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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 3 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 4 | Thermo-hydro-mechanical coupled mathematical model for controlling the pre-mining coal seam gas extraction with slotted boreholes显示文摘Drainage influence radius is the basic parameter for borehole arrangement, while the effect of high pressure water jet slotting technology on borehole drainage influence radius has not been studied systematically. In this paper, a fully thermo-hydro-mechanical(THM) coupled model which represents the non-linear responses of gas extraction was implemented to demonstrate the reliability of this model through history data matching. Based on this model, the susceptibilities of gas extraction with single slotted borehole, including the permeability, the gas pressure, the temperature, the coal adsorption characteristics and the radius of slot, were quantified through a series of simulations. The simulation results revealed that increasing the permeability, initial gas pressure and temperature could develop the influence radius of single slotted borehole. This finite element model and its simulation results can improve the understanding of the coal-gas interactions of underground gas drainage and provide a scientific basis for the optimization of drainage systems. | Xue Yi Gao Feng Gao Yanan Liang Xin Zhang Zhizhen Xing Yan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 10 |
| 5 | Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-κB signaling pathway in vitro and in vivo显示文摘尽管表明小径的原子 factor-kappaB (NF-B ) 的组成的激活在多重不同人的肿瘤被报导了,在食道的有鳞的房间癌(ESCC ) 的 NF-B 小径的角色留下不清楚。丰富的来源提供了有趣的卓见进化疗和 chemopreventive 在癌症上完成的 curcumin 可以由调停的多重机制。在这研究,我们首先在二 ESCC 房间线 Eca109 和 EC9706 分析了 NF-B 小径的地位,然后进一步调查了 curcumin 是否能独自或在有 5 氟尿嘧啶(5-FU ) 的联合在 vitro 并且在 vivo 调制 NF-B 小径。结果证明 NF-B 发信号小径组成地在 ESCC 房间线被激活。Curcumin 经由 IB phosphorylation,和 downregulated 的抑制压制了 NF-B 的激活在 ESCC 房间线的 Bcl-2 和 CyclinD1 的表情。与 5-FU 相结合的 Curcumin 比独自对待的 5-FU 导致了更低的房间生存能力和更高的 apoptosis。在一个人的 ESCC 异种皮移植模型, curcumin 或 5-FU 独自减少了肿瘤体积,但是他们的联合有最强壮的 anticancer 效果。而且, curcumin 能也禁止在 vivo 通过 IB phosphorylation 和房间 apoptosis 的正式就职的 downregulation 表明小径的 NF-B。总的来说,我们的结果显示组成地激活的 NF-B 发信号小径在二个 ESCC 房间存在, curcumin 的 chemopreventive 效果与表明小径和它的下游的基因的 NF-B 的 downregulation 被联系。 | Fang Tian Tianli Fan Yan Zhang Yanan Jiang Xiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 10 |
| 6 | Preparation and properties of CMAS resistant bixbyite structured high-entropy oxides RE_(2)O_(3)(RE=Sm,Eu,Er,Lu,Y,and Yb):Promising environmental barrier coating materials for Al_(2)O_(3)f/Al_(2)O_(3) composites显示文摘Y_(2)O_(3) is regarded as one of the potential environmental barrier coating(EBC)materials for Al_(2)O_(3)f/Al_(2)O_(3)ceramic matrix composites owing to its high melting point and close thermal expansion coefficient to Al_(2)O_(3).However,the relatively high thermal conductivity and unsatisfactory calcium-magnesium-aluminosilicate(CMAS)resistance are the main obstacles for the practical application of Y_(2)O_(3).In order to reduce the thermal conductivity and increase the CMAS resistance,four cubic bixbyite structured high-entropy oxides RE_(2)O_(3),including(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Eu_(0.2)Er_(0.2)Y_(0.2)Yb_(0.2))2O_(3),and(Sm_(0.2)Eu_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)were designed and synthesized,among which(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)bulks were prepared by spark plasma sintering(SPS)to investigate their mechanical and thermal properties as well as CMAS resistance.The mechanical properties of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) are close to those of Y_(2)O_(3) but become more brittle than Y_(2)O_(3).The thermal conductivities of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb02)2O_(3)(5.1 and 4.6 W·m^(-1)·K^(-1))are only 23.8%and 21.5%respectively of that of Y_(2)O_(3)(21.4 W·m^(-1)·K^(-1)),while their thermal expansion coefficients are close to those of Y_(2)O_(3) and A12O_(3).Most importantly,HE RE_(2)O_(3) ceramics exhibit good CMAS resistance.After being attacked by CMAS at 1350℃for 4 h,the HE RE_(2)O_(3) ceramics maintain their original morphologies without forming pores or cracks,making them promising as EBC materials for Al_(2)O_(3)f/Al_(2)O_(3) composites. | Yanan SUN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Yan XING Xiaojun ZHAO Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 10 |
