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| 1 | MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells显示文摘Monocyte chemoattractant protein-1(MCP-1)is a chemotactic cytokine that can bind to its receptor cysteine-cysteine chemokine receptor 2(CCR2)and plays an important role in breast cancer cell metastasis.However,the molecular mechanisms underlying MCP-1-induced alterations in cellular functions during tumor progression are poorly understood.Here,we showed that MCP-1 stimulated the epithelial-mesenchymal transition(EMT)and induced the tumorigenesis of breast cancer cells by downregulating E-cadherin,upregulating vimentin and fibronectin,activating matrix metallopeptidase-2(MMP-2),and promoting migration and invasion.Moreover,MCP-1 treatment reduced glycogen synthase kinase-3β(GSK-3β)activity via the MEK/ERK-mediated phosphorylation of serine-9 in MCF-7 cells.The inhibition of MEK/ERK by U0126 attenuated the MCP-1-induced phosphorylation of GSK-3βand decreased the expression of Snail,an EMT-related transcription factor,leading to the inhibition of MCF-7 cell migration and invasion.Inactivation of GSK-3βby LiCl(lithium chloride)treatment notably increased MMP-2 activity,vascular endothelial growth factor expression and EMT of MCF-7 cells.These findings revealed that MCP-1-induced EMT and migration are mediated by the ERK/GSK-3β/Snail pathway,and identified a potential novel target for therapeutic intervention in breast cancer. | Shun Li Juan Lu Yu Chen Niya Xiong Li Li Jing Zhang Hong Yang Chunhui Wu Hongjuan Zeng Yiyao Liu | 2017 | Cellular & Molecular Immunology2017，14，7： | 14 |
| 2 | Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis显示文摘Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fractures cellular and matrix architecture normality through biochemical and mechanical means,abetting tumorigenesis and treatment resistance.Tumor cells sense and respond to the strength,direction,and duration of mechanical cues in the TME by various mechanotransduction pathways.However,far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction.Due to the great therapeutic difficulties brought by the mechanical changes in the TME,emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves,which has been proven to be a potential therapeutic approach.In this review,we discussed the origins and roles ofmechanical factors in the TME,cell sensing,mechano-biological coupling and signal transduction,in vitro construction of the tumormechanicalmicroenvironment,applications and clinical significance in the TME. | Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu | 2022 | Cancer Communications2022，42，5： | 3 |
| 3 | Improvement of the lubrication properties of grease with Mn_(3)O_(4)/graphene (Mn_(3)O_(4)#G) nanocomposite additive显示文摘Although grease can effectively lubricate machines,lubrication failure may occur under high speed and heavy load conditions.In this study,Mn_(3)O_(4)/graphene nanocomposites(Mn_(3)O_(4)#G)were synthetized using a hydrothermal method as lubricant additives.The lubrication properties of compound grease with Mn_(3)O_(4)#G nanocomposite additive under heavy contact loads of 600–900 N(3.95–4.59 GPa)were investigated.First,the nanocomposites were dispersed into L-XBCEA 0 lithium grease via successive electromagnetic stirring,ultrasound vibration,and three-roll milling.Compound grease with additives of commercial graphene(Com#G)was also investigated for comparison.Tribological test results revealed that the trace amounts of Mn_(3)O_(4)#G(as low as 0.02 wt%)could reduce the coefficient of friction(COF)of grease significantly.When the concentration of Mn_(3)O_(4)#G was 0.1 wt%,the COF and wear depth were 43.5%and 86.1%,lower than those of pure graphene,respectively.In addition,under the effect of friction,the microstructure of graphene in Mn_(3)O_(4)#G nanocomposites tends to be ordered and normalized.Furthermore,most of the Mn_(3)O_(4) transformed into Mn_(2)O_(3) owing to the high temperature generated from friction.Using the Ar gas cluster ion beam sputtering method,the thickness of the tribofilm was estimated to be 25–34 nm.Finally,the improvement of the lubrication properties was attributed to the synergistic effect of the adsorbed tribofilm,i.e.,the graphene island effect and the filling effect of Mn_(3)O_(4)#G. | Bao JIN Guangyan CHEN Jun ZHAO Yongyong HE Yiyao HUANG Jianbin LUO | 2021 | Friction2021，9，6： | 2 |
