|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prediction of pathological nodal stage of locally advanced rectal cancer by collective features of multiple lymph nodes in magnetic resonance images before and after neoadjuvant chemoradiotherapy显示文摘Objective:To predict pathological nodal stage of locally advanced rectal cancer by a radiomic method that uses collective features of multiple lymph nodes(LNs)in magnetic resonance images before and after neoadjuvant chemoradiotherapy(NCRT).Methods:A total of 215 patients were included in this study and chronologically divided into the discovery cohort(n=143)and validation cohort(n=72).In total,2,931 pre-NCRT LNs and 1,520 post-NCRT LNs were delineated from all visible rectal LNs in magnetic resonance images.Geometric,first-order and texture features were extracted from each LN before and after NCRT.Collective features are defined as the maximum,minimum,mean,median value and standard deviation of each feature from all delineated LNs of each participant.LN-model is constructed from collective LN features by logistic regression model with L1 regularization to predict pathological nodal stage(ypN0 or ypN+).Tumor-model is constructed from tumor features for comparison by using DeLong test.Results:The LN-model selects 7 features from 412 LN features,and the tumor-model selects 7 features from 82 tumor features.The area under the receiver operating characteristic curve(AUC)of LN-model in the discovery cohort is 0.818[95%confidence interval(95%CI):0.745-0.878],significantly(Z=2.09,P=0.037)larger than 0.685(95%CI:0.602-0.760)of the tumor-model.The AUC of LN-model in validation cohort is 0.812(95%CI:0.703-0.895),significantly(Z=3.106,P=0.002)larger than 0.517(95%CI:0.396-0.636)of the tumor-model.Conclusions:The usage of collective features from all visible rectal LNs performs better than the usage of tumor features for the prediction of pathological nodal stage of locally advanced rectal cancer. | Haitao Zhu Xiaoyan Zhang Xiaoting Li Yanjie Shi Huici Zhu Yingshi Sun | 2019 | Chinese Journal of Cancer Research2019，31，6： | 13 |
| 2 | 4 K high frequency pulse tube cryocooler used for terahertz space application显示文摘Terahertz(THz) frequency region, defined from0.1 to 10 THz, is an important frequency band for radio astronomy and atmospheric science. As NbN Superconductor-Insulator-Superconductor(SIS) mixers used for terahertz detection, which are studied by the Purple Mountain Observatory(PMO), Chinese Academy of Sciences(CAS), work at 8–10 K, and require condition of micro vibrations, its astronomical observation in aerospace is limited by suitable refrigeration method. 4 K high frequency pulse tube cryocooler developed by Key Laboratory of Space Energy Conversion Technologies(SECT), Technical Institute of Physics and Chemistry(TIPC), CAS, offers an opportunity for the application of SIS mixers. This article introduces the progress of the two-stage high frequency pulse tube cryocooler researched by TIPC. The cryocooler has reached a no load temperature of 4.5 K which is the lowest temperature for this kind of cryocooler reported so far. The successful coupling between the THz component and the high frequency pulse tube cryocooler lays a solid foundation for space detection in the terahertz band. | Jia Quan Yanjie Liu Dong Liu Kun Zhang Jingtao Liang Jing Li Qijun Yao Shengcai Shi | 2014 | Chinese Science Bulletin2014，59，27： | 12 |
| 3 | MYB56 Encoding a R2R3 MYB Transcription Factor Regulates Seed Size in Arabidopsis thaliana显示文摘Plant seed size is tightly regulated by the development of seed coat,embryo,and endosperm;however,currently,its underlying mechanism remains unclear.In this study,we revealed a regulatory role of an R2R3 MYB transcription factor MYB56 in controlling seed size specifcally in Arabidopsis thaliana L.Loss-of-function or knock-down of MYB56 yielded smaller seeds as compared with the wild type.Conversely,overexpression of MYB56 produced larger seeds.Further observation using semi-thin sections showed that myb56 developed smaller contracted endothelial cells and reduced cell number in the outer