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| 1 | A New Arg54Gly Transthyretin Gene Mutation Associated with Vitreous Amyloidosis in Chinese显示文摘Purpose:To analyse the hereditary features of a Chinese pedigree with familial vitreous amyloidosis in Liaoning Province,China,and to investigate the correlation between the clinical appearance of the disease and transthyretin(TTR)gene mutation,including the locus and type of TTR gene mutation.Methods:Five patients (10 eyes) from one Chinese family were diagnosed with vitreous amyloidosis between July 1996 and April 2009.Family members were followed up subsequently,and peripheral venous blood was obtained from 13 subjects (including 2 patients,and 11 controls without clinical signs of disease).DNA samples were extracted and 4 exons of the TTR gene were amplified by polymerase chain reaction (PCR).The gene fragments were subjected to sequencing analysis.The results were analyzed with DNAMAN Windows 5.2.2.0 and Chromas sequence chart analysis software,TTR gene exons were compared between affected patients and normal controls.Results:Family pedigree analysis revealed that patients were distributed in three generations.Male and female subjects had equal prevalence,and only one parent of affected patients had signs of disease.TTR gene exon sequencing showed that the sequence of patients was identical to that of normal individuals.No TTR gene mutations were noted in 10 unaffected family members.However,a TTR Gly-54 point mutation in the 2nd exon was detected in two patients and 1 unaffected family member (one of the patients' daughters).Vitreous samples in 4 cases (7 eyes) showed positive Congo red staining,suggesting that these family members suffered from familial vitreous amyloidosis.Conclusion:This pedigree affected with familial vitreous amyloidosis was characterized by autosomal dominant inheritance;.a TTR Gly-54 point mutation in the 2nd exon is presumed to be the cause.This Gly-54 point mutation of the TTR gene is a novel mutation in vitreous amyloidosis. | Yining Shi Jing Li Jia Hu Jun Hu Lijun Sun Huijin Li Rui Shi Le Yang Ye Sun Chan Li | 2011 | Eye Science2011，26，4： | 9 |
| 2 | Genetic control of compound leaf development in the mungbean(Vigna radiata L.)显示文摘Many studies suggest that there are distinct regulatory processes controlling compound leaf development in different clades of legumes.Loss of function of the LEAFY(LFY)orthologs results in a reduction of leaf complexity to different degrees in inverted repeat-lacking clade(IRLC)and non-IRLC species.To further understand the role of LFY orthologs and the molecular mechanism in compound leaf development in non-IRLC plants,we studied leaf development in unifoliate leaf(un)mutant,a classical mutant of mungbean(Vigna radiata L.),which showed a complete conversion of compound leaves into simple leaves.Our analysis revealed that UN encoded the mungbean LFY ortholog(VrLFY)and played a significant role in leaf development.In situ RNA hybridization results showed that STM-like KNOXI genes were expressed in compound leaf primordia in mungbean.Furthermore,increased leaflet number in heptafoliate leaflets1(hel1)mutants was demonstrated to depend on the function of VrLFY and KNOXI genes in mungbean.Our results suggested that HEL1 is a key factor coordinating distinct processes in the control of compound leaf development in mungbean and its related non-IRLC legumes. | Keyuan Jiao Xin Li Shihao Su Wuxiu Guo Yafang Guo Yining Guan Zhubing Hu Zhenguo Shen Da Luo | 2019 | Horticulture Research2019，6，1： | 2 |
| 3 | Clinical and Hereditary Features of Familial Vitreous Amyloidosis in Chinese显示文摘Purpose:To investigate the clinical and hereditary features of a Chinese Han pedigree with familial vitreous amyloidosis.Methods:The hereditary features of familial traits were detected by drawing genealogy,and the clinical menifestations were observed.Results:This family with 4 generations of 32 family members had the characteristics of euchromosome dominant inheritance.The age of onset in heterozygotes was over 40 years old in male and over 55 in female.All affected individuals had curly hair.Among the 23 family members of the first 3 generations,7 had the final diagnosis.Four of the cases treated by vitrectomy was found to have open angle glaucoma during the follow-up.Conclusion:We reported a Chinese Han pedigree with familial vitreous amyloidosis which is a rare condition in Chinese and described the clinical and hereditary features.The genetic sequencing and animal model are undergoing. | Yining Shi Le Yang Jing Li Jia Hu Rui Shi Ye Sun Chuntao Zhang | 2011 | Eye Science2011，26，1： | 2 |
