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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 3 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 4 | Principles and construction of MSD adder in ternary optical computer显示文摘The two remarkable features of ternary values and a massive unit with thousands bits of parallel computation will make the ternary optical computer (TOC) with modified signed-digit (MSD) adder more powerful and e?cient than ever before for numerical calculations. Based on the decrease-radix design presented previously, a TOC can satisfy either a user requiring huge capacity for data calculations or one with a moderate amount of data, if it is equipped with a prepared adder. Furthermore, with the application of pipelined operations and the proposed data editing technique, the e?ciency of the prepared adder can be greatly improved, so that each calculated result can be obtained almost within one clock cycle. It is hopeful that by employing a MSD adder, users will be able to enter a new dimension with the creation of a new multiplier, new divider, as well as new matrix operator in a TOC in the near future. | JIN Yi SHEN YunFu PENG JunJie XU ShiYi DING GuangTai YUE DongJian YOU HaiHang | 2010 | Science China(Information Sciences)2010，53，11： | 26 |
| 5 | Blood Lipid Profile and Prevalence of Dyslipidemia in Chinese Adults显示文摘Objective To investigate the plasma lipid levels in a national representative sample of subjects and to determine the prevalence of dyslipidemia in the Chinese population.Methods Plasma lipid profile was analyzed using the data obtained during the Chinese national nutrition and health survey(CNHS)in 2002 which involved 14 252 participants at the age of 18 years or older.Results The mean levels of total cholesterol(TC),triglyceride(TG)and high density lipoprotein cholesterol(HDL-C)in the participants were 3.81 mmol/L,1.10 mmol/L,and 1.30 mmol/L,respectively.In the groups of participants at the age of 18-44 years,45-59 years,and over 60 years the mean TC level was 3.70 mmol/L,4.09 mmol/L and 4.21 mmol/L,respectively,and the mean TG level was 07 mmol/L,1.21 mmol/L,1.20 mmol/L,1.29 mmol/L,1.33 mmol/L,and 1.33 mmol/L,respectively.The prevalence of dyslipidemia in Chinese adults was 18.6% and 22.2% in males and 15.9% in females.Dyslipidemia prevalence was higher in urban districts than in rural areas(21.0% vs.17.7%).The prevalence of hypercholesterolemia,hypertriglyceridemia,and low HDL cholesterol was 2.9%,11.9%,and 7.4% respectively among the participants.Conclusion Dyslipidemia has become one of the important health risk factors in the Chinese population.There is no significantly difference in the prevalence of dyslipidemia between the groups of participants at the age of 45-59 years and over 60 years.This study provides important lipid profile data for policy making and guideline development for the prevention of dyslipidemia in the Chinese population. | WEN-HUA ZHAO JIAN ZHANG YI ZHAI YUE YOU QING-QING MAN CHUN-RONG WANG HONG LI YING LI XIAO-GUANG YANG | 2007 | Biomedical and Environmental Sciences2007，20，4： | 22 |
