|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anti-tumor activities of active ingredients in Compound Kushen Injection显示文摘Kushen (根值 Sophorae Flavescentis ) 在繁体中文药为肿瘤,发炎和另外的疾病的治疗有使用的长历史。复合 Kushen 注射(CKI ) 是从 Kushen 和 Baituling (根茎 Smilacis Glabrae ) 提取的自然混合物的混合物。CKI 的主要原则是 matrine (MT ) 和展出许多药理学活动的 oxymatrine (OMT ) ,包括反煽动性,反过敏,抗病毒, anti-fibrotic 和心血管的保护的效果。最近的证据证明这些混合物也产生反癌症行动,例如禁止癌症房间增长,导致房间周期拘捕,加速 apoptosis ,制止 angiogenesis ,导致房间区别,禁止癌症转移和侵略,逆行的 multidrug 抵抗,并且阻止或减少化疗--或导致放射疗法的毒性当与化学疗法的药结合了时。在这评论,我们在学习 MT, OMT 和 CKI 和他们的潜在的分子的目标的反癌症活动总结最近的进步,它为进一步的学习提供线索和参考书。 | Wei WANG Rong-li YOU Wen-jie QIN Li-na HAI Ming-jing FANG Guo-hua HUANG Rui-xia KANG Ming-hua LI Yu-feng QIAO Jian-wei LI An-ping LI | 2015 | Acta Pharmacologica Sinica2015，36，6： | 41 |
| 2 | Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.)显示文摘Gibberellin (GA) 2-oxidase plays a key role in the GA catabolic pathway through 2β-hydroxylation.In the present study,we isolated a CaMV 35S-enhancer activation tagged mutant,H032.This mutant exhibited a dominant dwarf and GA-deficient phenotype,with a final stature that was less than half of its wild-type counterpart.The endogenous bioactive GAs are markedly decreased in the H032 mutant,and application of bioactive GAs (GA3 or GA4) can reverse the dwarf phenotype.The integrated T-DNA was detected 12.8 kb upstream of the OsGA2ox6 in the H032 genome by TAIL-PCR.An increased level of OsGA2ox6 mRNA was detected at a high level in the H032 mutant,which might be due to the enhancer role of the CaMV 35S promoter.RNAi and ectopic expression analysis of OsGA2ox6 indicated that the dwarf trait and the decreased levels of bioactive GAs in the H032 mutant were a result of the up-regulation of the OsGA2ox6 gene.BLASTP analysis revealed that OsGA2ox6 belongs to the class III of GA 2-oxidases,which is a novel type of GA2ox that uses C20-GAs (GA12 and/or GA53) as the substrates.Interestingly,we found that a GA biosynthesis inhibitor,paclobutrazol,positively regulated the OsGA2ox6 gene.Unlike the over-expression of OsGA2ox1,which led to a high rate of seed abortion,the H032 mutant retained normal flowering and seed production.These results indicate that OsGA2ox6 mainly affects plant stature,and the dominant dwarf trait of the H032 mutant can be used as an efficient dwarf resource in rice breeding. | Jian Huang Ding Tang Yi Shen Baoxiang Qin Lilan Hong Aiqing You Ming Li Xin Wang Hengxiu Yu Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，1： | 36 |
| 3 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 4 | Th22 cells are associated with hepatocellular carcinoma development and progression显示文摘Objective: IL-22-producing CD4+ T helper cells(Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathogenesis of hepatocellular carcinoma(HCC). The study aimed to determine the biological function of Th22 cells and its effector IL-22 in HCC patients.Methods: Forty-five HCC patients and 19 healthy controls were recruited and their peripheral blood was collected. The fresh HCC tissues, adjacent HCC tissues and ten normal liver tissues were also collected. Flow cytometry analysis was used to determine the frequencies of circulating Th22 cells and Th17 cells. Serum IL-22 levels were tested by enzyme-linked immunosorbent assay(ELISA). Immunohistochemical staining and real-time polymerase chain reaction(PCR) were used to detect IL-22 protein and