|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer显示文摘因为高发生和高死亡,肺癌症是在中国的最致命的癌症之一。Cyclooxygenase-2 (COX-2 ) 和容器 endothelial 生长因素 C (VEGF-C ) 被发现在恶意的肿瘤的 lymphangiogenesis 起一个重要作用。在这研究,我们调查了淋巴的 microvessel 密度(LMVD ) 是否与在非小的房间肺癌症(NSCLC ) 的预后有关是 COX-2 和 VEGF-C 的病人,和表情以便在 NSCLC lymphangiogenesis 决定 COX-2 和 VEGF-C 的可能的角色。嵌入的织物 NSCLC 取样的 65 修理福尔马林的石蜡被染色的 immunohistochemical 为 COX-2 和 VEGF-C 评估。估计肿瘤 lymphangiogenesis, LMVD 被 immunohistochemical 染色 VEGFR-3 polyclonal 决定抗体。在 COX-2 和 VEGF-C 表示, LMVD,和 clinicopathologic 参数之中的关系被分析。在 65 件样品之中,高 LMVD 显著地与淋巴节点转移和差的幸存被联系。Multivariate 幸存分析证明那 LMVD 价值和淋巴节点转移是独立预示的因素。COX-2 和 VEGF-C 的表示水平比邻近的纸巾的那些显著地高。在 NSCLC 的 COX-2 和 VEGF-C 表情显著地与淋巴节点转移,然而并非与耐心的性,年龄,肿瘤尺寸,或肿瘤相关,节点,转移分类舞台。COX-2- 或 VEGF-C-positive 肿瘤的吝啬的 LMVD 价值比 COX-2- 或 VEGF-C-negative 肿瘤的高。重要关联在 COX-2 和 VEGF-C 的表情之间被发现。这研究建议 LMVD 可以是为 NSCLC 病人的重要预示的因素之一。VEGF-C 可能在 COX-2 lymphangiogenic 小径起一个重要作用。COX-2 和 VEGF-C 可以由刺激 lymphangiogenesis 在肿瘤前进起一个重要作用。lymphangiogenesis, COX-2,或 VEGF-C 活动的抑制可以在 NSCLC 的控制有一个重要治疗学的好处。 | Xufeng Guo Yongbing Chen Zhonghua Xu Zhonghen Xu Yongyue Qian Xueyan Yu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 34 |
| 2 | DNA microarray analysis of fluconazole resistance in a laboratory Candida albicans strain显示文摘几机制为获得的 fluconazole (FLC ) 负责在 Candida albicans 的抵抗。在这研究,我们开发了 FLC 抵抗的 C。通过 FLC 易受影响的 C 的连续文化的 albicans 紧张。有 FLC 的禁止的集中的 albicans 紧张。赞美 DNA 微数组分析和即时反向的抄写聚合酶链反应被用来在易受影响的父母紧张和抵抗女儿紧张在 azole 抵抗的获得期间调查基因表示变化。表示基因代表了的差别工作象运输 ers 一样多样(例如 CDR1, PDR17 ) ,麦角固醇生合成(例如 ERG2, ERG9 ) ,甾醇新陈代谢(例如 ARE2, IPF6464 ) ,精力新陈代谢(例如 ADH3, AOX2 ) 并且抄写因素(例如 FCR1, ECM22 ) 。功能的分析表明膜运输 ers 的那项精力依赖者流出活动增加了,那个麦角固醇内容作为与易受影响的紧张相比在抵抗紧张与甾醇中介的累积减少了。我们发现在导致了 Tac1 的活动过度的抄写因素 TAC1 的一个点变化(N977K ) 能是原因为在在抵抗紧张的 CDR1, CDR2,和 PDR17 的表示上。而且,在导致的 ERG3 的单个氨基酸差别(D19E ) 在里面 Erg3 的激活能在这抵抗紧张在麦角固醇生合成基因的表示说明两甾醇先锋累积和变化。这些调查结果在临床的 C 扩展 FLC 抵抗的潜在的新奇分子的目标的理解。albicans 孤立。 | Lan Yan Jundong Zhang Miaohai Li Yongbing Cao Zheng Xu Yingying Cao Pinghui Gao Yan Wang Yuanying Jiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 11 |
| 3 | Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy显示文摘Hepatocellular carcinoma(HCC)is one of the deadliest cancers due to its complexities,reoccurrence after surgical resection,metastasis and heterogeneity.In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA,various strategies including transarterial chemoembolization,radiotherapy,locoregional therapy and chemotherapy have been investigated in clinics.Recently,cancer nanotechnology has got great attention for the treatment of various cancers including HCC.Both passive and active targetings are progressing at a steady rate.Herein,we describe the lessons learned from pathogenesis of HCC and the understanding of targeted and non-targeted nanoparticles used for the delivery of small molecules,monoclonal antibodies,miRNAs and peptides.Exploring current efficacy is to enhance tumor cell response of chemotherapy.It highlights the opportunities and challenges faced by nanotechnologies in contemporary hepatocellular carcinoma therapy,where personalized medicine is increasingly becoming the mainstay.Overall objective of this review is to enhance our understanding in the design and development of nanotechnology for treatment of HCC. | Yongbing Sun Wen Ma Yuanyuan Yang Mengxue He Aimin Li Lei Bai Bin Yu Zhiqiang Yu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 8 |
