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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015,25,3: | 23 |
| 2 | CD146 is essential for PDGFRβ-induced pericyte recruitment显示文摘 | Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan | 2018 | Protein & Cell2018,9,8: | 9 |
| 3 | Constitutive Modeling of Slip, Twinning and Detwinning for Mg Alloy and Inhomogeneous Evolution of Microstructure显示文摘 | Yuan Chen Guijuan Hu Yongting Lan Keshi Zhang Ganwei Cai | 2018 | Acta Mechanica Solida Sinica2018,31,4: | 3 |
| 4 | A Light Space Manipulator with High Load-to-Weight Ratio: System Development and Compliance Control显示文摘In order to meet the requirements of the space environment for the lightweight and load capacity of the manipulator,this paper designs a lightweight space manipulator with a weight of 9.23 kg and a load of 2 kg.It adopts the EtherCAT communication protocol and has the characteristics of high load-to-weight ratio.In order to achieve constant force tracking under the condition of unknown environmental parameters,an integral adaptive admittance control method is proposed.The control law is expressed as a third-order linear system equation,the operating environment is equivalent to a spring model,and the control error transfer function is derived.The control performance under the step response is further analyzed.The simulation results show that the proposed integral adaptive admittance control method has better performance than the traditional method.It has no steady-state error,overcomes the problems caused by nonlinear discrete compensation,and can facilitate analysis in the frequency domain,realize parameter optimization,and improve calculation accuracy. | Zhiwei Wu Yongting Chen Wenfu Xu | 2021 | Space(Science & Technology)2021,,1: | 3 |
| 5 | Pro-inflammatory cytokine network in peripheral inflammation response to cerebral ischemia显示文摘 | Lili Zeng Yongting Wang Jianrong Liu Ling Wang Suiqing Weng Kewei Chen Edward F. Domino Guo-Yuan Yang | 2013 | Neuroscience Letters2013,,: | 1 |
| 6 | Cocktail Blood Biomarkers: Prediction of Clinical Outcomes in Patients with Acute Ischemic Stroke显示文摘 | Zeng Lili Liu Jianrong Wang Yongting Wang Ling Weng Suiqing Chen Shengdi Yang Guo-yuan | 2013 | European Neurology2013,,2: | 1 |
| 7 | Pro-inflammatory cytokine network in peripheral inflammation response to cerebral ischemia显示文摘 | Lili Zeng Yongting Wang Jianrong Liu Ling Wang Suiqing Weng Kewei Chen Edward F. Domino Guo-Yuan Yang | 2013 | Neuroscience Letters2013,,: | 1 |
| 8 | Cocktail Blood Biomarkers: Prediction of Clinical Outcomes in Patients with Acute Ischemic Stroke显示文摘 | Zeng Lili Liu Jianrong Wang Yongting Wang Ling Weng Suiqing Chen Shengdi Yang Guo-yuan | 2013 | European Neurology2013,,2: | 1 |
| 9 | A Chemical Dealloying Approach for Pt Surface-enriched Pt_(3)Co Alloy Nanoparticles as Oxygen Reduction Reaction Electrocatalysts显示文摘Pt-based alloys are the optimal electrocatalysts for oxygen reduction reaction(ORR)currently.Dealloying of Pt-based alloys has shown to be an effective approach to improving ORR activity.Electrochemical dealloying is controllable for morphology by changing electrochemical parameters but is difficult to scale up due to complex operation and energy consumption.Chemical dealloying is suitable for a large scale but it is not easy to control the morphology because highly corrosive acids(HNO_(3) or H2SO4)are commonly used.In this work,a facile chemical dealloying method for Pt_(3)Co/C has been employed to synthesize electrocatalysts for ORR using weak acids and buffer solutions of different pH,which could slow down the dissolution rate for Co atoms and increase the diffusion time for Pt atoms to improve ORR activity.It can be observed that the mass activities(MA)of the Pt_(3)Co/C alloy after dealloying with H3PO4 and NaH2PO4/Na2HPO4 buffer solution of pH=6 are close to that after electrochemical dealloying process,and are more than two times that of commercial Pt/C.In addition,Pt_(3)Co/C after dealloying with a buffer solution of pH=6 only showed a slight degradation in the half-wave potential and electrochemical surface area(ECSA)after stability test for 5000 cycles,which is more stable than commercial Pt/C.It shows that by controlling pH of the solvent,the ORR activity can be further increased.This facile approach provides a new strategy to control morphology of Pt-based electrocatalysts by chemical dealloying,which can contribute to promising application for cathodic electrocatalysts design of proton exchange membrane fuel cells(PEMFCs). | CHEN Yuanda CHEN Yongting LIO Yuxiang CHEN Shengli | 2022 | Chemical Research in Chinese Universities2022,38,4: | 0 |