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| 1 | Enzyme extraction by ultrasound from sludge flocs显示文摘Enzymes play essential roles in the biological processes of sludge treatment.In this article,the ultrasound method to extract enzymes from sludge flocs was presented.Results showed that using ultrasound method at 20 kHz could extract more types of enzymes than that at 40 kHz and ethylenediamine tetraacetic acid(EDTA) methods.The optimum parameters of ultrasound extraction at 20 kHz were duration of 10 min and intensity of 552 W/g TSS.Under the optimum condition,ultrasound could break the cells and extract both the extracellular and a small part of intercellular enzymes.Ultrasound intensity was apparently more susceptive to enzyme extraction than duration,suggesting that the control of intensity during ultrasound extraction was more important than that of duration.The Pearson correlation analysis between enzyme activities and cation contents revealed that the different types of enzymes had distinct cation binding characteristics. | YU Guanghui,HE Pinjing,SHAO Liming,ZHU Yishu State Key Laboratory of Pollution Control and Resource Reuse,Key Laboratory of Yangtze River Water Environment,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China. | 2009 | Journal of Environmental Sciences2009，21，2： | 8 |
| 2 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 3 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 4 | Interactions between water vapor and atmospheric aerosols have key roles in air quality and climate change显示文摘INTRODUCTION Atmospheric aerosols,which are ubiquitous in the planetary boundary layer, have received much attention due to their effects on visibility,climate and human health.Water,a semi-volatile species,is ubiquitous in the atmosphere as well.The interaction between water vapor and aerosols plays a key role in determining the aerosol properties in the atmosphere and therefore has great effects on both air quality (Fig.la and b)and climate change (Fig.lc),which is depicted in Fig.1 as a function of atmospheric relative humidity (RH)and temperature. | Zhijun Wu Jie Chen Yu Wang Yishu Zhu Yuechen Liu Bai Yao Yuanhang Zhang Min Hu | 2018 | National Science Review2018，5，4： | 4 |
| 5 | Compositional and structural study of ash deposits spatially distributed in superheaters of a large biomass-fired CFB boiler显示文摘Recognizing the nature and formation progress of the ash deposits is essential to resolve the deposition problem hindering the wide application of large-scale biomass-fired boilers.Therefore,the ash deposits in the superheaters of a 220 t/h biomass-fired CFB boiler were studied,including the platen(PS),the high-temperature(HTS),the upper and the lower low-temperature superheaters(LTS).The results showed that the deposits in the PSs and HTSs were thin(several millimeters)and compact,consisting of a yellow outer layer and snow-white inner layer near the tube surface.The deposits in the upper LTS appeared to be toughly sintered ceramic,while those in the lower LTS were composed of dispersive coarse ash particles with an unsintered surface.Detailed characterization of the cross-section and the initial layers in the deposits revealed that the dominating compositions in both the PSs and the HTSs were Cl and K(approximately 70%)in the form of KCl.Interestingly,the cross-section of the deposition in the upper LTS exhibited a unique lamellar structure with a major composition of Ca and S.The contents of Ca and Si increased from approximately 10%to approximately 60%in the deposits from the high temperature surfaces to the low temperature ones.It was concluded that the vaporized mineral matter such as KCl played the most important role in the deposition progress in the PS and the HTS.In addition,although the condensation of KCl in the LTSs also happened,the deposition of ash particles played a more important role. | Yishu XU Xiaowei LIU Jiuxin QI Tianpeng ZHANG Minghou XU Fangfang FEI Dingqing LI | 2021 | Frontiers in Energy2021，15，2： | 3 |
| 6 | Climate Characteristics of Abnormal Double-Blocking Activities over the Ural Mountains and Sea of Okhotsk显示文摘By using NCEP–NCAR daily reanalysis data for June–August of 1948–2009, the synoptic situation of the doubleblocking high pressure process over the Ural Mountains–Sea of Okhotsk region was identified objectively, and the climatic characteristics and dynamic mechanism during the double blockings were also investigated. The results suggest that the Urals–Okhotsk double-blocking high experienced obviously an abrupt change around 1977. After the change, the occurrence frequency and number of sustained days of the blocking high reduced significantly.Moreover, the zonal spacing between the Urals blocking and the Okhotsk blocking also decreased, while their meridional locations did not change much. The double blockings became strengthened in general, and the blocking high over the Sea of Okhotsk extended northward