| 4 | A MICROPAYMENT SCHEME BASED ON WEIGHTED MULTI-DIMENSIONAL HASH CHAIN显示文摘Hash chain and its generalization—Multi-Dimensional Hash Chain (MDHC) have been widely used in the design of micropayment due to its simplicity and efficiency. In this letter, a more efficient variant of MDHC, called WMDHC, which endows in the structure of MDHC a weight value for each hash value through a well-defined mapping, is proposed. The average hash operation number of WMDHC is log(2 m / t ),which is better than log( m )of MDHC when the parameter t is typically suggested as t = 7. | Liu Yining Hu Lei Liu Heguo | 2006 | Journal of Electronics(China)2006，23，5： | 2 |
| 5 | Factors influencing Li^(+)migration in garnet-type ceramic electrolytes显示文摘Garnet-type ceramic electrolyte with exceptionally high Li^(+) conductivity has attracted wide interests for the development of safe electrochemical devices.However,the factors affecting the ionic migration still deserve more attentions.In this study,five garnet-types ceramic electrolyte were chosen to investigate the factors.The thermal behavior of garnet-type electrolyte during sintering was studied to achieve high conductivity.The electrochemical properties are correlated with crystal structure,migrating route and lattice parameters.Nine influening factors were discussed to analyze the ionic migration in garnet-type ceramic electrolyte. | Yu Huan Yi Fan Yining Li Baoyi Yin Xun Hu Dehua Dong Tao Wei | 2019 | Journal of Materiomics2019，5，2： | 2 |
| 6 | An improved method to analyse tooth and restoration contour using image analysis: Application in the maxillary anterior teeth in Chinese population显示文摘 | Hao Yu Qing Li Jian Hu Yining Wang | 2008 | Archives of Oral Biology2008，，6： | 1 |
| 7 | Thermostable Nitrogen-Doped HTiNbO5 Nanosheets with a High Visible-Light Photocatalytic Activity显示文摘做氮的 HTiNbO5 nanosheets 被第一 exfoliating 成功地综合了在 tetrabutylammonium 氢氧化物(TBAOH ) 到的分层的 HTiNbO5 获得 HTiNbO5 nanosheets 然后与脲加热 nanosheets。产生样品被 X 光检查描绘衍射(XRD ) ,传播电子显微镜学(TEM ) ,扫描电子显微镜学(SEM ) ,精力散的 X 光检查(EDX ) , X 光检查光电子光谱学(XPS ) ,紫外力的光谱学和 N2 吸附解吸附作用大小。在分层的结构,内在的 bandgap 变窄和可见轻回答的高得多的 thermostability 结果,被发现那做 N。做的氮原子主要位于 TiNbO5 lamellae 的空隙的地点并且化学上跳了到氢离子。与做 N 的 HTiNbO5 相比,做 N 的 HTiNbO5 nanosheets 由于 titanoniobate nanosheets 的相当松开、不规则的安排有一个大得多的特定的表面区域和更富有的 mesoporosity。做 N 的分层的 HTiNbO5 和 HTiNbO5 nanosheets 为玫瑰精 B (RhB ) 的降级显示出一项很高可见光的 photocatalytic 活动水的答案。而且由于更加更大的表面区域,更富有的 mesoporosity 和更强壮的酸味,做 N 的 HTiNbO5 nanosheets 比做 N 的 HTiNbO5 举办了一项甚至更高的活动,尽管后者在可见区域有更强壮的吸收。染料分子主要被降级到脂肪族的有机化合物并且部分使矿物化到 CO2 或公司,而非简单地被将脱色。photosensitization 的效果是不足道的, RhB 主要经由典型 photocatalytic 反应线路被降级。为在在做 N 的 HTiNbO5 nanosheets 上的可见轻照耀下面的 RhB 的 photodegradation 的二条不同反应线路被建议了。现在的方法能被扩大到有置闰和脱落的特征的很多分层的金属氧化物,因此为高度有效、潜在地实际的可见光的光催化剂的制造提供新机会。 | Zheng Zhai Yucheng Huang Lin Xu Xiaoyan Yang Chenhui Hu Lihong Zhang Yining Fan Wenhua Hou | 2011 | Nano Research2011，4，7： | 1 |
| 8 | Inhibition of HIF-1αAffects Autophagy Mediated Glycosylation in Oral Squamous Cell Carcinoma Cells显示文摘 | YiNing Li JiAn Hu HuiMing Wang | 2015 | Disease markers2015，2015，23： | 1 |
| 9 | Study on the Reduction Behavior of Zirconia Supported Iron Oxide Catalysts by Temperature-programmed Reduction Combined with in Situ Moessbauer Spectroscopy显示文摘 | CHEN Kaidong FAN Yining HU Zheng | 1996 | Journal of Solid State Chemistry (S0022-4596)1996，121，1： | 1 |
| 10 | Using an efficient hash chain and delaying function to improve an e-tottery seheme显示文摘 | Liu Yining Hu Lei | 2007 | Intemational Journal of Computer Mathematics2007，87，7： | 1 |
| 11 | Rotating ring-disk studies of oxidized nickel hydrous oxide: oxygen evolution and pseudocapacitanc 显示文摘 | Yining Hu Yuriy V Tolmachev Daniel A Seherson | 1999 | J Electro-analytical Chemistry1999，468，： | 1 |