integument layer of the seed coat during the seed development;by contrast,MYB56 overexpressing lines had expanded endothelial cells and increased cell number in the outer integument layer of the seed coat,suggesting the essential role of MYB56 in regulating seed development.In addition,reciprocal cross-analysis showed that MYB56 affected the seed development maternally.MYB56 was shown to be dominantly expressed in developing seeds,consistently with its function in seed development.Moreover,quantitative reverse transcription polymerase chain reaction analysis revealed that MYB56 regulates the expression of genes involved in cell wall metabolism such as cell division and expansion.Altogether,our results demonstrated that MYB56 represents an unknown pathway for positively controlling the seed size. | Yanjie Zhang Wanqi Liang Jianxin Shi Jie Xu Dabing Zhang | 2013 | Journal of Integrative Plant Biology2013，55，11： | 8 |
| 4 | A Novel Artificial Neuron-Like Gas Sensor Constructed from CuS Quantum Dots/Bi2S3 Nanosheets显示文摘Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental monitoring.Gas sensors based on conventional bulk materials often suffer from their poor surface-sensitive sites,leading to a very low gas adsorption ability.Moreover,the charge transportation efficiency is usually inhibited by the low defect density of surface-sensitive area than that in the interior.In this work,a gas sensing structure model based on CuS quantum dots/Bi_(2)S_(3) nanosheets(CuS QDs/Bi_(2)S_(3) NSs)inspired by artificial neuron network is constructed.Simulation analysis by density functional calculation revealed that CuS QDs and Bi_(2)S_(3) NSs can be used as the main adsorption sites and charge transport pathways,respectively.Thus,the high-sensitivity sensing of NO_(2) can be realized by designing the artificial neuron-like sensor.The experimental results showed that the CuS QDs with a size of about 8 nm are highly adsorbable,which can enhance the NO_(2) sensitivity due to the rich sensitive sites and quantum size effect.The Bi_(2)S_(3) NSs can be used as a charge transfer network channel to achieve efficient charge collection and transmission.The neuron-like sensor that simulates biological smell shows a significantly enhanced response value(3.4),excellent responsiveness(18 s)and recovery rate(338 s),low theoretical detection limit of 78 ppb,and excellent selectivity for NO_(2).Furthermore,the developed wearable device can also realize the visual detection of NO2 through real-time signal changes. | Xinwei Chen Tao Wang Jia Shi Wen Lv Yutong Han Min Zeng Jianhua Yang Nantao Hu Yanjie Su Hao Wei Zhihua Zhou Zhi Yang Yafei Zhang | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 5 | Health risk assessments of polycyclic aromatic hydrocarbons and chlorinated/brominated polycyclic aromatic hydrocarbons in urban air particles in a haze frequent area in China显示文摘The potential threats of polycyclic aromatic hydrocarbons(PAHs)and chlorinated/brominated PAHs(Cl/Br-PAHs)to human health from particulate matter in the urban ambient air were studied using human health risk assessments.The risk to human health caused by exposure to PAHs was evaluated in Shijiazhuang,China,from January to December 2018.The PAHs concentration range was 16.02e475.21 ng/m3 and the toxic equivalent was 13.605 ng/m3.For adults,the average carcinogenic risk caused by respiratory exposure was 5.163×10^-6 and the resulting loss of life expectancy was 32.10 min.The human health risks of respiratory exposure to Cl/Br-PAHs in atmospheric samples from the Haidian District,Beijing,China,were evaluated from November 2017 to July 2018.The concentration ranges for the Cl-and Br-PAHs were 60.38e482.17 pg/m3 and 1.32e25.35 pg/m3,respectively.The average carcinogenic equivalent concentrations were 0.3274 pg/m3 and 0.0061 pg/m3 for the Cl-and Br-PAHs,respectively.For adults the average carcinogenic risks caused by respiratory exposure were 1.243×10^-10 and 2.316×10^-12 for the Cl-and Br-PAHs,respectively.The resulting loss of life expectancy values were 0.001 min(Cl-PAHs)and 0.00 min(Br-PAHs).The pollution concentrations and toxic equivalents of the Cl/Br-PAHs in Beijing and of the PAHs in Shijiazhuang both showed toxicity was high in the winter.The average carcinogenic risk for exposure of adults to PAHs in Shijiazhuang was low with certain potential hazards.The concentration of Cl-PAHs in Beijing was higher than that of Br-PAHs,and the average carcinogenic risk for exposure of adults to Cl/Br-PAHs was very low with slight harm. | Miwei Shi Rongzhi Zhang Yunxia Wang Yan Zhang Yuan Zhang Yanjie Zhang | 2020 | Emerging Contaminants2020，6，1： | 2 |
