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| 1 | Recent advances in periodontal regeneration: A biomaterial perspective显示文摘Periodontal disease(PD)is one of the most common inflammatory oral diseases,affecting approximately 47%of adults aged 30 years or older in the United States.If not treated properly,PD leads to degradation of periodontal tissues,causing tooth movement,and eventually tooth loss.Conventional clinical therapy for PD aims at eliminating infectious sources,and reducing inflammation to arrest disease progression,which cannot achieve the regeneration of lost periodontal tissues.Over the past two decades,various regenerative periodontal therapies,such as guided tissue regeneration(GTR),enamel matrix derivative,bone grafts,growth factor delivery,and the combination of cells and growth factors with matrix-based scaffolds have been developed to target the restoration of lost tooth-supporting tissues,including periodontal ligament,alveolar bone,and cementum.This review discusses recent progresses of periodontal regeneration using tissue-engineering and regenerative medicine approaches.Specifically,we focus on the advances of biomaterials and controlled drug delivery for periodontal regeneration in recent years.Special attention is given to the development of advanced bio-inspired scaffolding biomaterials and temporospatial control of multi-drug delivery for the regeneration of cementum-periodontal ligament-alveolar bone complex.Challenges and future perspectives are presented to provide inspiration for the design and development of innovative biomaterials and delivery system for new regenerative periodontal therapy. | Yongxi Liang Xianghong Luan Xiaohua Liu | 2020 | Bioactive Materials2020，5，2： | 17 |
| 2 | An efficient high-power femtosecond laser based on periodic-layered-Kerr media nonlinear compression and a Yb:YAG regenerative amplifier显示文摘We demonstrate an efficient ultrafast source with 195 fs pulse duration,54 W average power at 200 kHz repetition rate and near diffraction-limited beam quality.The compact setup incorporates a thin-disk Yb:YAG regenerative amplifier(RA)and a subsequent nonlinear pulse compression stage with periodic-layered Kerr media(PLKM),which is one of the multiple-thin-solid-plate schemes based on nonlinear resonator theory.In virtue of the formation of quasi-stationary spatial soliton in PLKM,the near diffraction-limited beam quality of the RA remained almost undisturbed after post-compression.The nonlinear pulse compression module is simple and efficient with a transmission of 96%.To the best our knowledge,for pulse energy over 200μJ,this is the highest output power reported for the multiple-thin-solid-plate scheme.This source manifests an economical combination to mitigate the bandwidth limitations of Yb-based high-power chirped pulse amplifiers. | Jie Guo Zichen Gao Di Sun Xiao Du Yongxi Gao Xiaoyan Liang | 2022 | High Power Laser Science and Engineering2022，10，2： | 1 |
| 3 | Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T_(1)-weighted magnetic resonance imaging显示文摘Plant polyphenol-based coordination polymers(CPs) with ultra-small particle size and tailorable compositions are highly desired in biomedical applicatio ns,but their synthesis is still challenging due to the sophisticated coordination assembly process and unavoidable self-oxidation polymerization of polyphenol. He rein,a general ligand covalent-modification mediated coordination assembly strategy is proposed for the synthesis of water-dispersible CPs with tunable metal species(e.g., Gd,Cu,Ni,Zn,Fe)and ultra-small diameter(8.6-37.8 nm) using nontoxic plant polyphenol(e.g..tannic acid,gallic acid) as a polymerizable ligand.Polyphenol molecules react with formaldehyde firstly,which can effectively retard the oxidation induced self-polymerization of polyphenol and lead to the formation of metal ions containing CPs colloidal nanoparticles.These ultrafine nanoparticles with stably chelated metal io ns are highly water dispersible and thus advantageous for bioimaging.As an example,ultra-small Gd contained CPs exhibit higher longitudinal relaxivity(r_(1)=25.5 L mmol^(-1) s^(-1)) value with low r2/r1(1.19) than clinically used Magnevist(Gd-DTPA,r1=3.7 L mmol^(-1) s^(-1)) .Due to the enhanced permeability and retention effect,they can be further used as a positive contrast agent for T1-weighted MR imaging of tumour. | Jing Qin Guohai Liang Bingxi Feng Gen Wang Na Wu Yonghui Deng Ahmed AElzatahry Abdulaziz Alghamdi Yongxi Zhao Jing Wei | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
