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| 1 | Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway显示文摘Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the anti-tumor potency on breast cancer was evaluated in vitro and in vivo for the first time. Our results indicated that lycorine inhibited breast cancer cells growth, migration and invasion as well as induced their apoptosis.In in vivo study, lycorine not only suppressed breast tumor growth in xenograft models and inhibited breast tumor metastasis in MDA-MB-231 tail vein model. More importantly, we found lycorine had less toxicity than first-line chemotherapy drug paclitaxel at the same effective dose in vivo. Furthermore, on mechanism, lycorine inhibited tumor cell migration and invasion via blocking the Src/FAK(focal adhesion kinase)-involved pathway. In conclusion, our study implied lycorine was a potential candidate for the treatment of breast cancer by inhibition of tumor growth and metastasis. | Xuexiang Ying Anling Huang Yajing Xing Liping Lan Zhengfang Yi Pingqing He | 2017 | Science China(Life Sciences)2017，60，4： | 15 |
| 2 | Potential regulation of small RNAs on bacterial function activities in pig farm wastewater treatment plants显示文摘Small RNAs(sRNAs)are key players in the regulation of bacterial gene expression.However,the distribution and regulatory functions of sRNA in pig farm wastewater treatment plants(WWTPs)remains unknown.In this study,the wastewaters in anoxic and oxic tanks of the WWTPs were collected.The profiles of the community structure,mRNA expression,and sRNA expression of bacteria in pig farm wastewater were investigated using transcriptome sequencing and qPCR.This study demonstrated that there was a higher abundance of sRNA in the pig farm WWTPs and 52 sRNAs were detected.The sRNAs were mainly present in Proteobacteria and Firmicutes,including the potential human pathogenic bacteria(HPB)(Escherichia,Shigella,Bordetella and Morganella),crop pathogen(Pectobacterium)and denitrifying bacteria(Zobellella).And the sRNAs were involved in the bacterial functional activities such as translation,transcription,drug resistance,membrane transport and amino acid metabolism.In addition,most sRNAs had a higher abundance in anoxic tanks which contained a higher abundance of the genes associated with infectious diseases and drug resistance than that in oxic tanks.The results presented here show that in pig farm WWTPs,sRNA played an important role in bacterial function activities,especially the infectious diseases,drug resistance and denitrification,which can provide a new point of penetration for improving the pig farm WWTPs. | Yiwen Yang Sicheng Xing Sumin Li Yajing Niu Cheng Li Tuoxin Huang Xindi Liao | 2020 | Journal of Environmental Sciences2020，32，5： | 1 |
| 3 | Spatio-temporal Evolution of the Agricultural Eco-efficiency Network and Its Multidimensional Proximity Analysis in China显示文摘As a traditional agricultural country,China has always prioritized agricultural development,and has increasingly focused on green and sustainable agricultural development.Based on the inter-provincial panel data for China from 1997 to 2019,this study divided these data into five periods according to the Five-Year Plan(FYP)of China,measured the agricultural eco-efficiency(AEE)values using the Super-SBM model,and then determined the spatial association network of the inter-provincial AEE of China using the improved gravity model.Finally,social network analysis(SNA)was used to further analyze the evolution process of AEE,and we de-veloped a framework of how multidimensional proximity,which includes geographical,economic,technological,cognitive,and institutional proximity,made an influence on the formation of AEE spatial relation network.The findings indicated that:1)in 1997−2019,the AEE in China was present in some spatial and temporal differences characteristics at the provincial scale,and we specifically found that national macro-regulation and policy incentives played a positive role in the long-term development of AEE.2)The spatial correlation of AEE development among provincial regions were becoming closer and exhibits obvious spatial correlation and spillover effects.The evolution of the AEE network has clearly observable trends of hierarchization and aggregation,and the complexity of the correlation network continues to increase and exhibits spatial clustering characteristics that are dense in the east and sparse in the west.The network structure has changed from monocentric radiation to a multicentric network,and network nodes select the more advantageous nodes with which to connect.3)Finally,the geographical proximity had a significant negative effect;the economic,technological,and institutional proximities were all observed to contribute to the AEE network formation,and cognitive proximity did not significantly influence this network formation. | QU Hongjiao YIN Yajing LI Junli XING Wenwen WANG Weiyin ZHOU Cheng ZHANG Yunhua | 2022 | Chinese Geographical Science2022，32，4： | 0 |
| 4 | Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement显示文摘Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 gene.The patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial features.Familial whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein family.The p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in vivo.Additionally,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index patient.The human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by E13.5.RNA-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development. | Yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang Chenming Xu | 2024 | Protein & Cell2024，15，1： | 0 |
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