| 12 | Sentiment Analysis for MOOC Course Reviews显示文摘Currently,increasing users are using MOOC platforms to choose courses and leave text comments with emotional overtones.The traditional words vector representationmethod uses static method to extract text information,which ignores the text position information.The traditional convolutional neural network fails to make full use of the semantic features and association information of the text between channels,which will cause inaccurate text sentiment classification.In order to solve the problems,a text classification model based on Albert and Capsule Network and attention mechanism is proposed.The model was verified on the MOOC comment data set,and compared with the traditional user comment sentiment analysis model.The results show the accuracy of the model was improved to a certain extent. | Tianyi Liu Wei Hu Fang Liu Yining Li | 2021 | 国际计算机前沿大会会议论文集2021，，2： | 0 |
| 13 | Application of Auger electron spectroscopy in lithium-ion conducting oxide solid electrolytes显示文摘Garnet-type oxide solid electrolytes are the critical materials for all-solid-state lithium ion batteries.Nanoscale spectroscopic analysis on solid electrolytes plays a key role in bridging the gap between microstructure and properties.In this work,Auger electron spectroscopy(AES),which can directly detect lithium element and distinguish its valence state,was applied to characterize the garnet-type Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6O12)(LLZTO).Different spectroscopy parameters were evaluated and optimal acquisition conditions were provided.Electron induced precipitation of lithium metal from LLZTO was observed.By exploring the influence factors of precipitation and combining transmission electron microscopy(TEM)and focused ion beam(FIB)experiments,the underlying mechanism of the phenomenon was revealed and previous controversy was resolved.The analysis method was also extended to other types of solid electrolytes,and this work provides a reference for future in-depth research on the structure-property relationship of solid electrolytes using AES. | Yue Zhang Wenbo Zhai Xiangchen Hu Yilan Jiang Shaojie Chen Yining Zhang Wei Liu Yi Yu | 2023 | Nano Research2023，16，3： | 0 |
| 14 | MCMOD:The Multi-Category Large-Scale Dataset for Maritime Object Detection显示文摘The marine environment is becoming increasingly complex due tothe various marine vehicles,and the diversity of maritime objects poses a challengeto marine environmental governance.Maritime object detection technologyplays an important role in this segment.In the field of computer vision,there is no sufficiently comprehensive public dataset for maritime objects inthe contrast to the automotive application domain.The existing maritimedatasets either have no bounding boxes(which are made for object classification)or cover limited varieties of maritime objects.To fulfil the vacancy,this paper proposed the Multi-Category Large-Scale Dataset for MaritimeObject Detection(MCMOD)which is collected by 3 onshore video camerasthat capture data under various environmental conditions such as fog,rain,evening,etc.The whole dataset consists of 16,166 labelled images alongwith 98,590 maritime objects which are classified into 10 classes.Comparedwith the existing maritime datasets,MCMOD contains a relatively balancedquantity of objects of different sizes(in the view).To evaluate MCMOD,this paper applied several state-of-the-art object detection approaches fromcomputer vision research on it and compared their performances.Moreover,a comparison between MCMOD and an existing maritime dataset was conducted.Experimental results indicate that the proposed dataset classifies moretypes of maritime objects and covers more small-scale objects,which canfacilitate the trained detectors to recognize more types of maritime objects anddetect maritime objects over a relatively long distance.The obtained resultsalso showthat the adopted approaches need to be further improved to enhancetheir capabilities in the maritime domain. | Zihao Sun Xiao Hu Yining Qi Yongfeng Huang Songbin Li | 2023 | Computers, Materials & Continua2023，，4： | 0 |