evidently. However, during the process without double-blocking activities, the intensity and location of the double-blocking high showed no noticeable variation before and after the abrupt change. In addition, dynamic diagnosis shows that after the abrupt change, the energy of the double-blocking high mainly propagated vertically from low to high levels, and transferred horizontally from low to high latitudes; whereas, previously, before the abrupt change, this occurred from high to low latitudes. Meanwhile, the development of a low pressure system was fueled between the double blockings, which meant that the double-blocking activity was beneficial to the maintenance and development of the Northeast China cold vortex. In short, diagnosis of the wave energy has provided us with a better explanation of the life cycle characteristics of this double-blocking phenomenon before and after 1977. | Gang LIU Tao WANG Xueyan YANG Yishu WANG Xu YANG Yan CUI | 2017 | Journal of Meteorological Research2017，31，4： | 3 |
| 7 | LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice显示文摘The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion.Here,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked defects.Pinch deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column formation.Pinch loss drastically reduces Smad2/3 protein expression in proliferative zone(PZ)chondrocytes and increases Runx2 and Col10a1 expression in both PZ and hypertrophic zone(HZ)chondrocytes.Pinch loss increases sclerostin and Rankl expression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone mass.In vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of chondrocytes.Through its C-terminal region,Pinch1 interacts with Smad2/3 proteins.Pinch loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary BMSCs.Interestingly,compared to those from single mutant mice,BMSCs from dKO mice express dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation capacity.Finally,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb shortening.Collectively,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms. | Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao | 2020 | Bone Research2020，8，4： | 2 |
| 8 | Formation and emission characteristics of VOCs from a coal-fired power plant显示文摘On-site measurements of volatile organic compounds(VOCs)in different streams of flue gas were carried out on a real coal-fired power plant using sampling bags and SUMMA canisters to collect gas samples,filters to collect particle samples.Gas chromatography-flame ionization detector/mass spectrometry and gas chromatography-mass spectrometry was the offline analysis method.We found that the total mass concentration of the tested 102 VOC species at the outlet of wet flue gas desulfuration device was(13456±47)μg·m^(-3),which contained aliphatic hydrocarbons(57.9%),aromatic hydrocarbons(26.8%),halogen-containing species(14.5%),and a small amount of oxygen-containing and nitrogencontaining species.The most abundant species were 1-hexene,n-hexane and 2-methylpentane.The top ten species in terms of mass fraction(with a total mass fraction of 75.3%)were mainly hydrocarbons with a carbon number of 6 or higher and halogenated hydrocarbons with a lower carbon number.The mass concentration of VOC species in the particle phase was significantly lower than that in the gas phase.The change of VOC mass concentrations along the air pollution control devices indicates that conventional pollutant control equipment had a limited effect on VOC reduction.Ozone formation potential calculations showed that aromatic hydrocarbons contributed the highest ozone formation(46.4%)due to their relatively high mass concentrations and MIR(maximum increment reactivity)values. | Jingying Xu Yue Lyu Jiankun Zhuo Yishu Xu Zijian Zhou Qiang Yao | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 2 |
| 9 | Much enhanced electromagnetic wave absorbing properties from the synergistic effect of graphene/γ-graphyne heterostructure in both gigahertz and terahertz band ranges显示文摘Exploring advanced electromagnetic wave(EMW)absorbers is one of the most feasible ways to solve the increasing electromagnetic pollution in both military and civil fields.In this work,γ-graphyne(γ-GY)is synthesized by a mechanochemical route using CaC2 and hexabromobenzene(PhBr6).Then three-dimensional(3D)reduced graphene oxide/γ-GY(RGO/GY)heterostructures are prepared through facile solvothermal self-assembly and subsequent thermal reduction.The influences of calcination temperature and the content ofγ-GY of the composite on EMW absorption performance are fully investigated.The minimum reflection loss(RL)value of the RGO/GY composite foam is−71.73 dB at 10.48 GHz with the matching thickness of 3.54 mm,and the effective absorption bandwidth(EAB)less than−10 dB is 7.36 GHz.Moreover,excellent terahertz(THz)absorption property is also obtained at 0.2–1.6 THz.The RL of 84.08 dB is acquired,and the EAB covers 100%of the entire measured bandwidth.In addition,the composite is also a promising anticorrosive EMW absorber.This work provides encouraging findings,which are also instructive for the potential advantages of graphyne-based materials as highly efficient EMW absorbers in both gigahertz and terahertz band ranges. | Zhiwei Zhang Zhuo Li Lun Xia Ruofeng Wang Yishu Cao Zheng Cheng Yi Huang | 2023 | Nano Research2023，16，1： | 2 |
