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| 1 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 2 | Radiotherapy targeting cancer stem cells “awakens” them to induce tumour relapse and metastasis in oral cancer显示文摘Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic, recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying mechanism remains unclear. Cancer stem cells(CSCs), considered the 'seeds'of cancer, have been confirmed to be in a quiescent state in most established tumours, with their innate radioresistance helping them survive more easily when exposed to radiation than differentiated cancer cells. There is increasing evidence that CSCs play an important role in recurrence and metastasis post-radiotherapy in many cancers. However, little is known about how oral CSCs cause tumour recurrence and metastasis post-radiotherapy. In this review article, we will first summarise methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation, hereafter referred to as 'awakened'CSCs, to highlight their response to radiotherapy and potential role in tumour recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs. In addition, we explore potential therapeutic strategies targeting these 'awakened' CSCs to solve the serious clinical challenges of recurrence and metastasis in oral cancer after radiotherapy. | Yangfan Liu Miao Yang Jingjing Luo Hongmei Zhou | 2020 | International Journal of Oral Science2020，12，2： | 4 |
| 3 | A low power global shutter pixel with extended FD voltage swing range for large format high speed CMOS image sensor显示文摘A low power 8T global shutter pixel with extended FD voltage swing range is proposed for large format high speed CMOS image sensor. The pixel has a negative threshold reset transistor, two in-pixel source followers, and a sample-and-hold circuit. The in-pixel first source follower is employed for reducing the pixel average current and maximum transient current. The negative threshold reset transistor is applied to extend the voltage swing of FD. Using pixel level sample-and-hold circuit, the k TC noise on FD node can be effectively nullified by correlated double sampling operation. A high speed 1000 fps 256×256 CMOS image sensor is implemented in 0.18 μm CMOS process. Two 10-bit cyclic ADC arrays are integrated in this prototype sensor chip. The active area of the chip is 10 mm×7 mm with a pixel size of 14 μm×14 μm. The developed sensor achieves an average current of 23 n A per pixel, a maximum transit current per pixel as low as 1113 n A, and a large FD voltage swing of 1.78 V. The sensor temporal noise level is 103 e-and full well capacity has 27000 e-which results in 48.3 d B signal dynamic range. | ZHOU YangFan CAO ZhongXiang HAN Ye LI QuanLiang SHI Cong DOU RunJiang QIN Qi LIU Jian WU NanJian | 2015 | Science China(Information Sciences)2015，58，4： | 4 |
| 4 | Dynamics of methanogenesis,ruminal fermentation and fiber digestibility in ruminants following elimination of protozoa: a meta-analysis显示文摘Background: Ruminal microbes are vital to the conversion of lignocellulose-rich plant materials into nutrients for ruminants.Although protozoa play a key role in linking ruminal microbial networks,the contribution of protozoa to rumen fermentation remains controversial; therefore,this meta-analysis was conducted to quantitatively summarize the temporal dynamics of methanogenesis,ruminal volatile fatty acid(VFA) profiles and dietary fiber digestibility in ruminants following the elimination of protozoa(also termed defaunation).A total of 49 studies from 22 publications were evaluated.Results: The results revealed that defaunation reduced methane production and shifted ruminal VFA profiles to consist of more propionate and less acetate and butyrate,but with a reduced total VFA concentration and decreased dietary fiber digestibility.However,these effects were diminished linearly,at different rates,with time during the first few weeks after defaunation,and eventually reached relative stability.The acetate to propionate ratio and methane production were increased at 7 and 11 wk after defaunation,respectively.Conclusions: Elimination of protozoa initially shifted the rumen fermentation toward the production of more propionate and less methane,but eventually toward the production of less propionate and more methane over time. | Zongjun Li Qi Deng Yangfan Liu Tao Yan Fei Li Yangchun