| 7 | Deep ultraviolet light-emitting diodes based on a well-ordered AlGaN nanorod array显示文摘The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs fabricated by the nanosphere lithography and dry-etching technique. Nanorod DUV LED devices with good electrical properties are successfully realized. Compared to planar DUV LEDs, nanorod DUV LEDs present>2.5 times improvement in light output power and external quantum efficiency. The internal quantum efficiency of nanorod LEDs increases by 1.2 times due to the transformation of carriers from the exciton to the free electron–hole, possibly driven by the interface state effect of the nanorod sidewall surface. In addition, the nanorod array significantly facilitates photons escaping from the interior of LEDs along the vertical direction, contributing to improved light extraction efficiency. A three-dimensional finite-different time-domain simulation is performed to analyze further in detail the TE-and TM-polarized photon extraction mechanisms of the nanostructure. Our results demonstrate the nanorod structure is a good candidate for high-efficiency DUV emitters. | LIANG ZHANG YANAN GUO JIANCHANG YAN QINGQING WU YI LU ZHUOHUI WU WEN GU XUECHENG WEI JUNXI WANG JINMIN LI | 2019 | Photonics Research2019，7，9： | 8 |
| 8 | A review:Photonics devices,architectures,and algorithms for optical neural computing显示文摘The explosive growth of data and information has motivated various emerging non-von Neumann computational approaches in the More-than-Moore era.Photonics neuromorphic computing has attracted lots of attention due to the fascinating advantages such as high speed,wide bandwidth,and massive parallelism.Here,we offer a review on the optical neural computing in our research groups at the device and system levels.The photonics neuron and photonics synapse plasticity are presented.In addition,we introduce several optical neural computing architectures and algorithms including photonic spiking neural network,photonic convolutional neural network,photonic matrix computation,photonic reservoir computing,and photonic reinforcement learning.Finally,we summarize the major challenges faced by photonic neuromorphic computing,and propose promising solutions and perspectives. | Shuiying Xiang Yanan Han Ziwei Song Xingxing Guo Yahui Zhang Zhenxing Ren Suhong Wang Yuanting Ma Weiwen Zou Bowen Ma Shaofu Xu Jianji Dong Hailong Zhou Quansheng Ren Tao Deng Yan Liu Genquan Han Yue Hao | 2021 | Journal of Semiconductors2021，42，2： | 7 |
| 9 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 10 | Characterization of the soybean Gm ALMT family genes and the function of Gm ALMT5 in response to phosphate starvation显示文摘A potential mechanism to enhance utilization of sparingly soluble forms of phosphorus(P) is the root secretion of malate, which is mainly mediated by the ALMT gene family in plants. In this study, a total of 34 Gm ALMT genes were identified in the soybean genome. Expression patterns diverged considerably among Gm ALMTs in response to phosphate(Pi) starvation in leaves, roots and flowers, with expression altered by P availability in 26 of the 34 Gm ALMTs. One root-specific Gm ALMT whose expression was significantly enhanced by Pi-starvation,Gm ALMT_5, was studied in more detail to determine its possible role in soybean P nutrition. Analysis of Gm ALMT_5 tissue expression patterns, subcellular localization, and malate exudation from transgenic soybean hairy rootsoverexpressing Gm ALMT_5, demonstrated that Gm ALMT_5 is a plasma membrane protein that mediates malate efflux from roots. Furthermore, both growth and P content of transgenic Arabidopsis overexpressing Gm ALMT_5 were significantly increased when sparingly soluble Ca-P was used as the external P source. Taken together, these results indicate that members of the soybean Gm ALMT gene family exhibit diverse responses to Pi starvation. One member of this family, Gm ALMT_5, might contribute to soybean P efficiency by enhancing utilization of sparingly soluble P sources under P limited conditions. | Wenting Peng Weiwei Wu Junchu Peng Jiaojiao Li Yan Lin Yanan Wang Jiang Tian Lili Sun Cuiyue Liang Hong Liao | 2018 | Journal of Integrative Plant Biology2018，60，3： | 7 |
