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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 3 | Evaluation of Chinese tea by the electronic nose and gas chromatography–mass spectrometry: Correlation with sensory properties and classification according to grade level显示文摘 | Zihan Qin Xueli Pang Dong Chen Huan Cheng Xiaosong Hu Jihong Wu | 2013 | Food Research International2013，，： | 5 |
| 4 | Rational design of hierarchically porous Fe-N-doped carbon as efficient electrocatalyst for oxygen reduction reaction and Zn-air batteries显示文摘The rational design and construction of hierarchically porous nanostructure for oxygen reduction reaction (ORR) electrocatalysts is crucial to facilitate the exposure of accessible active sites and promote the mass/electron transfer under the gas-solid-liquid triple-phase condition. Herein, an ingenious method through the pyrolysis of creative polyvinylimidazole coordination with Zn/Fe salt precursors is developed to fabricate hierarchically porous Fe-N-doped carbon framework as efficient ORR electrocatalyst. The volatilization of Zn species combined with the nanoscale Kirkendall effect of Fe dopants during the pyrolysis build the hierarchical micro-, meso-, and macroporous nanostructure with a high specific surface area (1,586 m^(2)·g^(−1)), which provide sufficient exposed active sites and multiscale mass/charge transport channels. The optimized electrocatalyst exhibits superior ORR activity and robust stability in both alkaline and acidic electrolytes. The Zn-air battery fabricated by such attractive electrocatalyst as air cathode displays a higher peak power density than that of Pt/C-based Zn-air battery, suggesting the great potential of this electrocatalyst for Zn-air batteries. | Zihan Meng Neng Chen Shichang Cai Jiawei Wu Rui Wang Tian Tian Haolin Tang | 2021 | Nano Research2021，14，12： | 4 |
| 5 | Uplift mechanism for a shallow-buried structure in liquefi able sand subjected to seismic load: centrifuge model test and DEM modeling显示文摘Based on a centrifuge model test and distinct element method(DEM), this study provides new insights into the uplift response of a shallow-buried structure and the liquefaction mechanism for saturated sand around the structure under seismic action. In the centrifuge test, a high-speed microscopic camera was installed in the structure model, by which the movements of particles around the structure were monitored. Then, a two-dimensional digital image processing technology was used to analyze the microstructure of saturated sand during the shaking event. Herein, a numerical simulation of the centrifuge experiment was conducted using a two-phase(solid and fl uid) fully coupled distinct element code. This code incorporates a particle-fl uid coupling model by means of a 'fi xed coarse-grid' fl uid scheme in PFC3D(Particle Flow Code in Three Dimensions), with the modeling parameters partially calibrated based on earlier studies. The physical and numerical models both indicate the uplifts of the shallow-buried structure and the sharp rise in excess pore pressure. The corresponding micro-scale responses and explanations are provided. Overall, the uplift response of an underground structure and the occurrence of liquefaction in saturated sand are predicted successfully by DEM modeling. However, the dynamic responses during the shaking cannot be modeled accurately due to the restricted computer power. | Zhou Jian Wang Zihan Chen Xiaoliang Zhang Jiao | 2014 | Earthquake Engineering and Engineering Vibration2014，13，2： | 4 |
| 6 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 7 | AGRICULTURAL GREEN DEVELOPMENT TO ACHIEVE FOOD SECURITY AND CARBON REDUCTION IN THE CONTEXT OF CHINA'S DUAL CARBON GOALS显示文摘The agricultural sector,a major source of greenhouse gas emissions,and emissions from agriculture must be reduced substantially to achieve carbon(C)neutrality.Based on a literature analysis and other research results,this study investigated the effects and prospects of C reduction in agricultural systems under different scenarios(i.e.,methods and approaches)in the context of China's dual C goals,as those working in the agricultural sector have yet to reach a consensus on how to move forward.Different views,standards,and countermeasures were analyzed to provide a reference for agricultural action supporting China's C neutrality goal. | Yulong YIN Kai HE Zhong CHEN Yangyang LI Fengling REN Zihan WANG Yingcheng WANG Haiqing GONG Qichao ZHU Jianbo SHEN Xuejun LIU Zhenling CUI | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 2 |
