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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Effects of modified multi-walled carbon nanotubes on the curing behavior and thermal stability of bo- ron phenolic resin显示文摘 | LIU Lin YE Ziping | 2009 | Polymer Degradation and Stability2009，94，11： | 1 |
| 3 | A study on the distribution characteristics and existing states of cadmium in the Jinding Pb-Zn deposit,Yunnan Province,China显示文摘The distribution characteristics and existing state of cadmium in the Jinding Pb-Zn deposit were studied. It was discovered that Cd was mainly distributed in sphalerite as an isomorphic impurity. There was a good correlation between Cd and Zn in the primary ore. With the oxidation and resolution of pyrite, sphalerite, sulfide, and etc., many secondary minerals, such as colloform sphalerite and smithsonite, were formed. The distribution of Cd is not symmetrical, and enrichment and dilution were observed in partial area of the oxidation zone in the deposit. Cd, except in external pore space or cracks of secondary minerals as independent minerals, such as greenockite, was mainly distributed in sphalerite as an isomorphic impurity in the secondary sphalerate and smithsonite in the oxidation zone. The research showed that Cd showed a very strong active transfer ability in the oxidation process, not only indicating that supergene leaching might be the main reason for Cd enrichment in some Pb-Zn deposits, but also reflecting that Cd was easily mobilizeed and transferred to pollute ore areas in the oxidation process. Furthermore, Cd in oxidation ore was more easily mobilized and transferred to induce bad hazards for ore areas with the effect from AMD which was produced from oxidation of sulfides. | YE Lin CHENG Zengtao PAN Ziping LIU Tiegeng GAO Wei | 2010 | Chinese Journal Of Geochemistry2010，29，3： | 1 |
| 4 | Effects of modified multi-walled carbon nanotubes on the curing behavior and thermal stability of boron phenolic resin显示文摘 | Lin Liu Ziping Ye | 2009 | Polymer Degradation and Stability2009，94，11： | 1 |
| 5 | Effects of modified multi-walled carbon nanotubes on the curing behavior and thermalstability of boron phenolic resin显示文摘 | Lin Liu Ziping Ye | 2009 | Polymer Degradation and Stability2009，，94： | 1 |
| 6 | A simulation experimental study on oxidative kinetics of sphalerite under hypergene condition显示文摘The sphalerite oxidative kinetics under hypergene condition was simulated and studied by means of a mixed flow reactor over a pH range of 1.0 7.8,and at dissolution temperatures from 20 to 55℃,ferric ion concentrations from 1.0×10-5 to 1.0×10-2 mol/L,O 2 flux of 0.5 L/min,and oxidants of ferric ion and O 2.It is indicated that with ferric ion as oxidant,the oxidation rate of sphalerite increases with increasing ferric ion concentration,temperature and decreasing pH value,and under the studied conditions,the dissolution rates of Zn and Cd are approximately identical,with the values of activation energy being 41.75 and 42.51 kJ·mol-1,respectively,suggesting that the oxidation rate of sphalerite is controlled by chemical reactions on mineral surface.However,with O 2 as oxidant,the oxidation mechanism of sphalerite varies with pH value.Oxidation rate decreases with increasing pH value when pH is lower than 5.95,whereas the increase of pH value results in an increase in oxidation rate when pH value is higher than 7.The oxidation rate of sphalerite can be expressed as:R Zn =10 1.1663 [Fe3+] 0 0.154 ·[H+] 0.2659 ·e-41.75/RT or R Cd =10 1.7292 [Fe3+] 0 0.170 ·[H+] 0.2637 ·e-42. | PAN Ziping YE Lin LIU Tiegeng CHENG Zengtao GAO Wei YANG Yulong | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 0 |
| 7 | The environmental effect of cadmium-rich Pb-Zn deposit, as exemplified by Niujiaotang Cd-rich Zn deposit, Guizhou, China显示文摘 | Lin YE Ziping PAN Chaoyang LI Tiegeng LIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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