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| 1 | Re-Os and U-Pb Geochronology of the Erlihe Pb-Zn Deposit,Qinling Orogenic Belt,Central China,and Constraints on Its Deposit Genesis显示文摘The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs concordantly at the transitional location of an upright fold.Re and Os isotopic analyses for paragenetic pyrites with sphalerite and galena from the ore body have been used to determine the timing of mineralization and to trace the source of metallogenic materials.The Re-Os isotopic data of four pyrite samples construct an isochron,yielding a weighted average age of 226±17 Ma(mean square weighted deviation=1.7),which is considered the main mineralization age.A dioritic porphyrite vein sample,showing weaker mineralization,was also dated using the SHRIMP zircon UPb isotopic method to constrain the youngest metallogenic age of the ore deposit,because it distributes along a group of tensional joints cutting not only the upright fold in the deposit field,but also the main ore bodies.The dioritic porphyrite sample yields a weighted mean ^(206)Pb/^(238)U age of 221±3 Ma,which is slightly younger than the Re-Os isotopic isochron age of the pyrites,considered as the upper age limit of the mineralization,namely the ending age of the mineralization.The Os isotopic compositions of sulfide minerals distribute within a range between Os isotopic compositions of the crust and the mantle, indicating that the ore deposit can be derived from magma-related fluid,and the metallogenic materials are most likely derived from the mixing source of the crust and the mantle.The Erlihe Pb-Zn deposit and associated dioritic porphyrite vein,important records of Qinling tectonic-magmatism-mineralization activities,were formed during the Triassic collisional orogeny processes. | ZHANG Fan LIU Shuwen LI Qiugen SUN Yali WANG Zongqi YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 30 |
| 2 | A Review of Seasonal Climate Prediction Research in China显示文摘The ultimate goal of climate research is to produce climate predictions on various time scales. In China, efforts to predict the climate started in the 1930 s. Experimental operational climate forecasts have been performed since the late 1950 s,based on historical analog circulation patterns. However, due to the inherent complexity of climate variability, the forecasts produced at that time were fairly inaccurate. Only from the late 1980 s has seasonal climate prediction experienced substantial progress, when the Tropical Ocean and Global Atmosphere project of the World Climate Research program(WCRP) was launched. This paper, following a brief description of the history of seasonal climate prediction research, provides an overview of these studies in China. Processes and factors associated with the climate variability and predictability are discussed based on the literature published by Chinese scientists. These studies in China mirror aspects of the climate research effort made in other parts of the world over the past several decades, and are particularly associated with monsoon research in East Asia. As the climate warms, climate extremes, their frequency, and intensity are projected to change, with a large possibility that they will increase. Thus, seasonal climate prediction is even more important for China in order to effectively mitigate disasters produced by climate extremes, such as frequent floods, droughts, and the heavy frozen rain events of South China. | WANG Huijun FAN Ke SUN Jianqi LI Shuanglin LIN Zhaohui ZHOU Guangqing CHEN Lijuan LANG Xianmei LI Fang ZHU Yali CHEN Hong ZHENG Fei | 2015 | Advances in Atmospheric Sciences2015，32，2： | 20 |
