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| 1 | The oldest basement rock in the Yangtze Craton revealed by zircon U-Pb age and Hf isotope composition显示文摘Here we report an integrated study of zircon U-Pb age and Hf isotope composition for a gneiss sample from the Kongling terrain in the Yangtze Craton. CL imaging reveals that most zircons are magmatic, and a few of them have thin metamorphic rims. The magmatic zircons gave a weighted mean U-Pb age of 3218±13 Ma, indicating the gneiss is the oldest basement rock in the Yangtze Craton found to date. They have εHf(t) value of -2.33±0.51,and two-stage Hf model age of 3679±49 Ma,indicating that the gneiss was derived from partial melting of >3.6 Ga crustal rock. The metamorphic rims yielded an age of 2732±16 Ma, implying that the metamorphic event occurred in the Neoarchean era, which may be also a major tectono-thermal event in the Yangtze Craton. | JIAO WenFang WU YuanBao YANG SaiHong PENG Min WANG Jing | 2009 | Science China Earth Sciences2009，52，9： | 57 |
| 2 | Paleoproterozoic mafic dyke from Kongling terrain in the Yangtze Craton and its implication显示文摘Mafic dyke is a sign of regional extension, and thus has important tectonic significance. A great amount of mafic dykes occur in the Kongling terrain of the Yangtze Craton, which have great bearing on the early evolution of the Yangtze Craton. Their ages, however, have not been well constrained. In this paper we report an integrated study of zircon U-Pb age and Hf isotope compositions for a mafic dyke in the Kongling terrain. The zircons yielded a weighted mean 207Pb/206Pb age of 1852±11Ma, which represents its intrusion age. They have εHf(t) values of -6.3 to 0.5, with a weighted mean of -3.06±0.88, suggesting that the mafic dyke came from metasomatic mantle. The results indicate that the Yangtze Block had transformed into post-collisional extensional regime at ca. 1850 Ma. In the same period, the Yangtze Craton shows enough rigidity to produce brittle rupture, and thus has the characteristics of a craton. | PENG Min WU YuanBao WANG Jing JIAO WenFang LIU XiaoChi YANG SaiHong | 2009 | Chinese Science Bulletin2009，54，6： | 10 |
| 3 | Aquaporin-4 and ischemic brain edema显示文摘OBJECTIVE:To investigate the relationship of aquaporin 4(AQP4)and brain edema.DATA SOURCES:Using the terms of 'aquaporin-4,brain edema',we searched PubMed database to identify studies published from January 1997 to April 2006 in the English languages.Meanwhile,we also searched China National Knowledge Infrastructure(CNKI)for related studies.STUDY SELECTION:The collected data were selected firstly.Studies on AQP4 and brain edema were chosen and their full-texts were searched for,and those with repetitive or review studies were excluded.DATA EXTRACTION:Totally 146 related studies were collected,42 of them were involved and the other 104 studies were used for reading reference data.DATA SYNTHESIS:AQP4 is a selective water permeable integral membrane protein.It is mainly expressed in astrocytes and ependymocyte,and is the important structural basis for water regulation and transportation between glial cells and cerebrospinal fluid or vessels.Phosphorylation is involved in the regulation of AQP4.AQP4 participates in the formation of brain edema caused by various factors.Studies on the structure and pathological changes of AQP4 are still in the initial stage,and the role and mechanism of AQP4 in the formation of brain edema is very unclear.CONCLUSION:AQP4 plays a critical regulating role in the formation of ischemic brain edema,but whether it is regulated by drugs lacks reliable evidence. | Saihong Dun Yang Guo | 2007 | Neural Regeneration Research2007，2，4： | 6 |
| 4 | Drug resistance mutation profiles of the drug-nave and first-line regimen-treated HIV-1-infected population of Suzhou, China显示文摘Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance(TDR) and acquired drug resistance mutation(ADR) profiles, we collected blood specimens from 127 drug-naive and 117 first-line drugtreated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified po/fragments from 100 drug-naive and 20 drug-treated samples. We then determined the drugresistant mutations to protease(PR) and reverse-transcriptase(RT) inhibitors according to the Stanford drug resistance database. Overall, 11 and 13 individuals had transmitted(drug-naive group) and acquired(treated group) resistance mutations, respectively. Six transmitted drugresistant mutations were found, including two mutations(L33F and L76V) in the protease region and four(K70N/E and V179D/E) in the RT region. Only L76 V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors. All 13 treated participants who had major drug resistance mutations demonstrated intermediate to high resistance to efavirenz and nevirapine, and six had a treatment duration of less than three months. No major mutations to RT inhibitors were found, implying that the epidemic of transmitted resistance mutations was not significant in this area. Our results suggest that more frequent virus load and drug resistance mutation tests should be conducted for individuals receiving antiretroviral treatment, especially for newly treated patients. Our research provides insights into the occurrence of HIV-1 drug resistance in Suzhou and will help to optimize the treatment strategy for this population. | Tingting Li Feng Qian Ting Yuan Weilu Xu Li Zhu Jinlong Huang Haiyan Wang Yueping Zhu Yinling Wang Xiaohong Li Saihong Gu Zhuqing Tan Hui Chen Xiangrong Luo Wei Zhu Weniuan Lu Ping Xu Ming Li Yuying Chen Yong Gao Rongge Yang Chuanwu Zhu Binlian Sun | 2017 | Virologica Sinica2017，32，4： | 2 |
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