|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro显示文摘Liver X receptor(LXR) plays an important role in reverse cholesterol transport(RCT), and activation of LXR could reduce atherosclerosis. In the present study we used a cell-based screening method to identify new potential LXRβ agonists. A novel benzofuran-2-carboxylate derivative was identified with LXRβ agonist activity: E17110 showed a significant activation effect on LXRβ with an EC50 value of 0.72 μmol/L. E17110 also increased the expression of ATP-binding cassette transporter A1(ABCA1) and G1(ABCG1) in RAW264.7 macrophages. Moreover, E17110 significantly reduced cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages. Interestingly, we found that the key amino acids in the LXRβ ligand-binding domain had distinct interactions with E17110 as compared to TO901317. These results suggest that E17110 was identified as a novel compound with LXRβ agonist activity in vitro via screening, and could be developed as a potential anti-atherosclerotic lead compound. | Ni Li Xiao Wang Peng Liu Duo Lu Wei Jiang Yanni Xu Shuyi Si | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 3 |
| 2 | Modeling the Epidemic Trend of the 2019 Novel Coronavirus Outbreak in China显示文摘A new coronavirus disease(COVID-19)with infection by a novel coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally since December 2019.By 22th September 2020,more than 200 countries worldwide have reported about 30 million confirmed cases and more than 950,000 deaths.1 China has reported a total of 85,307(including 2,758 imported)cases and 4,634 deaths. | Mingwang Shen Zhihang Peng Yanni Xiao Lei Zhang | 2020 | The Innovation2020，1，3： | 3 |
| 3 | Hydrogel-based flexible materials for diabetes diagnosis,treatment,and management显示文摘Diabetes is a chronic metabolic disease characterized by high glucose concentration in blood.Conventional management of diabetes requires skin pricking and subcutaneous injection,causing physical pain and physiological issues to diabetic individuals.Hydrogels possess unique advantages such as lightweight,stretchability,biocompatibility,and biodegradability,offering the opportunities to be integrated as flexible devices for diabetes management.This review highlights the development of hydrogels as flexible materials for diabetes applications in glucose monitoring,insulin delivery,wound care,and cell transplantation in recent years.Challenges and prospects in the development of hydrogel-based flexible devices for personalized management of diabetes are discussed as well. | Jiang Song Yanni Zhang Siew Yin Chan Zhaoyi Du Yinjia Yan Tengjiao Wang Peng Li Wei Huang | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 4 | Smarandache Multiplicative Function显示文摘 | Liu Yanni ang Gao Peng | 2006 | Scientia Magna2006，1，1： | 1 |
| 5 | Agent communication languages: the current landscape显示文摘 | Yannis Labrou Tim Finin Yun Peng | 1999 | Intelligent Systems and Their Applications IEEE March-April 19991999，14，2： | 1 |
| 6 | Agent Communication Languages:The Current Landscape显示文摘 | Tim Finin Yun Peng | 1999 | IEEE1999，3，： | 1 |
| 7 | Agent Communication Languages: The Current Landscape显示文摘 | Yannis 1_abrov Tim Finin Yun Peng | 1999 | IEEE1999，3，： | 1 |
| 8 | Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects显示文摘Stem cell-based tissue engineering has provided a promising platform for repairing of bone defects.However,the use of exogenous bone marrow mesenchymal stem cells(BMSCs)still faces many challenges such as limited sources and potential risks.It is important to develop new approach to effectively recruit endogenous BMSCs and capture them for in situ bone regeneration.Here,we designed an acoustically responsive scaffold(ARS)and embedded it into SDF-1/BMP-2 loaded hydrogel to obtain biomimetic hydrogel scaffold complexes(BSC).The SDF-1/BMP-2 cytokines can be released on demand from the BSC implanted into the defected bone via pulsed ultrasound(p-US)irradiation at optimized acoustic parameters,recruiting the endogenous BMSCs to the bone defected or BSC site.Accompanied by the daily p-US irradiation for 14 days,the alginate hydrogel was degraded,resulting in the exposure of ARS to these recruited host stem cells.Then another set of sinusoidal continuous wave ultrasound(s-US)irradiation was applied to excite the ARS intrinsic resonance,forming highly localized acoustic field around its surface and generating enhanced acoustic trapping force,by which these recruited endogenous stem cells would be captured on the scaffold,greatly promoting them to adhesively grow for in situ bone tissue regeneration.Our study provides a novel and effective strategy for in situ bone defect repairing through acoustically manipulating endogenous BMSCs. | Yanni He Fei Li Peng Jiang Feiyan Cai Qin Lin Meijun Zhou Hongmei Liu Fei Yan | 2023 | Bioactive Materials2023，，3： | 1 |