| 4 | LEARNING STRATEGIES AND THEIR RELATIONSHIP TO LEARNING ACHIEVEMENT IN READING COMPREHENSION——A REPORT ON NON-ENGLISH MAJORS IN CHINA显示文摘This paper reports on a study of the relationship between learning strategies and reading comprehension. To establish the variables, a learning strategies’ questionnaire was administered to about 200 students in the second-year of a non-English majors degree course in a university in Changchun. Their learning achievement was established by their scores on a reading comprehension test. The relationship between learning strategies and achievement was then examined through the SPSS 8.0 statistical analysis system. It was found that cognitive strategies were the strongest predictor to reading achievement and four other variables (metacognitive strategies, social-affective strategies, reading habits and examination strategies) also demonstrated a significant relationship with reading achievement to differing degrees. Among these variables, social-affective strategies were the only negative predictor. In addition, a significant difference existed between the high-score group and the low-score group in the use of cognitive strategies, metacognitive strategies and examination strategies. | Zhou Xiaorong Changchun University of Science and Technology, Changchun Liu Yongbing Jilin University of Technology, Changchun | 2000 | Chinese Journal of Applied Linguistics2000，23，1： | 8 |
| 5 | Enhancing the leaching effect of an ion-absorbed rare earth ore by ameliorating the seepage effect with sodium dodecyl sulfate surfactant显示文摘Ameliorating the problem of low leaching efficiency,long leaching period,and high agent consumption should be studied to efficiently exploit ion-absorbed rare earth ore resources.In this study,the surfactant sodium dodecyl sulfate(SDS) is used to enhance the leaching effect of an ion-absorbed rare earth ore by ameliorating the seepage effect for the first time.The effects of surfactant concentration,leaching agent dosage,solution flow velocity,and solution pH on the leaching rate were explored,and the mechanism of SDS was discussed.Under the optimum conditions,the addition of a small amount of SDS(mass fraction0.04%) can increase the leaching rate by about 5%,shorten the leaching period,and reduce the consumption of the leaching agent.SDS significantly ameliorates the seepage effect of the ore body by reducing the surface tension of the leaching agent and ameliorating the wettability of the mineral surface.This effect is the main factor that improves the leaching efficiency.DFT(density functional theory) calculation results show that SDS can react with rare earth ions,which reduces the adsorption strength on clay mineral surfaces.Hence,rare earth ions are easily exchanged by ammonium ions,and mass transfer is enhanced. | Yongbing Zhang Boyuan Zhang Siqi Yang Zhigang Zhong Hepeng Zhou Xianping Luo | 2021 | International Journal of Mining Science and Technology2021，31，6： | 8 |
| 6 | Graphene-carbon nanotube hybrid films for high- performance flexible photodetectors显示文摘Graphene 活跃地为灵活、可拉长的设备作为候选人材料正在被探索。然而,基于 graphene 的灵活 photonic 设备的发展,即光电探测器,被碳原子的单个层的低吸收度妨碍。最近,货车 der Waals 结合了碳 nanotube 和 graphene 混血儿电影证明了像静脉的碳 nanotube 网络的优秀 photoresponsivity,和使用导致了显著地更高的机械力量。这里,我们第一次报导,有 51 A/W 和快回答 ~ 预定的 ~ 的高 photoresponsivity 的一个灵活光电探测器在可见范围上的 40 ms,揭示这个新兴的所有碳混血儿的唯一的潜力为灵活设备拍摄。另外,设备对重复弯曲展出好坚韧性,建议它在大区域的矩阵数组的适用性灵活光电探测器。 | Yujie Liu Yuanda Liu Shuchao Qin Yongbing Xu Rong Zhang Fengqiu Wang | 2017 | Nano Research2017，10，6： | 7 |
| 7 | Effects of Surface-activated Coal Gangue Aggregates on Properties of Cement-based Materials显示文摘Effects of calcined coal gangue(CG) aggregates treated by the surface thermal activation on the flowability and strength, and paste-CG aggregate interfaces of the cement-based material were investigated. The experimental results show that the compressive and flexural strength of the cement-based material with the calcined CG aggregates is much higher than that of the material with the natural CG aggregates, but the flowability of the material with calcined CG is significantly reduced with the calcined time. The strength of the material with the calcined CG aggregates only increases little with the calcined time at the same w/c ratio, but is reduced with the calcined time at the same flowability. The CG aggregates calcined by the surface thermal activation obviously overcomes the disadvantages of fully calcined CG. | YANG Quanbing Lü Miaoxiong LUO Yongbing | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 6 |
