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| 1 | BMPs functionally replace KLf4, and support efficient reprogramming of mouse fibroblasts by Oct4 alone显示文摘由定义因素的导致的 pluripotent 干细胞的产生成为了一个有用模型调查 reprogramming 和房间命运决心的机制。然而,基于因素的 reprogramming 的精确机制仍然保持不清楚。这里,我们证明 Klf4 主要在 reprogramming 的起始的阶段行动开始 mesenchymal-to-epithelial 转变并且能是机能上地由骨头代替了形态基因的蛋白质(BMP ) 。BMP 增加了老鼠的 Oct4/Sox2-mediated reprogramming 的效率胚胎的成纤维细胞(MEF ) 到 ~1% 。BMP 也支持了 MEF 和尾巴的单个因素的基于 Oct4 的 reprogramming 胫骨的成纤维细胞。我们的研究在 reprogramming 澄清 Klf4 的贡献并且在区分的房间作为 pluripotency 的单个 setter 建立 Oct4。 | Jiekai Chen Jing Liu Jiaqi Yang You Chen Jing Chen Su Ni Hong Song Lingwen Zeng Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，1： | 26 |
| 2 | Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*显示文摘 | Hai-tao MENG Li ZHU Wan-mao NI Liang-shun YOU Jie JIN Wen-bin QIAN | 2011 | Acta Pharmacologica Sinica2011，32，4： | 10 |
| 3 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 4 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 5 | Defects as a factor limiting carrier mobility in WSe2: A spectroscopic investigation显示文摘二维的转变金属 dichalcogenides (TMD ) 的电的表演被结构的缺点的数字强烈影响。在这个工作,我们提供一条光分光镜的描述途径相关结构的缺点的数字和 WSe 2 设备的电的表演。electron-beam-lithographyprocessed WSe 2 的低温度的光致发光(PL ) 系列由于缺点一定的激子展出清楚的导致缺点的 PL 排出物,它将强烈降级电的表演。由采用一种 electron-beam-free 转移电极技术,我们成功地准备了包含缺点的有限数量的一台 backgated WSe 2 设备。约 200 厘米 2 | Zhangting Wu Zhongzhong Luo Yuting Shen Weiwei Zhao Wenhui Wang Haiyan Nan Xitao Guo Litao Sun Xinran Wang Yumeng You Zhenhua Ni | 2016 | Nano Research2016，9，12： | 8 |
| 6 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 7 | Interfacial amplification for graphene-based position-sensitive-detectors显示文摘Position-sensitive-detectors(PSDs)based on lateral photoeffect have been widely used in diverse applications1–9,including optical engineering,aerospace and military fields.With increasing demand in long distance,low energy consumption,and weak signal sensing systems,the poor responsivity of conventional PSDs has become a bottleneck limiting their applications,for example,silicon p–n or p–i–n junctions2–5,or other materials and architectures6–10.Herein,we present a high-performance graphene-based PSDs with revolutionary interfacial amplification mechanism.Signal amplification in the order of~10^(4) has been demonstrated by utilizing the ultrahigh mobility of graphene and long lifetime of photo-induced carriers at the interface of SiO_(2)/Si.This would improve the detection limit of Si-based PSDs fromμW to nW level,without sacrificing the spatial resolution and response speed.Such interfacial amplification mechanism is compatible with current Si technology and can be easily extended to other sensing systems11,12. | Wen-Hui Wang Ru-Xia Du Xi-Tao Guo Jie Jiang Wei-Wei Zhao Zhong-Hua Ni Xin-Ran Wang Yu-Meng You Zhen-Hua Ni | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 8 | Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in gastric cancer显示文摘As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer. | Siwan Wang Hui Jiang Jia Wang Haisi Wu Ting Wu Mengnan Ni Qianqian Zhao You Ji Ziting Zhang Chunming Tang Huae Xu | 2021 | The Journal of Biomedical Research2021，35，4： | 5 |
| 9 | Multichannel Financing Reduces Economic Burden and Improves the Medical Security Level for Tuberculosis Patients显示文摘Tuberculosis(TB)is one of the main infectious diseases to simultaneously cause poverty and be caused by poverty.Reducing the economic burden of TB patients in China is essential to improving patient compliance and reducing the impact of the TB epidemic.In accordance with the national reform of the medical and health system and the current status of the country’s TB prevention and treatment service system,representatives of the government proposed the concept of a multichannel financing mechanism. | Fei Huang Ni Wang You Li Hui Zhang Yanli Yuan Xiaomeng Wang Xiaolin Wang Shitong Huan Lixia Wang Mingting Chen Yanlin Zhao | 2020 | China CDC weekly2020，2，12： | 3 |