Cao Junhu Yao | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 5 | The involvement of PybZIPa in light-induced anthocyanin accumulation via the activation of PyUFGT through binding to tandem G-boxes in its promoter显示文摘To gain insight into how anthocyanin biosynthesis is controlled by light in fruit,transcriptome and metabolome analyses were performed in the Chinese sand pear cultivar“Mantianhong”(Pyrus pyrifolia)after bagging and bag removal.We investigated transcriptional and metabolic changes and gene-metabolite correlation networks.Correlation tests of anthocyanin content and transcriptional changes revealed that 1,530 transcripts were strongly correlated with 15 anthocyanin derivatives(R2>0.9,P-value<0.05),with the top 130 transcripts categorized as being associated with flavonoid metabolism,transcriptional regulation,and light signaling.The connection network revealed a new photosensitive transcription factor,PybZIPa,that might play an important role during light-induced anthocyanin accumulation.The overexpression of PybZIPa promoted anthocyanin accumulation in pear and strawberry fruit as well as tobacco leaves.Dual luciferase and Y1H assays further verified that PybZIPa directly activated the expression of PyUFGT by binding to tandem G-box motifs in the promoter,which was key to differential anthocyanin accumulation in debagged pear skin,and the number of G-box motifs affected the transcriptional activation of PyUFGT by PybZIPa.The results indicate that the light-induced anthocyanin biosynthesis regulatory mechanism in pear differs from that described in previous reports suggesting that a bZIP family member co-regulates anthocyanin biosynthesis with other transcription factors in apple and Arabidopsis.It was found that,in response to light,PybZIPa promoted anthocyanin biosynthesis by regulating important transcription factors(PyMYB114,PyMYB10,and PyBBX22)as well as structural genes(PyUFGT)via binding to G-boxes within promoters.This activation was amplified by the self-binding of PybZIPa to activate its own promoter.Overall,we demonstrate the utility of a multiomics integrative approach for discovering new functional genes and pathways underlying light-induced anthocyanin biosynthesis. | Hainan Liu Jun Su Yangfan Zhu Gaifang Yao Andrew C.Allan Charles Ampomah-Dwamena Qun Shu Kui Lin-Wang Shaoling Zhang Jun Wu | 2019 | Horticulture Research2019，6，1： | 3 |
| 6 | Capacity-Based Channel Assignment Scheme in Multi-radio Multi-channel Wireless Mesh Networks显示文摘The capacity of wireless mesh networks can be greatly enhanced by equipping each mesh router with multiple radios and by exploiting multiple channels to reduce network interference. It has been proved that an efficient channel assignment scheme is critical to achieve the optimal network throughput. This paper presents a centralized channel assignment scheme for multi-radio multichannel wireless mesh networks. The scheme includes a spanner-based topology control operation and a linkranking channel assignment algorithm. In the topology control procedure, several links that cause intense interference are removed from the network without damage to the basic network connectivity. The channel assignment procedure improves the network throughput via ranking links based on the principle of load balance. The simulation results demonstrate that the proposed scheme outperforms the compared centralized channel assignment approach in terms of network throughput. The experimental results also indicate that the effectiveness of the proposed scheme is even evident in the case of heavy input traffic load where the potential interference in the network is severe. | LI Yangfan WU Peng LIU Xinhua | 2015 | Chinese Journal of Electronics2015，24，2： | 2 |
| 7 | TiC/C core/shell nanowires arrays as advanced anode of sodium ion batteries显示文摘High-perfo rmance anodes of sodium ion batteries(SIBs)largely depends on rational architecture design and binder-free smart hybridization.Herein,we report TiC/C core/shell nanowires arrays prepared by a one-step chemical vapor deposition(CVD)method and apply it as the anode of SIBs for the first time.The conductive TiC core is intimately decorated with carbon shell.The as-obtained TiC/C nanowires are homogeneously grown on the substrate and show core/shell heterostructure and porous architecture with high electronic conductivity and reinforced stability.Owing to these merits,the TiC/C electrode displays good rate performance and outstanding cycling performance with a capacity of 135.3 mAh/g at 0.1 A/g and superior capacity retention of 90.14%after 1000 cycles at 2 A/g.The reported strategy would provide a promising way to construct binder-free arrays electrodes for sodium ion storage. | Yanbin Shen Yahao Li Shengjue Deng Guoxiang Pan Qinqin Xiong Xiaokun Ding Yangfan Lu Qi Liu Xinhui Xia Xiuli Wang Jiangping Tu | 2020 | Chinese Chemical Letters2020，31，3： | 2 |
