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| 1 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 2 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 3 | Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study显示文摘To determine the interdependence of intracranial pressure(ICP) and intraocular pressure(IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure(LCP), optic nerve subarachnoid space pressure(ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP(via shunting cerebrospinal fluid(CSF) from the ventricle) were recorded. At baseline, all examined pressures were different(ICP>LCP>ONSP), but correlated(P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient(TLPG) remained stable(ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined(ICP-IOP independent zone). The optic nerve pressure gradient(ONPG) and trans-optic nerve pressure gradient(TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma. | Ruowu Hou Zheng Zhang Diya Yang Huaizhou Wang Weiwei Chen Zhen Li Jinghong Sang Sumeng Liu Yiwen Cao Xiaobin Xie Ruojing Ren Yazhuo Zhang Bernhard A. Sabel Ningli Wang | 2016 | Science China(Life Sciences)2016，59，5： | 11 |
| 4 | Dissecting and Enhancing the Contributions of High-Molecular-Weight Glutenin Subunits to Dough Functionality and Bread Quality显示文摘Dear Editor, Seed storage proteins (SSPs) are frequently important determinants of crop quality traits (Shewry and Casey,1999).Dissecting and enhancing the genetic contributions of individual SSPs to their target traits are essential for effectively improving crop quality attributes.However,such a task is often difficult to accomplish,because SSPs are frequently expressed from multigene families and exhibit strong allelic variation.Consequently,detailed knowledge of the function of individual SSPs in crop quality trait is still limited.This scenario is well illustrated by high-molecular-weight glutenin subunits (HMWGSs),a complex family of SSPs that are involved in wheat enduse quality through affecting dough functionality (Békés,2012;Rasheed et al.,2014). | Yiwen Li Xuefi An Ran Yang Xiaomin Guo Guidong Yue Renchun Fan Bin Li Zhensheng Li Kunpu Zhang Zhenying Dong Luyan Zhang Jiankang Wang Xu Jia Hong-Qing Ling Aimin Zhang Xiangqi Zhang Daowen Wang | 2015 | Molecular Plant2015，8，2： | 9 |
| 5 | LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project显示文摘The datasets of two Ocean Model Intercomparison Project(OMIP)simulation experiments from the LASG/IAP Climate Ocean Model,version 3(LICOM3),forced by two different sets of atmospheric surface data,are described in this paper.The experiment forced by CORE-II(Co-ordinated Ocean–Ice Reference Experiments,Phase II)data(1948–2009)is called OMIP1,and that forced by JRA55-do(surface dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis)data(1958–2018)is called OMIP2.First,the improvement of LICOM from CMIP5 to CMIP6 and the configurations of the two experiments are described.Second,the basic performances of the two experiments are validated using the climatological-mean and interannual time scales from observation.We find that the mean states,interannual variabilities,and long-term linear trends can be reproduced well by the two experiments.The differences between the two datasets are also discussed.Finally,the usage of these data is described.These datasets are helpful toward understanding the origin system bias of the fully coupled model. | Pengfei LIN Zhipeng YU Hailong LIU Yongqiang YU Yiwen LI Jirong JIANG Wei XUE Kangjun CHEN Qian YANG Bowen ZHAO Jilin WEI Mengrong DING Zhikuo SUN Yaqi WANG Yao MENG Weipeng ZHENG Jinfeng MA | 2020 | Advances in Atmospheric Sciences2020，37，3： | 9 |
