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| 1 | Effects of Parental Migration on Mental Health of Left-behind Children: Evidence from Northwestern China显示文摘瓷器快速的开发和都市化劝诱了大量农村居民寻找更高的工资在农村从他们的家移居到城市的区域。有超过 6000 万 “left-behind children” ,这被估计(LBC ) 在他们的父母移居以后,留在农村,典型地与代理人 caregivers 住在一起。广泛的研究在孩子上集中了于父母外面迁居的影响心理健康,而是更少的注意被付了到父母回来迁居的效果。在第四和第五的父母分级学生外面移居或回来移居前后,现在的论文处于心理健康检验变化。我们在 252 所农村小学的超过 19000 个学生的作者在西北的中国收集的面板数据集上绘画。使用做了并且倾向分数匹配途径,我们的结果显示父母外面迁居在 LBC 的心理健康上有重要否定影响,,他们趋于展出焦虑的高水平和自尊的底层。然而,我们发现父母回来迁居没在 LBC 的心理健康上有重要效果。 | Yaojiang Shi Yu Bai Yanni Shen, Kaleigh Kenny Scott Rozelle | 2016 | China & World Economy2016，24，3： | 8 |
| 2 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 3 | POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation显示文摘Sterol-regulatory element binding proteins(SREBPs)are the key transcriptional regulators of lipid metabolism.The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi,where it is sequentially cleaved by site-1 protease(S1P)and site-2 protease and releases a nuclear form to modulate gene expression.To search for new genes regulating cholesterol metabolism,we perform a genome-wide CRISPR/Cas9 knockout screen and find that partner of site-1 protease(POSH),encoded by C120RF49,is critically involved in the SREBP signaling.Ablation of POSH decreases the generation of nuclear SREBP and reduces the expression of SREBP target genes.POSH binds S1P,which is synthesized as an inactive protease(form A)and becomes fully mature via a two-step autocatalytic process involving forms B/B and C/C.POSH promotes the generation of the functional S1P-C/C from S1P-B/B(canonical cleavage)and,notably,from S1P-A directly(non-canonical cleavage)as well.This POSH-mediated S1P activation is also essential for the cleavages of other S1P substrates including ATF6,CREB3 family members and the a/p-subunit precursor of N-acetylglucosamine-1-phospho-transferase.Together,we demonstrate that POSH is a cofactor controlling S1P maturation and plays important roles in lipid homeostasis,unfolded protein response,lipoprotein metabolism and lysosome biogenesis. | Jian Xiao Yanni Xiong Liu-Ting Yang Ju-Qiong Wang Zi-Mu Zhou Le-Wei Dong Xiong-Jie Shi Xiaolu Zhao Jie Luo Bao-Liang Song | 2021 | Protein & Cell2021，12，4： | 3 |
| 4 | Regioisomerism effect(RIE) on optimizing ultralong organic phosphorescence lifetimes显示文摘Organic phosphorescence materials demonstrate potential optoelectronic applications due to their remarkably ultralong organic phosphorescence(UOP)lifetime and abundant optical characteristics prior to the fluorescence materials.For a better insight into the intrinsic relationship among regioisomeric molecules,crystalline interactions,and phosphorescence properties,three crystalline dicarbazol-9-yl pyrazine-based regioisomers with para-,meta-and ortho-convergent substitutions(p-DCzP,m-DCzP,and o-DCzP)were designed and presented gradually increased UOP lifetimes prolonging from 63.14,127.93 to 350.46 ms,respectively,due to the regioisomerism effect(RIE)which would be an effective strategy for better understanding of structure-property of UOP materials. | Yanni Zhang Jianfeng Zhao Caixia Zhu Lifang Bian Huifang Shi Shiming Zhang Huili Ma Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 5 | Enhanced inhibition of talc flotation using acidified sodium silicate and sodium carboxymethyl cellulose as the combined inhibitor显示文摘The flotation separation of chalcopyrite and talc is challenging due to their similar natural floatability characteristics.Besides,it is usually difficult to effectively inhibit talc by adding sodium carboxymethyl cellulose(CMC)alone during chalcopyrite flotation.Here,a combined inhibitor comprising acidified sodium silicate(ASS)and CMC was employed to realize effective flotation separation of chalcopyrite and talc,and the combined inhibition mechanism was further investigated.Microflotation results showed that adding ASS strengthened the inhibitory effect of CMC on talc and improved the separation of chalcopyrite and talc.The zeta potential,Fourier transform infrared,and X-ray photoelectron spectroscopy analysis indicated that CMC was mainly adsorbed on the talc surface via hydroxyl and carboxyl groups.Moreover,the addition of ASS improved the adsorption of carboxyl groups.Furthermore,the adsorption experiments and apparent viscosity measurements revealed that adding ASS dispersed the pulp well,which reduced the apparent viscosity,improved the adsorption amount of CMC on the talc surface,and enhanced the inhibition of talc in chalcopyrite flotation. | Jiwei Xue Huazhen Tu Jin Shi Yanni An He Wan Xianzhong Bu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，7： | 1 |
