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| 1 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 2 | Network pharmacology analysis to explore mechanism of Three Flower Tea against nonalcoholic fatty liver disease with experimental support using high-fat diet-induced rats显示文摘Objective:Nonalcoholic fatty liver disease(NAFLD)has become a common chronic liver disease that is harmful to human health.Moreover,there is currently no FDA-approved first-line drug for the treatment of nonalcoholic steatohepatitis(NASH)or NAFLD.Traditional Chinese medicine(TCM)is widely used to ameliorate liver diseases,such as the traditional ancient recipe called Three Flower Tea(TFT),which consists of double rose(Rosa rugosa),white chrysanthemum(Chrysanthemum morifolium),and Daidaihua(Citrus aurantium).However,the mechanisms of the action of TFT are not clear.Therefore,this study aimed to elucidate the mechanisms of TFT against NAFLD in high-fat diet(HFD)-induced rats.Methods:This study utilized bioinformatics and network pharmacology to establish the active and potential ingredient-target networks of TFT.Furthermore,a protein–protein interaction(PPI)network was constructed,and enrichment analysis was performed to determine the key targets of TFT against NAFLD.Furthermore,an animal experiment was conducted to evaluate the therapeutic effect and confirm the key targets of TFT against NAFLD.Results:A total of 576 NAFLD-related genes were searched in Gene Cards,and under the screening criteria of oral bioavailability(OB)≥30%and drug-likeness(DL)≥0.18,a total of 19 active ingredients and 210 targets were identified in TFT.Network pharmacology analysis suggested that 55 matching targets in PPIs were closely associated with roles for NAFLD treatment.Through the evaluation of network topology parameters,four key central genes,PPARγ,SREBP,AKT,and RELA,were identified.Furthermore,animal experiments indicated that TFT could reduce plasma lipid profiles,hepatic lipid profiles and hepatic fat accumulation,improve liver function,suppress inflammatory factors,and reduce oxidative stress.Through immunoblotting and immunofluorescence analysis,PPARγ,SREBP,AKT,and RELA were confirmed as targets of TFT in HFD-induced rats.Conclusion:In summary,our results indicate that TFT can prevent and treat NAFLD via multiple targets,including lipid accumulation,antioxidation,insulin sensitivity,and inflammation. | Peixuan Wu Shufei Liang Yanping He Rui Lv Bendong Yang Meng Wang Chao Wang Yong Li Xinhua Song Wenlong Sun | 2022 | Chinese Herbal Medicines2022，14，2： | 2 |
| 3 | Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole显示文摘 | WU Yi ZHAO Yanping GUO Jing LV Haoze ZHENG Nan WANG Ensi | 2016 | Chemical Research in Chinese Universities2016，32，5： | 2 |
| 4 | Isolation and Preliminary Identification of Broad-spectrum Bacteriocin-producing Lactobacillus Strain CW3显示文摘[Objective]This study aimed to screen and preliminarily identify Lactobacillus strain CW3. [Method]Oxford cup double-plate method was used for preliminary screening of broad-spectrum bacteriocin-producing Lactobacillus strain; after eliminating the interference of organic acid and hydrogen peroxide,antibacterial substances containing protein properties produced by the screened strain were detected; finally,the obtained strain was identified. [Result]After elimination of interference factors such as organic acid and hydrogen peroxide,the fermentation supernatant of strain CW3 could still inhibit the growth of indicator strains; the antibacterial activity of fermentation broth was significantly reduced after treatment with trypsase and pepsase,which indicated that the produced antibacterial substances were bacteriocins. Results of physiological and biochemical identification showed that strain CW3 belonged to Lactobacillus plantarum. [Conclusion]CW3is a broad-spectrum bacteriocin-producing Lactobacillus plantarum strain. | Haoxin LV Weidong WANG Zhongfang TAN Feifei YANG Yingchun JIAO Yanping WANG Zongwei LI | 2014 | Agricultural Biotechnology2014，3，1： | 2 |
| 5 | Rhynchophylline prevents cardiac dysfunction and improves survival in lipopolysaccharide-challenged mice via suppressing macrophage I-κBα phosphorylation显示文摘 | Wenjuan Cao Yuan Wang Xiuxiu Lv Xiaohui Yu Xiaojian Li Hongmei Li Yanping Wang Daxiang Lu Renbin Qi Huadong Wang | 2012 | International Immunopharmacology2012，，3： | 1 |