| 6 | Experimental demonstrations of high-Q superconducting coplanar waveguide resonators显示文摘We successfully designed and fabricated an absorption-type of superconducting coplanar waveguide (CPW) resonators. The resonators are made from a niobium film (about 160 nm thick) on a high-resistance Si substrate, and each resonator is fabricated as a meandered quarter-wavelength transmission line (one end is short to the ground and another end is capacitively coupled to a through feedline). With a vector network analyzer we measured the transmissions of the applied microwave through the resonators at ultra-low temperature. The obtained loaded quality factors are significantly high, i.e. up to ~10 6 . When the temperature increases slowly from the base temperature (20 mK), the resonance frequencies of the resonators are blue shifted and the quality factors are lowered slightly. In principle, this type of device can integrate a series of CPW resonators with a common feedline, making it a promising candidate as the data bus for coupling distant solid-state qubits and the sensitive detector of single photons. | LI HaiJie WANG YiWen WEI LianFu ZHOU PinJia WEI Qiang CAO ChunHai FANG YuRong YU Yang WU PeiHeng | 2013 | Chinese Science Bulletin2013，58，20： | 8 |
| 7 | Geochemical Characters of Water Coproduced with Coalbed Gas and Shallow Groundwater in Liulin Coalfield of China显示文摘To reveal the geochemical characters of water coproduced with coalbed gas and shallow groundwater,water samples were collected from 12 wells of coalbed methane and 7 wells of shallow groundwater.The pH,CODMn,fCO2,total dissolved solids(TDS),total hardness,and concentrations of metasilicic acid,sodium and kalium,calcium ion,magnesium ion,ammonium iron,bicarbonate ion,carbonate,chloride,sulfate ion,nitrate ion,fluoride,lithium,zinc,nickel,manganese,iron,boron,barium,etc.of the samples were measured.Research results showed the following:(1)Concentrations of TDS,chloride,fluoride,sodium and kalium,ammonium,iron,and barium in the water coproduced with coalbed gas exceeded the national standards of China;however,physical,chemical,and biological properties of shallow groundwater could meet the national standard.(2)The water produced from coalbed contained mainly Na–Cl·HCO3,with average TDS of 4588.5 ppm,whereas shallow groundwater contained a mixture of chemicals including Na·Mg·Ca-HCO3·SO4and Na·MgHCO3·SO4,with average TDS of 663.8 ppm.(3)In general,it was observed that bicarbonate and sodium accumulated in a reducing environment and deeper system,while depletion of hydrogen ions and dissolution of sulfate,calcium,and magnesium occurred in a redox environment and shallow system.(4)Sodium and kalium,ammonium,chloride,and bicarbonate ions were the main ions found in the study area. | YANG Mei JU Yiwen LIU Guijian TONG Li KANG Yu HOU Quanlin | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 6 |
| 8 | Investigation of MHD power generation with supersonic non-equilibrium RF discharge显示文摘Magnetohydrodynamic(MHD) power generation with supersonic non-equilibrium plasma is demonstrated. Capacitively coupled radio frequency(RF) discharge(6 MHz, maximum continual power output of 200 W) was adopted to ionize the Mach number 3.5(650 m/s),0.023 kg/m3 airflow. In a MHD channel of 16 mm*10mm*20 mm, MHD open voltage of 10 V is realized in the magnetic field of 1.25 T, and power of 0.12 m W is extracted steadily and continuously in the magnetic field of 1 T. The reasons for limited power generation are proposed as:low conductivity of RF discharge; large touch resistance between MHD electrode and plasma;strong current eddies due to flow boundary layer. In addition, the cathode voltage fall is too low to have obvious effects on MHD power generation. | Yang Pengyu Zhang Bailing Li Yiwen Wang Yutian Duan Chengduo Fan Hao Gao Ling | 2016 | Chinese Journal of Aeronautics2016，29，4： | 6 |
| 9 | Molecular Basis of Disease Resistance and Perspectives on Breeding Strategies for Resistance Improvement in Crops显示文摘Crop diseases are major factors responsible for substantial yield losses worldwide,which affects global food security.The use of resistance(R)genes is an effective and sustainable approach to controlling crop diseases.Here,we review recent advances on R gene studies in the major crops and related wild species.Current understanding of the molecular mechanisms underlying R gene activation and signaling,and susceptibility(S)gene-mediated resistance in crops are summarized and discussed.Furthermore,we propose some new strategies for R gene discovery,how to balance resistance and yield,and how to generate crops with broad-spectrum disease resistance.With the rapid development of new genome-editing technologies and the availability of increasing crop genome sequences,the goal of breeding next-generation crops with durable resistance to pathogens is achievable,and will be a key step toward increasing crop production in a sustainable way. | Yiwen Deng Yuese Ning Dong-Lei Yang Keran Zhai Guo-Liang Wang Zuhua He | 2020 | Molecular Plant2020，13，10： | 6 |
