|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Principles,structures,and implementation of reconfigurable ternary optical processors显示文摘This paper discusses the principles,structures,and implementation procedures for reconfiguring a ternary optical processor (TOP).Typical structures,classifications,and naming of the TOP and basic operation units (BOUs) are described in this paper.The circuit implementations,commands,and processes for the reconfiguration are also discussed in detail.A simple analysis of the high performance and low power consumption of ternary optical computers is presented.Finally,an experiment is performed on reconfiguring a 1-bit BOU,which shows that the principles of reconfigurable TOPs are valid,and that the implementations and commands for the reconfiguration are effective. | JIN Yi WANG HongJian OUYANG shan ZHOU Yu SHEN YunPu PENG JunJie LIU XueMin | 2011 | Science China(Information Sciences)2011，54，11： | 23 |
| 2 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 3 | Methane–air explosion characteristics with different obstacle configurations显示文摘To investigate the flame and overpressure characteristics of methane–air explosion with different obstacle configurations,an experimental study has been conducted,taking account of the number of obstacles,obstacle distance from ignition source,and stream-wise and cross-wise obstacle positions.The results show that the flame speed and peak overpressure increase with the increasing number of obstacles,while the time to reach the peak is not fully determined by it.And the configuration having the farthest obstacle produces a higher overpressure and takes a longer time to reach the peak,but a slower flame propagation speed is obtained.Similar explosion characteristics are also observed in the configurations with two obstacles fixed at different stream-wise positions.Furthermore,the experimental results demonstrate that the peak overpressures and flame speeds in configurations with central or staggered obstacles are relatively higher,which should to be avoided in practical processes to minimize the risk associated with methane–air explosion. | Wen Xiaoping Yu Minggao Ji Wentao Yue Meng Chen Junjie | 2015 | International Journal of Mining Science and Technology2015，25，2： | 16 |
| 4 | PM_(2.5) and PM_(10-2.5) chemical composition and source apportionment near a Hong Kong roadway显示文摘Twenty-four-hour PM_(2.5) and PM_(10) samples were collected simultaneously at a highly trafficked roadside site in Hong Kong every sixth day from October 2004 to September 2005.The mass concentrations of PM_(2.5),PM_(10-2.5)(defined as PM_(10)- PM_(2.5)),organic carbon(OC),elemental carbon(EC),water-soluble ions,and up to 25 elements were determined.Investigation of the chemical compositions and potential sources revealed distinct differences between PM_(2.5) and PM_(10-2.5).The annual average mass concentrations were 55.5±25.5 and 25.9±15.7 ug/m^3 for PM_(2.5) and PM_(10-2.5),respectively.EC,OM(OM =OC×1.4),and ammonium sulfate comprised over ~82% of PM_(2.5),accounting for^29%,~27%,and ~25%,respectively,of the PM_(2.5) mass.Low OC/EC ratios(less than 1) for PM_(2.5) suggested that fresh diesel-engine exhaust was a major contributor.Seven sources were resolved for PM_(2.5) by positive matrix factorization(PMF) model,including vehicle emissions(~29%),secondary inorganic aerosols(~27%),waste incinerator/biomass burning(~23%),residual oil combustion(~10%),marine aerosols(~6%),industrial exhaust(~4%),and resuspended road dust(~1%).EC and OM comprised only ~19%of PM_(10-2.5).The average OC/EC ratio of PM_(10-2.5) was 7.8±14.2,suggesting that sources other than vehicular exhaust were important contributors.The sources for PM_(10-2.5) determined by the PMF model included ~20%traffic-generated resuspension(e.g.,tire dust/brake linear/petrol evaporation),~17% locally resuspended road dust,~17% marine aerosols,~12% secondary aerosols/field burning,and ~11%vehicle emissions. | Yan Cheng Shuncheng Lee Zhaolin Gu Kinfai Ho Yunwei Zhang Yu Huang Judith C.Chow John G.Watson Junji Cao Renjian Zhang | 2015 | Particuology2015，13，1： | 14 |