| 11 | A study on JA-and BTH-induced resistance of Rosa rugosa‘Plena’to powdery mildew(Sphaerotheca pannosa)显示文摘Different concentrations of jasmonic acid(JA)and benzothiadiazole(BTH) were sprayed on 2-year-old Rosa rugosa‘Plena’ seedlings. The induced resistance of JA and BTH to Sphaerotheca pannosa(Wallr.) and the changes of their related physiological indices were investigated. Results showed that JA and BTH treatments had inhibitory impacts on S. pannosa infection. The optimal concentration of JA and BTH was 0.5 mmol/L for the disease-resistance induction of the leaves, its inductive effect was up to 66.36% for BTH and 54.49% for JA. Our results confirmed that exogenous JA and BTH significantly improved R. rugose ‘Plena’ resistance to S. pannosa. When treated with JA and BTH, activities of the three defense enzymes(POD, PPO, and PAL) increased significantly.Contents of total phenolics, flavonoids, and lignin also increased significantly. It is inferred from these results that exogenous JA and BTH could improve the resistance of R.rugose ‘Plena’ to S. pannosa through enhancing activities of the defensive enzymes and accumulation of secondary metabolites in the leaves. | Junxin Yan Yanan Deng Jia Yu Yongqiang Zhang Defu Chi | 2018 | Journal of Forestry Research2018，29，3： | 6 |
| 12 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 13 | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury显示文摘Sentrin-specific protease 3(SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion(MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species(ROS) production in response to MIR injury. By utilizing si RNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function. Mechanistic studies indicated that SENP3 silencing ameliorated myocardial apoptosis mainly via suppression of endoplasmic reticulum(ER) stress and mitochondrial-mediated apoptosis pathways. By contrast, adenovirusmediated cardiac SENP3 overexpression significantly exaggerated MIR injury. Further molecular analysis revealed that SENP3 promoted mitochondrial translocation of dynamin-related protein 1(Drp1) in reperfused myocardium. In addition, mitochondrial division inhibitor-1(Mdivi-1), a pharmacological inhibitor of Drp1, significantly attenuated the exaggerated mitochondrial abnormality and cardiac injury by SENP3 overexpression after MIR injury. Taken together, we provide the first direct evidence that SENP3 upregulation pivotally contributes to MIR injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | Lingchen Gao Yichao Zhao Jie He Yang Yan Longwei Xu Nan Lin Qingqi Ji Renyang Tong Yanan Fu Yu Gao Yuanyuan Su Ancai Yuan Ben He Jun Pu | 2018 | Journal of Genetics and Genomics2018，45，3： | 5 |
| 14 | Splicing of Receptor-Like Kinase-Encoding SNC4 and CERK1 is Regulated by Two Conserved Splicing Factors that Are Required for Plant Immunity显示文摘植物免疫者受体属于像受体的 kinase (RLK ) 家庭在微生物引起的病原体的识别和下游的防卫回答的激活起重要作用。Arabidopsis 变异的 snc4-1D 在 RLK SNC4 包含一个 gain-of-function 变化(NPR1-1 的 SUPPRESSOR, CONSTITUTIVE4 ) ,它导致防卫回答的组成的激活。snc4-1D 的 suppressor 异种的分析鉴别二保存了拼接的因素, SUA (ABI3-5 的 SUPPRESSOR ) 和 RSN2 (为 SNC4-1D 2 要求了) ,那在 snc4-1D 为组成的防卫回答被要求。在 sua 和 rsn2 异种,拼接的 SNC4 被改变, SNC4 抄本的数量被减少。进一步的分析证明 SUA 和 RSN2 也为 CERK1 (几丁质 ELICITOR 受体 KINASE1 ) 的合适的拼接被要求,它编码为几丁质作为受体工作的另一 RLK。在 sua 和 rsn2 异种,由几丁质的反应的氧种类的正式就职被减少并且非病原的细菌 Pseudomonas syringae pv。西红柿 DC3000hrcC 比在野类型的植物成长到更高的 titers。我们的学习建议拼接的 pre-mRNA 在植物免疫的规定起重要作用由 RLK SNC4 和 CERK1 调停了。 | Zhibin Zhang Yanan Liu Pingtao Ding Yan Li Qing Kong Yuelin Zhang | 2014 | Molecular Plant2014，7，12： | 5 |
