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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Giant electric field-induced magnetization in a magnetoelectric composite at high frequeney显示文摘 | ZHOU Jianping GUO Yangyang XI Zengzhe | 2008 | Appl Phys Lett2008，93，15： | 1 |
| 3 | The level of bile salt-stimulated lipase in the milk of Chinese women and its association with maternal BMI显示文摘This study aimed to investigate the bile salt-stimulated lipase(BSSL) concentration in the milk of Chinese women and its correlation with maternal body mass index(BMI), gestational diabetes mellitus(GDM) and gestational hypertensive disorder(GHD). The BSSL levels in the milk samples were measured by enzyme-linked immunosorbent assay(ELISA). BSSL level in colostrum milk of mothers with full-term infants was positively correlated with pregnancy week and negatively correlated with maternal pre-pregnancy BMI and BMI late in pregnancy. Moreover, the BSSL concentration in mature milk was positively correlated with BMI gain during pregnancy. The BSSL concentration in colostrum milk was lower in GDM mothers than in normal mothers. The BSSL helps infants digest fat in early life and its level was associated with lactation. The changes in BSSL characteristics with maternal BMI and GDM in this study may have clinical implications regarding the effects of pregnancy weight and metabolism on the nutrition and health of the offspring. | Lijun Sha Shanshan Zhou Yangyang Xi Rong Li Xiaonan Li | 2020 | The Journal of Biomedical Research2020，34，2： | 1 |
| 4 | Improved Initial Charging Capacity of Na-poor Na0.44MnO2 via Chemical Presodiation Strategy for Low-cost Sodium-ion Batteries显示文摘Sodium-ion batteries(SIBs)are promising for grid-scale energy storage applications due to the natural abundance and low cost of sodium.Among various Na insertion cathode materials,Na0.44MnO2 has attracted the most attention because of its cost effectiveness and structural stability.However,the low initial charge capacity for Na-poor Na0.44MnO2 hinders its practical applications.Herein,we developed a facile chemical presodiated method using sodiated biphenly to transform Na-poor Na0.44MnO2 into Na-rich Na0.66MnO2.After presodiation,the initial charge capacity of Na0.44MnO2 is greatly enhanced from 56.5 mA·h/g to 115.7 mA·h/g at 0.1 C(1 C=121 mA/g)and the excellent cycling stability(the capacity retention of 94.1%over 200 cycles at 2 C)is achieved.This presodiation strategy would open a new avenue for promoting the practical applications of Na-poor cathode materials in sodium-ion batteries. | ZHOU Xi LAI Yangyang WU Xiangjiang CHEN Zhongxue ZHONG Faping Al Xinping YANG Hanxi CAO Yuliang | 2021 | Chemical Research in Chinese Universities2021，37，2： | 1 |
| 5 | Analysis on nasal airway by using scale-adaptive simulation combined with standard κ-ω model and 3D printing modeling physical experiment显示文摘The physiological structure of the upper respiratory tract is complex and varies with each individual,and the circulating air has turbulent performance.In this paper,based on computed tomography(CT)medical images published online and the three-dimensional(3D)printing technology,a 3D model of the human upper respiratory tract was reconstructed and an experimental device of the upper respiratory tract was made.We implemented the respiratory experiment and measured the flow rate,and a scale-adaptive κ-ω model is applied for numerical simulation,the results are in good agreement.The flow field during respiratory was analyzed by coronal velocity cross section,vortex line and particle tracks.We found that the relatively strong shear effect happens at the areas of nasal valve and nasopharynx.In the middle and upper nasal tract,vortex line separation occurs and there is significant passage effect.The results indicate that SAS method is effective in studying upper respiratory airflow. | Jiemin Zhan Yangyang Xi Kay Lin Weiguang Yu Wenqing Hu | 2019 | Theoretical & Applied Mechanics Letters2019，9，4： | 1 |