| 10 | Effects of the Fhb1 gene on Fusarium head blight resistance and agronomic traits of winter wheat显示文摘The gene Fhb1 has been used in many countries to improve wheat Fusarium head blight(FHB) resistance. To make better use of this gene in the Yellow-Huai River Valleys Winter Wheat Zone(YHWZ), the most important wheat-producing region of China, it is desirable to elucidate its effects on FHB resistance and agronomic traits in different genetic backgrounds. Based on a diagnostic marker for Fhb1, six BC2 populations were developed by crossing dwarf-male-sterile(DMS)-Zhoumai 16 to three Fhb1 donors(Ningmai 9, Ningmai 13, and Jianyang 84) and backcrossing to Zhoumai 16 and Zhoumai16’s derivative cultivars(Lunxuan 136 and Lunxuan 13) using marker-assisted backcross breeding. The progenies were assessed for FHB resistance and major agronomic traits.The Fhb1 alleles were identified using the gene-specific molecular marker. The plants with the Fhb1-resistant genotype(Fhb1-R) in these populations showed significantly fewer infected spikelets than those with the Fhb1-susceptible genotype(Fhb1-S). When Lunxuan 136 was used as the recurrent parent, Fhb1-R plants showed significantly fewer infected spikelets per spike than Fhb1-R plants produced using Lunxuan 13 as the recurrent parent, indicating that the genetic backgrounds of Fhb1 influence the expression of FHB resistance. Fhb1-R plants from the DMS-Zhoumai 16/Ningmai 9//Zhoumai 16/3/Lunxuan 136 population showed the highest FHB resistance among the six populations and a significantly higher level of FHB resistance than the moderately susceptible control Huaimai 20. No significant phenotypic differences between Fhb1-R and Fhb1-S plants were observed for the eight agronomic traits investigated. These results suggest that it is feasible to improve FHB resistance of winter wheat withoutreducing yield potential by introgressing Fhb1 resistance allele into FHB-susceptible cultivars in the YHWZ. | Teng Li Hongjun Zhang Yiwen Huang Zhenqi Su Yun Deng Hongwei Liu Chunyan Mai Guangjun Yu Huili Li Liqiang Yu Tongquan Zhu Li Yang Hongjie Li Yang Zhou | 2019 | The Crop Journal2019，7，6： | 6 |
| 11 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 12 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 13 | Hybridization of metal–organic framework and monodisperse spherical silica for chromatographic separation of xylene isomers显示文摘Metal–organic frameworks(MOFs) packed in the column have been a promising candidate as the stationary phase for high performance liquid chromatography(HPLC). However, the direct packing of irregular MOF powder could raise some problems like high back pressure and low column efficiency in the HPLC separation. In this work, UiO-66 capable of separating xylenes was supported effectively on the surface of the monodisperse spherical silica microspheres by one-pot method. The hybridization of Ui O-66 and silica microspheres(termed UiO-66@SiO2 shell–core composite) was prepared by stirring the suspension of the precursors of Ui O-66 and\\COOH terminated silica in the N,N-dimethylformamide with heating. The shell–core composite material UiO66@SiO2 was characterized by SEM, TEM, PXRD and FTIR. Then, it was used as a packing material for the chromatographic separation of xylene isomers. Xylene isomers including o-xylene, m-xylene and p-xylene were efficiently separated on the column with high resolution and good reproducibility. Moreover, the Ui O-66@SiO2 shell–core composites packed column still remained reverse shape selectivity as Ui O-66 possessed, and the retention of xylenes was probably ascribed to the hydrophobic effect between analytes and the aromatic rings of the Ui O-66 shell. The Ui O-66@SiO2 shell–core composites obtained in this study have some potential for the separation of structural isomers in HPLC. | Bixuan Gao Minhui Huang Zhiguo Zhang Qiwei Yang Baogen Su Yiwen Yang Qilong Ren Zongbi Bao | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 4 |