| 10 | Effect of Rapeseed Straw on Growth and Slaughter Performance of Sichuan White Goose显示文摘[Objective] The paper was to study the effects of rapeseed straw on growth and slaughter performance of Sichuan white goose.[Method]Totally 4003-day-old Sichuan white geese were randomly divided into four groups; geese in control group were fed with the fundamental diet; geese in group 1,group 2 and group 3 were fed with the fundamental diet containing 5%,10% and 10% rapeseed straw instead of equal amount of wheat bran,respectively.The body weight and slaughter performance of Sichuan white geese in control group,group 1 and group 2 were determined at 10 weeks of age,while those in group 3 were determined at14 weeks of age.[Result] There was no significant difference in gross weight,slaughter weight,eviscerated weight with giblet,head weight,sole weight,wing weight,neck weight,muscular stomach weight and intestine indexes of 10-week-old white geese between group 1 and control group,and between group 2 and control group( P > 0.05); the live weight slightly decreased.The growth and slaughter performance of 14-week-old Sichuan white geese were significantly higher than that of 10-week-old geese( P < 0.05),with better meat and flavor,but relatively low average daily gain( P < 0.05); there was no significant impact on muscular stomach p H and intestinal p H( P > 0.05).[Conclusion]Substituting partial wheat bran with rapeseed straw can satisfy the diet requirement of Sichuan white geese,but has no significant impact on its growth and slaughter performance( P > 0.05). | Yang Ting Lei Zhengda Zhang Yishu Yu Zhiqiang Wang Dayi | 2017 | Animal Husbandry and Feed Science2017，9，6： | 1 |
| 11 | Preparation andProperties of Poly ( ether-Ester-Amide )/Poly ( acryloni- trile-co-butadiene-co-styrene) Antistatic Blends 显示文摘 | Fu Yishu Wang Jikui Zhao Guang | 2011 | Jour- nal of Applied Polymer Science2011，122，： | 1 |
| 12 | Compact electro-optic modulator on lithium niobate显示文摘Fast electro-optic modulators with an ultracompact footprint and low power consumption are always highly desired for optical interconnects.Here we propose and demonstrate a high-performance lithium niobate electro-optic modulator based on a new 2×2 Fabry–Perot cavity.In this structure,the input and reflected beams are separated by introducing asymmetric multimode-waveguide gratings,enabling TE_(0)−TE_(1)mode conversion.The measured results indicate that the fabricated modulator features a low excess loss of∼0.9dB,a high extinction ratio of∼21dB,a compact footprint of∼2120μm^(2),and high modulation speeds of 40 Gbps OOK and 80 Gbps PAM4 signals.The demonstrated modulator is promising for high-speed data transmission and signal processing. | Bingcheng Pan Hongyuan Cao Yishu Huang Zong Wang Kaixuan Chen Huan Li Zejie Yu Daoxin Dai | 2022 | Photonics Research2022，10，3： | 1 |
| 13 | Melatonin in Chinese medicinal herbs显示文摘 | Chert Guofang Huo Yishu Tan Dunxian | 2003 | Life Sciences2003，73，： | 1 |
| 14 | Dynamical simulation of laboratory microGrid显示文摘 | YISHU ZHAO LI GUO | 2009 | IEEE Power and Energy Engineering Conference2009，27，1： | 1 |
| 15 | Experimental study on mixed mode crack propagation显示文摘 | Zhao Yishu | 1989 | Engineering Fracture Mechanics1989，34，4： | 1 |
| 16 | A tabu search approach for the deterministic and stochastic vehicle fleet mix and routing problem显示文摘 | WU Taihsi HUANG Chinchih YANG Yishu | 2001 | Journal of the Chinese Institute of Industrial Engineers2001，18，5： | 1 |
| 17 | Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering显示文摘 | Xuebin Chen Fang Zhang Xinhong He Yinsheng Xu Zhiping Yang Li Chen Shaomei Zhou Yishu Yang Zhixiang Zhou Wang Sheng Yi Zeng | 2012 | Injury2012，，： | 1 |
| 18 | The role of steam in silica vaporization and ultrafine particulate matter formation during wet oxy-coal combustion显示文摘 | Yishu Xu Xiaowei Liu Zijian Zhou Lei Sheng Chao Wang Minghou Xu | 2014 | Applied Energy2014，，： | 1 |
| 19 | A tabu search approach for the deterministic and stochastic vehicle fleet mix and routing problem 显示文摘 | Wu Taihsi Huang Chinchih Yang Yishu | 2001 | Journal of the Chinese Institute of Industrial Engineers2001，18，5： | 1 |
| 20 | Association of Parkinson’s disease with six single nucleotide polymorphisms located in four PARK genes in the northern Han Chinese population显示文摘 | Yishu Zhou Xiaoguang Luo Fengrui Li Xiaofei Tian Lanhui Zhu Yichun Yang Yan Ren Hao Pang | 2011 | Journal of Clinical Neuroscience2011，，7： | 1 |
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