mRNA in tissues specimens, respectively.Results: Circulating Th22 cells, Th17 cells and serum IL-22 levels were significantly elevated in HCC patients compared with those of healthy controls(P<0.001). Th22 cells were showed to be positively correlated with IL-22 in HCC patients(P<0.05), but not in healthy controls. No significant differences were found in HCC patients with HBeAg positivity or negativity in term of Th22 cells and serum IL-22 levels. The expression of IL-22 protein and mRNA was highest in HCC tissues, followed by adjacent HCC tissues and normal liver tissues. Furthermore, Th22 cells, serum IL-22 levels and IL-22 mRNA were elevated at stage III-IV compared with stage I-II of HCC(P<0.05).Conclusions: Elevation of circulating Th22 cells and IL-22 may be implicated in the pathogenesis of HCC, and potentially be cellular targets for therapeutic intervention. | Shanyu Qin Shijia Ma Xiaoli Huang Donghong Lu You Zhou Haixing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，2： | 25 |
| 5 | Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis显示文摘AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P < 0.001).CONCLUSION AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients. | Qun-Qun Jiang Mei-Fang Han Ke Ma Guang Chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-Yu Wu Yong-Li Wang Jie You Qin Ning | 2018 | World Journal of Gastroenterology2018，24，21： | 25 |
| 6 | DNA-based vaccination induces humoral and cellular immune responses against hepatitis B virus surface antigen in mice without activation of Cmyc显示文摘AIM To develop a safe and effective DNAvaccine for inducing humoral and cellularimmunological responses against hepatitis Bvirus surface antigen(HBsAg).METHODS BALB/c mice were inoculated withNV-HB/s,a recombinant plasmid that had beeninserted S gene of hepatitis B virus genome andcould express HBsAg in eukaryotes.HBsAgexpression was measured by ABC immunohis-tochemical assay,generation of anti-HBs byELISA and cytotoxic T lymphocyte(CTL),byMTT method,existence of vaccine DNA bySouthern blot hybridization and activation ofoncogene C-myc by in situ hybridization,RESULTS With NV-HB/s vaccination byintramuscular injection,anti-HBs was initiallypositive 2 weeks after inoculation while all micetested were HBsAg positive in the muscles.Thetiters and seroconversion rate of anti-HBs weresteadily increasing as time went on and weredose-dependent.All the mice inoculated with100 μg NV-HB/s were anti-HBs positive onemonth after inoculation,the titer was 1:1024 ormore.The humoral immune response was similarinduced by either intramuscular or intradermalinjection.CTL activities were much stronger(45.26%)in NV-HB/s DNA immunized mice as compared with those(only 6%)in plasma-derived HBsAg vaccine immunized mice.Twomonths after inoculation,all muscle sampleswere positive by Southern-blot hybridization forNV.HB/s DNA detection,but decreased to 25%and all were undetectable by in situhybridization after 6 months.No oncogene C-myc activation was found in the muscle ofinoculation site.CONCLUSION NV-HB/s could generatehumoral and cellular immunological responsesagainst HBsAg that had been safely expressed insitu by NV-HB/s vaccination. | Lian San Zhao Shan Qin Tao You Zhou Hong Tang Li Liu Bing Jun Lei | 2000 | World Journal of Gastroenterology2000，6，2： | 24 |