| 8 | Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARg/NF-kB/IL-6 signaling pathway显示文摘Traumatic brain injury(TBI)is the major cause of high mortality and disability rates worldwide.Pioglitazone is an activator of peroxisome proliferator-activated receptor-gamma(PPARγ)that can reduce inflammation following TBI.Clinically,neuroinflammation after TBI lacks effective treatment.Although there are many studies on PPARγin TBI animals,only few could be converted into clinical,since TBI mechanisms in humans and animals are not completely consistent.The present study,provided a potential theoretical basis and therapeutic target for neuroinflammation treatment after TBI.First,we detected interleukin-6(IL-6),nitric oxide(NO)and Caspase-3 in TBI clinical specimens,confirming a presence of a high expression of inflammatory factors.Western blot(WB),quantitative real-time PCR(qRTPCR)and immunohistochemistry(IHC)were used to detect PPARγ,IL-6,and p-NF-kB to identify the mechanisms of neuroinflammation.Then,in the rat TBI model,neurobehavioral and cerebral edema levels were investigated after intervention with pioglitazone(PPARγactivator)or T0070907(PPARγinhibitor),and PPARγ,IL-6 and p-NF-kB were detected again by qRT-PCR,WB and immunofluorescence(IF).The obtained results revealed that:1)increased expression of IL-6,NO and Caspase-3 in serum and cerebrospinal fluid in patients after TBI,and decreased PPARγin brain tissue;2)pioglitazone could improve neurobehavioral and reduce brain edema in rats after TBI;3)the protective effect of pioglitazone was achieved by activating PPARγand reducing NF-kB and IL-6.The neuroprotective effect of pioglitazone on TBI was mediated through the PPARγ/NF-kB/IL-6 pathway. | Yongbing Deng Xue Jiang Xiaoyan Deng Hong Chen Jie Xu Zhaosi Zhang Geli Liu Zhu Yong Chengfu Yuan Xiaochuan Sun Changdong Wang | 2020 | Genes & Diseases2020，7，2： | 6 |
| 9 | Differential gene expression analysis of ‘Chili’ (Pyrus bretschneideri) fruit pericarp with two types of bagging treatments显示文摘Preharvest bagging is a simple,grower-friendly and safe physical protection technique commonly applied to many fruits,and the application of different fruit bags can have various effects.To explore the molecular mechanisms underlying the fruit quality effects of different bagging treatments,digital gene expression(DGE)profiling of bagged and unbagged‘Chili’(Pyrus bretschneideri Rehd.)pear pericarp during development was performed.Relative to unbagged fruit,a total of 3022 and 769 differentially expressed genes(DEGs)were detected in the polyethylene(PE)-bagged and non-woven fabric-bagged fruit,respectively.DEGs annotated as photosynthesis-antenna proteins and photosynthesis metabolism pathway were upregulated in non-woven fabric-bagged fruit but downregulated in the PE-bagged fruit.Non-woven fabric bagging inhibited lignin synthesis in‘Chili’pear pericarp by downregulating DEGs involved in phenylpropanoid biosynthesis;consequently,the fruit lenticels in non-woven fabric-bagged fruit were smaller than those in the other treatments.The results indicate that the non-woven fabric bagging method has a positive effect on the appearance of‘Chili’pear fruit but neither of the two bagging treatments is conducive to the accumulation of soluble sugar. | Yuling Wang Xinfu Zhang Ran Wang Yingxin Bai Chenglian Liu Yongbing Yuan Yingjie Yang Shaolan Yang | 2017 | Horticulture Research2017，4，1： | 6 |
| 10 | Adsorption of platinum(Ⅳ)onto D301R resin显示文摘磅(IV ) 是 D301R 树脂在 pH = 的媒介吸附的份量上 3.47。静态地浸透的吸附能力是 410 mg/g。在 D301R 树脂上吸附的磅(IV ) 能是由 1.0-2.0 mol/L NaOH 的 eluted。率常数是 k298 = 5. | MO Jianjun SHI Linmei GU Yongbing YAN Guobing | 2008 | Rare Metals2008，27，3： | 6 |