| 9 | Estimating the time interval between transmission generations and the presymptomatic period by contact tracing surveillance data from 31 provinces in the mainland of China显示文摘The global pandemic of 2019 coronavirus disease(COVID-19)is a great assault to public health.Presymptomatic transmission cannot be controlled with measures designed for symptomatic persons,such as isolation.This study aimed to estimate the interval of the transmission generation(TG)and the presymptomatic period of COVID-19,and compare the ftting effects of TG and serial interval(S)based on the SEIHR model incorporating the surveillance data of 3453 cases in 31 provinces.These data were allocated into three distributions and the value of AIC presented that the Weibull distribution fitted well.The mean of TG was 5.2 days(95%C:4.6-5.8).The mean of the presymptomatic period was 2.4 days(95%CI:1.5-3.2).The dynamic model using TG as the generation time performed well.Eight provinces exhibited a basic reproduction number from 2.16 to 3.14.Measures should be taken to control presymptomatic transmission in the COVID-19 pandemic. | Zhongxing Ding Kai Wang Mingwang Shen Kai Wang Shi Zhao Wenyu Song Rui Li Zhongjie Li Liping Wang Ganzhu Feng Zhiliang Hu Hongxia Wei Yanni Xiao Changjun Bao Jianli Hu Liguo Zhu Yong Li Xufeng Chen Yi Yin Weiming Wang Yongli Cai Zhihang Peng Hongbing Shen | 2021 | Fundamental Research2021，1，2： | 1 |
| 10 | Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo显示文摘Neutralizing monoclonal antibodies(mAb)are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection.The continuous emergence of new SARS-CoV-2 variants worldwide has increased the urgency for the development of new mAbs.In this study,we immunized mice with the receptor-binding domain(RBD)of the SARS-CoV-2 prototypic strain(WIV04)and screened 35 RBDspecific mAbs using hybridoma technology.Results of the plaque reduction neutralization test showed that 25 of the mAbs neutralized authentic WIV04 strain infection.The 25 mAbs were divided into three categories based on the competitive enzyme-linked immunosorbent assay results.A representative mAb was selected from each category(RD4,RD10,and RD14)to determine the binding kinetics and median inhibitory concentration(IC_(50))of WIV04 and two variants of concern(VOC):B.1.351(Beta)and B.1.617.2(Delta).RD4 neutralized the B.1.617.2 variant with an IC50 of 2.67 ng/mL;however,it completely lost neutralizing activity against the B.1.351 variant.RD10 neutralized both variants with an IC50 exceeding 100 ng/mL;whereas RD14 neutralized two variants with a higher IC50(>1 mg/mL).Animal experiments were performed to evaluate the protective effects of RD4 and RD10 against various VOC infections.RD4 could protect Adv-hACE2 transduced mice from B.1.617.2 infection at an antibody concentration of 25 mg/kg,while RD10 could protect mice from B.1.351 infection at an antibody concentration of 75 mg/kg.These results highlight the potential for future modifications of the mAbs for practical use. | Qianran Wang Lu Peng Yanqiu Nie Yanni Shu Huajun Zhang Zidan Song Yufeng Li Hengrui Hu Liushuai Li Xi Wang Jia Liu Jiang Li Zhengli Shi Fei Deng Yu Guo Yiwu Zhou Bing Yan Zhihong Hu Manli Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 11 | A Rapid and Simple Method for Quantitative Aziridination from Aminobrominated Derivatives of Olefins under Solvent-free and Mild Conditions显示文摘从石蜡的 aminohalogenation 导出的 1,2-vicinal haloamines 的催化脲的 aziridination 被开发了。这个快速、简单的方法被简单地在空中在房间温度磨底层, K2CO3 和脲的催化数量的稳固的混合执行。反应在包括的石蜡的 aminohalogenated 衍生物的一个大范围为 aziridines 的量的准备提供一个协议,不饱和的酉同类,,不饱和的酉旨和简单石蜡。包含支持 deprotonation 的 H 契约的可能的机制为这反应被建议了。 | Wei,Junfa Chen,Zhanguo Gao,Yanni Zhang,Peng Wang,Chuanning Zhao,Pengfei Wang,Yun Shi,Xianying | 2012 | Chinese Journal of Chemistry2012，30，2： | 0 |