| 6 | Structure and preparation of octenyl succinic esters of granular starch, microporous starch and soluble maltodexlrin 显示文摘 | Bai Yanjie Shi Yongcheng | 2011 | Carbohydrate Polymers2011，83，： | 1 |
| 7 | Structure and preparation of octenyl succinic esters of granular starch,microporous starchand solublemaltodextrin显示文摘 | BAI Yanjie SHI Yongcheng | | 0，，02： | 1 |
| 8 | Study of octenyl succinic anhydride modified waxy maize starch by nuclear magnetic resonance spectroscopy显示文摘 | BAI Yanjie SHI Yongcheng HERRERA A | | 0，，02： | 1 |
| 9 | Structure and preparation ofoctenyl succinic esters of granular starch, microporous starchand soluble maltodextrin 显示文摘 | Yanjie Bai Yong-Cheng Shi | 2011 | Carbohydrate Polymers2011，，83： | 1 |
| 10 | Structure and preparation of octenyl succinic esters of granular starch, microporous starch and soluble mahodextrin显示文摘 | Yanjie Bai Yong-Cheng Shi | 2011 | Carbohydrate Polymers2011，，83： | 1 |
| 11 | Structure and preparation of octenyl succinic esters of granular starch,microporous starch and soluble mahodextrin显示文摘 | Yanjie Bai Yong-Cheng Shi | 2011 | Carbohydrate Polymers2011，，： | 1 |
| 12 | Construction of oxygen-vacancies-rich S-scheme BaTiO_(3)/red phosphorous heterojunction for enhanced photocatalytic activity显示文摘The S-scheme heterojunctions can effectively separate photogenerated electrons and holes,retain their high redox capacity,and provide great prospects for enhancing the photocatalytic activity of the composites in different fields.Herein,S-scheme heterojunction photocatalytic materials were rationally designed and prepared by a simple hydrothermal method between narrow-bandgap red phosphorus(HRP)and wide-bandgap BaTiO_(3)(BTO)photocatalysts.Owing to the effective charge separation and redox ability from the S-scheme mechanism and oxygen vacancies,BTO/HRP exhibited good photoelectrochemical and photocatalytic degradation ability.Systematic photoreaction tests demonstrated that BTO/HRP had high practicality in the removal of pollutants from wastewater;its photodegradation rate of Rhodamine B reached 3.029×10^(−1) min^(−1) in 12 min;and it could inactivate 1.8×10^(9) CFU/mL of Escherichia.coli in 1 h,with an antibacterial rate of 99.8%.This paper provided a promising photocatalyst for pollutant removal and a new strategy for the fabrication of efficient RP-based photocatalytic materials. | Yuhua Ma Xiadiye Aihemaiti Kezhen Qi Shiyin Wang Yanjie Shi Zhuanhu Wang Minghe Gao Fuhe Gai Yulian Qiu | 2023 | Journal of Materials Science & Technology2023，，25： | 1 |
| 13 | Deep learning model improves radiologists'performance in detection and classification of breast lesions显示文摘Objective:Computer-aided diagnosis using deep learning algorithms has been initially applied in the field of mammography,but there is no large-scale clinical application.Methods:This study proposed to develop and verify an artificial intelligence model based on mammography.Firstly,mammograms retrospectively collected from six centers were randomized to a training dataset and a validation dataset for establishing the model.Secondly,the model was tested by comparing 12 radiologists’performance with and without it.Finally,prospectively enrolled women with mammograms from six centers were diagnosed by radiologists with the model.The detection and diagnostic capabilities were evaluated using the freeresponse receiver operating characteristic(FROC)curve and ROC curve.Results:The sensitivity of model for detecting lesions after matching was 0.908 for false positive rate of 0.25 in unilateral images.The area under ROC