| 6 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 7 | Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)显示文摘圆锥花序建筑学是仔细与产量有关形成。qPE9-1 基因被证明了广泛地在产量很高的米饭栽培变种开发被过去常,授与在装饰用的梨树米饭的直立的圆锥花序特性。最近, qPE9-1 成功地被克隆;然而,谷物产量上的基因效果还每直立的圆锥花序等位基因 qPE9-1 的植物是争论的。在现在的学习,低垂的圆锥花序父母 Nongken 57,带 qpe9-1 等位基因,被用作周期性父母到连续地回交到从双 haploid (DH ) 的一根典型直立的圆锥花序线人口(Wuyunjing 8/Nongken 57 ) ,它以前被显示带 qPE9-1 等位基因。因此,一双 near-isogenic 线(无) 被开发。在无之间的农学的特点的比较证明当 qpe9-1 被 qPE9-1 代替时,圆锥花序建筑学从低垂树立被改变;而且,圆锥花序长度,植物高度, 1000 谷物重量和 tillers 显著地被减少,因而在 30% 每植物导致谷物产量的戏剧的减少。因此,我们断定 qPE9-1 是控制圆锥花序建筑学的一个主要因素,并且 qPE9-1 有多种的自然,与每植物的谷物产量上的否定效果。这结果强烈建议直立的圆锥花序等位基因 qPE9-1 应该在产量很高的繁殖实践和另外的有利基因被使用。另外,吃并且煮质量上的 qPE9-1 的效果也在现在的学习被讨论。 | Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan | 2011 | Journal of Genetics and Genomics2011，38，5： | 20 |
| 8 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 9 | Seasonal variations and size distributions of water-soluble ions in atmospheric aerosols in Beijing, 2012显示文摘The characteristics of water-soluble ions in airborne particulate matter in Beijing were investigated using ion chromatography. The results showed that the total concentrations of ions were 83.7 ± 48.9 μg/m3 in spring, 54.0 ± 17.0 μg/m3 in summer, 54.1 ± 42.9 μg/m3 in autumn, and 88.8 ± 47.7 μg/m3 in winter, respectively. Furthermore, out of all the ions, NO3-,SO42-and NH4+accounted for 81.2% in spring, 78.5% in summer, 74.6% in autumn, and 76.3%in winter. Mg2+and Ca2+were mainly associated with coarse particles, with a peak that ranged from 5.8 to 9.0 μm. Na+, NH4+and Cl-had a multi-mode distribution with peaks that ranged from 0.43 to 1.1 μm and 4.7 to 9.0 μm. K+, NO3-, and SO42-were mainly associated with fine particles, with a peak that ranged from 0.65 to 2.1 μm. The concentrations of Na+, K+,Mg2+, Ca2+, NH4+, Cl-, NO3-and SO42-were 2.69, 2.32, 1.01, 4.84, 16.9, 11.8, 42.0, and 44.1 μg/m3 in particulate matter(PM) on foggy days, respectively, which were 1.4 to 7.3 times higher than those on clear days. The concentrations of these ions were 2.40, 1.66, 0.92, 4.95, 17.5,7.00, 32.6, and 34.7 μg/m3 in PM on hazy days, respectively, which were 1.2–5.7 times higher than those on clear days. | Yongjie Yang Rui Zhou Jianjun Wu Yue Yu Zhiqiang Ma Lejian Zhang Yi'an Di | 2015 | Journal of Environmental Sciences2015，27，8： | 19 |
| 10 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 11 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 12 | Catalytic oxidation of benzene over Ce-Mn oxides synthesized by flame spray pyrolysis显示文摘Flame spray pyrolysis(FSP) was utilized to synthesize Ce-Mn oxides in one step for catalytic oxidation of benzene.Cerium acetate and manganese acetate were used as precursors.The materials synthesized were characterized using X-ray diffraction(XRD),N_2 adsorption,X-ray photoelectron spectroscopy(XPS).transmission electron microscopy(TEM),Raman spectroscopy,and Fh-temperature programmed reduction(H_2-TPR) and their benzene catalytic oxidation behavior was evaluated.Mn ions were evidenced in multiple chemical states.Crystalline Ce-Mn oxides consist of particles with size <40 nm and specific surface areas(SSA) of 20-50m^2/g.Raman spectrums and H_2-TPR results indicated the interaction between cerium and manganese oxides.Flame-made 12.5%-Ce-Mn oxide exhibited excellent catalytic activity at relatively low temperatures(T95 about 260 C) compared to other Ce-Mn oxides with different ceriumto-manganese ratios.Redox mechanism and strong interaction conform to structure analysis that Ce-Mn strong interaction formed during the high temperature flame process and the results were used to explain catalytic oxidation of benzene. | Gang Liu Renliang Yue Yi Jia Yong Ni Jie Yang Haidi Liu Zhen Wang Xiaofeng Wu Yunfa Chen | 2013 | Particuology2013，11，4： | 17 |