| 6 | Estimating the time interval between transmission generations and the presymptomatic period by contact tracing surveillance data from 31 provinces in the mainland of China显示文摘The global pandemic of 2019 coronavirus disease(COVID-19)is a great assault to public health.Presymptomatic transmission cannot be controlled with measures designed for symptomatic persons,such as isolation.This study aimed to estimate the interval of the transmission generation(TG)and the presymptomatic period of COVID-19,and compare the ftting effects of TG and serial interval(S)based on the SEIHR model incorporating the surveillance data of 3453 cases in 31 provinces.These data were allocated into three distributions and the value of AIC presented that the Weibull distribution fitted well.The mean of TG was 5.2 days(95%C:4.6-5.8).The mean of the presymptomatic period was 2.4 days(95%CI:1.5-3.2).The dynamic model using TG as the generation time performed well.Eight provinces exhibited a basic reproduction number from 2.16 to 3.14.Measures should be taken to control presymptomatic transmission in the COVID-19 pandemic. | Zhongxing Ding Kai Wang Mingwang Shen Kai Wang Shi Zhao Wenyu Song Rui Li Zhongjie Li Liping Wang Ganzhu Feng Zhiliang Hu Hongxia Wei Yanni Xiao Changjun Bao Jianli Hu Liguo Zhu Yong Li Xufeng Chen Yi Yin Weiming Wang Yongli Cai Zhihang Peng Hongbing Shen | 2021 | Fundamental Research2021，1，2： | 1 |
| 7 | Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo显示文摘Neutralizing monoclonal antibodies(mAb)are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection.The continuous emergence of new SARS-CoV-2 variants worldwide has increased the urgency for the development of new mAbs.In this study,we immunized mice with the receptor-binding domain(RBD)of the SARS-CoV-2 prototypic strain(WIV04)and screened 35 RBDspecific mAbs using hybridoma technology.Results of the plaque reduction neutralization test showed that 25 of the mAbs neutralized authentic WIV04 strain infection.The 25 mAbs were divided into three categories based on the competitive enzyme-linked immunosorbent assay results.A representative mAb was selected from each category(RD4,RD10,and RD14)to determine the binding kinetics and median inhibitory concentration(IC_(50))of WIV04 and two variants of concern(VOC):B.1.351(Beta)and B.1.617.2(Delta).RD4 neutralized the B.1.617.2 variant with an IC50 of 2.67 ng/mL;however,it completely lost neutralizing activity against the B.1.351 variant.RD10 neutralized both variants with an IC50 exceeding 100 ng/mL;whereas RD14 neutralized two variants with a higher IC50(>1 mg/mL).Animal experiments were performed to evaluate the protective effects of RD4 and RD10 against various VOC infections.RD4 could protect Adv-hACE2 transduced mice from B.1.617.2 infection at an antibody concentration of 25 mg/kg,while RD10 could protect mice from B.1.351 infection at an antibody concentration of 75 mg/kg.These results highlight the potential for future modifications of the mAbs for practical use. | Qianran Wang Lu Peng Yanqiu Nie Yanni Shu Huajun Zhang Zidan Song Yufeng Li Hengrui Hu Liushuai Li Xi Wang Jia Liu Jiang Li Zhengli Shi Fei Deng Yu Guo Yiwu Zhou Bing Yan Zhihong Hu Manli Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 8 | Clinical characteristics,risk factors,and prognoses of fungal keratitis caused by three common fungal species in Northern China显示文摘Background:To evaluate the clinical characteristics,risk factors,and treatment outcomes of fungal keratitis(FK)caused by three common fungal species in northern China.Methods:A total of 203 cases of FK caused by Fusarium,Aspergillus or Alternaria treated at Shandong Eye Institute were included.Clinical features were analyzed in the following aspects:(I)risk factors,including physical trauma,ocular surface diseases,contact lens wear,and non-identified risk factors;(II)clinical manifestations;(III)treatment approaches and prognosis.Results:There were 151 cases of Fusarium keratitis,35 cases of Aspergillus keratitis,and 17 cases of Alternaria keratitis.Trauma(71.9%)ranked first among the risk factors for all 3 kinds of FK(P=0.015).Plant matter was most common in FK caused by Fusarium(54.1%)and Alternaria(63.6%),while grit was predominant in Aspergillus keratitis(61.5%).The main clinical manifestations were pseudopodia(74.2%in Fusarium keratitis and 64.7%in Alternaria keratitis)and hypopyon(51.4%in Aspergillus keratitis).The lesion area was less than 10 mm2 in 64.7%of Alternaria infection and more than 10 mm2 in 60.9%of Fusarium infection.Recurrence was found in Fusarium(9.9%)and Aspergillus(5.7%)keratitis,but not in Alternaria keratitis.Conclusions:FK associated with Fusarium,Aspergillus,and Alternaria seems to have various risk factors,clinical characteristics,and prognoses.Awareness of the specific differences may help to guide the clinical treatment before the results of culture and susceptibility testing are available. | Xiuxian Wang Suxia Li Yanni Jia Xiaolin Qi Weiyun Shi Hua Gao | 2020 | Annals of Eye Science2020，，4： | 0 |