| 8 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 9 | A photo-assisted electrochemical-based demonstrator for green ammonia synthesis显示文摘Bridging laboratory research and practical utilization is of crucial importance for the development of green ammonia synthetic technologies. A decentralized photo-assisted electrochemical-based demonstrator has been proposed for green ammonia synthesis from renewable electricity, air and water, where well-known defect-laden WO_(3) is used as the working electrode, and a commercially available PV panel supplies renewable electricity. In this demonstrator, defect-laden WO_(3) exhibits the optimum electrochemical NH_(3) formation rate(4.51 × 10^(-12)mol s^(-1)cm^(-2)) in 0.1 M K_(2)SO_(4)in a photovoltaic electrochemical(PV-EC) system. A system-level energy and cost analysis was conducted to investigate its economic viability and a general evaluation tool for system performance and cost estimation was proposed. This advance enables the possibility of integrating the small-scale green ammonia demonstrator into a stand-alone farm system. | Xiaolu Liu Zhurui Shen Xinyue Peng Lu Tian Ran Hao Lu Wang Yangfan Xu Yuping Liu Christos T.Maravelias Wei Li Geoffrey A.Ozin | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 10 | Explo- sion power and pressure desensitization resisting property of emulsion explosives sensitized by MgH2 显示文摘 | Cheng Yangfan Ma Honghao Liu Rong | 2014 | Journal of Energetic Materials2014，32，3： | 1 |
| 11 | Pres- sure desensitization influential factors and mechanism of' magnesium hydride sensitized emulsion explosives 显示文摘 | Cheng Yangfan Ma Honghao Liu Ror~g | 2014 | Propellants Explosives Pyrotechnics2014，39，2： | 1 |
| 12 | Screening for new thermoelectric material: A semiconducting TaS_(3) with nanoporous structure显示文摘Transition-metal sulfides,such as 1T-and 2H-TaS_(2),are attracting considerable interest in modern condensed matter physics for their diverse behaviors of the Mott state,peculiar charge-density-wave phase and superconductivity.The intrinsically low thermal conductivities along the cross-plane direction can advantage the potential high thermoelectric performance;yet,their insignificant power factors severely hampered the practical applications as thermoelectric devices.In this perspective,we herein present a new semiconducting phase in TaS_(3) with the space group C2/m predicted by the swarmintelligence structure-searching method.The C2/m-TaS_(3) phase exhibits anisotropic multivalley band dispersions,which is beneficial for electronic transport.Meanwhile,the unique structure within nanopores leads to strong anharmonic scattering,significantly reducing the lattice thermal conductivity.As a result,the calculated figure of merit ZT can reach up to 1.68 and 1.57 at 800 K for p-and n-type,respectively that is comparable with conventional thermoelectric materials(e.g.PbTe,Bi_(2)Te_(3)).Therefore,our calculation reveals that the C2/m-TaS_(3) phase can be a potential high-performance candidate as nontoxic and eco-friendly thermoelectrics,and will stimulate further experimental exploration for understanding and tailoring thermoelectric capability in related transition-metal sulfides. | Yangfan Cui Xiaojun Wang Shuai Duan Xin Chen Xiaobing Liu | 2022 | Journal of Materiomics2022，8，5： | 1 |