| 3 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 4 | Epidermal growth factor improves intestinal morphology by stimulating proliferation and differentiation of enterocytes and mTOR signaling pathway in weaning piglets显示文摘Epidermal growth factor(EGF) has been shown to improve piglet intestinal morphology and epithelial recovery. In an attempt to further understand the mechanisms behind these improvements, this study tested the hypothesis that dietary EGF may affect intestinal morphology by stimulating the proliferation and differentiation of enterocytes in weaning piglets. In piglets receiving200 μg kg^-1 EGF, crypt depth and villus height increased(P<0.05). Adding 400 μg kg^-1 EGF increased villus height-to-crypt depth ratio(P<0.05), but reduced crypt depth(P<0.05). Dietary supplementation with 200 μg kg^-1 EGF significantly increased the number of Ki67-positive cells(P<0.01) and tended to increase the mRNA level of proliferating cell nuclear antigen(P<0.10).However, this supplementation decreased the expression level of intestinal fatty acid-binding protein(P<0.05). Piglets fed with400 μg kg^-1 EGF had an increased mRNA level of intestinal alkaline phosphatase(P<0.05). The phosphorylation of m TOR(mammalian target of rapamycin) was observed in the 200 μg kg^-1 EGF group. These results suggest that dietary supplementation with a low level of EGF improved piglet intestinal morphology through stimulating the proliferation and differentiation of enterocytes, and the mTOR signaling pathway may partly be involved in this process. | Lixia Wang Fan Zhu Huansheng Yang Jianzhong Li Yali Li Xueqin Ding Xia Xiong Fengjie Ji Hanlin Zhou Yulong Yin | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 5 | Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo显示文摘The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery systems were widely used to deliver chemotherapeutic drugs. The 5-fluorouracil loaded chitosan nanoparticles prepared in this paper have the above advantage. Here, we found that when the mass ratio of 5-fluorouracil and chitosan was 1:1, the maximum drug loading of nanoparticles was 20.13 ± 0.007%, the encapsulation efficiency was 44.28 ± 1.69%, the particle size was 283.9 ± 5.25 nm and the zeta potential was 45.3 ± 3.23 mV. The prepared nanoparticles had both burst-release and sustained-release phases in vitro release studies.In addition, the inhibitory effect of the prepared nanoparticles on gastric cancer SGC-7901 cells was similar to that of 5-fluorouracil injection, and the blank vector had no obvious inhibitory effect on SGC-7901 cells. In the pharmacokinetic study of rats in vivo, we found that AUC(0-t), MRT(0-t) and t1/2 z of nanoparticles were significantly increased in vivo compared with 5-fluorouracil solution, indicating that the prepared nanoparticles can play a role in sustained-release. | Li Sun Yunna Chen Yali Zhou Dongdong Guo Yufan Fan Fangyan Guo Yufeng Zheng Weidong Chen | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 6 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 7 | Platinum-group element geochemistry of Cenozoic basalts from the North China Craton: Implications for mantle heterogeneity显示文摘42 新生代(主要中新世) 从北方中国 Craton 的 Jining, Chifeng, Fansi, Xiyang,和 Zuoquan 区域的暗岩样品(NCC 暗岩此后) 为铂组元素(PGE,包括的 O,红外, Ru, Rh,磅,和 Pd ) 被分析。他们中的大多数是碱的暗岩和 tholeiites,所有几乎不他们显示很少外壳的污染。NCC 暗岩的全部的 PGE 内容从 0.1 ~ 0.9 ppb 变化,原始披风的比那些低的大部分 23.5 珍视 ppb。这些暗岩的原始使披风正常化的 PGE 模式定义积极斜坡和 Pd/Ir 比率从 1.2 ~ 25 变化。以 PGE 内容和 Pd/Ir 比率,他们相当类似于海中央山脉暗岩。在 PGE 之间没有明显的否定关联,显示在 magmatic 期间的橄榄石,辉石,或硫化物的部分结晶化处理对在 NCC 暗岩的 MgO, Ni,和 Cu 不能是为观察 PGE 变化的控制因素。NCC 暗岩的观察 Pd/Ir 变化要求异构的披风采购的 non-chondritic 的参与。基于 Sr-Nd-Pb-Hf 同位素的 systematics 和不兼容元素的签名,一混合部分在岩流圈的顶从 asthenospheric 橄榄岩和围住的披风 eclogites 融化为这些 NCC 暗岩的起源被建议。eclogites 的透镜从再循环的大陆人外壳的 upwelling 被导出在期间向西从 600 km 断绝地区的和平的板的 subduction。这些暗岩的 PGE 地球化学提供独立证据支持这个结论和观察 Pd/Ir 变化可以在拍的 peridotitic 的比例反映变化, eclogitic 融化。 | ZHANG WenHui ZHANG HongFu SUN YaLi FAN WeiMing HAN BaoFu TANG YanJie | 2015 | Science China Earth Sciences2015，58，6： | 4 |