curve(AUC)to distinguish the benign lesions from malignant lesions was0.855[95%confidence interval(95%CI):0.830,0.880].The performance of 12 radiologists with the model was higher than that of radiologists alone(AUC:0.852 vs.0.805,P=0.005).The mean reading time of with the model was shorter than that of reading alone(80.18 s vs.62.28 s,P=0.032).In prospective application,the sensitivity of detection reached 0.887 at false positive rate of 0.25;the AUC of radiologists with the model was 0.983(95%CI:0.978,0.988),with sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of94.36%,98.07%,87.76%,and 99.09%,respectively.Conclusions:The artificial intelligence model exhibits high accuracy for detecting and diagnosing breast lesions,improves diagnostic accuracy and saves time. | Yingshi Sun Yuhong Qu Dong Wang Yi Li Lin Ye Jingbo Du Bing Xu Baoqing Li Xiaoting Li Kexin Zhang Yanjie Shi Ruijia Sun Yichuan Wang Rong Long Dengbo Chen Haijiao Li Liwei Wang Min Cao | 2021 | Chinese Journal of Cancer Research2021，33，6： | 1 |
| 14 | Resonance and Bifurcation of Fractional Nonlinear Systems with Power Damping Term for Robot Grinding显示文摘A fractional nonlinear system with power damping term is introduced to study the forced vibration system in order to solve the resonance and bifurcation problems between grinding wheel and steel bar during robot grinding.The robot,grinding wheel and steel bar are reduced to a spring-damping second-order system model.The implicit function equations of vibration amplitude of the dynamic system with coulomb friction damping,linear damping,square damping and cubic damping are obtained by average method.The stability of the system is analyzed and explained,and the stability condition of the system is proposed.Then,the amplitude-frequency characteristic curves of the system under different fractional differential orders,nonlinear stiffness parameters,fractional differential term coefficients and external excitation amplitude are analyzed.It is shown that the fractional differential term in the dynamic system is the damping characteristic.Then the influence of four kinds of damping on the vibration amplitude of the system under the same parameter is investigated and it is proved that the cubic damping suppresses the vibration of the system to the maximum extent.Finally,based on the idea that the equilibrium point of the system is the constant part of the Fourier series expansion term,the bifurcation behavior caused by the change of damping parameters in linear damping,square damping and cubic damping systems with different values of fractional differential order is investigated. | Wei Shi Qingxue Huang Jinzhu Zhang Tao Wang Ziliang Li Yanjie Zhang Xiaoyan Xiong | 2023 | Journal of Beijing Institute of Technology2023，32，1： | 0 |
| 15 | Tropical Timber Trade Flows in P.R. China显示文摘The historical transition of timber distribution pattern in China was presented firstly with main parts of timber flows in China,which included timber markets,timber transport system and regulations of timber transport.Based on the overview on tropical timber flows in China,the trade flows of tropical timber from production and imports of tropical timber to export of tropical timber products were analyzed by vivid illustrations.At the same time,problems in timber trade flows in China were analysed in the end. | HU Yanjie LIN Fengming SHI Kunshan | 2007 | Chinese Forestry Science and Technology2007，6，2： | 0 |
| 16 | Large cell neuroendocrine carcinoma transformation:A novel acquired drug resistance mechanism in colorectal adenocarcinoma显示文摘Acquired resistance is a major problem limiting the clinical efficacy of treatments for metastatic colorectal cancer(mCRC).Histological transformation is an important mechanism underlying the acquired resistance of non-small cell lung cancer and prostate cancer to targeted therapy.However,no report has examined the role of histological transformation in mCRC.Here,we report the first case of histologically transformed large cell neuroendocrine carcinoma from primary colon adenocarcinoma during antiangiogenesis and anti-PD-1 combination