| 7 | A single center investigation of bare-metal or drug-eluting stent restenosis from 1633 consecutive Chinese Han ethnic patients显示文摘Background Stents are widely used in China but the clinical impression is somehow that restenosis is less common because of the lower prevalence of coronary artery disease (CAD) and associated risk factors in Chinese populations. However, no large-sample published studies are available on angiographic stent restenosis including those of bare-metal stent (BMS) or drug-eluting stent (DES) in Chinese Han ethnic population. Mothods A total of 1633 consecutive patients with CAD who had undergone coronary stenting, quantitative coronary angiography (QCA) were retrospectively studied. At the time of stent implantation and at 7 months post-stenting 675 patients had a follow-up angiography. Statistical analysis was made with the chi-square test for categorical variables, unpaired t test for continuous variables, univariate or multivariate regression for baseline and angiographic characteristics and the Kaplan-Meier method for rate of target lesion revascularization (TLR). Results Stent restenosis was defined as ≥50% diameter stenosis in the dilated segment. A total of 675 patients with 1074 lesions were subjected to angiographic follow-up for 7 months on average. Of these lesions, 448 were implanted with BMS whereas 626 lesions with DES. At 7 months, bare-metal in-stent restenosis occured in 148 lesions (33.0%), and bare metal in-segment restenosis in 155 lesions (34.6%) in contrast to drug-eluting in-stent restenosis in 48 lesions (7.7%) and drug-eluting in-segment restenosis in 73 lesions (11.7%) (P<0.001 compared with BMS respectively). Late loss in both in-stent and in segment was higher in BMS than in DES groups [(1.00±0.69) vs (0.28±0.52); (0.78±0.71) vs (0.21±0.52), P<0.001 respectively]. Angulated lesion, lesion length, pre-procedural minimal luminal diameter (MLD), and BMS were independent predictors for TLR, (P<0.01 respectively), whereas current smoker, ostial lesion, and stent overlapping, post-procedure in-stent MLD, lesion length, and stent types were independent predictors for in-segment restenosis (P<0.01 respectively). Standard coronary risk factors such as hypertension, hyperlipidemia, diabetes, and history of CAD were not associated with a higher rate of restenosis caused by BMS or DES implantation in our Chinese Han ethnic population. Conclusions Coronary stenting including BMS or DES implantation in Chinese Han ethnic patients is associated with a restenosis rate comparable to that demonstrated in previous studies from the western countries, and predictors of stent restenosis are somehow different from those in the western population. | XU Bo LI Jian-jun YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bin QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2006 | Chinese Medical Journal2006，，7： | 23 |
| 8 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 9 | Serum vascular endothelial growth factor is a potential biomarker of metastatic recurrence after curative resection of hepatocellular carcinoma显示文摘INTRODUCTIONHepatocellular carcinoma(HCC)is one of the mostcommon malignancies in China.To date,surgery is stillthe best solution to it.However,metastatic recurrencesafter curative hepatic resections are very common.Tang etal have reported that recurrence rate within 5 years | Qi Niu Zhao You Tang Zeng Chen Ma Lun Xiu Qin Lian Hai Zhang | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 10 | Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain显示文摘背景:心肌内冠的动脉被称为的 epicardial 分割的肌纤维 overlying 心肌的衔接(MB ) 。