| 8 | A green method for synthesizing novel nanoparticles and their application in flexible conductive patterns显示文摘A general and unified approach to synthesize Ag,Cu and Au nanoparticles(NPs)is developed at room temperature in air atmosphere under ultrasonication in poly(N-vinylpyrrolidone)(PVP)solutions with ascorbic acid and glucose as the reducing and nucleation agents,respectively.XRD,TEM,and HR-TEM analysis of the Ag,Cu,and Au NPs confirm purity and average diameters of 15.5±2.0 nm,50±3.0 nm,and 10±1.0 nm,respectively.An ultrasonic-assisted mechanism,wherein reduction occurs readily and produces anti-oxidation particles,is proposed and discussed.Fast infrared sintering was used to avoid damaging the substrate of conductive patterns whose resistivity at 10 W(~50℃)sintering power for less than 6 min reached up to 10±0.5 μΩ cm,40±3.0 μΩ cm,and 280±5 μΩ cm for Ag,Cu,and Au patterns,respectively.Paper-based electrodes were produced successfully and exhibited excellent flexibility and good conductivity.The potential of this method for large scale production is discussed. | Wei Li Qiongying Cen Wenjiang Li Zihan Zhao Wenlong Yang Yuqian Li Minfang Chen Guang Yang Jinjun Yang | 2020 | Journal of Materiomics2020，6，2： | 2 |
| 9 | Fabrication of nanozyme@DNA hydrogel and its application in biomedical analysis显示文摘Nanozymes 由于容易的准备和低费用的优点收到了大注意。不同于乐意地适应生理的环境的自然的酶,人工的 nanozymes 是容易的在复杂临床的样品使钝化(例如,浆液) ,它可以损坏催化能力并且因而在生物医学的分析限制申请。为了征服这个问题,在这研究,我们由把 nanozymes 合并到纯 DNA hydrogel 制作了新奇 nanozyme@DNA hydrogel 建筑学。金 nanoparticles (AuNPs ) 作为模型 nanozyme 被采用。当他们被 hydrogel 保护,结果显示在 DNA hydrogel 合并的 AuNPs 在浆液保留他们的催化能力,而 AuNPs 完全独自在浆液失去催化能力。在浆液的氢过氧化物和葡萄糖的察觉基于 AuNPs@DNA hydrogel 的催化作用被完成。分别地,各个的察觉限制到达 1.7 和 38 M 它等于用自然的酶获得的价值。除机制以外,一些另外的优点例如再循环能力和可获得性,也被探索了。这 nanozyme@DNA hydrogel 体系结构可以在复杂生理的样品为生物医学的分析象 nanozymes 的申请一样为 nanozymes 的利用有一个大潜力。 | Xiaoli Zhu Xiaoxia Mao Zihan Wang Chang Feng Guifang Chen Genxi Li | 2017 | Nano Research2017，10，3： | 2 |
| 10 | Tip-assisted ambient electric arc ionization mass spectrometry for rapid detection of trace organophosphorus pesticides in strawberry显示文摘In this study,an ambient mass spectrometry(AMS)based method was developed for rapid detection of organophosphorus pesticides in strawberry.This method combines an electric arc and a microsyringe tip to realize tip-assisted ambient electric arc ionization(TAAEAI).A high-voltage electric arc can be applied to the microsyringe tip to generate an electric field,which results in corona discharge at the microsyringe tip.The juiced strawberry sample loaded on the tip could be directly ionized with TAAEAI and then analyzed by a mass spectrometer.TAAEAI-MS was successfully applied to analyze 6 organophosphorus pesticides in three strawberry samples.Malathion and profenofos were detected from the investigated strawberry samples.This method could quantitatively determine the contents of organophosphorus pesticides in strawberry with high reproducibility,high precision,and high sensitivity.Sample matrices did not interfere with the pesticide analysis.The recoveries of organophosphorus pesticides spiked in strawberry samples varied between 82.6%and 116%with relative standard deviations(RSDs)less than 9.2%.The limits of detection(LODs)varied between 0.0124µg/g and 0.0245µg/g,while the limits of quantification(LOQs)varied between 0.0413µg/g and 0.0817µg/g.The coefficients of determination(R2)of the method were determined to be>0.995.The method established here may have potential application in the detection of organophosphorus pesticides in vegetables and fruits. | Zihan Ma Yuanji Gao Fengjian Chu Yunli Tong Yuwen He Yuan Li Zhan Gao Weiwei Chen Shuheng Zhang Yuanjiang Pan | 2022 | Chinese Chemical Letters2022，33，9： | 2 |