| 4 | Research Progress on the Monitoring of Precursor of Atmospheric Ozone——Volatile Organic Compounds显示文摘Volatile organic compounds(VOCs)are important precursors of ozone and PM_(2.5).At present,VOCs have gradually become the focus of air pollution control after fine particles in China,and a series of documents,standards and planning on VOCs were issued from the state to each area.The analysis on source apportionment and control of VOCs have also become a hot spot in atmospheric environmental protection research of China at present stage.The research work on VOCs in ambient air is the basis and premise of scientific and effective prevention and control of VOCs pollution.In this paper,research progress on the monitoring of VOCs is introduced systemically,and main monitoring and evaluation methods of atmospheric VOCs are explored from monitoring analysis method,chemical reaction activity and health risk assessment.Moreover,concentration characteristics and source apportionment of VOCs in the regions at home and abroad that have carried out VOCs research work are compared and summarized.The research could provide reference for source apportionment of VOCs in other cities of China. | Shuchi CHEN Yiyao HUANG Miao CHEN Juan LI Lianghong XIAO Yan GUO | 2020 | Meteorological and Environmental Research2020，11，2： | 1 |
| 5 | Adaptive evolution and structure modeling of rbcL gene in Ephedra显示文摘The adaptive evolution of the rbcL gene in 14 species of Ephedra and 9 other gymnosperms was tested by the PAML program. Three large-scale selections were found in the catalytic region of the RbcL protein by branch model. Species in Ephedra with positive selection at the 365th codon site in rbcL gene were detected by branch-site model. 3D structure modeling showed that the 365th codon could change the spatial structure of the β-sheet (βG, βH, or βE) of the RbcL protein. These changes may be associated with the adaptation of the protein in Ephedra to the environment. | LIU Nian WANG QingBiao CHEN Jie ZHU Yong TASHI Tsering HU YiYao CHEN Fan ZHONG Yang | 2010 | Chinese Science Bulletin2010，55，22： | 1 |
| 6 | Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration显示文摘Diabetes mellitus(DM)aggravates periodontitis,resulting in accelerated periodontal bone resorption.Disordered glucose metabolism in DM causes reactive oxygen species(ROS)overproduction resulting in compromised bone healing,which makes diabetic periodontal bone regeneration a major challenge.Inspired by the natural bone healing cascade,a mesoporous silica nanoparticle(MSN)-incorporated PDLLA(poly(DL-lactide))-PEG-PDLLA(PPP)thermosensitive hydrogel with stepwise cargo release is designed to emulate the mesenchymal stem cell“recruitment-osteogenesis”cascade for diabetic periodontal bone regeneration.During therapy,SDF-1 quickly escapes from the hydrogel due to diffusion for early rat bone marrow stem cell(rBMSC)recruitment.Simulta-neously,slow degradation of the hydrogel starts to gradually expose the MSNs for sustained release of metformin,which can scavenge the overproduced ROS under high glucose conditions to reverse the inhibited osteogenesis of rBMSCs by reactivating the AMPK/β-catenin pathway,resulting in regulation of the diabetic microenvironment and facilitation of osteogenesis.In vitro experiments indicate that the hydrogel markedly restores the inhibited migration and osteogenic capacities of rBMSCs under high glucose conditions.In vivo results suggest that it can effectively recruit rBMSCs to the periodontal defect and significantly promote periodontal bone regeneration under type 2 DM.In conclusion,our work provides a novel therapeutic strategy of a bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. | He Wang Xiaowei Chang Qian Ma Boyang Sun Han Li Jinmin Zhou Yiyao Hu Xiaoyu Yang Jie Li Xin Chen Jinlin Song | 2023 | Bioactive Materials2023，，3： | 1 |
| 7 | Comparison on Determination Results of Methane and Total Hydrocarbons by Glass Syringe Method and Air Bag Method显示文摘Samples at different setting time were determined by glass syringe method and air bag method, and their results were analyzed. The results showed that concentrations of methane and total hydrocarbons obviously declined with the prolonging of setting time by glass syringe method, and recovery rate of sample declined to 60% after 8 h. In air bag method, analysis results of methane and total hydrocarbons were stabler, and recovery rate of sample was 93% after 8 h. | Chen Miao Huang Yiyao Guo Yan Chen Shuchi | 2019 | Meteorological and Environmental Research2019，10，4： | 0 |
| 8 | Synthesis of amorphous Pd-based nanocatalysts for efficient alcoholysis of styrene oxide and electrochemical hydrogen evolution显示文摘Amorphous nanomaterials with long-range disordered structures could possess distinct properties and promising applications,especially in catalysis,as compared with their conventional crystalline counterparts.It is imperative to achieve the controlled preparation of amorphous noble metal-based nanomaterials for the exploration of their phase-dependent applications.Here,we report a facile wet-chemical reduction strategy to synthesize various amorphous multimetallic Pd-based nanomaterials,including PdRu,PdRh,and PdRuRh.The phase-dependent catalytic performances of distinct Pd-based nanomaterials towards diverse catalytic applications