therapy.The histologic conversion was confirmed by the observation that the transformed large cell neuroendocrine carcinoma lesion retained the original mutational signature found in the primary tumor.Sequential tumor biopsy and dynamic changes in tumor markers demonstrated the transformed process.The histological transformation not only resulted in discordant responses to the same treatment but also significantly shortened overall survival.This case calls for more attention to histological transformation in mCRC.Tumor rebiopsy upon disease progression and monitoring dynamic changes in tumor markers would help to identify such cases. | Feng Du Ying Han Xiao Hu Yanjie Xiao Youwu Shi Jing Sun Zhiwei Sun Ying Yang Jing Yu Xiaodong Zhang Jun Jia | 2023 | Cancer Innovation2023，2，2： | 0 |
| 17 | Multi-frequency magnetic resonance elastography of the pancreas:measurement reproducibility and variance among healthy volunteers显示文摘Background Patients with chronic pancreatitis often have irreversible pancreatic insufficiency before a clinical diagnosis.Pancreatic cancer is a fatal malignant tumor in the advanced stages.Patients having high risk of pancreatic diseases must be screened early to obtain better outcomes using new imaging modalities.Therefore,this study aimed to investigate the reproducibility of tomoelastography measurements for assessing pancreatic stiffness and fluidity and the variance among healthy volunteers.Methods Forty-seven healthy volunteers were prospectively enrolled and underwent two tomoelastography examinations at a mean interval of 7 days.Two radiologists blindly and independently measured the pancreatic stiffness and fluidity at the first examination to determine the reproducibility between readers.One radiologist measured the adjacent pancreatic slice at the first examination to determine the reproducibility among slices and measured the pancreas at the second examination to determine short-termrepeatability.The stiffness and fluidity of the pancreatic head,body,and tail were compared to determine anatomical differences.The pancreatic stiffness and fluidity were compared based on sex,age,and body mass index(BMI).Results Bland–Altman analyses(all P>0.05)and intraclass correlation coefficients(all>0.9)indicated near perfect reproducibility among readers,slices,and examinations at short intervals.Neither stiffness(P=0.477)nor fluidity(P=0.368)differed among the pancreatic anatomical regions.The mean pancreatic stiffness was 1.45±0.09 m/s;the mean pancreatic fluidity was 0.83±0.06 rad.Stiffness and fluidity did not differ by sex,age,or BMI.Conclusion Tomoelastography is a promising and reproducible tool for assessing pancreatic stiffness and fluidity in healthy volunteers. | Si-Ya Shi Liqin Wang Zhenpeng Peng Yangdi Wang Zhi Lin Xuefang Hu Jiaxin Yuan Li Huang Shi-Ting Feng Yanji Luo | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 18 | Effects of in-situZrB_2 nanoparticles and scandium on microstructure and mechanical property of 7N01 aluminum alloy显示文摘In this study, the in-situ synthesized ZrB_(2) nanoparticles and rare earth Sc were introduced to enhance the strength and ductility of 7N01 aluminum alloy, via the generation of high-melting and uniform nanodispersoids. The microstructure and mechanical property evolution of the prepared composites and the interaction between ZrB_(2) and Sc were studied in detail. The microstructure investigation shows that the introduction of rare earth scandium(Sc) can promote the distribution of ZrB_(2) nanoparticles, by improving their wettability to the Al melt. Meanwhile, the addition of rare earth Sc also modifies the coarse Al Zn Mg Mn Fe precipitated phases, refines the matrix grains and generates high-melting Al_3(Sc,Zr)/Al_3Sc nanodispersoids. Tensile tests of the composites show that with the combinatorial introduction of ZrB_(2) and Sc, the strength and ductility of the composites are improved simultaneously compared with the corresponding 7N01 alloy, ZrB_(2) /7N01 composite and Sc/7N01 alloy. And the optimum contents of ZrB_(2) and Sc are 3 wt% and 0.2 wt% in this study. The yield strength, ultimate strength and elongation of(3 wt% ZrB_(2) +0.2 wt% Sc)/7N01 composite are 477 MPa, 506 MPa and 9.8%, increased about 18.1%, 12.2%and 38% compared to 7N01 alloy. Furthermore, the cooperation strengthening mechanisms of ZrB_(2) and Sc are also discussed. | Xizhou Kai Yuhui Wang Ruikun Chen Yanjie Peng Anjun Shi Ran Tao Xiangfeng Liang Guirong Li Gang Chen Xiaojing Xu Yutao Zhao | 2024 | Journal of Rare Earths2024，42，3： | 0 |