MB 的可变流行与小、大的样品尺寸研究在尸体和 angiographic 系列被描述了。另外,没有类似的学习在中国人口被报导。这研究的目的是调查 MB 的 angiographic 流行在连续有从我们的中心的胸痛的 37,106 个中国病人。方法:我们进行了观察研究在经历的病人之中与 MB 评估连续案例选择冠的血管造影术,并且在很大的样品尺寸的这研究分析了 angiograhic 流行和 MB 的临床的特征。结果:在有胸痛的 37 105 个病人之中,我们以一种回顾的方式与 1011 MB 发现了 1002 个案例,并且全面流行是 2.70% 。尽管(991/1002 ) 超过 99% 病人有单个桥牌, 8 个案例被发现有超过二 MB (七与二,和一与三) 。没有动脉粥样硬化患者损害,总的来说 54.39% 案例(545/1002 ) 有 MB,并且(973/1011 )96.24% 在左前面的下降冠的动脉(男孩) 衔接定位了,主要在男孩的中间(792/1011, 78.33%) 。根据诺贝尔分类,单个桥(n=991 ) ,阻塞的 <50% 是占优势的(471/991, 47.52%) 。完全, 50%-69% 占了 34.81%(345/991 ) ,阻塞的 >70% 是 17.65%(175/991 ) 。结论:这些数据证明在有胸痛的中国病人的 angiographically 可检测的 MB 的流行类似于以前的研究的那些,与在这种很大的样品尺寸的 2.7% 流行。 | LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XU Bo XIA Ran GAO Run-lin | 2008 | Chinese Medical Journal2008，，5： | 17 |
| 11 | Role of plasma C-reactive protein in predicting in-stent restenosis in patients with stable angina after coronary stenting显示文摘背景血浆的角色高敏感在 in-stent 狭窄(ISR ) 的 C 反应的蛋白质(hs-CRP ) 仍然保持争论。我们在成功的冠的 stenting 以后与稳定的咽峡炎( SA )在病人在承认和后续调查了血浆 hs-CRP 水平以便为我们总结了的 ISR.Methods 澄清 hs-CRP 的预兆的价值有冠的 drug-eluting stent ( DES )的 303 个连续长期的 SA 病人 implantation.The ISR 被量的冠的分析分析( QCA )在一个平均数, 8 个月的后续,和病人作为 ISR 组( n=48 )和 non-ISR g 根据检测 ISR 被划分成二个组血浆 hs-CRP 在所有病人,在承认和 8 月的后续被检验在整个调查 period.Results QCA 继续的标准药介绍了那 48 个病人(15.8%) 在后续受不了 ISR。当血浆 hs-CRP 在在承认和后续的 non-ISR 组比那在 ISR 组是更高的时,基本临床的特征在二个组之间是类似的, P 0.001 分别地。 Multivariate 回归分析显示在承认或后续的那血浆 hs-CRP 水平能独立地预言 ISR 出现( OR=5.581 ,95% Cl 2.532-12.302 , P0.001and OR=6.299 ,95% CI 2.722-14.577 , P 0.001 ,分别地) .Conclusions 我们的数据显示那血浆 hs-CRP 水平可以独立地与冠的 DES 培植在 SA 病人在承认和后续预言 ISR ,它暗示长期的、持续全身的煽动性的回答可能涉及 ISR | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bin YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，6： | 17 |
| 12 | Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting显示文摘背景尽管在预言动脉粥样硬化患者损害的快速的前进的 C 反应的蛋白质(CRP ) 的角色强烈地在不稳定的冠的动脉疾病被学习了,从有稳定的咽峡炎(SA ) 的病人的数据大部分是不在的。现在的学习评估了一个中间尺寸的耐心的队与 stent 培植和后续经历了经皮的冠的干预(一种总线标准)冠的 angiography ( CAG )并且测试了高度敏感的 CRP 的那增加的血浆水平将显示的假设 de novo 非目标的快速的前进在有 SA.Methods 的中国病人的冠的动脉损害学习人口与长期的 SA 311 个连续病人包括了在起始的承认上经历了冠的 stent | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bing YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，19： | 17 |
| 13 | Discharge Characteristics of Long SF6 Gas Gap with and Without Insulator in GIS Under VFTO and LI显示文摘Gas insulator switchgears(GISs),widely used in electric power systems for decades,have many advantages due to their compactness,minimal environmental impact,and long maintenance cycles.However,very fast transient overvoltage(VFTO)increases caused by a rise in voltage levels can lead to GIS insulation failures.In this paper,a generating system of VFTO and standard lightning impulse(LI)is established.The insulation characteristics of SF6 gas with and without insulators under VFTO and standard LI are investigated.Experimental results show that the 50%breakdown voltages of the inhomogeneous electric field rod-plane gap under positive VFTO and standard LI are higher than that under negative VFTO and standard LI.The research shows that the 50%breakdown voltage under VFTO could be lower than that under standard LI at 0.5 MPa for the negative polarity.Moreover,the polarity effect of the insulator without defect