have been demonstrated.Specifically,the usage of PdRu nanocatalysts with amorphous and crystalline face-centered cubic(fcc)phases can efficiently switch the ring-opening route of styrene oxide to obtain different products with high selectivity through alcoholysis reaction and hydrogenation reaction,respectively.Moreover,when used as an electrocatalyst for hydrogen evolution reaction(HER),the synthesized amorphous PdRh nanocatalyst exhibits low overpotential and high turnover frequency values,outperforming its crystalline fcc counterpart and most of the reported Pd-based HER electrocatalysts. | Yiyao Ge Jingjie Ge Biao Huang Xixi Wang Guigao Liu Xiang-Huan Shan Lu Ma Bo Chen Guanghua Liu Songmo Du An Zhang Hongfei Cheng Qingbo Wa Shiyao Lu Lujiang Li Qinbai Yun Kuo Yuan Qinxin Luo Zhichuan J.Xu Yonghua Du Hua Zhang | 2023 | Nano Research2023，16，4： | 0 |
| 9 | Hard nanocrystalline gold materials prepared via high-pressure phase transformation显示文摘As one of the important materials,nanocrystalline Au(n-Au)has gained numerous interests in recent decades owing to its unique properties and promising applications.However,most of the current n-Au thin films are supported on substrates,limiting the study on their mechanical properties and applications.Therefore,it is urgently desired to develop a new strategy to prepare nAu materials with superior mechanical strength and hardness.Here,a hard n-Au material with an average grain size of~40 nm is prepared by cold-forging of the unique Au nanoribbons(NRBs)with unconventional 4H phase under high pressure.Systematic characterizations reveal the phase transformation from 4H to face-centered cubic(fcc)phase during the cold compression.Impressively,the compressive yield strength and Vickers hardness(HV)of the prepared n-Au material reach~140.2 MPa and~1.0 GPa,which are 4.2 and 2.2 times of the microcrystalline Au foil,respectively.This work demonstrates that the combination of high-pressure cold-forging and the in-situ 4H-to-fcc phase transformation can effectively inhibit the grain growth in the obtained n-Au materials,leading to the formation of novel hard n-Au materials.Our strategy opens up a new avenue for the preparation of nanocrystalline metals with superior mechanical property. | Chenlong Xie Wenxin Niu Penghui Li Yiyao Ge Jiawei Liu Zhanxi Fan Xiaoxiao Liu Ye Chen Ming Zhou Zihe Li Mengdong Ma Yonghai Yue Jing Wang Li Zhu Kun Luo Yang Zhang Yingju Wu Lin Wang Bo Xu Hua Zhang Zhisheng Zhao Yongjun Tian | 2022 | Nano Research2022，15，7： | 0 |
| 10 | Recent Progress on Monoelemental Nanomaterials with Unconventional Crystal Phases显示文摘As an important parameter of crystalline materials,the crystal phase describes the periodic atomic arrangement in their structures.For some monoelemental materials,e.g.,carbon and phosphorus,they can exist in more than one crystal phase.The different crystal phases of monoelemental materials result in different physicochemical properties and functions.Therefore,engineering the crystal phase of monoelemental materials gives an effective strategy to modulate their properties and functions.Conventionally,the crystal phase of monoelemental materials can be altered under some harsh conditions,e.g.,high temperature and high pressure.Recently,with the rapid development of nanotechnology,various monoelemental materials with unconventional crystal phases have been well developed on the nanoscale.For example,our group has successfully achieved the synthesis of Au nanomaterials with unconventional hexagonal close-packed(hcp)2H and 4H phases by wetchemical methods,which exhibit distinct optical properties as well as outstanding electrocatalytic performance when compared to those with a thermodynamically stable facecentered cubic(fcc)phase.In this Account,we give a comprehensive overview of the recent development of monoelemental nanomaterials with unconventional crystal phases and their crystal-phase-dependent properties and applications.We first introduce the typical strategies for the synthesis of monoelemental nanomaterials with unconventional crystal phases.By using a wet-chemical reduction method,template-assisted method,and thermal annealing method,monoelemental nanomaterials with unconventional crystal phases can be directly prepared.Besides,unconventional-phase monoelemental nanomaterials can also be obtained via the phase transformation from materials with conventional crystal phases under specific conditions.In addition,some other methods have also been reported for preparing monoelemental nanomaterials with unconventional crystal phases,such as controlled crystallization of amorphous structure,the chemical vapor transport(CVT)method,electrodeposition,galvanic replacement,sputter-deposition,and so on.Subsequently,we summarize the unique structural stability and magnetic,electronic,optical,and other properties of the obtained monoelemental nanomaterials with unconventional crystal phases.We also highlight their promising applications in catalysis and batteries.Finally,we present our personal perspectives on the challenges and future opportunities in this important research field. | Bo Chen Qinbai Yun Yiyao Ge Lujiang Li Hua Zhang | 2023 | Accounts of Materials Research2023，4，4： | 0 |
