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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 3 | Grain-size features of a Miocene loess-soil sequence at Qinan: Implications on its origin显示文摘In this study, grain-size of 507 bulk samples from the QA-I Miocene loess-soil sequence at Qinan were analyzed, and the grain-size features are compared with those of typical Quaternary loess and soil samples, representative lacustrine and fluvial samples. The results indicate that the grain-size distribution pattern of the Miocene loess is essentially similar to that of Quaternary loess, but greatly differs from the lacustrine and fluvial sediments. Loess layers are regularly coarser than soil layers, indicating cyclical climate changes. Median grain-size along the 253.1 m sequence varies from 6 to 13 μm and the >63 μm fraction represents only 5.3% in maximum, 0.9% in average. Long-term grain-size variations are consistent with the loess accumulation rate at Qinan and with the eolian mass accumulation rate in the North Pacific. These features firmly indicate an eolian origin of the studied sequence, and also reveal a coeval changes between the long-term changes of eolian grain-size and continental aridity in the dust source regions. | QIAO Yansong1,3, GUO Zhengtang2,1, HAO Qingzhen1, YIN Qiuzhen1, YUAN Baoyin1 & LIU Tungsheng1 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China 3. Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China | 2006 | Science China Earth Sciences2006，49，7： | 33 |
| 4 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 5 | Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes:A Randomized, Double-blind, Multicenter Clinical Trial显示文摘 | Xi Wang Dan HU Song Dang He Huang Cong-Xin Huang Ming-Jie Yuan Yan-Hong Tang Qing-Shan Zheng Fang Yin Shu Zhang Bo-Li Zhang Run-Lin Gao | 2017 | Chinese Medical Journal2017，，14： | 33 |
| 6 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 7 | A new scoring system for assessment of liver function after successful hepatectomy in patients with hepatocellular carcinoma显示文摘BACKGROUND:Whether a major liver resection is safe has been judged mainly from the patient's hepatic reserve.However,a safe limit for liver resection does not exist yet.This study aimed to construct a new scoring system as a guide to determine a safe limit for liver resection and avoid liver dysfunction after hepatectomy.METHODS:Eighty-six patients with hepatocellular carcinoma who had undergone hepatectomy in West China Hospital from March 2007 to June 2010 were reviewed.The patients were classified according to the levels of total bilirubin after hepatectomy and the parameters in the perioperative period were compared.Receiver operating characteristic (ROC) analysis was made to assess the liver function compensatory (LFC) value to predict liver dysfunction of the patients after hepatectomy.LFC value is defined as the preoperative KICG value×22.487+standard remnant liver volume (SRLV)×0.020.RESULTS:Patients were classified into group Ⅰ (normal group,n=69) and group Ⅱ (with total bilirubin >85.5 μmol/L for 7 days after hepatectomy,n=17) based on the levels of total bilirubin after hepatectomy.Group II was further divided into two subgroups:recovered subgroup (n=14) and fatal subgroup (n=3).There were no significant differences in preoperative data or intraoperative findings except the indocyanine green test parameters (KICG and ICG R15) and SRLV.ROC analysis showed that the sensitivity and specificity of an LFC value ≤13.01 were 94.1% and 82.6% respectively for predicting liver dysfunction of the patients after hepatectomy.CONCLUSIONS:The LFC value appears to be a good predictor of postoperative liver dysfunction in patients who undergo hepatectomy for HCC.An expected LFC value of 13.01 seems to be a safe limit for liver resection. | Zheng-Gui Du,Bo Li,Yong-Gang Wei,Jie Yin,Xi Feng and Xi Chen Department of Liver and Vascular Surgery,West China Hospital,Sichuan University,Chengdu 610041,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 23 |