| 12 | Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer显示文摘Objective:Immune checkpoint inhibitors(ICIs)have achieved remarkable results in cancer treatments.However,there is no effective predictive biomarker for gastrointestinal(GI)cancer.Methods:We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort(MSK-GI,n=227),the Janjigian cohort(n=40),and the Peking University Cancer Hospital&Institute cohort(PUCH,n=80)to determine the possible associations between DNA damage response and repair(DDR)gene mutations and clinical outcomes.Data from The Cancer Genome Atlas database were analyzed to determine the possible correlations between DDR gene mutations and the tumor microenvironment.Results:In the MSK cohort,the presence of≥2 DDR gene mutations was correlated with prolonged overall survival(OS).The Janjigian and PUCH cohorts further confirmed that subgroups with≥2 DDR gene mutations displayed a prolonged OS and a higher durable clinical benefit.Furthermore,the DDR gene mutation load could be considered as an independent prognostic factor,and exhibited a potential predictive value for survival in GI cancer patients treated with ICIs.Mechanistically,we showed that the presence of≥2 DDR gene mutations was correlated with higher levels of tumor mutation burden,neoantigen,and T cell infiltration.Conclusions:The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs,which could serve as a potential biomarker to guide patient selection for immunotherapy. | Yujiao Wang Xi Jiao Shuang Li Huan Chen Xin Wei Chang Liu Jifang Gong Xiaotian Zhang Xicheng Wang Zhi Peng Changsong Qi Zhenghang Wang Yanni Wang Na Zhuo Jianling Zou Henghui Zhang Jian Li Lin Shen Zhihao Lu | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 13 | Ordering Results on Largest Order Statistics from Multiple-Outlier Gamma Variables显示文摘In this article,we carry out stochastic comparisons on the maximum order statistics arising from two batches of multiple-outlier gamma random variables with different shape and scale parameters.It is proved that,under certain conditions,the majorization order between the vectors of shape parameters together with the weak majorization order[p-larger order]between the vectors of scale parameters implies the likelihood ratio order[hazard rate order]between the largest order statistics.The results established here strengthen and generalize some known ones in the literature. | Yiying Zhang Yanni Hu Peng Zhao | 2023 | Communications in Mathematics and Statistics2023，11，2： | 0 |
| 14 | Visual abstraction of dynamic network via improved multi-class blue noise sampling显示文摘Massive sequence view (MSV) is a classic timeline-based dynamic network visualization approach. However, it is vulnerable to visual clutter caused by overlapping edges, thereby leading to unexpected misunderstanding of time-varying trends of network communications. This study presents a new edge sampling algorithm called edge-based multi-class blue noise (E-MCBN) to reduce visual clutter in MSV. Our main idea is inspired by the multi-class blue noise (MCBN) sampling algorithm, commonly used in multi-class scatterplot decluttering. First, we take a node pair as an edge class, which can be regarded as an analogy to classes in multi-class scatterplots. Second, we propose two indicators, namely, class overlap and inter-class conflict degrees, to measure the overlapping degree and mutual exclusion, respectively, between edge classes. These indicators help construct the foundation of migrating the MCBN sampling from multi-class scatterplots to dynamic network samplings. Finally, we propose three strategies to accelerate MCBN sampling and a partitioning strategy to preserve local high-density edges in the MSV. The result shows that our approach can effectively reduce visual clutters and improve the readability of MSV. Moreover, our approach can also overcome the disadvantages of the MCBN sampling (i.e., long-running and failure to preserve local high-density communication areas in MSV). This study is the first that introduces MCBN sampling into a dynamic network sampling. | Yanni PENG Xiaoping FAN Rong CHEN Ziyao YU Shi LIU Yunpeng CHEN Ying ZHAO Fangfang ZHOU | 2023 | Frontiers of Computer Science2023，17，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员