| 13 | Optimal Planning of IDR-integrated Electricity-heat Systems Considering Techno-economic and Carbon Emission Issues显示文摘This study presents an optimal electricity-heat system(EHS)planning framework to promote the accommodation of wind power while considering technical,economic and environmental criteria.To this end,integrated demand response(IDR)is introduced as a flexibility resource to complement the inherent fluctuation of renewable energy sources and modeled by using price elasticity theory.Both the timing transferring and energy substitution potentials are considered in the proposed IDR program.Incorporating the effect of IDR into the EHS planning model,a two-stage stochastic programming model can be devised,in which the optimal EHS configuration design and associated operation control techniques are found simultaneously to minimize the system’s total economic and carbon-emission costs over the planning horizon.The multi-scale uncertainties arising from both long-term demand growth and operation-level variability of renewables/load demands are captured collectively by using a scenario-based method.The suggested planning approach is illustrated using a real EHS test case and the results show that it is effective in practical applications. | Bo Zeng Yu Liu Yangfan Luo Hao Xu Luqman Ahmed | 2023 | CSEE Journal of Power and Energy Systems2023，9，6： | 1 |
| 14 | Quantifying Contribution of DER-Integrated EV Parking Lots to Reliability of Power Distribution Systems显示文摘In the future smart cities,parking lots(PLs)can accommodate hundreds of electric vehicles(EVs)at the same time.This trend creates an opportunity for PLs to serve as a potential flexibility resource,considering growing penetration of EVs and integration of distributed energy resources DER(such as photovoltaic and energy storages).Given this background,this paper proposes a comprehensive evaluation framework to investigate the potential role of DER-integrated PLs(DPL)with the capability of vehicle-to-grid(V2G)in improving the reliability of the distribution network.For this aim,first,an overview for the distribution system with DPLs is provided.Then,a generic model for the available generation capacity(AGC)of DPLs with consideration of EV scheduling strategy is developed.On the above basis,an iterative-based algorithm leveraging sequential Monte Carlo simulation is presented to quantify the contribution of DPLs to the reliability of the system.In order to verify the effectiveness of the proposed method,a series of numerical studies are carried out.The simulation results show that the integration of DPLs with the V2G capability could help to improve the reliability performance of distribution grid to a great extent and reduce the adverse impact incurred by EV accommodation,if utilized properly. | Bo Zeng Yixian Liu Yangfan Luo | 2021 | Energy Engineering2021，118，6： | 0 |
| 15 | Analysis of local microstructure and strengthening mechanisms in adjustable-gap bobbin tool friction stir welds of Al-Mg显示文摘The bobbin tool friction stir welding process was used to join 6 mm thick 5A06 aluminum alloy plates.Optical microscope was used to characterize the microstructure.The electron backscatter diffraction(EBSD)identified the effect of non-homogeneous microstructure on the tensile properties.It was observed that the grain size in the top of the stir zone(SZ)is smaller than that in the centre region.The lowest ratio of recrystallization and density of the geometrically-necessary dislocations(GNDs)in the SZ was found in the middle near the thermo-mechanically affected zone(TMAZ)being 22%and 1.15×10^(−13) m^(−2),respectively.The texture strength of the heat-affected zone(HAZ)is the largest,followed by that in the SZ,with the lowest being in the TMAZ.There were additional interfaces developed which contributed to the strengthening mechanism,and their effect on tensile strength was analysed.The tensile tests identified the weakest part in the joint at the interfaces,and the specific reduction value is about 93 MPa. | Dong Wu Wenya Li Qiang Chu Yangfan Zou Xichang Liu Yanjun Gao | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，8： | 0 |
| 16 | Specificity of the proteasome cleavage to the antigen protein显示文摘In the MHC classⅠmolecule binding antigenic peptides processing and presentation pathway,the ubiquitin-proteasome system plays a key role in degrading the protein substrate.For the purpose of studying the specificities of proteasomal cleavage sites,partial least squares method is used to predict the proteasomal cleavage sites,and the predictive accuracy of the model is 82.8%.The specificities of the cleavage sites and the adjacent positions come from the contribution of the amino acids of the samples to the cleavage sites,showing the information of proteasome interacting with antigen protein.It demonstrates that the proteasome cleaving to target protein is selective,but not random. | SONG Zhe LIU Tao JIAO ChunBo LIU Wei ZHU MingHua GUO YangFan WANG XiaoGang | 2009 | Science China Chemistry2009，52，1： | 0 |