| 14 | Structural and Functional Tailoring of Melanin-Like Polydopamine Radical Scavengers显示文摘Melanin is a ubiquitous but poorly understood polymeric,dark brown to black pigment biomaterial found both in nature and by organic synthesis.Its structural heterogeneity and disordered covalent/noncovalent interactions make it a grand challenge to tune and improve the physical and biological properties of both melanin sources.Herein,we report a facile one-pot fabrication approach for synthetic melanins with controlled size and composition via copolymerization of dopamine and basic amino acid such as arginine in an aqueous solution.The resulting arginine-doped polydopamine melanin-like nanoparticles possess less ordered nonplanar microstructures within the particles,whereas the conventional polydopamine-based melanins contain a variety of compactπ-stacked microstructures.The assembly of these distinct polymeric microstructures could lead the preceding ones for greater accessibility to free radicals,with resultant stronger free-radical scavenging effect,and thus,exhibit superior antioxidant performance toward cellular oxidative stress.This work has inspired us to continue to fabricate new synthetic melanin pigments with tunable and improved functions by rational structural tailoring. | Peng Yang Zhipeng Gu Fang Zhu Yiwen Li | 2020 | CCS Chemistry2020，2，2： | 4 |
| 15 | Human Health Risk Assessment Model of Organic Pollution in Groundwater:Shijiazhuang Industrial Zone显示文摘在这研究,一个基于风险的管理模型被开发并且适用于一个工业地区。模特儿由美国环境保护机构和汉被在在半衰期煮并且删除相关参数以后增加不稳定的有机化合物(VOC ) 的剩余比率一直在改进求婚了。用这个改进模型,一个综合过程被用来在学习区域估计人的健康风险水平。与水质量分析相比,结果强调在风险层次和水保护上为决策使用一条综合途径的重要性。这研究的结果表明了那:(1 ) 与在中国(GB 38382002 ) 和美国的国家的主要喝酒水规定的这些可允许的水平标准相比,居民的日常生活没被地下水在这个区域影响了(除了 HB34 和 HB36 的相对的坏水质量) ;(2 ) 所有地下水样品的典型检测器官的沾染物是氯仿,碳四氯化物, trichloroethylene 和 tetrachloroethene,并且污染来源主要是由初步的调查的工业来源;(3 ) 至于地下水,所有样品的 non-carcinogenic 风险价值不超过 1.0 的可允许的水平, carcinogenic 风险价值比对 1.00E-04 的 1.00E-06 的可允许的水平相对低;(4 ) 喝 trichloroethylene 和 tetrachloroethylene 的水小径主要贡献在学习区域增加居民的健康风险;(5 ) 以 non-carcinogenic,风险和 carcinogenic 冒险,为喝水小径的健康风险顺序和真皮的接触小径:喝的水小径 > 真皮的接触小径。 | YANG Mei FEI Yuhong JU Yiwen LI Huaqi | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 4 |
| 16 | The influence of hyaluronic acid on vascular endothelial cell proliferation and the relationship with ezrin/merlin expression显示文摘它被建立了那玻尿的酸(哈) glycans (nHA ) 和 oligosaccharide (oHA ) 在脉管的 endothelial 房间(EC ) 的生物功能上施加不同效果,导致 angiogenesis 的改变的规定。然而,特定的机制仍然是不清楚的。我们的学习在 EC 在 ezrin 和灰背隼蛋白质上集中了于 nHA 和 oHA 的效果。ezrin 和灰背隼的表示在 EC 生长以及 mRNA 表示上是由 siRNA,和规定的 silenced, ezrin 和灰背隼的激活(phosphorylation ) 由 oHA 刺激了, nHA 被调查。结果表明当与 nHA 对待时,在 ezrin 表示或激活没有重要变化。在与 oHA 被对待以后,而在灰背隼表示没有明显的变化, ezrin 的表示和激活决定性地被增加(包括它的 phosphorylation ) 。与 ezrin 表示 silenced,象它的 phosphorylation 一样的灰背隼的表示在刺激 nHA 的人的脐的静脉 endothelial 房间铺平显著地被提高,当没有重要变化, oHA 导致时。与灰背隼表示 silenced,没有明显的变化在 ezrin 的表示被发现(包括它的 phosphorylation ) 由 nHA 导致了。相反地, ezrin 的表示和它的激活显著地在与 oHA 被对待以后被改进。结果建议为由 oHA 的 EC 增长的提升的机制与 ezrin 的表示和激活有关是可能的,并且由 nHA 的 EC 增长的抑制与灰背隼的表示和激活有关是可能的。 | Wei Mo Cuixia Yang Yiwen Liu Yiqing He Yingzhi Wang Feng Gao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 3 |
| 17 | Improved esophageal squamous cell carcinoma screening effectiveness by risk-stratified endoscopic screening:evidence from high-risk areas in China显示文摘Background:Risk-stratified endoscopic screening(RSES),which offers endoscopy to those with a high risk of esophageal cancer,has the potential to increase effectiveness and reduce endoscopic demands compared with the universal screening strategy(i.e.,endoscopic screening for all targets without risk prediction).Evidence of RSES in high-risk areas of China is limited.This study aimed to estimate whether RSES based on a 22-score esophageal squamous cell carcinoma(ESCC)risk prediction model could optimize the universal endoscopic screening strategy for ESCC screening in high-risk areas of China.Methods:Eight epidemiological variables in the ESCC risk prediction model were collected retrospectively from 26,618 individuals aged 40-69 from three high-risk areas of China who underwent endoscopic screening betweenMay 2015 and July 2017.The model’s performance was estimated using the area under the curve(AUC).Participants were categorized into a high-risk group and a low-risk group with a cutoff score having sensitivities of both ESCC and severe dysplasia and above(SDA)at more than 90.0%.Results:The ESCC risk prediction