| 8 | The TanSat mission: preliminary global observations显示文摘The Chinese global carbon dioxide monitoring satellite (Tan Sat) was launched successfully in December2016 and has completed its on-orbit tests and calibration. Tan Sat aims to measure the atmospheric column-averaged dry air mole fractions of carbon dioxide (XCO_2) with a precision of 4 ppm at the regional scale, and in addition, to derive global and regional CO2fluxes. Progress towards these objectives is reviewed and the first scientific results from Tan Sat measurements are presented. Tan Sat on-orbit tests indicate that the Atmospheric Carbon dioxide Grating Spectrometer is in normal working status and is beginning to produce L1B products. The preliminary Tan Sat XCO_2products have been retrieved by an algorithm and compared to NASA Orbiting Carbon Observatory-2 (OCO-2) measurements during an overlapping observation period. Furthermore, the XCO_2retrievals have been validated against eight groundsite measurement datasets from the Total Carbon Column Observing Network, for which the preliminary conclusion is that Tan Sat has met the precision design requirement, with an average bias of 2.11 ppm.The first scientific observations are presented, namely, the seasonal distributions of XCO_2over land on a global scale. | Yi Liu Jing Wang Lu Yao Xi Chen Zhaonan Cai Dongxu Yang Zengshan Yin Songyan Gu Longfei Tian Naimeng Lu Daren Lyu | 2018 | Science Bulletin2018，63，18： | 23 |
| 9 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 10 | PROPULSIVE PERFORMANCE AND VORTEX SHEDDING OF A FOIL IN FLAPPING MOTION显示文摘The propulsive performance and vortex shedding of oscillating foil, which mimics biological locomotion, were numerically investigated. The objectives of this study were to deal with unsteady force, in particular thrust force, exerted on the foil in pitching and plunging motions, and to explore the relation of the propulsive performance with vortex structures near the foil and vortex shedding in the near wake. The two dimensional incompressible Navier Stokes equations in the vorticity and stream function formulation were solved by fourth order essentially compact finite difference schemes for the space derivatives and a fourth order Runge Kutta scheme for the time advancement. To reveal the mechanism of the propulsive performance, the unsteady force and the shedding of the trailing and leading edge vortices of the foil were analyzed. The effects of some typical factors, such as the frequency and amplitude of the oscillation, the phase difference between the pitching and plunging motions, and the thickness ratio of the foil, on the vortex shedding and unsteady force were discussed. | Yang Yan, Lu Xi yun, Yin Xie zhen Department of Mechanics and Mechanical Engineering, University of Science and Technology of China, Hefei 230026, China, | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 11 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 12 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 13 | NK cell-based cancer immunotherapy: from basic biology to clinical application显示文摘Natural killer(NK) cells, which recognize and kill target cells independent of antigen specificity and major histocompatibility complex(MHC) matching, play pivotal roles in immune defence against tumors. However, tumor cells often acquire the ability to escape NK cell-mediated immune surveillance. Thus, understanding mechanisms underlying regulation of NK cell phenotype and function within the tumor environment is instrumental for designing new approaches to improve the current cell-based immunotherapy. In this review, we elaborate the main biological features and molecular mechanisms of NK cells that pertain to regulation of NK cell-mediated anti-tumor activity. We further overview current clinical approaches regarding NK cell-based cancer therapy, including cytokine infusion, adoptive transfer of autologous or allogeneic NK cells, applications of chimeric antigen receptor(CAR)-expressing NK cells and adoptive transfer of memory-like NK cells. With these promising clinical outcomes and fuller understanding the basic questions raised in this review, we foresee that NK cell-based approaches may hold great potential for future cancer immunotherapy. | LI Yang YIN Jie LI Ting HUANG Shan YAN Han LEAVENWORTH Jian Mei WANG Xi | 2015 | Science China(Life Sciences)2015，58，12： | 14 |