| 13 | Electromagnetic wave absorption in reduced graphene oxide functionalized with Fe3O4/Fe nanorings显示文摘我们与嵌入的 Fe 3 由化学热水的生长的 O 4/Fe nanorings (FeNR@rGO ) 。我们作为吸收材料的新奇电磁波说明这些 nanocomposites 的使用。有不同作文的 nanocomposites 的电磁波吸收性质被调查。准备过程和 nanocomposite 作文被优化完成最好的电磁波吸收性质。有 GO:-Fe 2 为 3 h 在 H 2/Ar 退火准备的 1:1 的 O 3 团比率展出了最好的性质。这件 nanocomposite 样品(厚度 = 4.0 公里) 在 9.16 GHz 显示出最小的反射率 of-23.09 dB。当反射率是更少的 than-10 dB,光谱宽度直到 3.9 GHz 时,乐队范围是 7.4-11.3 GHz。当时,优点的这些数字典型地具有一样的数量级与传统的铁的氧化物材料显示出的价值相比。然而, FeNR@rGO 能乐意地作为因为我们建议的生产方法与大量生产标准高度兼容,吸收材料的微波被使用。 | Yi Ding Long Zhang Qingliang Liao Guangjie Zhang Shuo Liu Yue Zhang | 2016 | Nano Research2016，9，7： | 17 |
| 14 | Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury显示文摘Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and bloodbrain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of bloodletting at Jing points(20 μL, twice a day, for 2 days) and mild induced hypothermia(6 hours) are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury. | Yue Tu Xiao-mei Miao Tai-long Yi Xu-yi Chen Hong-tao Sun Shi-xiang Cheng Sai Zhang | 2016 | Neural Regeneration Research2016，11，6： | 17 |
| 15 | Contrast-enhanced ultrasound improved performance of breast imaging reporting and data system evaluation of critical breast lesions显示文摘AIM: To determine whether contrast-enhanced ultrasound(CEUS) can improve the precision of breast imaging reporting and data system(BI-RADS) categorization. METHODS: A total of 230 patients with 235 solid breast lesions classified as BI-RADS 4 on conventional ultrasound were evaluated. CEUS was performed within one week before core needle biopsy or surgical resection and a revised BI-RADS classification was assigned based on 10 CEUS imaging characteristics. Receiver operating characteristic curve analysis was then conducted to evaluate the diagnostic performance of CEUS-based BI-RADS assignment with pathological examination as reference criteria. RESULTS: The CEUS-based BI-RADS evaluation classified 116/235(49.36%) lesions into category 3, 20(8.51%), 13(5.53%) and 12(5.11%) lesions into categories 4A, 4B and 4C, respectively, and 74(31.49%) into category 5. Selecting CEUS-based BI-RADS category 4A as an appropriate cut-off gave sensitivity and specificity values of 85.4% and 87.8%, respectively, for the diagnosisof malignant disease. The cancer-to-biopsy yield was 73.11% with CEUS-based BI-RADS 4A selected as the biopsy threshold compared with 40.85% otherwise, while the biopsy rate was only 42.13% compared with 100% otherwise. Overall, only 4.68% of invasive cancers were misdiagnosed.CONCLUSION: This pilot study suggests that evaluation of BI-RADS 4 breast lesions with CEUS results in reduced biopsy rates and increased cancer-to-biopsy yields. | Jun Luo Ji-Dong Chen Qing Chen Lin-Xian Yue Guo Zhou Cheng Lan Yi Li Chi-Hua Wu Jing-Qiao Lu | 2016 | World Journal of Radiology2016，8，6： | 17 |
| 16 | Impact of meteorological factors on the incidence of childhood hand,foot,and mouth disease(HFMD)analyzed by DLNMs-based time series approach显示文摘Background:Hand,foot,and mouth disease(HFMD)has become an emerging infectious disease in China in the last decade.There has been evidence that meteorological factors can influence the HFMD incidence,and understanding the mechanisms can help prevent and control HFMD.Methods:HFMD incidence data and meteorological data in Minhang District,Shanghai were obtained for the period between 2009 and 2015.Distributed lag non-linear models(DLNMs)were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend,weekdays and holidays.Results:There was a non-linear relationship between temperature and HFMD