| 11 | Surface coal mining impacts on land use change and ecological service value:a case study in Shengli coalfield,Inner Mongolia显示文摘Coal plays a crucial role in global economic development and remains the most common and widely distributed fossil fuel worldwide.As the world's largest developing country,China's mining and utilization of coal resources have contributed signifcantly to the country’s rapid economic growth.Inner Mongolia is an ecologically fragile arid and semi-arid area of China.The exploitation of opencast mining has seriously hindered the sustainable use of regional land and the residents'well-being.Using ENVI-based remote sensing images from 2000,2005,2010,2015,and 2020,this study employed a random forest algorithm to divide land utilization types into construction land,vegetation,cultivated land,bare land,and water areas and analyzed the characteristics of land use and ecosystem service value changes over the past 20 years.The results were as follows:(1)Construction land in the mining area changed minimally from 2000 to 2020;vegetation and water bodies showed a decreasing trend,whereas bare and cultivated lands showed an increasing trend.Bare land exhibited the largest change in area proportion and water bodies the smallest.(2)The total ecosystem service value of the mining area declined from 10.939 to 9.527 billion Yuan.Vegetation ecosystem service value was the highest,followed by cultivated land and water,with the bare land ecosystem service value the lowest.(3)On a spatial scale,the total ecosystem service value of the Shengli mining area decreased year by year,indicating that land use changes in the mining area do have an impact on ecosystem service value. | Lijia Zhang Xu Zhou Yan Zhou Ji Zhou Jiwang Guo Zihan Zhai Yan Chen Xiangyan Su Lingxiao Ying Liwei Wang Ying Qiao | 2022 | International Journal of Coal Science & Technology2022，9，5： | 1 |
| 12 | Evaluation and intelligent deployment of coal and coalbed methane coupling coordinated exploitation based on Bayesian network and cuckoo search显示文摘Coal and coalbed methane(CBM)coordinated exploitation is a key technology for the safe exploitation of both resources.However,existing studies lack the quantification and evaluation of the degree of coordination between coal mining and coalbed methane extraction.In this study,the concept of coal and coalbed methane coupling coordinated exploitation was proposed,and the corresponding evaluation model was established using the Bayesian principle.On this basis,the objective function of coal and coalbed methane coordinated exploitation deployment was established,and the optimal deployment was determined through a cuckoo search.The results show that clarifying the coupling coordinated level of coal and coalbed methane resource exploitation in coal mines is conducive to adjusting the deployment plan in advance.The case study results show that the evaluation and intelligent deployment method proposed in this paper can effectively evaluate the coupling coordinated level of coal and coalbed methane resource exploitation and intelligently optimize the deployment of coal mine operations.The optimization results demonstrate that the safe and efficient exploitation of coal and CBM resources is promoted,and coal mining and coalbed methane extraction processes show greater cooperation.The observations and findings of this study provide a critical reference for coal mine resource exploitation in the future. | Quanle Zou Zihan Chen Zhiheng Cheng Yunpei Liang Wenjie Xu Peiran Wen Bichuan Zhang Han Liu Fanjie Kong | 2022 | International Journal of Mining Science and Technology2022，32，6： | 1 |
| 13 | Evaluation of Chinese tea by the electronic nose and gas chromatography-mass spectrometry: Correlation with sensory properties and classification according to grade level显示文摘 | ZIHAN QIN XUELI PANG DONG CHEN | 2013 | Food Research International2013，，53： | 1 |
| 14 | Applications of ambient electric arc ionization mass spectrometry in saline samples显示文摘Salinity tolerance of ambient electric arc ionization(AEAI)was evaluated by comparing electrospray ionization for various samples at NaCl concentrations from 0 to 1000 mmol/L.AEAI-mass spectrometry(AEAI-MS)exhibited an excellent signal intensity even at NaCl concentrations of 1000 mmol/L,while the ESI-MS had no signal because high salinity has a strong inhibitory effect on analytes.The sodium adduct was verified using LiCl instead of NaCl.AEAI-MS successfully quantified saline samples with an excellent quantitative ability(R^(2)≥0.998).We also achieved some analytical samples in the buffer solution at a very high concentration and even in a saturated salt solution.Overall,AEAI-MS has protonated ions for most target analytes.In addition,the relationship between auxiliary temperature and the distance from the sample to the arc was investigated,and the results indicated that thermal desorption plays an important role in AEAI source. | Yuan Li Yuanji Gao Binpeng Zhan Weiwei Chen Fengjian Chu Hongru Feng Zhan Gao Zihan Ma Yuanjiang Pan | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 15 | Evaluation of Chinese tea by the electronic nose and gas chromatography-mass spectrometry:correlation with sensory properties and classification according to grade level显示文摘 | Qin Zihan Pang Xueli Chen Dong | 2013 | Food Research International2013，53，2： | 1 |
