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| 1 | Principles and construction of MSD adder in ternary optical computer显示文摘The two remarkable features of ternary values and a massive unit with thousands bits of parallel computation will make the ternary optical computer (TOC) with modified signed-digit (MSD) adder more powerful and e?cient than ever before for numerical calculations. Based on the decrease-radix design presented previously, a TOC can satisfy either a user requiring huge capacity for data calculations or one with a moderate amount of data, if it is equipped with a prepared adder. Furthermore, with the application of pipelined operations and the proposed data editing technique, the e?ciency of the prepared adder can be greatly improved, so that each calculated result can be obtained almost within one clock cycle. It is hopeful that by employing a MSD adder, users will be able to enter a new dimension with the creation of a new multiplier, new divider, as well as new matrix operator in a TOC in the near future. | JIN Yi SHEN YunFu PENG JunJie XU ShiYi DING GuangTai YUE DongJian YOU HaiHang | 2010 | Science China(Information Sciences)2010，53，11： | 26 |
| 2 | Principle of a one-step MSD adder for a ternary optical computer显示文摘While investigating a three-step MSD adder and the reliability thereof for ternary optical computers(TOC),the principle of one-step MSD addition was found.An important concept,the mid-bit transform,is proposed.Next,the important mid-bit transform table(MTT)for 3-bit MSD input and the corresponding mid-bit transform unit(MTU)are obtained.Using the principle,the concept structure of a one-step MSD adder is proposed such that the sum of the addition can be obtained easily in one step in parallel.By restricting the input symbols,a simplified MTT is obtained and the principle of a one-step adder with restricted input symbols is introduced,together with the corresponding simplified concept structure of a one-step MSD adder.Two examples are presented to demonstrate the principles of one-step MSD adders.This work lays the theoretic foundation for the design of an optical MSD adder in future study. | SHEN YunFu PAN Lei | 2014 | Science China(Information Sciences)2014，57，1： | 4 |
| 3 | The Space of Strong Types and an Open Map Theorem | Shen Yunfu (Department of Mathematics,Beijing Normal University,Beijin9 100875,China) | 1997 | Acta Mathematica Sinica,English Series1997，13，1： | 0 |
| 4 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 5 | Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation显示文摘Metabolic reprogramming,a newly recognized trait of tumor biology,is an intensively studied prospect for oncology medicines.For numerous tumors and cancer cell subpopulations,oxidative phosphorylation(OXPHOS)is essential for their biosynthetic and bioenergetic functions.Cancer cells with mutations in isocitrate dehydrogenase 1(IDH1)exhibit differentiation arrest,epigenetic and transcriptional reprogramming,and sensitivity to mitochondrial OXPHOS inhibitors.In this study,we report that berberine,which is widely used in China to treat intestinal infections,acted solely at the mitochondrial electron transport chain(ETC)complex I,and that its association with IDH1 mutant inhibitor(IDH1^(m)i)AG-120 decreased mitochondrial activity and enhanced antileukemic effect in vitro and in vivo.Our study gives a scientific rationale for the therapy of IDH1 mutant acute myeloid leukemia(AML)patients using combinatory mitochondrial targeted medicines,particularly those who are resistant to or relapsing from IDH1m i. | HUANG Zhe SHEN Yunfu LIU Wenjun YANG Yan GUO Ling YAN Qin WEI Chengming GUO Qulian FAN Xianming MA Wenzhe | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 0 |
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