is different from that with defect.Similarly,the breakdown voltage of the defective insulator under VFTO could be lower than that under standard LI by 8%.The flashover channel under VFTO is seen as more than that under standard LI.Based on the analysis of discharge images and experimental results,it is concluded that the polarity effect is related to the distortion effect of ion clusters formed by SF6 on the electric field.Additionally,the steepness and front time of impulse plays an important role in the initiation and further development of discharge on insulator surface.Finally,the research shows that different discharge characteristics between VFTO and standard LI may be caused by different wave fronts and oscillation on the tails of the impulses. | Tao Wen Qiaogen Zhang Jingtan Ma Can Guo Haoyang You Yifan Qin Yu Yin Weidong Shi Weijiang Chen | 2015 | CSEE Journal of Power and Energy Systems2015，1，3： | 17 |
| 14 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 15 | A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer rapamycin-eluting stent for the treatment of coronary artery disease in a “real world” setting:six-month follow-up results显示文摘背景几临床的试用证明了 rapamycin-eluting stents 显著地在经皮的冠的干预(一种总线标准) 以后减少狭窄的风险。鲜艳的小鸟 stent 和 Excel stent (与 bioabsorbable 聚合物涂) rapamycin-eluting stents 的二种不同类型在中国被做,两个最近被州的食物药品管理局在中国为临床的使用同意了。然而,是否在在在2006年6月的每日的 practice.Methods 的 stents 的二种类型之间的安全和功效地有差别,是不清楚的, 190 个连续病人的一个总数专门与鲜艳的小鸟 stents 被对待( n=93 ,鲜艳的小鸟组)或胜过 stents ( n=97 ,胜过组)在我们的中心并且在这研究被包括。主要不利心脏的事件的频率(向,一死亡,心肌的梗塞或目标损害 revascularization 合成) ,二进制狭窄,和迟了的腔损失和 stent 血栓在二个 groups.Results 病人之间在一个六月的后续时期期间被比较,损害特征在这些组之间是可比较的。主要不利心脏的事件率在医院里并且在 6 个月是低的(2.1% 在 Excel 组织, 0% 在鲜艳的小鸟组织, P 0.05 ) 。6 月的 angiographic in-stent 狭窄率在两个组是 0% ,与联系迟了的损失(0.15 更高显著地在 PES 组织((0.14 ???????琠牨浯潢祬楳 吗?? | LIU Hai-bo XU Bo QIAO Shu-bin YANG Yue-jin MA Wei-hua QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran LI Jian-jun CHEN Ji-lin GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 15 |
| 16 | Long-term clinical outcomes after bioabsorbable polymer- and durable polymer-based sirolimus-eluting stents implantation: two-year follow-up results from a large single-center database显示文摘背景几临床的试用证明了 sirolimus-eluting stents 显著地在经皮的冠的干预(一种总线标准) 以后减少狭窄的风险。鲜艳的小鸟 stent (与持久的聚合物涂) 并且 EXCEL stent (与 bioabsorbable 聚合物涂) sirolimus-eluting stents 的二种不同类型在中国被做;两个被州的食物药品管理局在中国为临床的使用同意了。期中考试(6 月) angiographic 和两 stents 的临床的结果被证实了使观点结果激动。然而,是否在在每日的 practice.Methods 的 stents 的二种类型之间的长期的安全和功效地有差别,是不清楚的经历选任的一种总线标准与的所有连续病人为佼佼者或在在在北京的 Fu Wai 医院的 6 月 1,2006 日和 2006 年 12 月 31 日之间的鲜艳的小鸟 stents 被包括。病人们根据 stent 类型从索引承认被分类(为佼佼者或鲜艳的小鸟) 使用。临床、程序的风险因素有希望地被收集。与倾向分数没有代替,匹配,主要不利心脏的事件的频率(向,一死亡,心肌的梗塞或目标容器 revascularization 合成)并且 stent 血栓在二 groups.Results 之间在一个2年的后续时期期间被比较 474 个病人的一个总数被对待与为佼佼者,并且 640 与鲜艳的小鸟被对待。 397 胜过病人被匹配到 397 个鲜艳的小鸟病人,2年的调整风险的向率是6.1%在胜过组,7.6%在鲜艳的小鸟组织( HR 0.84 , 95%CI 0.50-1.43 )而为死亡,心肌的梗塞和目标容器 revascularization 的各自的率是2.3%对2.8%(冷杉木 0.74 , 95%CI 0.30-0.85 ),1.8%对1.3%( HR 1.41,95%CI 0.45-4.43 )并且2.5%对4.0%( HR 0.62 , 95%CI 0.28-0.37 )分别地。在 2 年的 stent 血栓的累积发生在 EXCEL 组是1.8%对1.3%在 FIREBIRD 组织( P=0.5610 )而很迟了的 stent 血栓的率是0.5%对1.3%,( P=0.2550 ) .Conclusions 源于这种长期的、相对大的尺寸,单个中心的学习证明两个都, EXCEL 和 FIREBIRD , sirolimus-eluting stent 在每日的实践在一种总线标准以后有向的类似、更低的发生。 | LIU Hai-bo XU Bo YANG Yue-jin WANG Yang QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun MA Wei-hua LI Jian-jun QIAO Shu-bin CHEN Ji-lin LI Wei GAO Run-lin | 2009 | Chinese Medical Journal2009，，6： | 14 |