| 8 | Enhanced Potassium‑Ion Storage of the 3D Carbon Superstructure by Manipulating the Nitrogen‑Doped Species and Morphology显示文摘Potassium-ion batteries(PIBs)are attractive for gridscale energy storage due to the abundant potassium resource and high energy density.The key to achieving high-performance and large-scale energy storage technology lies in seeking eco-efficient synthetic processes to the design of suitable anode materials.Herein,a spherical sponge-like carbon superstructure(NCS)assembled by 2D nanosheets is rationally and efficiently designed for K+storage.The optimized NCS electrode exhibits an outstanding rate capability,high reversible specific capacity(250 mAh g^(−1) at 200 mA g^(−1) after 300 cycles),and promising cycling performance(205 mAh g^(−1) at 1000 mA g^(−1) after 2000 cycles).The superior performance can be attributed to the unique robust spherical structure and 3D electrical transfer network together with nitrogen-rich nanosheets.Moreover,the regulation of the nitrogen doping types and morphology of NCS-5 is also discussed in detail based on the experiments results and density functional theory calculations.This strategy for manipulating the structure and properties of 3D materials is expected to meet the grand challenges for advanced carbon materials as high-performance PIB anodes in practical applications. | Yanhua Li Kui Xiao Cong Huang Jin Wang Ming Gao Aiping Hu Qunli Tang Binbin Fan Yali Xu Xiaohua Chen | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 9 | VUV photoluminescence properties of KSrPO4:Dy^3+ phosphor显示文摘White-light-emitting phosphors based on phosphate host matrix, KSrPO_4 doped with Dy^(3+), were prepared by solid state reaction and their VUV luminescent properties were firstly investigated. The excitation band peaking at 125-153 nm corresponding to the absorption of PO_4^(3-) group exhibits very strong absorption. The phosphors emit warm-white luminescence under vacuum ultraviolet excitation of 147 nm, which consists of three main emission peaks located at 475, 570 and 662 nm, respectively.According to the luminescence and color chromaticity of the optimal sample KSrPO_4:1 mol%Dy^(3+),1.3 mol%Li^+, it can be a potential candidate for mercury-free fluorescent lamps. | Yali Chen Jingyan Fan Yajun Zhou Jing Gou Binxun Yu | 2018 | Journal of Rare Earths2018，36，8： | 2 |
| 10 | Enhancement of Fe3O4/Au Composite Nanoparticles Catalyst in Oxidative Degradation of Methyl Orange Based on Synergistic Effect显示文摘Fe 3 O 4/Au nanoparticles (Fe 3 O 4/Au NP ) 催化剂被采用 H 2 O 2 作为氧化剂。评估 Fe 3 O 4/Au nanoparticles,不同降级条件被调查例如催化剂的数量, H 2 O 2 集中和 pH 价值。基于我们的数据,甲基橘子在一短时间完全被降级。提高的催化活动和增加的氧化率常数可以被归功于到 synergistic H 2 O 2 到哦激进,它是强壮的氧化种类之一。而且, Fe 3 O 4/Au nanoparticles 展出了令人满意为潜在的工业申请再循环性能。 | Qin Gao Yan Xing Mingli Peng Yongshuai Liu Zhiyi Luo Yanyan Jin Haiming Fan Kebin Li Chao Chen Yali Cui | 2017 | Chinese Journal of Chemistry2017，35，9： | 2 |
| 11 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 12 | Study on the Resistance Phenotype end Expression Level of femA of Staphylococcus Aureus显示文摘 | Yali Xiong Xinjian Fan Lei Zhang | 2007 | J Sichuan Uni(Med Sd Edi)2007，38，2： | 1 |
| 13 | Effects of zinc, copper, and selenium on placental cadmium transport显示文摘 | Yali Zhang Yongcheng Zhao Jixian Wang Hongda Zhu Quingfen Liu Yaguang Fan Naifen Wang Aiping Liu Husheng Liu Li Ou-Yang Jinhui Zhao Tiqiang Fan | 2004 | Biological Trace Element Research (-)2004，，1： | 1 |
| 14 | Mesenchymal Stem Cells Promote Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer Though Paracrine Cues and Close Physical Contact显示文摘 | Zengfu Xue Xiumin Wu Xiong Chen Yali Liu Xin Wang Kaichun Wu Yongzhan Nie Daiming Fan | 2015 | Biochem2015，，4： | 1 |
| 15 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，： | 1 |
| 16 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，4： | 1 |