| 19 | Analysis of Seed Phenotypic and Metabolic Characteristics of Diploid and Tetraploid Tartary Buckwheat显示文摘Polyploid plants grow well,are stress tolerant,and are rich in nutrients and bioactive compounds.Thus,they are useful for improving crop quality and yield.In this study,we compared the seed characteristics and metabolite profiles of diploid and tetraploid tartary buckwheat,which was developed via an artificially induced chromosome doubling event.The length,width,area,and thousand-grain weight were greater for the tetraploid seeds than for the diploid seeds.However,the germination rate decreased for the tetraploid seeds.Additionally,there was a gap between the shell and kernel of the tetraploid seeds.Moreover,the water absorption rate was higher for the tetraploid than for the diploid seeds.Chromosome doubling increased the seed total flavonoid content and deepened the seed color.A principal component analysis of the ultrahigh-pressure liquid chromatography-high resolution mass spectrometry data revealed the clear separation between the diploid and tetraploid samples.An orthogonal partial least squares-discriminant analysis and other multivariate statistical analyses identified 83 differentially abundant compounds,with most of the flavonoid metabolites more abundant in the tetraploid than in the diploid seeds.Research on tartary buckwheat polyploidy may result in enhanced germplasm resources and may clarify the mechanism underlying the biosynthesis of bioactive compounds. | Xiaodong Shi Cong Wang Wenjian Li Hanlei Xiao Yanjie Li Bei Niu | 2022 | Phyton-International Journal of Experimental Botany2022，91，9： | 0 |
| 20 | Simultaneous bottom-up double-layer synergistic engineering by multifunctional natural molecules for efficient and stable SnO2-based planar perovskite solar cells显示文摘The performance and stability of perovskite solar cells(PSCs)is limited by detrimental defects,mostly distributed at the grain boundary(GB)of bulk perovskite film and interface,which induce serious carrier non-radiative recombination.Therefore,there is particularly urgent to realize simultaneous passivation of bulk defects and interfacial defects.In this work,a simple,low-cost and effective multifunctional modification strategy is developed by introducing theλ-Carrageenan(λ-C)as the interfacial layer of SnO_(2)/perovskite.The sulfate groups ofλ-C not only play a positive role in passivating the Sn4+from SnO_(2)film,resulting in high conductivity,but also effectively passivate the defects at the SnO_(2)/perovskite interface.Meanwhile,λ-C can effectively passivate the defects in the perovskite film due to the strong binding force between the high content of sulfate groups and PbI2.The synergistic effect ofλ-C simultaneously achieves interfacial defects and bulk defects passivation,better crystalline quality,suppressed charge recombination,released interfacial stress and more favorable interfacial energy level alignment.Based on the above efficient synergy,theλ-C-modified device achieves a high efficiency of 23.81%,which is~24.53%higher than the control device(19.12%).To our best knowledge,23.81%of power conversion efficiency(PCE)is the highest reported PCE value of PSCs employing green natural additives.Moreover,long-term and thermal stabilities are significantly improved after interface modification.Thus,this work provides an idea for developing multifunctional natural materials towards the attainment of the efficient and stable PSCs. | Yue Liu Yanbo Gao Tingting Li Xinyu Bao Zehua Xu Fujun Zhang Min Lu Zhennan Wu Yanjie Wu Guang Sun Xue Bai Zhifeng Shi Junhua Hu Yu Zhang | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员