| 11 | Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors显示文摘The tumor microenvironment(TME)significantly influences cancer evolution and therapeutic efficacy.Targeting biofunctional molecules to the TME has long been appreciated as a means of raising local drug concentrations and reducing systemic toxicities.The booming nanotechnology field has realized the importance of cathepsin B to derive a variety of intelligent enzyme-responsive nanosized drug delivery systems(nanoDDS)to improve treatment responses and clinical outcomes.In this tutorial review,after introducing the molecular structure and physiological/pathological functions of cathepsin B,the outstanding achievements of cathepsin B-responsive nanoplatforms in the precise diagnosis,targeted therapy,and synergistic theranostics of malignant tumors are systematically described.Finally,the challenges of enzyme-substrate incompatibility,low diagnostic sensitivity,mass production and biocompatibility of multifunctional nanoDDS are considered in order to successfully promote them to clinical applications. | Yanan Li Ting Mei Shupeng Han Tao Han Yongbing Sun Hui Zhang Feifei An | 2020 | Chinese Chemical Letters2020，31，12： | 5 |
| 12 | Preparation and application of ZnO doped Pt-CeO2 nanofibers as electrocatalyst for methanol electro-oxidation显示文摘ZnO doped Pt/CeO_2 nanocomposites were prepared by electrospinning and reduction impregnation.Xray diffraction(XRD),transmission electron microscopy(TEM),energy disperse spectroscopy(EDS) and X-ray photoelectron spectroscopy(XPS) were employed to characterize the nanocomposites.It is observed that ZnO and CeO_2 form the hexagonal wurtzite phase and cubic fluorite phase in the nanocomposite,respectively,whilst Pt nanoparticles(NPs) with the number-averaged size of ca.3.1 nm are uniformly distributed on the surface of nanofibers.The mass fraction of Pt NPs in the nanocomposites is about 10 wt%.The doping of ZnO is effective to promote reactive oxygen species,surface reaction sites and the interaction between Pt and oxides.The catalytic performance of nanocomposites was evaluated by the methanol electro-oxidation.indexed with the catalytic activity,stability of catalyst.As a result,it is found that the nanocomposite exhibits much higher activity and stability for methanol oxidation than the undoped Pt/CeO_2 catalyst. | Yingping Zheng Xin Zhang Zhengying Zhang Ying Li Yueming Sun Yongbing Lou Xiaojun Li Yang Lu | 2018 | Journal of Rare Earths2018，36，9： | 5 |
| 13 | Reaction mechanism and metal ion transformation in photocatalytic ozonation of phenol and oxalic acid with Ag^+/TiO_2显示文摘Photocatalytic ozonation of phenol and oxalic acid(OA) was conducted with a Ag+/TiO2 catalyst and different pathways were found for the degradation of different compounds. Ag+ greatly promoted the photocatalytic degradation of contaminants due to its role as an electron scavenger. It also accelerated the removal rate of OA in ozonation and the simultaneous process for its complex reaction with oxalate. Phenol could be degraded both in direct ozonation and photolysis, but the TOC removal rates were much higher in the simultaneous processes due to the oxidation of hydroxyl radicals resulting from synergetic effects. The sequence of photo-illumination and ozone exposure in the combined process showed quite different effects in phenol degradation and TOC removal. The synergetic effects in different combined processes were found to be highly related to the properties of the target pollutants. The color change of the solution and TEM result confirmed that Ag+ was easily reduced and deposited on the surface of TiO2 under photo-illumination, and dissolved again into solution in the presence of ozone. This simple cycle of enrichment and distribution of Ag+ can greatly benefit the design of advanced oxidation processes, in which the sequences of ozone and photo-illumination can be varied according to the needs for catalyst recycling and the different properties of pollutants. | Yingying Chen Yongbing Xie Jun Yang Hongbin Cao Yi Zhang | 2014 | Journal of Environmental Sciences2014，26，3： | 5 |