| 10 | Calibration procedures for the CHASE/HIS science data显示文摘The Hα line is an important optical line in solar observations containing the information from the photosphere to the chromosphere. To study the mechanisms of solar eruptions and the plasma dynamics in the lower atmosphere, the Chinese Hα Solar Explorer(CHASE) was launched into a Sun-synchronous orbit on October 14, 2021. The scientific payload of the CHASE satellite is the Hα Imaging Spectrograph(HIS). The CHASE/HIS acquires, for the first time, seeing-free Hα spectroscopic observations with high spectral and temporal resolutions. It consists of two observational modes. The raster scanning mode provides full-Sun or region-of-interest spectra at Hα(6559.7-6565.9 ?) and Fe I(6567.8-6570.6 ?) wavebands. The continuum imaging mode obtains full-Sun photospheric images at around 6689 ?. In this paper, we present detailed calibration procedures for the CHASE/HIS science data, including the dark-field and flat-field correction, slit image curvature correction, wavelength and intensity calibration, and coordinate transformation. The higher-level data products can be directly used for scientific research. | Ye Qiu ShiHao Rao Chuan Li Cheng Fang MingDe Ding Zhen Li YiWei Ni WenBo Wang Jie Hong Qi Hao Yu Dai PengFei Chen XiaoSheng Wan Zhi Xu Wei You Yuan Yuan HongJiang Tao XianSheng Li YuKun He Qiang Liu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 3 |
| 11 | The evolution of Epstein-Barr virus detection in nasopharyngeal carcinoma显示文摘The detection of Epstein-Barr virus(EBV)in nasopharyngeal carcinoma(NPC)has evolved over the last40 years,transitioning from simple serological tests of latent viral infection to extremely sensitive measurements of | You Quan Li Ni Sann Khin Melvin L.K.Chua | 2018 | Cancer Biology & Medicine2018，15，1： | 3 |
| 12 | A single-center retrospective long-term analysis of 80 cases of ovarian Sertoli-Leydig cell tumors显示文摘To the Editor:Sertoli-Leydig cell tumors(SLCTs)are a rare type of sex cord-stromal tumor of the ovary,accounting for<0.5%of all ovarian tumors.[1]An accurate diagnosis and the knowledge of prognosis based on clinical and pathological features have important therapeutic implications;however,the rarity of SLCT renders collecting reliable data difficult.We aimed to analyze the features of SLCTs to clarify their relationship with the behavior of the tumor and explore reasonable modes of therapy. | Ni Yang Ting Gui Dong-Yan Cao Keng Shen Yan You | 2021 | Chinese Medical Journal2021，，19： | 3 |
| 13 | Effectiveness Analysis on the Physical Activity and the Health Benefit of a Community Population Based Program显示文摘Objective To evaluate the community-based health promotion effect of physical activity. Methods The residents aged 18 and above from two communities in Gongshu District of Hangzhou City, Zhejiang province, were randomly selected and recruited for the multi-strategy and comprehensive physical activity intervention. Questionnaire survey, physical check up and blood biochemistry were conducted. Results After this two-year intervention, the time of the participant spent on weekly physical activity of moderate intensity increased from 464 min to 542 min (P<0.05), with an average increase of 78 min. Time spent in walking every week increased from 533 min to 678 min (P<0.05), with an average increase of 145 min. The body weight, waistline, blood pressure and heart rate all reduced significantly (P<0.05); the vital capacity increased significantly (P<0.05); and the related biochemical indicators were also improved. Conclusion Comprehensive and evidence-based physical activity interventions targeting community population can improve the levels of physical activity, related body measurement and biochemical indicators. | JIANG Ying Ying YANG Zheng Xiong NI Rong ZHU You Qun LI Zhi Yu YANG Li Chen ZHAI Yi ZHAO Wen Hua | 2013 | Biomedical and Environmental Sciences2013，26，6： | 3 |