| 9 | Constructing the maize inflorescence regulatory network by using efficient tsCUT&Tag assay显示文摘Maize ear development determines the crop yield,and many important transcription factors(TFs)have been identified to function in this process.However,their transcriptional regulation mechanisms are still elusive.In this study,we generated the genome-wide DNA binding sites for 8 TFs which are known to function or highly expressed in inflorescence by applying the ts CUT&Tag method in maize leaf protoplast.We exposed a regulatory grid of 4 WUSCHEL-related homeobox(WOX)genes and revealed their potential regulatory mechanisms.In addition,a hierarchical regulation network for the determinacy and specification of maize inflorescence meristems were also constructed using the binding profiles of a floral development gene INDETERMINATE FLORAL APEX1(IFA1)and 3 MADS-box genes.Our study provides an in-depth understanding and new insights of the regulatory mechanisms during maize inflorescence development. | Liang Dong Yanni Shi Pan Li Silin Zhong Yonghao Sun Fang Yang | 2023 | The Crop Journal2023，11，3： | 0 |
| 10 | Study on screening potential allergenic proteins from infant milk powders based on human mast cell membrane chromatography and histamine release assays显示文摘Cow's milk allergy is mainly observed in infants and young children. Most allergic reactions affect the skin, followed by the gastrointestinal and respiratory systems. Conventional diagnosis is based on positive allergy studies and evaluation of parameters including IgE and IgG1 levels, acute allergic skin response and anaphylactic shock reactions. We developed a cell membrane chromatographic(CMC)method based on human mast cells(HMC-1) for screening potential allergens in infant formula milk powders(IFMP). HMC-1 cell membranes were extracted and mixed with silica to prepare cell membrane chromatography columns(10 mm ? 2 mm i.d., 5 mm). Under the conditions of 0.2 mL/min flow rate and214 nm detection wavelength, human breast milk showed no retention. However, IFMP showed clear retention. The retained fractions were collected and analyzed through matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS). Four major milk proteins, i.e., α-casein, β-casein, α-lactalbumin, and β-lactoglobulin A, were identified. Furthermore, these proteins and β-lactoglobulin B showed clear retention on HMC-1/CMC columns. To test the degranulation effects of the five proteins, histamine and β-hexosaminidase release assays were carried out. All five proteins induced HMC-1 cells to release histamine and β-hexosaminidase. Also, we established a reversed phase liquid chromatographic(RPLC) method for the determination of the five proteins in IFMP and the results showed that 90% proteins in IFMP were α-casein and β-casein. We concluded that cow's milk proteins may be potential allergens and caseins cause more β-casein allergic risk than other proteins. This conclusion was consistent with other studies. | Ping Zhang Yingdi Shi Xiaoshuang He Wei Sun Yanni Lv Xiaofang Hou | 2019 | Journal of Pharmaceutical Analysis2019，9，1： | 0 |
| 11 | A Rapid and Simple Method for Quantitative Aziridination from Aminobrominated Derivatives of Olefins under Solvent-free and Mild Conditions显示文摘从石蜡的 aminohalogenation 导出的 1,2-vicinal haloamines 的催化脲的 aziridination 被开发了。这个快速、简单的方法被简单地在空中在房间温度磨底层, K2CO3 和脲的催化数量的稳固的混合执行。反应在包括的石蜡的 aminohalogenated 衍生物的一个大范围为 aziridines 的量的准备提供一个协议,不饱和的酉同类,,不饱和的酉旨和简单石蜡。包含支持 deprotonation 的 H 契约的可能的机制为这反应被建议了。 | Wei,Junfa Chen,Zhanguo Gao,Yanni Zhang,Peng Wang,Chuanning Zhao,Pengfei Wang,Yun Shi,Xianying | 2012 | Chinese Journal of Chemistry2012，30，2： | 0 |
| 12 | Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease显示文摘Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely unknown.Higher prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to ICAD.Methods Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke subtypes.Rare aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also investigated.Lastly,candidate genes were used for pathway and gene ontology enrichment analysis.Results Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of patients.Forty-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke subtypes.None of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke subtypes.Our study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of patients.Lastly,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic process.Conclusions Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients. | Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo Florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung | 2022 | Stroke & Vascular Neurology2022，7，3： | 0 |