| 11 | Characteristics and Meteorological Conditions of Ozone Pollution in Shantou City显示文摘Based on routine monitoring data of air quality and meteorological data in Shantou City during 2015-2019,temporal-spatial variation characteristics of O 3 pollution and its correlation with meteorological conditions in Shantou City were explored.The research results showed that O 3 pollution days in Shantou City showed an increasing trend year by year,and O 3 pollution had far-distance transportation and the development trend from offshore Nan ao Island to urban district.In spring and autumn,there was serious O 3 pollution,and it was the most prominent in October.Its diurnal variation in O 3 pollution days was mainly wide-peak type in the afternoon,showing as that O 3 concentration declined slowly after the noon.In O 3 pollution days,higher O 3 concentration was easy to appear at night,causing that O 3 peak in the second day was uplifted,and there was continuous O 3 pollution.Combining backward trajectory analysis chart,it was found that Shantou was mainly affected by coastal transport of northerly polluted air mass,and it was transported into Shantou City from the east to the northeast.O 3 from long-distance transmission superimposed with locally generated O 3,which commonly pushed up the level of O 3 concentration.The weather of O 3 pollution in Shantou City had the characteristics of high temperature and low humidity.There was 25-30℃of temperature interval and 46%-60%of relative humidity interval,and it was accompanied by grade-2 easterly wind. | Juan LI Chengliu LI Lianghong XIAO Yan GUO Yiyao HUANG Shuchi CHEN Miao CHEN Wenshu LI Yufeng ZHANG | 2021 | Meteorological and Environmental Research2021，12，1： | 0 |
| 12 | Reflections on nuclear safety culture from the perspective of traditional Chinese culture显示文摘Nuclear safety is a major concern given the rapid development of nuclear power in the modern era.Fostering a nuclear safety culture is an important means of ensuring nuclear safety.In China,a country with a rich historical and cultural heritage,traditional culture will influence the development of a nuclear safety culture.This study explored the origin and levels of nuclear safety culture and reflected on nuclear safety culture from the perspective of traditional Chinese culture.The purpose of this study is to integrate the essence of traditional culture into the nuclear safety culture and foster a nuclear safety culture with Chinese characteristics. | Haiyan Chen Yiyao Cao Yi Cao | 2022 | Radiation Medicine and Protection2022，3，4： | 0 |
| 13 | Voltage Profile Optimization of Active Distribution Networks Considering Dispatchable Capacity of 5G Base Station Backup Batteries显示文摘The penetration of distributed energy resources(DERs) and energy-intensive resources is gradually increasing in active distribution networks(ADNs), which leads to frequent and severe voltage violation problems. As a densely distributed flexible resource in the future distribution network, 5G base station(BS) backup battery is used to regulate the voltage profile of ADN in this paper. First, the dispatchable potential of 5G BS backup batteries is analyzed. Considering the spatial-temporal characteristics of electric load for 5G BS, the dispatchable capacity of backup batteries at different time intervals is evaluated based on historical heat map data. Then, a voltage profile optimization model for ADN is established, consisting of 5G BS backup batteries and other voltage regulation resources. In this model, the charging/discharging behavior of backup batteries is based on its evaluation result of dispatchable capacity. Finally, the range of charging/discharging cost coefficients of 5G BS that benefits ADN and 5G operators are analyzed respectively. Further, an incentive policy for 5G operators is proposed. Under this policy, the charging/discharging cost coefficients of 5G BS can achieve a win-win situation for ADN and 5G operators. As an emerging flexible resource in ADN, the effectiveness and economy of 5G BS backup batteries participating in voltage profile optimization are verified in a test distribution network. | Yiyao Zhou Qianggang Wang Yao Zou Yuan Chi Niancheng Zhou Xuefei Zhang Chen Li Qinqin Xia | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，6： | 0 |