| 17 | Significant coal combustion contribution to water-soluble brown carbon during winter in Xingtai, China: Optical properties and sources显示文摘To understand the characteristics of atmospheric brown carbon(BrC),daily PM2.5 samples in Xingtai,a small city in North China Plain(NCP),during the four seasons of 2018-2019,were collected and analyzed for optical properties and chemical compositions.The light absorption at 365 nm(abs λ=365 nm)displayed a strong seasonal variation with the highest value in winter(29.0±14.3 M/m),which was 3.2∼5.4-fold of that in other seasons.A strong correlation of abs λ=365 nm with benzo(b)fluoranthene(BbF)was only observed in winter,indicating that coal combustion was the major source for BrC in the season due to the enhanced domestic heating.The mass absorbing efficiency of BrC also exhibited a similar seasonal pattern,and was found to correlate linearly with the aerosol pH,suggesting a positive effect of aerosol acidity on the optical properties and formation of BrC in the city.Positive matrix factorization(PMF)analysis further showed that on a yearly basis the major source for BrC was biomass burning,which accounted for 34% of the total BrC,followed by secondary formation(26.7%),coal combustion(21.3%)and fugitive dust(18%).However,the contribution from coal combustionwas remarkably enhanced in winter,accounting for∼40%of the total.Our work revealed that more efforts of“shifting coal to clean energy”are necessary in rural areas and small cities in NCP in order to further mitigate PM2.5 pollution in China. | Dapeng Li Can Wu Si Zhang Yali Lei Shaojun Lv Wei Du Shijie Liu Fan Zhang Xiaodi Liu Lang Liu Jingjing Meng Yuesi Wang Jian Gao Gehui Wang | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 18 | Universality of Competitive Networks in Complex Networks显示文摘The paper proposes a model which helps to investigate the competitive aspect of real networks in quantitative terms. Through theoretical analysis and numerical simulations, it shows that the competitive model has the universality for a weighted network. The relation between parameters in the weighted network and the competitiveness in the competitive network is obtained by theoretical analysis. Based on the expression of the degree distribution of the competitive network, the strength and degree distributions of the weighted network can be calculated. The analytical solution reveals that the degree distribution of the weighted network is correlated with the increment and initial value of edge weights, which is verified by numerical simulations. Moreover, the evolving pattern of a clustering coefficient along with network parameters such as the size of a network, an updating coefficient, an initial weight and the competitiveness are obtained by further simulations. | GUO Jinli FAN Chao JI Yali | 2015 | Journal of Systems Science & Complexity2015，28，3： | 1 |
| 19 | Abietane derived diterpenoids as Ca_(v)3.1 antagonists from Salvia digitaloides显示文摘Nineteen diterpenoids, including saldigitin A(1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes(2, 3), and two new nor-abietanes(5, 6) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data,X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abietane skeleton. Biologically, 1–5 exhibited noticeable inhibitions on Ca_(v)3.1 low voltage-gated Ca2+channel(LVGCC), with IC50values in the range of 3.43–11.70 μmol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Ca_(v)3.1 antagonists. | Jianjun Zhao Shuzong Du Kun Hu Yali Hu Fan Xia Yansong Ye Jian Yang Yin Nian Gang Xu | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 20 | DDIT4通过p53和MAPK通路促进胃癌增殖和肿瘤发生显示文摘背景与目的胃癌(gastric cancer,GC)是世界上最常见的恶性肿瘤之一,在我国尤为常见。DNA损伤诱导转录因子4(DNAdamage-inducibletranscript4,DDIT4)是哺乳动物雷帕霉素靶蛋白抑制因子,由多种细胞应激诱导产生;然而,它在胃癌中的关键作用仍然未知。本研究旨在探讨DDIT4与胃癌发展的关系及其作用机制。方法我们采用蛋白免疫印迹法、实时聚合酶链反应、免疫组化或免疫荧光法检测DDIT4在胃癌细胞和组织中的表达情况。采用高通量筛选、细胞计数试剂盒-8、克隆形成和体内成瘤实验检测细胞增殖情况。采用流式细胞术检测细胞凋亡和细胞周期分布情况。结果 DDIT4在胃癌细胞和组织中表达上调。在胃癌细胞中下调DDIT4表达可抑制体外和体内的细胞增殖并增强了5-氟尿嘧啶诱导的细胞凋亡和细胞周期阻滞。与之相反,在正常胃上皮细胞中DDIT4的异位表达促进了细胞增殖、降低了化疗敏感性。进一步研究表明,丝裂原活化蛋白激酶和p53信号通路参与抑制细胞增殖并在DDIT4下调后增强化疗敏感性。结论 DDIT4促进了胃癌细胞增殖和肿瘤发生,为研究DDIT4在人类胃癌发生、发展中的作用提供了新思路。 | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2019 | 癌症2019，38，3： | 1 |
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