| 13 | Regeneration and reuse of anode graphite from spent lithium-ion batteries with low greenhouse gas (GHG) emissions显示文摘Regenerating spent graphite(SG)from retired lithium-ion batteries(LIBs)can effectively avoid resource waste.However,the technology is challenged by the impurity content and energy consumption.In this study,micro-expanded graphite(MEG)was synthesized by one-step oxidation method using waste LIBs anode graphite as material and perchloric acid as intercalation and oxidant agent.Then,its performance as a LIBs anode material were investigated as well as the greenhouse gas(GHG)emissions of the whole process were calculated.Perchloric acid was successfully embedded in the SG during the reaction,which effectively removed the impurities in the graphite.Defects introduced during intercalation and delamination,such as nanopores and intercrystalline cracks.Both provide additional space for Li ions during charging and discharging,thereby promoting capacity enhancement.The prepared MEG expresses a rate capability as high as 340.32 m Ah/g at a current density of 0.1 C and still retains 81.73%of the capacity after 100 cycles at a current density of 1 C.Additionally,the GHG emissions of the synthesis process of this article and other literatures are compared.The results demonstrated that perchloric acid treatment process provides a low-carbon,time-and energy-saving approach for regenerated SG as battery grade material. | Junjie Liu Hui Shi Ke Yu Yanni Geng Xingyu Hu Genping Yi Jianzhi Zhang Xubiao Luo | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
| 14 | A cost-effective ts CUT&Tag method for profiling transcription factor binding landscape显示文摘Knowledge of the transcription factor binding landscape(TFBL)is necessary to analyze gene regulatory networks for important agronomic traits.However,a low-cost and high-throughput in vivo chromatin profiling method is still lacking in plants.Here,we developed a transient and simplified cleavage under targets and tagmentation(tsCUT&Tag)that combines transient expression of transcription factor proteins in protoplasts with a simplified CUT&Tag without nucleus extraction.Our tsCUT&Tag method provided higher data quality and signal resolution with lower sequencing depth compared with traditional ChIP-seq.Furthermore,we developed a strategy combining tsCUT&Tag with machine learning,which has great potential for profiling the TFBL across plant development. | Leiming Wu Zi Luo Yanni Shi Yizhe Jiang Ruonan Li Xinxin Miao Fang Yang Qing Li Han Zhao Jiquan Xue Shutu Xu Tifu Zhang Lin Li | 2022 | Journal of Integrative Plant Biology2022，64，11： | 0 |
| 15 | Visual abstraction of dynamic network via improved multi-class blue noise sampling显示文摘Massive sequence view (MSV) is a classic timeline-based dynamic network visualization approach. However, it is vulnerable to visual clutter caused by overlapping edges, thereby leading to unexpected misunderstanding of time-varying trends of network communications. This study presents a new edge sampling algorithm called edge-based multi-class blue noise (E-MCBN) to reduce visual clutter in MSV. Our main idea is inspired by the multi-class blue noise (MCBN) sampling algorithm, commonly used in multi-class scatterplot decluttering. First, we take a node pair as an edge class, which can be regarded as an analogy to classes in multi-class scatterplots. Second, we propose two indicators, namely, class overlap and inter-class conflict degrees, to measure the overlapping degree and mutual exclusion, respectively, between edge classes. These indicators help construct the foundation of migrating the MCBN sampling from multi-class scatterplots to dynamic network samplings. Finally, we propose three strategies to accelerate MCBN sampling and a partitioning strategy to preserve local high-density edges in the MSV. The result shows that our approach can effectively reduce visual clutters and improve the readability of MSV. Moreover, our approach can also overcome the disadvantages of the MCBN sampling (i.e., long-running and failure to preserve local high-density communication areas in MSV). This study is the first that introduces MCBN sampling into a dynamic network sampling. | Yanni PENG Xiaoping FAN Rong CHEN Ziyao YU Shi LIU Yunpeng CHEN Ying ZHAO Fangfang ZHOU | 2023 | Frontiers of Computer Science2023，17，1： | 0 |
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