| 14 | Pore structure characterization and seepage analysis of ionic rare earth orebodies based on computed tomography images显示文摘Pore network structure of ore body is a diffusion channel of leaching agent solution that exerts a significant influence on seepage.The ore body structure,pore distribution,pore and throat size,and pore network characteristics of topsoil,weathered,and semiweathered layers of ionic rare earth ore in southern Jiangxi Province were explored in this study.The effect of leaching operation on the pore structure was investigated,and main factors affecting the seepage were analyzed.Results showed that the semiweathered layer presents a dense structure and a small number of unconnected pores.Pores of topsoil and weathered layers are mainly long and narrow column openings with some planar fractures.Even pore distribution and large size span were observed.Compared with the weathered layer,the topsoil layer demonstrates larger voids,smaller average pore volume and equivalent radius,and fewer coordination throats;however,the average equivalent radius of the throat in the topsoil layer is larger and largescale channels exist through ore body vertically.Hence,permeability of the topsoil layer is significantly higher than that of the weathered layer.Colloidal clay minerals migrate easily and the occurrence of silting in the small porosity blocks the throat and significantly decreases the permeability of the ore body in the leaching process.The equivalent radius of the throat is the key to the seepage.Reducing the migration of fine particles is an effective measure to protect the throat and shorten the leaching period. | Xianping Luo Yongbing Zhang Hepeng Zhou Kunzhong He Boyuan Zhang Dongming Zhang Weijing Xiao | 2022 | International Journal of Mining Science and Technology2022，32，2： | 5 |
| 15 | Rod-shaped thiocyanate-induced abnormal band gap broadening in SCN^- doped CsPbBr3 perovskite nanocrystals显示文摘 | Yongbing Lou Yandan Niu Dongwen Yang Qiaoling Xu Yuhang Hu Ying Shen Jing Ming Jinxi Chen Lijun Zhang Yixin Zhao | 2018 | Nano Research2018，11，5： | 5 |
| 16 | Activated carbon enhanced ozonation of oxalate attributed to HO·oxidation in bulk solution and surface oxidation: Effect of activated carbon dosage and pH显示文摘Ozonation of oxalate in aqueous phase was performed with a commercial activated carbon(AC)in this work. The effect of AC dosage and solution pH on the contribution of hydroxyl radicals(HOU) in bulk solution and oxidation on the AC surface to the removal of oxalate was studied. We found that the removal of oxalate was reduced by tert-butyl alcohol(tBA) with low dosages of AC,while it was hardly affected by tBA when the AC dosage was greater than 0.3 g/L. tBA also inhibited ozone decomposition when the AC dosage was no more than 0.05 g/L, but it did not work when the AC dosage was no less than 0.1 g/L. These observations indicate that HOUin bulk solution and oxidation on the AC surface both contribute to the removal of oxalate. HOU oxidation in bulk solution is significant when the dosage of AC is low, whereas surface oxidation is dominant when the dosage of AC is high. The oxalate removal decreased with increasing pH of the solution with an AC dosage of 0.5 g/L. The degradation of oxalate occurs mainly through surface oxidation in acid and neutral solution, but through HOUoxidation in basic bulk solution. A mechanism involving both HOUoxidation in bulk solution and surface oxidation was proposed for AC enhanced ozonation of oxalate. | Linlin Xing Yongbing Xie Daisuke Minakata Hongbin Cao Jiadong Xiao Yi Zhang John C. Crittenden | 2014 | Journal of Environmental Sciences2014，26，10： | 5 |