| 15 | Structure and function of the membrane microdomains in osteoclasts显示文摘The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases.Strong experimental evidence supports the existence of membrane microdomains in osteoclasts(OCs).However,the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized.Membrane microdomain components,such as scaffolding proteins and the actin cytoskeleton,as well as the roles of individual membrane proteins,need to be elucidated.In this review,we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle. | Jialong Hou Jian Liu Zhixian Huang Yining Wang Hanbing Yao Zhenxin Hu Chengge Shi Jiake Xu Qingqing Wang | 2023 | Bone Research2023，11，4： | 0 |
| 16 | A novel peptide-based probe^(99m)Tc-PEG_(6)-RD-PDP2 for the molecular imaging of tumor PD-L2 expression显示文摘Tumor-related PD-L2 expression is associated with the clinical efficacy of PD-1/PD-L1 blockade therapy.PD-L2-specific imaging can help selecting patients for appropriate immunotherapy.In this study,a PD-L2-targeting peptide(PDP2)was screened by the one-bead one-compound combinatorial library approach.Using the retro-inverso D-peptide of PDP2(RD-PDP2)and PEGylation strategies,we developed a novel Tc-99m-labeled PD-L2-targeting peptide as a SPECT tracer(^(99m)Tc-PEG_(6)-RD-PDP2)for imaging of tumor PD-L2 expression.The radiolabeling yield of ^(99m)Tc-PEG_(6)-RD-PDP2 was greater than 95%by the standard HYNIC/tricine/TPPTS labeling procedure.^(99m)Tc-PEG_(6)-RD-PDP2 displayed high PD-L2-binding specificity both in vitro and in vivo.SPECT/CT imaging with^(99m)Tc-PEG_(6)-RD-PDP2 showed that the A549-PD-L2tumors were clearly visualized,whereas the signals in PD-L2-negative A549 tumors were much lower.In vivo blocking study suggested that the tumor uptake of^(99m)Tc-PEG_(6)-RD-PDP2 was PD-L2 specifically mediated.^(99m)Tc-PEG_(6)-RD-PDP2 is a promising SPECT probe for the non-invasive imaging of tumor PD-L2expression and has a great potential in guiding the anti-PD-1 or anti-PD-L1 immunotherapy of cancer. | Qi Luo Yunwei Zhang Zihua Wang Yining Sun Linqing Shi Yue Yu Jiyun Shi Zhiyuan Hu Fan Wang | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 17 | Atomically precise gold nanoclusters for healthcare applications显示文摘The potential application of gold nanoparticles(GNPs)in biomedicine has been extensively reported.However,there is still too much puzzle about their real face and potential health risks in comparison with the commercial drug molecules.The emergence of atomically precise gold nanoclusters(APGNCs)provides the opportunity to address the puzzle due to their ultrasmall size,defined molecular formula,editable surface engineering,available structures and unique physicochemical properties including excellent biocompatibility,strong luminescence,enzyme-like activity and efficient renal clearance,et al.Recently,these advantages of APGNCs also endow them promising performances in healthcare such as bioimaging,drug delivery,antibacterial and cancer therapy.Especially,their clear composition and structures like the commercial drug molecules facilitate the study of their functions and the structure-activity relationship in healthcare,which is essential for the guided design of APGNC nanomedicine.Therefore,this review will focus the advantages and recent progress of APGNCs in health care and envision their prospects for the future. | Tiansheng Wei Congcong Mi Yan Sun Yining Chen Xiaoyang Hu Zibao Gan Xiuwen Zheng | 2023 | Biomedical Engineering Communications2023，2，4： | 0 |