| 17 | 论《母亲河》贺庆生的为官理念显示文摘为官者如何为官是《母亲河》中十分关注的问题,因此,探究贺庆生的为官理念,有助于让读者更加深刻地认识中国共产党的执政理念。通过对贺庆生为民解忧、为国效命、为党奉献为官形象的深入分析,在对历史的反思、当前的思考和未来的探究中,我们看到了一位高大的为民、为国、为党的'纯粹'共产党人形象。 | 崔剑波 金晶 Liu YangFan | 2018 | 绥化学院学报2018，38，11： | 0 |
| 18 | A General Linguistic Steganalysis Framework Using Multi-Task Learning显示文摘Prevailing linguistic steganalysis approaches focus on learning sensitive features to distinguish a particular category of steganographic texts from non-steganographic texts,by performing binary classification.While it remains an unsolved problem and poses a significant threat to the security of cyberspace when various categories of non-steganographic or steganographic texts coexist.In this paper,we propose a general linguistic steganalysis framework named LS-MTL,which introduces the idea of multi-task learning to deal with the classification of various categories of steganographic and non-steganographic texts.LS-MTL captures sensitive linguistic features from multiple related linguistic steganalysis tasks and can concurrently handle diverse tasks with a constructed model.In the proposed framework,convolutional neural networks(CNNs)are utilized as private base models to extract sensitive features for each steganalysis task.Besides,a shared CNN is built to capture potential interaction information and share linguistic features among all tasks.Finally,LS-MTL incorporates the private and shared sensitive features to identify the detected text as steganographic or non-steganographic.Experimental results demonstrate that the proposed framework LS-MTL outperforms the baseline in the multi-category linguistic steganalysis task,while average Acc,Pre,and Rec are increased by 0.5%,1.4%,and 0.4%,respectively.More ablation experimental results show that LS-MTL with the shared module has robust generalization capability and achieves good detection performance even in the case of spare data. | Lingyun Xiang Rong Wang Yuhang Liu Yangfan Liu Lina Tan | 2023 | Computer Systems Science & Engineering2023，46，8： | 0 |
| 19 | RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis显示文摘Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors.However,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely elusive.Here we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer metabolism.The level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant phenotype.RBM4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR cascade.Mechanistically,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in nucleus.Therefore,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine metabolism.Clinically,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high LKB1.The RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics. | Lei Chen Wenjing Zhang Dan Chen Quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei Liang Chaoqun Chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui Zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 20 | Multi-Material Topology Optimization of Structures Using an Ordered Ersatz Material Model显示文摘This paper proposes a new element-based multi-material topology optimization algorithm using a single variable for minimizing compliance subject to a mass constraint.A single variable based on the normalized elemental density is used to overcome the occurrence of meaningless design variables and save computational cost.Different from the traditional material penalization scheme,the algorithm is established on the ordered ersatz material model,which linearly interpolates Young’s modulus for relaxed design variables.To achieve a multi-material design,the multiple floating projection constraints are adopted to gradually push elemental design variables to multiple discrete values.For the convergent element-based solution,the multiple level-set functions are constructed to tentatively extract the smooth interface between two adjacent materials.Some 2D and 3D numerical examples are presented to demonstrate the effectiveness of the proposed algorithm and the possible advantage of the multi-material designs over the traditional solid-void designs. | Baoshou Liu Xiaolei Yan Yangfan Li Shiwei Zhou Xiaodong Huang | 2021 | Computer Modeling in Engineering & Sciences2021，，8： | 0 |
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