| 5 | Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing显示文摘Tracing the emergence of the first hematopoietic stem cells(HSCs)in human embryos,particularly the scarce and transient precursors thereof,is so far challenging,largely due to the technical limitations and the material rarity.Here,using single-cell RNA sequencing,we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis.The transcriptomically defined HSC-primed hemogenic endothelial cells(HECs)were captured at Carnegie stage(CS)12-14 in an unbiased way,showing an unambiguous feature of arterial endothelial cells(ECs)with the up-regulation of RUNX1,MYB and ANGPTL Importantly,subcategorizing CD34+CD45-ECs into a CD44+population strikingly enriched HECs by over 10-fold.We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells,and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs#including EMCN,PROCR and RUNX1T1.We also uncovered another temporally and molecularly distinct intra-embryonic HEC population,which was detected mainly at earlier CS 10 and lacked the arterial feature.Finally,we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSCprimed HECs.The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos,together with the ability to distinguish the HSC-primed HECs from others,will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells. | Yang Zeng Jian He Zhijie Bai Zongcheng Li Yandong Gong Chen Liu Yanli Ni Junjie Du Chunyu Ma Lihong Bian Yu Lan Bing Liu | 2019 | Cell Research2019，29，11： | 14 |
| 6 | Experiment on Leader Propagation Characteristics of Air Gaps in UHVDC Transmission Towers Under Positive Switching Impulse Voltages显示文摘Rapid developments in EHV/UHV transmission systems require a deeper understanding of the mechanism of long air gap discharge.Leader propagation is one of the main processes in long gap breakdown.In this paper,the leader propagation characteristics of real size±800 kV UHVDC transmission tower gaps under positive switching impulse voltages(185/2290μs)are investigated.An integrated observation platform consisting of an impulse voltage divider,a coaxial shunt,a high-speed video camera,and a set of integrated optical electric field sensors(IOES),is established.The waveforms of impulse voltage,discharge current,electric field variation at specific positions,and time-resolved photographs of discharge morphology are recorded.Axial leader velocity and the relationship between leader advancements and injected charge are obtained.The typical value of leader stable propagation velocity is 1.7–2.2 cm/μs,which varies slightly with the gap length and applied voltage amplitude.The leader velocity in the re-illumination process is much higher,and is seen as varying from 5 cm/μs to 30 cm/μs,with an average value around 10 cm/μs.The charge in leader channel per unit length is 20–40μC/m,which illustrates a near-direct proportion relationship between discharge current and leader velocity.The observed parameters are important for further simulation of the tower gap breakdown processes. | Xuan Zhou She Chen Hai Wang Rong Zeng Chijie Zhuang Junjie Yu Yujian Ding | 2015 | CSEE Journal of Power and Energy Systems2015，1，3： | 12 |
| 7 | The intrinsic mechanism of corrosion resistance for FCC high entropy alloys显示文摘The concept of high entropy alloys(HEAs) or multi-principal component alloys has inspired a great progress of physical metallurgy along with several unusual phenomena. The high corrosion resistance of HEAs was frequently mentioned but without convincing explanations. In this paper, the intrinsic mechanism of corrosion resistance in FCC HEAs was revealed by designing equal atomic alloys with single solid solution phase. The results showed that the Cr element in FCC HEAs played the dominant role in the corrosion resistance rather than the simple structure from high entropy effect or uniform element distribution. | shang xuliang wang zhijun he feng wang jincheng li junjie yu jiakang | 2018 | Science China(Technological Sciences)2018，61，2： | 11 |
| 8 | MicroRNA-125b-5p inhibits proliferation and promotes adipogenic differentiation in 3T3-L1 preadipocytes显示文摘以前的证据显示了 microRNA-125b (miR-125b ) 家庭戏在癌症房间生长,开发,区别,和 apoptosis 的规定的重要角色。然而,他们是否贡献 adipocyte 区别的过程,仍然保持不清楚。在现在的学习,我们表明表示 miR-125b-5p 铺平, miR-125b 家庭的一个成员,在进成熟 adipocyte 的 3T3-L1 preadipocyte 的区别期间是戏剧性地起来调整的。进 3T3-L1 房间的 miR-125b-5p 的补充支持了由增加的类脂化合物微滴和 adipocyte 特定的分子的标记的 mRNA 层次证实了的 adipogenic 区别,包括 peroxisome 激活 proliferators 的受体, CCAAT/enhancer-binding 蛋白质,丰满的酸绑定的蛋白质 4,并且脂蛋白脂肪分解酵素,并且由 triglyceride 累积。CCK-8 试金证明 miR-125b-5p 补充显著地禁止了房间增长。流动 cytometry 分析证明 miR-125b-5p 象 mRNA 和 G1/S-related 基因的蛋白质表示一样损害了 G1/S 阶段转变,例如 Cyclin D2, Cyclin D3,和 CDK4。不过,它没在 apoptosis 上有效果。由目标基因预言,另外,我们证明 smad4 可以是在鼠标 3T3-L1 preadipocytes 的 miR-125b-5p 的一个潜在的目标,为一些 miR-125b-5p 的函数的财务。一起拿,这些数据显示 miR-125b-5p 可以在 adipocyte 区别用作一个重要积极管理者,至少部分通过下面调整的 smad4。 | Dan Ouyang Yaqiong Ye Dongguang Guo Xiaofang Yu Jian Chen Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 9 |