| 4 | Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer显示文摘Dear Editor,Early diagnosis is critical for successful treatment of gastric adenocarcinoma(GA).However,the sensitivities of tumor markers carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and CA72-4 for GA detection are approximately 20%[1],and the sensitivities of all markers combined for early gastric cancer detection is still very low[2].DNA methylation plays a major role in tumorigenesis and therefore has obvious potential as a non-invasive biomarker for cancer detection[3].Through genome-wide methylation analysis and histological verification,we previously identified ring finger protein 180(RNF180)as a novel preferentially methylated gene in GA[4,5]. | Yongzhan Nie Xianchun Gao Xiqiang Cai Zhen Wu Qiaoyi Liang Guobing Xu Na Liu Peng Gao Jingyu Deng Hongzhi Xu Zhanlong Shen Changqi Cao Fenrong Chen Nannan Zhang Yongxi Song Mingjun Sun Chengyin Liu Guangpeng Zhou Weili Han Jianhua Dou Huahong Xie Liping Yao Zhiguo Liu Gang Ji Xin Wang Qingchuan Zhao Lei Shang Daiming Fan Xiaoliang Han Jianlin Ren Han Liang Zhenning Wang Jinhai Wang Qi Wu Jun Yu Kaichun Wu the MAGIS Study Group | 2023 | Cancer Communications2023，43，11： | 0 |
| 5 | Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a nasty disease with extremely high malignancy and poor prognosis.Annexin A3(ANXA3)is a potential prognosis biomarker,displaying an excellent correlation of ANXA3 overexpression with patients'poor prognosis.Silencing the expression of ANXA3effectively inhibits the proliferation and metastasis of TNBC,suggesting that ANXA3 can be a promising therapeutic target to treat TNBC.Herein,we report a first-in-class ANXA3-targeted small molecule(R)-SL18,which demonstrated excellent anti-proliferative and anti-invasive activities to TNBC cells.(R)-SL18 directly bound to ANXA3 and increased its ubiquitination,thereby inducing ANXA3 degradation with moderate family selectivity.Importantly,(R)-SL18 showed a safe and effective therapeutic potency in a high ANXA3-expressing TNBC patient-derived xenograft model.Furthermore,(R)-SL18 could reduce theβ-catenin level,and accordingly inhibit the Wnt/β-catenin signaling pathway in TNBC cells.Collectively,our data suggested that targeting degradation of ANXA3 by(R)-SL18 possesses the potential to treat TNBC. | Yongxi Liang Delin Min Hulin Fan Kunlin Liu Juchuanli Tu Xueyan He Bingjie Liu Lu Zhou Suling Liu Xun Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
| 6 | Strategic design of lysine-targeted irreversible covalent NDM-1 inhibitors显示文摘New Delhi metallo-β-lactamase 1(NDM-1) can hydrolyze most β-lactam antibiotics, which is the major factor for drug resistance of Gram-negative bacteria. The binding of most reversible inhibitors to NDM-1 is relatively weak due to the shallow active pocket of NDM-1. Alternatively, irreversible covalent inhibitors can prevent their dissociation from the target, leading to permanent inactivation of the protein.Herein, we report a series of irreversible covalent inhibitors of NDM-1 targeting the conserved Lys211 in the active pocket. Several methods, including mass spectrometry, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, fluorescent labeling, and coumarin probe were used to demonstrate that pentafluorophenyl ester formed a covalent bond with Lys211. Moreover, our target inhibitor, in combination with meropenem, achieved an antibacterial effect on drug-resistant bacteria, along with an excellent safety profile. Our new strategy in designing lysine-targeted irreversible covalent NDM-1 inhibitors provides a potential option for the clinical treatment of Gram-negative bacteria. | Youzhen Ma Yongxi Liang Menglu Guo Delin Min Lulu Zheng Yun Tang Xun Sun | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
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