model had an AUC of 0.80(95% confidence interval:0.75-0.84)in this external population.We found that a score of 8(ranging from 0 to 22)had a sensitivity of 94.2% for ESCC and 92.5% for SDA.The RSES strategy using this threshold score would allow 50.6% of endoscopies to be avoided and save approximately US$0.59 million compared to universal endoscopic screening among 26,618 participants.In addition,a higher prevalence of SDA(1.7%vs.0.9%),a lower number need to screen(60 vs.111),and a lower average cost per detected SDA(US$3.22 thousand vs.US$5.45 thousand)could have been obtained by the RSES strategy.Conclusions:The RSES strategy based on individual risk has the potential to optimize the universal endoscopic screening strategy in ESCC high-risk areas of China. | He Li Chao Ding Hongmei Zeng Rongshou Zheng Maomao Cao Jiansong Ren Jufang Shi Dianqin Sun Siyi He Zhixun Yang Yiwen Yu Zhe Zhang Xibin Sun Guizhou Guo Guohui Song Wenqiang Wei Wanqing Chen Jie He | 2021 | Cancer Communications2021，41，8： | 3 |
| 18 | Metal ion-promoted fabrication of melanin-like poly(L-DOPA)nanoparticles for photothermal actuation显示文摘Melanin-inspired polymers are currently the focus of growing interest for a wide range of applications ranging from energy to biomedical area.Whilst researchers have made numerous attempts to prepare and utilize polydopamine nanoparticles(PDA NPs),they have made limited progress in developing and discovering another typical functional mimic of natural melanin,poly(levodopa)(P(L-DOPA))NPs,probably due to the lack of facile synthetic strategies towards satisfactory structural and functional control of melanin-like NPs.Herein,we reported a one-pot preparation method towards P(L-DOPA)NPs with good yields and controllable size/property in an aqueous solution assisted by various metal ions(i.e.,Ni(II),Mg(II),Ca(II),Fe(III),Mn(II),Co(II),Zn(II)and Cd(II)).Interestingly,the resulting P(L-DOPA)NPs exhibited enhanced light absorption and photothermal behaviors compared with well-established PDA NPs,which can be employed to further fabricate kinds of photothermal composite actuators with promising performances such as folding,switching,and forward-moving.This study offers a facile and robust way to synthesize new synthetic melanins beyond PDA,and facilitates further functional discovery and evolution of melanin-inspired polymers and composites. | Xianheng Wang Lei Yang Peng Yang Wancai Guo Quan-Ping Zhang Xianhu Liu Yiwen Li | 2020 | Science China Chemistry2020，63，9： | 3 |
| 19 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 20 | Blue light-emitting polyfluorenes containing dibenzothiophene-S,S-dioxide unit in alkyl side chain显示文摘Blue light-emitting polyfluorenes containing dibenzothiophene-S,S-dioxide(SO) unit in alkyl side chain(PF-FSOs and PF-CzSOs) were synthesized. All the polymers show high thermal stability with the decomposition temperatures over400 °C. The highest occupied molecular orbital(HOMO) and the lowest unoccupied molecular orbital(LUMO) energy levels of the copolymer slightly decrease with the increase of SO content in side chain. PL spectra of the polymers show slightly red shift and broadening with the increase of solvent polarities, indicating unremarkable intramolecular charge transfer(ICT) effect in the polymers containing SO unit in alkyl side chain. EL spectra of the polymers are almost unchanged in the current densities from 100 to 400 mA cm.2, indicating the superb EL stability of the resulted polymers. The EL spectra of the copolymers exhibit obvious blue-shift and narrowing with the CIE of(0.18, 0.11) for PF-FSO10 and(0.17, 0.11) for PF-CzSO10, respectively,compared with PF-SO10 containing SO unit in main chain with the CIE of(0.16, 0.17) and PFO with the CIE of(0.18, 0.18).The superior device performances were obtained with the luminous efficiency(LEmax) of 1.17 and 0.68 cd A.1 for PF-FSO15 and PF-CzSO20, respectively, compared with the LEmax of 0.37 cd A.1 for PFO. The results indicate that linking SO unit to alkyl side chain of the polyfluorene is a promising strategy for efficient blue light-emitting polymers. | Yiwen Fang Jie Liu Yuhao Zhang Ting Guo Fei Huang Wei Yang Yong Cao | 2017 | Science China Chemistry2017，60，10： | 2 |
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