| 14 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
| 15 | Measurement of the expression levels of BLyS and its receptors mRNA in patients with systemic lupus erythematosus显示文摘Objective: To measure the expression levels of BLyS and its receptors mRNA in peripheral blood mononuclear cells (PBMC) using real-time fluorescence quantitative polymerase chain reaction(RFQ-PCR) method and to investigate the relationship between BLyS and its receptors mRNA expression and systemic lupus erythematosus (SLE). Methods: Specific primers and TaqMan probe were designed, and RFQ-PCR was performed. According to the standard curve of plasmid DNA, the level of BLyS and its receptors mRNA expression in 23 patients with SLE and 23 healthy subjects were determined. The ratio of the copy number of BLyS mRNA to that of β2-microgluobulin (β2M) mRNA and the ratio of the copy number of BLyS receptors mRNA to that of β2M mRNA were regarded as indicator for the levels of BLyS and BLyS mRNA expression. Results: The concentration of RFQ-PCR was in the range of 10-109 pg/ml, and the coefficient of variation values for both intra-experimental and inter-experimental reproducibility ranged from 2.40% to 10.12% and from 4.26% to 12.29%, respectively. In 23 SLE patients, the level of BLyS and its receptors(BCMA, TACI, BAFF-R) mRNA were in the ranges of 1.27~1.49, 0.64~0.77, 0.83~1.05 and 0.98~1.37, respectively. The mean values were 1.38±0.07, 0.70±0.04, 0.91±0.06 and 1.15±0.12, respectively. In 23 healthy donors, the levels of BLyS and its receptors(BCMA, TACI, BAFF-R) mRNA were: 0.60~1.0, 0.55~0.80, 0.54~0.74 and 0.54~0.77, respectively. The mean values were 0.83±0.13, 0.68±0.08, 0.65±0.07 and 0.68±0.06, respectively. Conclusion: This results suggest that BLyS, TACI and BAFF-R might be involved in the pathogenesis of SLE and the mRNA expression levels might be used as new markers for the diagnosis of SLE. | Shaoqing Ju Donglei Zhang Yueguo Wang Hongbing Ni Xudong Wang Jian You Shijian Su Huiming Wang Xiantao Kong Renqian Zhong | 2006 | Journal of Nanjing Medical University2006，20，2： | 2 |
| 16 | Enhanced Crystallization Rate of Poly(L-lactide)/Hydroxyapatite-graftpoly(D-lactide) Composite with Different Processing Temperatures显示文摘Hydroxyapatite-graft-poly(D-lactide)(HA-g-PDLA)was synthesized by ring-opening polymerization with HA as initiator and stannous octanoate(Sn(Oct)2)as catalyst.Thermogravimetric analysis(TGA)and Fourier transform infrared spectroscopy(FUR)results indicate that PDLA chains are successfully grafted onto HA particles by covalent bond.Under two different processing temperatures(190 and 230℃),the effect of the grafted PDLA chains on the crystallization behavior of poly(L-lactide)/HA-g-PDLA(PLLA/HA-g-PDLA)composite was investigated in the current study,comparing to neat PLLA and its four composites(PLLA/HA,PLLA/HA-g-PLLA,PLLA/PDLA,and PLLA/HA/PDLA).The crystallization rate of PLLA/HA-g-PDLA composite is highly enhanced comparing to PLLA,PLLA/HA and PLLA/HA-g-PLLA composites in which there are no stereocomplex(SC)crystallites.In addition,when the processing temperature rises from 190℃ to 230℃,the acceleration of PLLA crystallization in PLLA/HA-g-PDLA composite is not influenced so much as other composites containing SC crystallites,such as PLLA/HA/PDLA or PLLA/PDLA.The differential scanning calorimetry(DSC)results demonstrate that even without SC crystallites,the crystallization of PLLA can still be accelerated a lot in this composite.This may be related to the interaction between the grafted PDLA chains and the amorphous PLLA chains in PLLA/HA-g-PDLA composite.The isothermal crystallization kinetics studies indicate that the nature of nucleation and crystal growth of PLLA/HAg-PDLA composite are more likely 3D crystalline growth with heterogeneous nucleation mode,which are different from PLLA or other composites.This investigation could shed new light on the application of PLLA/HA composites. | Min Wang Lei-Chu You Yu-Qi Guo Ni Jiang Zhi-Hua Gan Zhen-Bo Ning | 2020 | Chinese Journal of Polymer Science2020，38，6： | 2 |