incidence,the RR of 5th percentile compared to the median is 0.836(95%CI:0.671-1.042)and the RR of 95th percentile is 2.225(95%CI:1.774-2.792),and the effect of temperature varied across age groups.HFMD incidence increased with increasing average relative humidity(%)(RR=1.009,95%CI:1.005-1.015)and wind speed(m/s)(RR=1.197,95%CI:1.118-1.282),and with decreasing daily rainfall(mm)(RR=0.992,95%CI:0.987-0.997)and sunshine hours(h)(RR=0.966,95%CI:0.951-0.980).Conclusions:There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District,Shanghai.This information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions. | Hongchao Qi Yue Chen Dongli Xu Hualin Su Longwen Zhan Zhiyin Xu Ying Huang Qianshan He Yi Hu Henry Lynn Zhijie Zhang | 2018 | Infectious Diseases of Poverty2018，7，1： | 17 |
| 17 | Higher CO_2-insufflation pressure inhibits the expression of adhesion molecules and the invasion potential of colon cancer cells显示文摘AIM:To investigate the influence of CO2-insufflation pressure on adhesion,invasion and metastatic potential of colon cancer cells based on adhesion molecules expression.METHODS:With an in vitro artificial pneumoperitoneum model,SW1116 human colon carcinoma cells were exposed to CO2-insufflation in 5 different pressure groups:6 mmHg,9 mmHg,12 mmHg,15 mmHg and control group,respectively for 1 h.Expression of E-cadherin,ICAM-1,CD44 and E-selectin was measured at 0,12,24,48 and 72 h after CO2-insufflation using flow cytometry.The adhesion and invasion capacity of SW1116 cells before and after exposure to CO2-insufflation was detected by cell adhesion/invasion assay in vitro.Each group of cells was injected intraperitoneally into 16 BALB/C mice.The number of visible abdominal cavity tumor nodules,visceral metastases and survival of the mice were recorded in each group.RESULTS:The expression of E-cadherin,ICAM-1,CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO2 insufflation at different pressures(P<0.05).The expression of E-cadherin,CD44 and ICAM-1 decreased with increasing CO2-insufflation pressure.The adhesive/invasive cells also decreased gradually with increasing pressure as determined by the adhesion/invasion assay.In animal experiments,the number of abdominal cavity tumor nodules in the 15 mmHg group was also signif icantly lower than that in the 6 mmHg group(29.7±9.91 vs 41.7±14.90,P=0.046).However,the survival in each group was not statistically different.CONCLUSION:CO2-insufflation induced a temporary change in the adhesion and invasion capacity of cancer cells in vitro.Higher CO2-insufflation pressure inhibited adhesion,invasion and metastatic potential in vitro and in vivo,which was associated with reduced expression of adhesion molecules. | Jun-Jun Ma Bo Feng Yi Zhang Jian-Wen Li Ai-Guo Lu Ming-Liang Wang Yuan-Fei Peng Wei-Guo Hu Fei Yue Min-Hua Zheng | 2009 | World Journal of Gastroenterology2009，15，22： | 16 |
| 18 | Investigation on the broadband electromagnetic wave absorption properties and mechanism of Co3O4- nanosheets/reduced-graphene-oxide composite显示文摘cobaltosic-oxide-nanosheets/reduced-graphene-oxide 合成(CoNSs@RGO ) 成功地作为一个小宽带电磁波吸收器被准备。样品厚度的效果和数量合成在吸收上补充说性质彻底地被调查到石蜡样品。由于公司 3 O 4, 很高,波浪吸收材料的 surface-to-volume 比率在吸收性质正在导致大改进。为 3.6 公里的厚度的 CoNSs@RGO 合成 was-45.15 dB 的最大的茶点损失,和有思考损失 below-10 dB 的最好的吸收带宽是有 2.9 公里的厚度的 7.14 GHz。另外,微波吸收的山峰与增加吸收涂层的厚度向低频率区域变了。电磁波吸收的机制被归因于阻抗象 RGO 的绝缘的松驰和极化一样匹配 CoNSs@RGO。比作以前报导的吸收材料, CoNSs@RGO 在高频率乐队为申请作为一个无足轻重的人和高度有效的吸收材料显示出更好的性能。 | Yi Ding Zheng Zhang Baohe Luo Qingliang Liao Shuo Liu Yichong Liu Yue Zhang | 2017 | Nano Research2017，10，3： | 16 |