| 14 | Diastereodivergent[4+2]annulation of biphenylenes with enones via nickel(0)-catalyzed C-C bond activation显示文摘Ni(0)-catalyzed regio-and diastereodivergent[4+2]annulation of biphenylenes withα,βunsaturated ketones is described.This solvent-controlled diastereodivergent reaction integrates C-C bond cleavage of biphenylene and C=C double bond insertion selectivity,offering a mild approach to all possible diastereoisomers of 9,10-dihydrophenanthrene derivatives from the same starting materials. | Junyan Chen Dachang Bai Xiuli Guo Yiyao Wang Xingwei Li | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 15 | Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement显示文摘Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 gene.The patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial features.Familial whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein family.The p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in vivo.Additionally,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index patient.The human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by E13.5.RNA-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development. | Yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang Chenming Xu | 2024 | Protein & Cell2024，15，1： | 0 |
| 16 | Research Progress of Catalysts and Initiators for Promoting the Cracking of Endothermic Hydrocarbon Fuels显示文摘Catalytic/initiated cracking of endothermic hydrocarbon fuels is an eff ective technology for cooling a hypersonic aircraft with a high Mach number(over 5).Catalysts and initiators can promote fuel cracking at low temperatures,increase fuel conversion and the heat sink capacity,and suppress coke deposition,thereby reducing waste heat.Catalysts mainly include metal oxide catalysts,noble metal catalysts and metal nanoparticles,zeolite catalysts,nanozeolite catalysts,and coating catalysts.Moreover,initiators roughly include nitrogenous compounds,oxygenated compounds,and hyperbranched polymer initiators.In this review,we aim to summarize the catalysts and initiators for cracking endothermic hydrocarbon fuels and their mechanisms for promoting cracking.This review will facilitate the development of the synthesis and exploration of catalysts and initiators. | Yiyao Liu Ran Chen Jie Liu Xiangwen Zhang | 2022 | Transactions of Tianjin University2022，28，3： | 0 |
| 17 | Heavy Metal Emission Characteristics of Urban Road Runoff显示文摘Pavement runoff sampling points were set up on the main roads of Chengdu city.Six rainfall-runoff events from July to September in 2017 were sampled by synchronous observation of rainfall,runoff and pollution.The concentration changes of copper,lead,zinc,chromium and cadmium in the runoff process were monitored,and the pollution emission regularity and initial scouring effect were studied.The results show that the emission regularity of pavement runoff pollution is closely related to rainfall characteristics and pollutant occurrence,and the concentration of dissolved heavy metals reaches its peak at the initial stage of runoff.The peak time of particulate heavy metal concentration lagged slightly behind that of rainfall intensity.There is a big difference between the strength of initial scouring degree and dissolved heavy metals the stronger the initial scouring degree of total heavy metals,the weaker the dissolved heavy metals.Reducing pavement runoff in the early stage of rainfall is an effective means to control heavy metal pollution. | Xintuo Chen Chengyue Lai Yibin YuanJia She Yiyao Wang Jiayang Chen Zhaoli Wang Ke Zhong | 2020 | Journal of Environmental & Earth Sciences2020，2，1： | 0 |
| 18 | Phase engineering of metal nanocatalysts for electrochemical CO_(2) reduction显示文摘The electrochemical CO_(2) reduction reaction(CO_(2)RR)offers a green and sustainable process to convert CO_(2) into valuable chemical stocks and fuels.Metal is one of the most promising types of catalysts to drive an efficient and selective CO_(2)RR.The catalytic performance of metal nanocatalysts is strongly dependent on their structural features.Recently,phase engineering of nanomaterials(PEN)has emerged as a prominent tactic to regulate the catalytic performance of metal nanocatalysts for the CO_(2)RR.A broad range of metal nanocatalysts with conventional and unconventional crystal phases has been developed,and remarkable achievements have been made.This review summarizes the most recent developments in phase engineering of metal nanocatalysts for the electrochemical CO_(2)RR.We first introduce the different crystal phases of metal nanocatalysts used in the CO_(2)RR and then discuss various synthetic strategies for unconventional phases of metal nanocatalysts.After that,detailed discussions of metal nanocatalysts with conventional and unconventional phases,including amorphous phases,are presented.Finally,the challenges and perspectives in this emerging area are discussed. | Yanjie Zhai Peng Han Qinbai Yun Yiyao Ge Xiao Zhang Ye Chen Hua Zhang | 2022 | eScience2022，2，5： | 0 |
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