| 14 | An efficient ranging method based on Chinese remainder theorem for RIPS measurement显示文摘The radio interferometric positioning system(RIPS) measures the phase difference of the interference signal to provide high accuracy and at the same time maintain simple hardware configuration for wireless sensor networks.However, it suffers from phase ambiguity problem because of the periodicity of phase, which makes it hard to determine the actual distance difference only from a single phase measurement.To solve the problem, RIPS makes multiple measurements at different frequencies so as to determine the distance difference from multiple phases.However, this is a computationally intensive searching process and not suitable for energyconstrained wireless sensor nodes.In this paper, we introduce the Chinese remainder theorem(CRT) to RIPS to solve the phase ambiguity problem.Meanwhile, we utilize some properties of the coefficients in the CRT algorithm to avoid the over-sensitivity of the traditional CRT, which increases the robustness of the algorithm.We apply this robust CRT algorithm to the ranging process which calculates the distance difference directly from a closed-form equation and therefore reduces the response time and the energy consumption of the ranging procedure. | WANG Chen , YIN QinYe & WANG WenJie Ministry of Education Key Lab for Intelligent Networks and Network Security, Xi’an Jiaotong University, Xi’an 710049, China | 2010 | Science China(Information Sciences)2010，53，6： | 13 |
| 15 | Vegetation dynamics and its response to climate change in Central Asia显示文摘The plant ecosystems are particularly sensitive to climate change in arid and semi-arid regions. However, the responses of vegetation dynamics to climate change in Central Asia are still unclear. In this study, we used the normalized difference vegetation index(NDVI) data to analyze the spatial-temporal changes of vegetation and the correlation of vegetation and climatic variables over the period of 1982–2012 in Central Asia by using the empirical orthogonal function and least square methods. The results showed that the annual NDVI in Central Asia experienced a weak increasing trend overall during the study period. Specifically, the annual NDVI showed a significant increasing trend between1982 and 1994, and exhibited a decreasing trend since 1994. The regions where the annual NDVI decreased were mainly distributed in western Central Asia, which may be caused by the decreased precipitation. The NDVI exhibited a larger increasing trend in spring than in the other three seasons. In mountainous areas, the NDVI had a significant increasing trend at the annual and seasonal scales; further, the largest increasing trend of NDVI mainly appeared in the middle mountain belt(1,700–2,650 m asl). The annual NDVI was positively correlated with annual precipitation in Central Asia, and there was a weak negative correlation between annual NDVI and temperature. Moreover, a one-month time lag was found in the response of NDVI to temperature from June to September in Central Asia during 1982–2012. | YIN Gang HU Zengyun CHEN Xi TIYIP Tashpolat | 2016 | Journal of Arid Land2016，8，3： | 13 |
| 16 | Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China显示文摘To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency. | Song Chen Shaowen Liu Xi Zheng Min Yin Guang Chu Chunmei Xu Jinxiang Yan Liping Chen Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，6： | 13 |
| 17 | Combining Endometrium Sampling Device and SurePath Preparation to Screen for Endometrial Carcinoma: A Validation Study显示文摘 | Jia Wen Rui Chen Jian Zhao Yin Dong Xi Yang Qin-Ping Liao | 2015 | Chinese Medical Journal2015，，5： | 11 |