| 18 | Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target显示文摘Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease.At present,no definite ALS biomarkers are available.In this study,exosomes from the plasma of patients with ALS and healthy controls were extracted,and differentially expressed exosomal proteins were compared.Among them,the expression of exosomal coronin-1a(CORO1A)was 5.3-fold higher than that in the controls.CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice.CORO1A was also overexpressed in NSC-34 motor neuron-like cells,and apoptosis,oxidative stress,and autophagic protein expression were evaluated.CORO1A overexpression resulted in increased apoptosis and oxidative stress,overactivated autophagy,and hindered the formation of autolysosomes.Moreover,CORO1A activated Ca^(2+)-dependent phosphatase calcineurin,thereby blocking the fusion of autophagosomes and lysosomes.The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes.In conclusion,the role of CORO1A in ALS pathogenesis was discovered,potentially affecting the disease onset and progression by blocking autophagic flux.Therefore,CORO1A might be a potential biomarker and therapeutic target for ALS. | Qinming Zhou Lu He Jin Hu Yining Gao Dingding Shen You Ni Yuening Qin Huafeng Liang Jun Liu Weidong Le Sheng Chen | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 19 | Laser capture microdissection for biomedical research: towards high-throughput, multi-omics, and single-cell resolution显示文摘Spatial omics technologies have become powerful methods to provide valuable insights into cells and tissues within a complex context,significantly enhancing our understanding of the intricate and multifaceted biological system.With an increasing focus on spatial heterogeneity,there is a growing need for unbiased,spatially resolved omics technologies.Laser capture microdissection(LCM)is a cutting-edge method for acquiring spatial information that can quickly collect regions of interest(ROIs)from heterogeneous tissues,with resolutions ranging from single cells to cell populations.Thus,LCM has been widely used for studying the cellular and molecular mechanisms of diseases.This review focuses on the differences among four types of commonly used LCM technologies and their applications in omics and disease research.Key attributes of application cases are also highlighted,such as throughput and spatial resolution.In addition,we comprehensively discuss the existing challenges and the great potential of LCM in biomedical research,disease diagnosis,and targeted therapy from the perspective of high-throughput,multi-omics,and single-cell resolution. | Wenbo Guo Yining Hu Jingyang Qian Lidan Zhu Junyun Cheng Jie Liao Xiaohui Fan | 2023 | Journal of Genetics and Genomics2023，50，9： | 0 |
| 20 | Detection and Analysis of Lead,Cadmium and Arsenic Content in Common Vegetables显示文摘This study was carried out to detect content of heavy metals( Pb,Cd,and As) in vegetables,understand the current situation of heavy metal contamination in vegetables,and to provide scientific reference for further researches. It randomly selected 6 large vegetable markets and 6 supermarkets in Changsha City,selected 8 types of typical vegetables,and detected 96 samples. In accordance with maximum level of contaminants in foods in existing GB2762- 2012 standard,Nemerow composite pollution index( Pt) and grading standards,it made evaluation: uncontaminated( Pt≤ 1),mildly contaminated( 1 < Pt≤2),moderately contaminated( 2 < Pt≤3),and highly contaminated( Pt>3). Among 96 samples,range of content of Pb,Cd and As is( 0. 06- 1. 41),( 0. 06- 1. 26) and( 0. 00- 0. 91) mg / kg respectively; the over- limit rate of these metals exceeding the safety level is 78. 13%,45. 83%,and 34. 38% separately; the composite pollution index is in( 0. 90-6. 05),the eggplant is 6. 05 and hot pepper is 3. 24; the content of Pb( F =23. 908,P =0. 001) and Cd( F =64. 908,P =0. 000)are significantly different between 8 types of vegetables and there is no significant difference between the content of As( F = 4. 634,P = 0. 705> 0. 05) in 8 types of vegetables. Study shows that common vegetables in Changsha City has problem of excess Pb,Cd and As,and the Pb over- limit rate is the highest. The composite pollution index indicates that most heavy metal contamination of vegetables is mild and moderate contamination,melon,fruit and vegetable contamination is high contamination,and Cd is the major factor leading to contamination of melons,fruits and vegetables. | Yining HE Peixia CHENG Ming WANG Minyu HU | 2014 | Asian Agricultural Research2014，6，11： | 0 |
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