| 15 | Paleomagnetic results from Late Carboniferous to Early Permian rocks in the northern Qiangtang terrane, Tibet, China, and their tectonic implications显示文摘Results of a systematic paleomagnetic study are reported based on Late Carboniferous to Early Permian sedimentary rocks on the north slope of the Tanggula Mountains,in the northern Qiangtang terrane(NQT),Tibet,China.Data revealed that magnetic minerals in limestone samples from the Zarigen Formation(CP^z)are primarily composed of magnetite,while those in sandstone samples from the Nuoribagaribao Formation(Pnr)are dominated by hematite alone,or hematite and magnetite in combination.Progressive thermal,or alternating field,demagnetization allowed us to isolate a stable high temperature component(HTC)in 127 specimens from 16 sites which successfully passed the conglomerate test,consistent with primary remnance.The tilt-corrected mean direction for Late Carboniferous to Early Permian rocks in the northern Qiangtang terrane is D_s=30.2°,I_s=-40.9°,k_s=269.0,a_(95)=2.3°,N=16,which yields a corresponding paleomagnetic pole at 25.7°N,241.5°E(dp/dm=2.8°/1.7°),and a paleolatitude of 23.4°S.Our results,together with previously reported paleomagnetic data,indicate that:(1)the NQT in Tibet,China,was located at a low latitude in the southern hemisphere,and may have belonged to the northern margin of Gondwana during the Late Carboniferous to Early Permian;(2)the Paleo-Tethys Ocean was large during the Late Carboniferous to Early Permian,and(3)the NQT subsequently moved rapidly northwards,perhaps related to the fact that the Paleo-Tethys Ocean was rapidly contracting from the Late Permian to Late Triassic while the Bangong Lake-Nujiang Ocean,the northern branch of the Neo-Tethys Ocean,expanded rapidly during this time. | YANG XingFeng CHENG Xin ZHOU YaNan MA Lun ZHANG XiaoDong YAN ZhaoSheng PENG XiMing SU HaiLun WU HanNing | 2017 | Science China Earth Sciences2017，60，1： | 5 |
| 16 | Complications and risk factors for complications of implanted subcutaneous ports for intraperitoneal chemotherapy in gastric cancer with peritoneal metastasis显示文摘Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods:In retrospective screening of 301 patients with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results:Of the 249 analyzed patients,57(22.9%)experienced port complications.Subcutaneous liquid accumulation(42.1%)and infection(28.1%)were the main complications,and other complications included port rotation(14.1%),wound dehiscence(12.3%),inflow obstruction(1.7%)and subcutaneous metastasis(1.7%).The median interval between port implantation and occurrence of complications was 3.0 months.Eastern Cooperative Oncology Group(ECOG)performance status[odds ratio(OR),1.74;95%confidence interval(95%CI),1.12-2.69],albumin(OR,3.67;95%CI,1.96-6.86),implantation procedure optimization(OR,0.33;95%CI,0.18-0.61)and implantation groups(OR,0.37;95%CI,0.20-0.69)were independent risk factors for port complications(P<0.05).ECOG performance status was the only factor that related to the grades of port complications(P=0.016).Conclusions:Port complications in GC patients who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM. | Zhongyin Yang Chen Li Wentao Liu Yanan Zheng Zhenglun Zhu Ziehen Hua Zhentian Ni Sheng Lu Min Yan Chao Yan Zhenggang Zhu | 2020 | Chinese Journal of Cancer Research2020，32，4： | 5 |
| 17 | Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis显示文摘Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage polarization remain largely unknown. Here, we show that suppressing serine metabolism, either by inhibiting the activity of the key enzyme phosphoglycerate dehydrogenase in the serine biosynthesis pathway or by exogenous serine and glycine restriction, robustly enhances the polarization of interferon-γ-activated macrophages (M(IFN-γ)) but suppresses that of interleukin-4-activated macrophages (M(IL-4)) both in vitro and in vivo. Mechanistically, serine metabolism deficiency increases the expression of IGF1 by reducing the promoter abundance of S-adenosyl methionine-dependent histone H3 lysine 27 trimethylation. IGF1 then activates the p38-dependent JAK–STAT1 axis to promote M(IFN-γ) polarization and suppress STAT6-mediated M(IL-4) activation. This study reveals a new mechanism by which serine metabolism orchestrates macrophage polarization and suggests the manipulation of serine metabolism as a therapeutic strategy for macrophage-mediated immune diseases. | Xiao Shan Penghui Hu Lina Ni Long Shen Yanan Zhang Zemin Ji Yan Cui Meihua Guo Haoan Wang Liyuan Ran Kun Yang Ting Wang Lei Wang Bin Chen Zhi Yao Vingjie Wu Qiujing Yu | 2022 | Cellular & Molecular Immunology2022，19，11： | 5 |
