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| 1 | Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia显示文摘脉管的光滑的肌肉房间(VSMC ) 的增加的增长和移植是在动脉粥样硬化患者损害的开发的关键事件。Baicalin,导出植物的 flavonoid 混合物,以前被显示了通过多重小径在癌症房间导致 apoptosis 和生长抑制。然而,在 VSMC 增长和心血管的疾病的预防的规定的 baicalin 的潜在的角色仍然保持未经勘探。在这研究,我们证明有 baicalin 的那个预告的处理有一个剂量依赖者 PDGF-BB-stimulated VSMC 增长上的禁止的效果,与增殖的减小伴随了房间原子抗原(PCNA ) 表示。我们也证明导致 baicalin 的生长抑制在在 p27 的激活和增加在刺激 PDGF 的 VSMC 铺平的 cyclin E-CDK2 与减少被联系,它看起来是部分至少由 PDGF 受体尾的封锁调停了(PDGFR 尾) 发信号的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 。另外, baicalin 也被发现禁止 PDGF-BB 在 VSMC 导致的粘附分子表达式和房间移植。而且,使用一根动物颈动脉动脉的汽球损害模型,我们发现 baicalin 显著地禁止了 neointimal 增生。一起拿,我们的结果在导致生长揭示 baicalin 的新奇功能在汽球损害以后刺激 PDGF 的 VSMC 和压制的 neointimal 增生逮捕,并且建议内在的机制经由 PDGFR 尾 - 的封锁包含在 p27 累积的 cyclin E-CDK2 激活和增加的抑制 ERK1/2 发信号串联。 | Li-Hua Dong Jin-Kun Wen Sui-Bing Miao Zhenhua Jia Hai-Juan Hu Rong-Hua Sun Yiling Wu Mei Han | 2010 | Cell Research2010，20，11： | 30 |
| 2 | TIME DOMAIN SOLUTION OF UNSTEADY FLOW AROUND A SHIP显示文摘The unsteady flow around a ship advancing at constant speed is studied in time domain using a higher-order boundary element method. The Rankine source is employed and the ship hull and free surface are discretized into 8-node isoparametric elements. A modified Green formula is used to overcome the numerical difficulty arising from the singular or quasi-singular integrals in the integral equation. In the case of τ> 0. 25, a rigid wall condition is applied to the upstream and a numerical beach is applied downstream to absorb the outgoing waves. The numerical results are satisfactory, compared with the experimental results. | Li, Yile Liu, Yingzhong Miao, Guoping | 1998 | Journal of Hydrodynamics1998，10，4： | 1 |
| 3 | Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRI^-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia显示文摘 | Li-Hua Dong Jin-Kun Wen Sui-Bing Miao Zhenhua Jia Hai-Juan Hu Rong-Hua Sun Yiling Wu Mei Han | 2011 | Cell Research2011，21，8： | 1 |
| 4 | A comparison of genetic variation among wild and cultivated Morus species (Moraceae:Morus) as revealed by ISSR and SSR markers显示文摘 | Zhao Weiguo Miao Xuxiaa Pan Yile | 2007 | Biodiversity and Conversation2007，16，2： | 1 |
| 5 | Intrinsic persistent room temperature phosphorescence derived from 1H-benzo[f]indole itself as a guest显示文摘The influence of 1H-benzo[f]indole(Bd) and its derivatives on room temperature phosphorescence(RTP)has raised great concern since they were found to significantly affect RTP of the extensively studied carbazole(Cz) derivatives. However, the role of Bd itself existing in Cz-based or other doping systems was still unclear. In order to clarify its intrinsic phosphorescent property, Bd was introduced as a guest into different organic matrixes including substituted Cz derivatives and polymers. The phosphorescence located in 560–620 nm was confirmed to be derived from Bd itself, which can be detected whatever Bd was doped in the crystal or amorphous state of Cz derivatives. The suitable energy gap between Cz derivatives and Bd is the key to achieve ultralong RTP of Bd. Additionally, when doped in polymers with plenty of hydrogen bonds, RTP of Bd with lifetime over 280 ms was easily obtained. Among them, Bd@PHEMA(poly(hydroxyethyl methacrylate) exhibited superior phosphorescence, with yellow afterglow lasting for over 2.5 s. Therefore, this work demonstrated that a new organic RTP phosphor, Bd, is discovered, and ultralong RTP of Bd can be achieved not only doped in Cz derivatives but also in polymers as the hosts. | Danman Guo Yuyuan Wang Jinzheng Chen Yifeng Cao Yiling Miao Huahua Huang Zhenguo Chi Zhiyong Yang | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 6 | Environmental control of rice flowering time显示文摘Correct measurement of environmental parameters is fundamental for plant fitness and survival,as well as for timing developmental transitions,including the switch from vegetative to reproductive growth.Important parameters that affect flowering time include day length(photoperiod)and temperature.Their response pathways have been best described in Arabidopsis,which currently offers a detailed conceptual framework and serves as a comparison for other species.Rice,the focus of this review,also possesses a photoperiodic flowering pathway,but 150 million years of divergent evolution in very different environments have diversified its molecular architecture.The ambient temperature perception pathway is strongly intertwined with the photoperiod pathway and essentially converges on the same genes to modify flowering time.When observing network topologies,it is evident that the rice flowering network is centered on EARLY HEADING DATE 1,a rice-specific transcriptional regulator.Here,we summarize the most important features of the rice photoperiodic flowering network,with an emphasis on its uniqueness,and discuss its connections with hormonal,temperature perception,and stress pathways. | Giulio Vicentini Marco Biancucci Lorenzo Mineri Daniele Chirivı Francesca Giaume Yiling Miao Junko Kyozuka Vittoria Brambilla Camilla Betti Fabio Fornara | 2023 | Plant Communications2023，4，5： | 0 |
| 7 | Clinical characteristics of acute lobar nephronia in renal allograft显示文摘To the Editor:Acute lobar nephronia(ALN),also known as acute focal bacterial nephritis,is a severe form of upper urinary tract infection(UTI)that is characterized by the presence of an inflammatory mass lesion in the kidney without abscess formation.It is considered to be the midpoint between acute pyelonephritis and renal abscess.^([1])ALN was first described in 1979 as a radiologic diagnosis in ten adults and two children.^([2]) | Yuchen Wang Yu He Yanna Liu Ziyan Yan Wenli Zeng Wenfeng Deng Yiling Fang Genxia Wei Jian Xu Yun Miao | 2022 | Chinese Medical Journal2022，，7： | 0 |
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