| 19 | Size-resolved aerosol water-soluble ions at a regional background station of Beijing, Tianjin, and Hebei, North China显示文摘The characteristics of water-soluble ions in size-resolved particulate matter were investigated usingion chromatography at Shangdianzi,a regional background station of Beijing,Tianjin,and Hebei.Seasonal total concentrations of ions(Na^+,Mg^(2+),K^+,Ca^(2+),NH_4^+,Cl^-,SO_4^(2-) and NO_3^-) were75.5±52.9 μg/m^3 in spring,26.5±12.3μg/m^3 in summer,22.7±20.4μg/m^3 in autumn,and31.1±23.9 μg/m^3 in winter,respectively.The secondary ions(NO_3^-,SO_4^(2-) and NH_4^+),mainly associated with fine particles,accounted for 84.2%in spring,82.1%in summer,81.5%in autumn and 76.3%in winter of all ions.Strong correlations were found between NH_4^+ and SO_4^(2-)(r=0.95,p<0.01) as well as NH_4^+ and NO_3^-(r=0.90,p<0.01) in fine particles;while in coarse particles,correlations between Mg^(2+) and NO_3^-(r=0.80,p<0.01),and Ca^(2+) and NO_3^-(r=0.85,p<0.01) were found.The concentrations of Na^+,K^+,Mg^(2+),Ca^(2+),NH_4^+,Cl^-,NO_3^-,and SO_4^(2-) were 2.02,0.81,0.36,1.65,9.58,4.01,18.9,and 18.4 μg/m^3 in particulate matter from southeast-derived air masses,which were typically 1.58-3.37 times higher than in northwest trajectories.Thus,concentrations of water-soluble ions at this background station were heavily influenced by regional transport of serious pollution derived from biomass burning,coal combustion,industrial and vehicle exhaust emissions from Beijing,Tianjin,and Hebei. | Yongjie Yang Rui Zhou Yue Yu Yan Yan Yan Liu Yi'an Di Dan Wu Weiqi Zhang | 2017 | Journal of Environmental Sciences2017，29，5： | 16 |
| 20 | Anti-fibrotic Effects of Salvia miltiorrhiza and Ligustrazine Injection on LX-2 Cells Involved with Increased N-myc Downstream-Regulated Gene 2 Expression显示文摘Objective: To investigate the effects of Salvia miltiorrhiza and Ligustrazine Injection(SML) on proliferation and apoptosis of human hepatic stellate cell LX-2 and the expression of N-myc downstreamregulated gene 2(NDRG2, a tumor suppressor gene). Methods: HSCs from the LX-2 cell line were cultured in vitro. The proliferative state of different initial LX-2 cell numbers was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) colorimetric assay. LX-2 cells were plated in 96-well plates at an approximate density of 2.50×10~4 cells/mL and cultured for 24 h followed by the application of different concentrations of SML(1, 2, 4 and 8 μL/mL). Cell proliferation was measured using the MTT assay at 24 and 48 h. Apoptosis was detected by flow cytometry at 24 h. LX-2 cells were treated with different concentrations of SML and extracted with protein lysis buffer. The levels of NDRG2 and β-catenin were measured by Western blot. Results: With the exception of the 1 and 2 μL/mL concentrations, 4 and 8 μL/mL SML inhibited cell proliferation in a concentration-dependent manner at 24 and 48 h(P<0.05). With the exception of the 1 and 2 μL/mL concentrations, the NDRG2 expression level was greatly increased in a concentration-dependent manner. However, the level of β-catenin was unaffected. Conclusion: SML inhibit LX-2 cell proliferation in a concentration-dependent manner, and the mechanism may be associated with NDRG2 over-expression. | zheng jin ma li-tian ren qin-you hu yue bai yang bian huan zhang yi zhou yong-chun yang ming-hui | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 13 |
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