| 18 | Soil Aggregate Stability and Iron and Aluminium Oxide Contents Under Different Fertiliser Treatments in a Long-Term Solar Greenhouse Experiment显示文摘Soil in greenhouses is likely to suffer a gradual decline in aggregate stability. Determination of the effects of different fertiliser practices on soil aggregate stability is important for taking advantage of solar greenhouses. Soil aggregate stability and iron(Fe) and aluminium(Al) oxide contents were investigated in a 26-year long-term fertilisation experiment in greenhouse in Shenyang, China,under eight fertiliser treatments: manure(M), fertiliser N(FN), fertiliser N with manure(MN), fertiliser P(FP), fertiliser P with manure(MP), fertiliser NP(FNP), fertiliser NP with manure(MNP), and control without any fertiliser(CK). A wet sieving method was used to determine aggregate size distribution and water-stable aggregates(WSA), mean weight diameter and geometric mean diameter as the indices of soil aggregate stability. Different fertiliser treatments had a statistically significant influence on aggregate stability and Fe and Al oxide contents. Long-term application of inorganic fertilisers had no obvious effects on the mass proportion of aggregates. By contrast, manure application significantly increased the mass proportion of macroaggregates at the expense of microaggregates. All treatments, with the exception of FNP, significantly increased the stability of macroaggregates but decreased that of microaggregates when compared with CK. Aggregation under MP and MN was better than that under M and MNP; however,no significant differences were found among inorganic fertiliser treatments(i.e., FN, FP, and FNP). A positive relation was found between pyrophosphate-extractable Fe and WSA(r = 0.269), but no significant relations were observed between other Fe and Al oxides and aggregate stability. | YIN Yan WANG Li LIANG Chenghua XI Fengming PEI Zhongjian DU Liyu | 2016 | Pedosphere2016，26，5： | 11 |
| 19 | Differences in the predictive value of red cell distribution width for the mortality of patients with heart failure due to various heart diseases显示文摘BackgroundIncreased 红血房间分发宽度(RDW ) 与心失败(HF ) 在病人与不利结果被联系。学习是回顾地由于不同 causes.MethodsWe 在病人在 RDW 的预兆的价值把差别与 HF 作比较的这的目的在 Fuwai 医院(中国北京) 从 2009 年 10 月调查了 1,021 个 HF 病人到 2011 年 12 月。在这些病人的 HF 被三疾病引起;冠的心疾病(CHD ) ,扩大心肌症(DCM ) 和瓣膜的心疾病(VHD ) 。病人们为 21 ± 是跟随起来的;9 months.ResultsThe RDW,死亡和幸存持续时间在三个组之中是显著地不同的。Kaplan-Meier 分析证明累积幸存在病人与增加的 RDW 显著地减少了, HF 由 CHD 和 DCM 引起了,然而并非在那些,与 HF,病人们由 VHD 引起了。在一个 multivariable 模型, RDW 与 CHD 为 HF 病人的死亡作为一个独立预言者被识别(P <0.001, HR 1.315, 95% CI 1.122-1.543 ) 。有更高的 N 终端支持大脑的 natriuretic 肽(NT-proBNP ) 和更高的 RDW 的组比中部由于 DCM.ConclusionsRDW 与 HF 由于 CHD 与 HF 在病人,然而并非在病人有最低累积幸存为有 HF 的病人的预示的指示物被 CHD 和 DCM 引起;因此, RDW 补充说到在 CHD 的 NT-proBNP 的重要信息引起了 HF 病人。 | Yang ZHANG Yan WANG Jin-Suo KANG Jin-Xing YU Shi-Jie YIN Xiang-Feng CONG Xi CHEN | 2015 | Journal of Geriatric Cardiology2015，12，6： | 10 |
| 20 | Association between well-characterized lung cancer IncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer显示文摘基于铂的化疗是为大多数肺癌症病人的标准首要的治疗。然而,基于铂的化疗极大地导致的毒性阻碍它的临床的使用。以前的研究证明有在长度的超过 200 核苷酸的长非编码的 RNA (lncRNAs ) 影响药反应和毒性。在现在的学习,我们与肺癌症在中国病人与基于铂的化疗毒性调查了描绘得好的肺癌症 lncRNA 多型性的协会。467 个肺癌症病人的一个总数与基于铂的化疗对待因为至少二个周期被招募。我们首先集中了于胃肠并且 hematological 毒性。在 8 lncRNAs (HOTTIP, HOTAIT, H19, ANRIL, CCAT2, MALAT1, MEG3,和 POLR2E ) 以内的 14 潜在地功能的多型性的一个总数是 genotyped。无条件的后勤的回归分析被进行估计协会。基因基因和基因环境相互作用用软件被识别概括 multifactor 维数减小(GMDR ) 。ANRIL rs1333049 在一个添加剂模型与严重全面毒性被联系(调整 OR=0.723, 95% CI=0.541-0.965, P=0.028 ) 。ANRIL rs1333049 也在两个与严重胃肠的毒性被联系添加剂(调整 OR=0.690, 95% CI=0.489-0.974, P=0.035 ) 并且主导(调整 OR=0.558, 95% CI=0.335-0.931, P=0.025 ) 模型。MEG3 rs116907618 在一个添加剂模型与严重胃肠的毒性被联系(调整 OR=1.717, 95% CI=1.007-2.927, P=0.047 ) 。GMDR 为 hematological 毒性作为最好的预兆的模型识别了 POLR2E rs3787016-HOTTIP rs3807598 化疗政体的三因素的相互作用模型。在结论, ANRIL 和 MEG3,基因多型性与严重的铂毒性被联系并且能与肺癌症在中国病人为预告的处理评估被看作 biomarkers。 | Wei-jing GONG Jing-bo PENG Ji-ye YIN Xiang-ping LI Wei ZHENG Ling XIAO Li-ming TAN Di XIAO Yi-xin CHEN Xi LI Hong-hao ZHOU Zhao-qian LIU | 2017 | Acta Pharmacologica Sinica2017，38，4： | 10 |
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