| 16 | Alteration of gut microbiota in type 2 diabetes complicated with cholelithiasis patients显示文摘To the Editor:Type 2 diabetes(T2D)and cholelithiasis are both common diseases with a high,prevalence.In China,the,prevalence of T2D,is.0.90% and that offadult cholelithiasis is 6.83%. | Jiajia Chen Linlin Yan Xingfan Ma Ping Yuan Fan Zhao Zihan Han Jingshan Liu Wenbo Wang Donghai Zhou Hongyu Zhao Nan Feng Dandan Huang Shoukui Hu Jin Gui | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 17 | Metagenomic insights into the variation of bacterial communities and potential pathogenic bacteria in drinking water treatment and distribution systems显示文摘High-throughput sequencing of 16S rRNA gene amplicons was conducted to characterize the changing patterns of bacterial community and potential pathogens in full-scale drinking water treatment and distribution systems.Results showed that Actinobacteria was the predominant phylum in source water,while Proteobacteria dominated after chlorine disinfection and its relative abundance increased from 40.88%±9.45%to 67.86%±27.10%.The genera Pseudarthrobacter,Arenimonas,and Limnohabitans were effectively removed by chlorination,while Phreatobacter,Undibacterium,Pseudomonas,and Sphingomonas within the Proteobacteria phylum were greatly enriched after chlorination.Metagenomic analyses revealed the occurrence of 56 species of potential pathogenic bacteria within 17 genera in drinking water,mainly including Pseudomonas fluorescens and five mycobacteria species,which were also persistent in tap water samples.The bacteria were found to be involved in various pathways,among which considerable groups were related to human diseases,including infectious diseases and even cancers. | Ruiming Jiang Zihan Li Qisheng Li Yunqi Liu Yuning Zhu Zimo Chen Peng Liu Shuyu Jia Hongqiang Ren Xu-Xiang Zhang | 2022 | National Science Open2022，1，2： | 1 |
| 18 | Recyclable tertaaryphosphonium supported chiral imidazolidin-4-one organocatalyst for Diels Alder reactions显示文摘 | Lin Zihan Chen Zuxing Yang Guichun | 2013 | Catalysis Communications2013，35，： | 1 |
| 19 | Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure显示文摘Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis. | Hongxia Ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng Zheng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 20 | Analysis of Conducted Disturbance via Current Transformer Due to Switch Operation of GIS Disconnector in UHV Substation显示文摘The characteristics of conducted disturbances via current transformer(CT)caused by switch operations in 1000 kV UHV substations are studied in this paper.Since the broadband circuit models might have limitations on the stability and accuracy for CT conducted disturbance simulation,a frequencydomain simulation method without circuit synthesis is proposed based on VFTC spectrum and CT transfer characteristics.To improve VFTC simulation accuracy,both the bushing radiation loss and frequency-dependent earth impedance are taken into consideration.Transfer characteristics of three types of windings for the 1000 kV GIS CT are ingeniously measured from a combination of fast and slow impulse tests.Through conducted disturbances simulations in UHV Wuhu substation,bushing radiation loss is found to have a suppression effect on the highfrequency response but the effect of frequency-dependent earth impedance can be ignored.As a result,the maximum amplitude of 84.5 A for the conducted disturbance is obtained,thus a fast damped oscillatory wave immunity test with no lower than Level 4 from IEC standard is suggested to test the anti-interference performance of the secondary equipment in UHV substation. | Jun Zhao Weijiang Chen Kejie Li Zihan Teng Ni Li Tao Wen Xing Fan | 2023 | CSEE Journal of Power and Energy Systems2023，9，3： | 0 |
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