| 6 | A novel quantum-inspired immune clonal algorithm with the evolutionary game approach显示文摘The quantum-inspired immune clonal algorithm(QICA) is a rising intelligence algorithm.Based on evolutionary game theory and QICA,a quantum-inspired immune algorithm embedded with evolutionary game(EGQICA) is proposed to solve combination optimization problems.In this paper,we map the quantum antibody's finding the optimal solution to player's pursuing maximum utility by choosing strategies in evolutionary games.Replicator dynamics is used to model the behavior of the quantum antibody and the memory mechanism is also introduced in this work.Experimental results indicate that the proposed approach maintains a good diversity and achieves superior performance. | Qiuyi Wu,Licheng Jiao,Yangyang Li,Xiaozheng Deng Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China,Institute of Intelligent Information Processing,Xidian University,Xi’an 710071,China | 2009 | Progress in Natural Science:Materials International2009，19，10： | 1 |
| 7 | Numerical study of the flowing sequence of a pouring liquid显示文摘Liquid flows in a particular sequence when it is poured out from an open-top receptacle. Since the sequence is hard to catch by experiment, a numerical simulation was performed in this pouring process with the moving particle semi-implicit (MPS) method. A modified solid-liquid boundary condition was verified and employed with a new definition of static liquid layers. The whole system was discretized by a set of particles and the liquid particles were marked and tracked in the pouring process. The flowing sequence of the liquid can be calculated by restoring the liquid particles back to their initial positions before it is poured. The mass transfer property is found to depend on the position of the rotation axis and the rotation speed, as well as the viscosity of the liquid. The mechanism of the flowing sequence results from a temporal vortex and its motion during the process. The character vortex is generated by the rotation of the container. The results reveal a principle for a versatile pouring process and may contribute to the applications in flowing control in many fields. | SUN ZhongGuo LIANG YangYang XI Guang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，8： | 1 |
| 8 | Numerical simulation of the flow in straight blade agitator with the MPS method显示文摘 | SUN Zhongguo LIANG Yangyang XI Guang | 2011 | International Journal for Numerical Methods in Fluids2011，67，12： | 1 |
| 9 | Targeting iron metabolism using gallium nanoparticles to suppress ferroptosis and effectively mitigate acute kidney injury显示文摘Ferroptosis plays a critical pathophysiological role in several types of acute kidney injury(AKI).The development of nanomaterials targeting iron metabolism and ferroptosis is a promising approach for AKI treatment.Herein,we synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles(GGP NPs)as a potential iron-scavenging agent because of their nearly ionic radius and chemical similarity with iron.The results indicated that GGP NPs accumulated in tubular epithelial cells and showed good biocompatibility.GGP NPs significantly inhibited cisplatin(CP)-induced ferroptosis in HK-2 cells by reducing the accumulation of intracellular free iron and mitochondrial dysfunction,and suppressing the perturbations of ferroptosis processes,including lipid peroxidation,nicotinamide adenine dinucleotide phosphate(NADPH)and glutathione(GSH)levels,glutathione peroxidase 4(GPX4)activity,and ferritinophagy.An in vivo study demonstrated that treatment with GGP NPs significantly ameliorated the renal tubular injury and mitochondrial damage induced by CP treatment or ischemia-reperfusion injury.Our study suggests that GGP NPs may be an effective and promising candidate for AKI treatment and enable potential clinical translation. | Xishao Xie Yunjing Zhang Xinwan Su Junni Wang Xi Yao Dou Lv Qin Zhou Jianhua Mao Jianghua Chen Fei Han Yangyang Li Weiqiang Lin | 2022 | Nano Research2022，15，7： | 0 |