| 6 | IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection显示文摘 | Na Li Qianqian Zhu Zhu Li Qunying Han Jinghong Chen Yi Lv Yawen Wang Xiaoyan Zeng Yanping Chen Cuiling Yang Zhengwen Liu | 2013 | Human Immunology2013，，： | 1 |
| 7 | Synthesis,Characterizations,Magnetism and Thermal Degradation of a 2-Fold Interpenetrated 3D Cobalt-Organic Framework显示文摘A new coordination polymer,[Co_(2)(L)_(2)(4,4'-bipy)]_(n)·3nH_(2)O(1)based on 5-(3-methyl-5-phenyl-4H-1,2,4-tri-azol-4-yl)isophthalic acid(H_(2)L)and 4,4'-bipyridine(4,4'-bipy)has been hydrothermally synthesized and character-ized by single-crystal X-ray diffraction,XRPD,IR,and elemental analysis.Temperature-dependent magnetic sus-ceptibility and thermal degradation for 1 were also studied.The asymmetric unit of compound 1 consists of two crystallographically independent Co(II)ion,two L^(2−)ligand,one 4,4'-bipy ligand,and three lattice water molecules.The 2D triangle networks were linked by the bridging 4,4'-bipy ligand to give rise to a 2-fold interpenetrated 3D architecture.The simplest cyclic motif of the 2D networks is a triangle ring consisting of three Co(II)cations and three L^(2−)ligands.So we can define Co(II)ions as 4-connected nodes and the L^(2−)ligands as 3-connected nodes.Thus,the 3D structure can be described as a 2-fold parallel interpenetrated ins InS 3,4-conn topology. | Linyan Yang Liangliang Xin Wen Gu Shengyun Liao Peiyao Du Jinlei Tian Yanping Zhang Rui Lv Xiaohua Wei Xin Liu Daizheng Liao | 2014 | Chinese Journal of Chemistry2014，32，3： | 1 |
| 8 | Multiplicity and uniqueness for a class of discrete fractional boundary value problems显示文摘 | Lv Zhanmei Gong Yanping Chen Yi | 2014 | Appl Math2014，59，6： | 1 |
| 9 | Nitric oxide-mediated immunosuppressive effect of Human amniotic membrane-derived mesenchymal stem cells on the viability and migration of microglia显示文摘 | Ke Yan Run Zhang Lei Chen Fanfan Chen Yi Liu Lingmei Peng Haitao Sun Weiyi Huang Chengmei Sun Bingke Lv Feng Li Yingqian Cai Yanping Tang Yuxi Zou Mouxuan Du Lingsha Qin Hengzhu Zhang Xiaodan Jiang | 2014 | Brain Research2014，，： | 1 |
| 10 | Genome-wide analysis of primary auxin-responsive Aux/IAA gene family in maize (Zea mays. L.)显示文摘 | Yijun Wang Dexiang Deng Yunlong Bian Yanping Lv Qin Xie | 2010 | Molecular Biology Reports2010，，8： | 1 |
| 11 | Tracking Tonoplast Protein Behaviors in Intact Vacuoles Isolated from Arabidopsis Leaves显示文摘 | Lv, Xueqin Jing, Yanping Wu, Hongyang Lin, Jinxing | 2017 | Molecular Plant2017，10，2： | 1 |
| 12 | Remote sensing image enhancement based on orthogonal wavelet transformation analysis and pseudo-color processing 显示文摘 | Zhiwen Wang Shaozi Li Yanping Lv | 2010 | International Journal of Computational Intelligence Sys- tems2010，3，6： | 1 |
| 13 | Application of Boron-doped Diamond Film Electrode in Fast Detection of Samonella in Water显示文摘[Objective]The study aimed to discuss the application of boron-doped diamond( BDD) film electrode in fast detection of samonella in water. [Method]Boron-doped diamond film electrode was prepared and used as the working electrode in fast detection of salmonella in water using chronoamperometry,and the oxidation mechanism of the electrode acting on salmonella was discussed. [Result]Compared with traditional biological methods,chronoamperometry could detect the number of salmonellae in water more simply,rapidly and sensitively. [Conclusion]The method of using BDD electrode to detect salmonella quantity will be widely applied in future. | Baoying Lv Zhaoyu Mo Yanping Tang Yanxian Nong | 2013 | Meteorological and Environmental Research2013，4，10： | 0 |
| 14 | Bird specimen number linked with species trait and climate niche breadth显示文摘Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and conservation.However,there are few systematic studies on the patterns and drivers of bird specimen number at regional scales.This study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple comparisons.The results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen number.Bird specimen number significantly increased with larger temperature niche breadth and precipitation niche breadth.Specimen number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body size.These findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch sizes.This research enhances the use of bird specimen data to study and preserve biodiversity. | Xiaoyu Duan Xiongwei Huang Jingya Zhang Shuo Lv Gang Song Yanping Wang Gang Feng | 2024 | Avian Research2024，15，1： | 0 |
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