| 18 | Existing Problems in Energy Exploitation and Eco-environment Sustainable Development and Their Countermeasures in Northern Shaanxi显示文摘The exploitation of coal, petroleum and natural gas in northern Shaanxi not only promoted the rapid development of economy, but also brought about enormous pressure to fragile ecology and resulted to severe water pollution, water and soil loss, vegetation destruction and other ecological environmental problems, so many countermeasures were put forward according to these problems, such as greatly developing circular economy, conducting cleaner production in petroleum enterprises, continuously renewing mining technology and so on. | GUO Jun-quan1, YANG Zhi-guo2 1. Department of Agriculture and Forestry Architecture, Yan’an Vocational and Technical College, Yan’an 716000, China 2. Yanan Municipal Environmental Protection Monitoring Station, Yan’an 716000, China | 2011 | Meteorological and Environmental Research2011，2，4： | 4 |
| 19 | Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-β peptide(1–42)-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway显示文摘Tongluojiunao(TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. However, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with Aβ1–42(10 μmol/L) significantly increased the release of lactate dehydrogenase, which was markedly reduced by TLJN(2 μL/mL), specifically by the component geniposide(26 μmol/L), but not ginsenoside Rg1(2.5 μmol/L). The estrogen receptor inhibitor, ICI182780(1 μmol/L), did not block TLJN- or geniposide-mediated decrease of lactate dehydrogenase under Aβ1–42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002(50 μmol/L) or U0126(10 μmol/L), respectively blo cked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. Therefore, these results suggest that the non-classical estrogen pathway(i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, specifically its component, geniposide, against Aβ1–42-mediated cell death in primary cultured hippocampal neurons. | Jiao Li Feng Wang Haimin Ding Chunyan Jin Jinyan Chen Yanan Zhao Xiaojing Li Wenju Chen Ping Sun Yan Tan Qi Zhang Xu Wang Angran Fan Qian Hua | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 20 | Endoplasmic reticulum stress contributed to β1-adrenoceptor autoantibody-induced reduction of autophagy in cardiomyocytes显示文摘Autophagy reduction has been confirm ed as an im portant mechanism in apoptosis induction.Our previous study showed that decreased autophagy induced by Pi-adrenoceptor autoantibodies(Pi-AAs)enhanced cardiom yocyte apoptosis and contributed to heart failure progression.Endoplasmic reticulum stress(ERS)is known to be an im portant mechanism in intracellular homeostasis and is closely related to autophagy.However,ERS in pi-AA-induced autophagy dysfunction of cardiom yocytes remains unclear.In this study,we used an active im m unization rat model and H9c2 cardiom yocytes to study the role of ERS in Pi-AA-induced autophagy.Results showed that prolonged action of Pi-AAs significantly reduced the autophagy of myocardial tissues and H9c2 cardiom yocytes,and ERS and its related apoptotic pathways were significantly activated.Moreover,mRFP-GFP-LC3 double-labeled adenoviruses were used to detect cardiom yocyte autophagic flux to confirm that Pi-AAs caused a significant decrease in autophagic flux in H9c2 cardiom yocytes.The ERS inhibitor,4-phenylbutyrate(4-PBA),partially attenuated the β1-AA-induced reduction of cardiom yocyte autophagy,consistent w ith the effect of the m am m alian target of rapam ycin inh ibito r rapamycin(Rapa).Compared to the pretreatm ent with 4-PBA or Rapa alone,pretreatm ent w ith the com bination of 4-PBA and Rapa had a greater effect on attenuating the pi-AA-induced decrease in autophagy and Pi-AA-induced apoptosis in cardiomyocytes.This study provides an experim ental basis fo r the role of Pi-AAs in the homeostatic maintenance of cardiom yocytes in patients w ith heart failure w ith respect to autophagy and ERS. | Li Wang Na Ning Changtu Wang Xiaohong Hou Yuan Yuan Yanan Ren Cong Sun Zi Yan Xiaohui Wang Huirong Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 3 |
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