| 10 | Accurate quantification of 3'-terminal 2'-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR显示文摘The continuing discoveries of novel classes of RNA modifications in various organisms have raised the need for improving sensitive,convenient,and reliable methods for quantifying RNA modifications.In particular,a subset of small RNAs,including microRNAs(miRNAs)and Piwi-interacting RNAs(piRNAs),are modified at their 3'-terminal nucleotides via 2'-0-methylation.However,quantifying the levels of these small RNAs is difficult because 2'-0-methylation at the RNA 3'-terminus inhibits the activity of polyadenylate polymerase and T4 RNA ligase.These two enzymes are indispensable for RNA labeling or ligation in conventional miRNA quantification assays.In this study,we profiled 3'-terminal 2'-0-methyl plant miRNAs in the livers of rice-fed mice by oxidative deep sequencing and detected increasing amounts of plant miRNAs with prolonged oxidation treatment.We further compared the efficiency of stem-loop and poly(A)-tailed RT-qPCR in quantifying plant miRNAs in animal tissues and identified stem-loop RT-qPCR as the only suitable approach.Likewise,stem-loop RT-qPCR was superior to poly(A)-tailed RT-qPCR in quantifying 3'-terminal 2'-0-methyl piRNAs in human seminal plasma.In summary,this study established a standard procedure for quantifying the levels of 3'-terminal 2'-0-methyl miRNAs in plants and piRNAs.Accurate measurement of the 3'-terminal 2'-0-methylation of small RNAs has profound implications for understanding their pathophysiologic roles in biological systems. | Yan Kong Huanhuan Hu Yangyang Shan Zhen Zhou Ke Zen Yulu Sun Rong Yang Zheng Fu Xi Chen | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 11 | 用一颗温暖的心告别癌症病痛——武汉同济医院2010年暖心联欢会(英文)显示文摘On January 14th,2010,the 2010 year's heart-warming party was held in the Tongji Cancer Center of Wuhan Tongji Hospital. | Yi Cheng Qiaoli Peng(Photo) Xi Yang(Photo) Yangyang Yu(Photo) | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，2： | 0 |
| 12 | Study on Air-Purifying Performance of Semi-Flexible Asphalt Samples Coated with Titanium Dioxide Using Different Methods显示文摘Titanium dioxide(TiO_(2))was recently employed to apply onto road surfaces to degrade the harmful compounds from vehicle emissions.However,it remains a challenging task to find a highly compatible pavement type for TiO_(2)application to achieve durable and efficient air-purifying performance.This study proposed to coat TiO_(2)particles onto semi-flexible pavement surface and tried to investigate an optimum coating method.Three coating methods,including direct mixing TiO_(2)(MT)with asphalt mixture,spraying dry TiO_(2)(ST)coating and watersolution-based TiO_(2)(WT)coating on semi-flexible pavement surface.To achieve this objective,semi-flexible samples were prepared to evaluate and compare the performances of three coating methods by employing resistance to wearing,NO removal efficiency tests and residual texture depth tests.It was found that the ST method not only provided better NO degrading efficiency but also improved the resistance to wearing than the other two methods. | Shoujing Yan Yangyang Wang Fengxia Chi Xue Luo Tianjie Zhang Chenchen Xi | 2022 | Journal of Renewable Materials2022，10，5： | 0 |
| 13 | Efficient enzymatic synthesis of(S)-1-(30-bromo-20-methoxyphenyl)ethanol,the key building block of lusutrombopag显示文摘(S)-1-(30-Bromo-20-methoxyphenyl)ethanol((S)-1b)is the key precursor for the synthesis of Lusutrombopag.The bioreduction of 1-(30-bromo-20-methoxyphenyl)ethanone(1a)offers an attractive method to access this important compound.Through screening the available carbonyl reductases,we obtained a carbonyl reductase from Novosphingobium aromaticivorans(CBR),which could completely convert 100 g/L of 1a to(S)-1b.Furthermore,a carbonyl reductase from Novosphingobium sp.Leaf2(NoCR)was identified to completely convert 200 g/L of 1a to(S)-1b with excellent enantioselectivity(>99%ee)and 77%isolated yield using FDH/formate system for NADH regeneration.The K_(m) and k_(cat) of recombinant NoCR towards 1a were 0.66 mmol/L and 7.5 s-1,and the catalytic efficiency k_(cat)/K_(m) was 11.3 mmol/s.L.Meanwhile,NoCR showed high catalytic activity and stereoselectivity towards acetophenone derivatives with halogen or methoxy substitution on the benzene ring,indicating that NoCR is a valuable biocatalyst with potential practical applications. | Yunfeng Cui Yangyang Ji Xi Chen Jianjiong Li Jinhui Feng Qing Zhao Peiyuan Yao Qiaqing Wu Dunming Zhu | 2023 | Green Synthesis and Catalysis2023，4，3： | 0 |
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