| 17 | Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells显示文摘 | Lan NI Peng FANG Zhuang-li HU Hai-yun ZHOU Jian-guo CHEN Fang WANG You JIN | 2018 | Current Medical Science2018，38，3： | 2 |
| 18 | A very bright (i=16.44) quasar in the ‘redshift desert’ discovered by the Guoshoujing Telescope (LAMOST)显示文摘The redshift range from 2.2 to 3 is known as the 'redshift desert' of quasars because quasars with redshifts in this range have similar optical colors as normal stars and are thus difficult to find in optical sky surveys.A quasar candidate, SDSS J085543.40001517.7, which was selected by a recently proposed criterion involving near-IR Y-K and optical g-z colors, was identified spectroscopically as a new quasar with a redshift of 2.427 by the Guoshoujing Telescope (LAMOST) commissioning observation in 2009 December and confirmed by the observation made with the NAOC/Xinglong 2.16 m telescope in 2010 March.This quasar was not identified in the SDSS spectroscopic survey.Comparing with other SDSS quasars, we found that this new quasar, with an i magnitude of 16.44, is apparently the brightest one in the redshift range from 2.3 to 2.7.From its spectral properties, we derived its central black hole mass to be (1.4~3.9)×1010 M and its bolometric luminosity to be 3.7×1048 erg s?1, which indicates that this new quasar is intrinsically very bright and belongs to the class of the most luminous quasars in the universe.Our identification supports the notion that quasars in the redshift desert can be found by the quasar selection criterion involving the near-IR colors.More missing quasars are expected to be uncovered by future LAMOST spectroscopic surveys, which is important to the study of the cosmological evolution of quasars at redshifts higher than 2.2. | Xue-Bing Wu Zhao-Yu Chen Zhen-Dong Jia Wen-Wen Zuo Yong-Heng Zhao A-Li Luo Zhong-Rui Bai Jian-Jun Chen Hao-Tong Zhang Hong-Liang Yan Juan-Juan Ren Shi-Wei Sun Hong Wu Yong Zhang Ye-Ping Li Qi-Shuai Lu You Wang Ji-Jun Ni Hai Wang Xu Kong Shi-Yin Shen | 2010 | Research in Astronomy and Astrophysics2010，10，8： | 2 |
| 19 | Design, synthesis, and biological evaluation of N-hydroxycinnamamide/salicylic acid hybrids as histone deacetylase inhibitors显示文摘Novel histone deacetylase(HDAC) inhibitors 9a–l were designed and synthesized by coupling the carboxyl group of salicylic acid(SA) with N-hydroxycinnamamides through various alkylol amines, and their in vitro biological activities were evaluated. The N-hydroxycinnamamide/SA hybrids 9b–f and 9h showed good to moderate anti-tumor activities. Notably, compound 9e had a greater potency, comparable to vorinostat(SAHA), in human colon carcinoma cells, which was probably, or at least partially, attributable to the positive effects of the chain length noted in alkylol amines. Furthermore, the HDAC inhibitory activities of 9e against Hela cell nuclear were also similar to that of vorinostat(SAHA), while the tested compounds 9c–f did not exhibit any isoform selectivity in the inhibition of HDACs. In addition, compound 9e could selectively inhibit tumor cells, but not inhibit non-tumor cell proliferation in vitro. Our findings suggest that the N-hydroxycinnamamide/SA hybrids may hold significant promise as therapeutic agents for the intervention of human cancers. | Tao You Ke Chen Fei-Hai Wang Pi-Hong Li Li-Yi Li Zhi-Hao Wu Kong-Hai Ni Zhi-Qiang Zheng | 2014 | Chinese Chemical Letters2014，25，3： | 2 |
| 20 | Lowering glucose level elevates [Ca^2+] in hypothalamic arcuate nucleus NPY neurons through P/Q-type Ca^2+ channel activation and GSK31~ inhibition显示文摘 | Yu CHEN Jun ZHOU Na XIE Chao HUANG Jun-qi ZHANG Zhuang-li HU Lan NI You JIN Fang WANG Jian-guo CHEN Li-hong LONG | 2012 | Acta Pharmacologica Sinica2012，33，5： | 1 |
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