| 17 | Impact of depressed left ventricular function on outcomes in patients with three-vessel coronary disease undergoing percutaneous coronary intervention显示文摘 | GAO Zhan XU Bo Ajay J. Kirtane YANG Yue-jin YUAN Jin-qing CHEN Ji-lin QIAO Shu-bin WU Yong-jian QIN Xue-wen YAN Hong-bin YAO Min LIU Hai-bo CHEN Jue YOU Shi-jie GAO Run-lin | 2013 | Chinese Medical Journal2013，，4： | 11 |
| 18 | Plumbagin inhibits cell growth and potentiates apop-tosis in human gastric cancer cells -in vitro through the NF-KB signaling pathway显示文摘 | Jing LI Lin SHEN Fu-rong LU You QIN Rui CHEN Jia LI fan LI Han-zi ZHAN Yuan-qiao HE | 2012 | Acta Pharmacologica Sinica2012，33，2： | 11 |
| 19 | Comparison of immediate and followup results between transradial and transfemoral approach for percutaneous coronary intervention in true bifurcational lesions显示文摘在为在分叉的经皮的冠的干预(一种总线标准) 的 transradial 和 transfemoral 途径之间的功效和安全的背景 A 比较没被做。这研究评估了 transradial 一种总线标准(TRI ) 的可行性并且在 bifurcations.Methods 把立即、紧跟的结果与 transfemoral 一种总线标准(TFI ) 作比较有分叉的 134 个连续病人从 2004 年 4 月在我们的医院里与打印机控制语言被对待到 2005 年 10 月。这些,在 TFI 组在 TRI 组和 74 个病人(101 损害) 有 60 个病人(88 损害) 。分叉类型根据因斯蒂图特·卡迪奥瓦苏莱雷·帕里斯·苏德 Classification.Results TRI 组的意见被分类有的更小的 stent 直径((3. | YANG Yue-jin XU Bo CHEN Ji-lin KANG Sheng QIAO Shu-bin QIN Xue-wen YAO Min CHEN Jue WU Yong-jian LIU Hai-bo YUAN Jin-qing YOU Shi-jie LI Jian-jun DAI Jun GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 11 |
| 20 | Hierarchical Magnetic Network Constructed by CoFe Nanoparticles Suspended Within “Tubes on Rods” Matrix Toward Enhanced Microwave Absorption显示文摘Hierarchical magnetic-dielectric composites are promising functional materials with prospective applications in microwave absorption(MA)field.Herein,a three-dimension hierarchical“nanotubes on microrods,”core–shell magnetic metal–carbon composite is rationally constructed for the first time via a fast metal–organic frameworksbased ligand exchange strategy followed by a carbonization treatment with melamine.Abundant magnetic CoFe nanoparticles are embedded within one-dimensional graphitized carbon/carbon nanotubes supported on micro-scale Mo2N rod(Mo2N@CoFe@C/CNT),constructing a special multi-dimension hierarchical MA material.Ligand exchange reaction is found to determine the formation of hierarchical magnetic-dielectric composite,which is assembled by dielectric Mo2N as core and spatially dispersed CoFe nanoparticles within C/CNTs as shell.Mo2N@CoFe@C/CNT composites exhibit superior MA performance with maximum reflection loss of−53.5 dB at 2 mm thickness and show a broad effective absorption bandwidth of 5.0 GHz.The Mo2N@CoFe@C/CNT composites hold the following advantages:(1)hierarchical core–shell structure offers plentiful of heterojunction interfaces and triggers interfacial polarization,(2)unique electronic migration/hop paths in the graphitized C/CNTs and Mo2N rod facilitate conductive loss,(3)highly dispersed magnetic CoFe nanoparticles within“tubes on rods”matrix build multi-scale magnetic coupling network and reinforce magnetic response capability,confirmed by the off-axis electron holography. | Chunyang Xu Lei Wang Xiao Li Xiang Qian Zhengchen Wu Wenbin You Ke Pei Gang Qin Qingwen Zeng Ziqi Yang Chen Jin Renchao Che | 2021 | Nano-Micro Letters2021，13，3： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员