| 17 | Dendritic BiVO4 decorated with MnOx co-catalyst as an efficient hierarchical catalyst for photocatalytic ozonation显示文摘An appropriate co-catalyst can significantly promote the photocatalytic efficacy, but this has been seldom studied in the visible-light photocatalysis combined with ozone, namely photocatalytic ozonation. In this work, a dendritic bismuth vanadium tetraoxide (BiVO4) material composited with highly dispersed MnOv nanoparticles was synthesized, and its catalytic activity is 86.6% higher than bare BiVO4 in a visible light and ozone combined process. Catalytic ozonation experiments, ultraviolet- visible (UV-Vis) diffuse reflectance spectra and photoluminescence spectra jointly indicate that MnOA plays a triple role in this process. MnOv strengthens the light adsorption and promotes the charge separation on the composite material, and it also shows good activity in catalytic ozonation. The key reactive species in this process is OH, and various pathways for its generation in this process is proposed. This work provides a new direction of catalyst preparation and pushes forward the application of photocatalytic ozonation in water treatment. | Jin Yang Xuelian Liu Hongbin Cao Yanchun Shi Yongbing Xie Jiadong Xiao | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 5 |
| 18 | Porous nanostructured ZnCo2O4 derived from MOF-74:High-performance anode materials for lithium ion batteries显示文摘Nanostructured metal oxides derived from metal organic frameworks have been shown to be promising materials for application in high energy density lithium ion batteries. In this work, porous nanostructured ZnCo_2O_4 and Co_3O_4 were synthesized by a facile and cost-effective approach via the calcination of MOF-74 precursors and tested as anode materials for lithium ion batteries. Compared with Co_3O_4, the electrochemical properties of the obtained porous nanostructured ZnCo_2O_4 exhibit higher specific capacity, more excellent cycling stability and better rate capability. It demonstrates a reversible capacity of 1243.2 m Ah/g after 80 cycles at 100 m A/g and an excellent rate performance with high average discharge specific capacities of 1586.8, 994.6, 759.6 and 509.2 m Ah/g at 200, 400, 600 and 800 m A/g, respectively.The satisfactory electrochemical performances suggest that this porous nanostructured ZnCo_2O_4 is potentially promising for application as an efficient anode material for lithium ion batteries. | Mengjuan Du Dan He Yongbing Lou Jinxi Chen | 2017 | Journal of Energy Chemistry2017，26，4： | 4 |
| 19 | Characterization of microstructure evolution and mechanical properties of the spray-deposited AZ31 magnesium alloy显示文摘The cylindrical billets of a Mg-3Al-1Zn (AZ31) alloy were synthesized by spray deposition processing. The microstruc-ture evolution and mechanical properties of the alloy were investigated. The results reveal that the microstructure of the AZ31 alloy is refined significantly by spray deposition processing. A homogeneous and equiaxial-grain structure with an average grain size of 17 μm is obtained. Further grain refinement with an average grain size of 5 μm is attributed to dynamic recrystallization during extru-sion processing. The great increase in the density of grain boundary nucleation sites by the finer initial grain sizes makes the disloca-tion pile-ups near subgrain boundaries being absorbed easily by the boundaries, resulting in an accelerated recrystallization process. The average tensile ultimate and yield strengths of the extruded rods are 321 MPa and 237 MPa, respectively, with an elongation of 15.2% at room temperature, which are remarkably higher than those of the conventional as-cast AZ31 alloy. | Yongbing Li Jinfeng Huang Hua Cui kai Tao Kui Zhang Jishan Zhang | 2008 | Journal of University of Science and Technology Beijing2008，15，6： | 4 |
| 20 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员