianyan Huang Yunhe Jiang Liwen Jiang Jihua Ding Jia Wang Caiguo Xu Xianghua Li Qifa Zhang | 2012 | Science2012，，6100： | 1 |
| 15 | Comparative analysis of microsatellite DNA polymorphism in landraces and cultivars of rice显示文摘 | G. P. Yang M. A. Saghai Maroof C. G. Xu Qifa Zhang R. M. Biyashev | 1994 | MGG Molecular & General Genetics1994，，2： | 1 |
| 16 | Relationships of differential gene expression in leaves with heterosis and heterozygosity in a rice diallel cross显示文摘 | L. Z. Xiong G. P. Yang C. G. Xu Qifa Zhang M. A. Saghai Maroof | 1998 | Molecular Breeding1998，，2： | 1 |
| 17 | Molecular marker heterozygosity and hybrid performance in indica and japonica rice显示文摘 | Qifa Zhang Z. Q. Zhou G. P. Yang C. G. Xu K. D. Liu M. A. Saghai Maroof | 1996 | Theoretical and Applied Genetics1996，，8： | 1 |
| 18 | Targeting xa13 , a recessive gene for bacterial blight resistance in rice显示文摘 | Zhaohui Chu Binying Fu Hong Yang Caiguo Xu Zhikang Li A. Sanchez Y. J. Park J. L. Bennetzen Qifa Zhang Shiping Wang | 2006 | Theoretical and Applied Genetics2006，，3： | 1 |
| 19 | Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study显示文摘Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group. | Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang Yajing Xu Na Xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han Xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang Xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li Xuan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 20 | Construction of UHVAC Test Base显示文摘The construction of the UHVAC test base of SGCC is an important component of the pilot project on UHVAC power transmission and transformation in China. This paper introduces the layout, technical requirements and main test functions of the UHVAC test base as well as difficulties during construction. It lays stress on the characterization of a 1 000-kV single-circuit test line, a 1 000-kV one-tower double-circuit test line, a full voltage test site for UHV equipment, a climate laboratory, a corona cage and a long-wave-front impulse voltage generator. | Yang Yingjian,Hu Yi,Wu Xiong,Wu Zhirong,Wan Qifa,Liu Xianjin and Cai Wei State Grid Electric Power Research Institute | 2009 | Electricity2009，20，4： | 0 |
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