| 9 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 10 | Controllable optical activity with non-chiral plasmonic metasurfaces显示文摘Optical activity is the rotation of the plane of linearly polarized light along the propagation direction as the light travels through optically active materials.In existing methods,the strength of the optical activity is determined by the chirality of the materials,which is difficult to control quantitatively.Here we numerically and experimentally investigated an alternative approach to realize and control the optical activity with non-chiral plasmonic metasurfaces.Through judicious design of the structural units of the metasurfaces,the right and left circular polarization components of the linearly polarized light have different phase retardations after transmitting through the metasurfaces,leading to large optical activity.Moreover,the strength of the optical activity can be easily and accurately tuned by directly adjusting the phase difference.The proposed approach based on non-chiral plasmonic metasurfaces exhibits large optical activity with a high controllable degree of freedom,which may provide more possibilities for applications in photonics. | Ping Yu Jianxiong Li Chengchun Tang Hua Cheng Zhaocheng Liu Zhancheng Li Zhe Liu Changzhi Gu Junjie Li Shuqi Chen Jianguo Tian | 2016 | Light(Science & Applications)2016，5，1： | 8 |
| 11 | Fabrication and Evaluation of a Bioactive Sr–Ca–P Contained Micro-Arc Oxidation Coating on Magnesium Strontium Alloy for Bone Repair Application显示文摘Considering the compatibility between degradation and bioactivity of magnesium-based implants for bone repair, micro-arc oxidation is used to modify the magnesium alloy surface in aqueous electrolytes,allowing strontium, calcium, and phosphorus to be incorporated into the coating. The thickness, composition, morphology and phase of this Sr–Ca–P containing coating are characterized by scanning electron microscopy equipped with energy dispersive X-ray spectrometer and X-ray diffraction. The in vitro and in vivo degradation of the coating is evaluated by immersion test, electrochemical test and implantation test. Moreover, the cytocompatibility is tested with osteoblast cell according to ISO 10993. The results show that Sr, Ca and P elements are incorporated into the oxide coating, and a refined structure with tiny discharging micro-pores is observed on the surface of the coating. The Sr–Ca–P coating possesses a better corrosion resistance in vitro and retards the degradation in vivo. Such coating is expected to have significant medical applications on orthopedic implants and bone repair materials. | Junjie Han Peng Wan Yu Sun Zongyuan Liu Xinmin Fan Lili Tan Ke Yang | 2016 | Journal of Materials Science & Technology2016，32，3： | 8 |
| 12 | Flavonoid content and radical scavenging activity in fruits of Chinese dwarf cherry(Cerasus humilis) genotypes显示文摘The Chinese dwarf cherry(Cerasus humilis(Bge.) Sok.) is a small shrub with edible fruits. It is native to northern and western China. This species was included as a medicinal plant in the ‘‘Chinese Pharmacopeia'' and has emerged as an economically important crop for fresh fruit consumption, processing into juice and wine and nutraceutical products as well. To gain a better understanding of flavonoid biosynthesis and help develop value added products and better cultivars with greater health benefits, we analyzed total flavonoid content(TFC), composition, and radical scavenging activities in fruit extracts of 16 Chinese dwarf cherry genotypes. Fruit peel TFC ranged from 33.5 to72.8 mg/g REáFW(RE: rutin equivalent, FW: fresh weight)while fruit flesh TFC ranged from 4.3 to 16.9 mg/g REáFW.An HPLC analysis revealed that fruit extracts contained 14 flavonoids with considerable variation in their profiles across genotypes. The most abundant flavonoids in most genotypes were proanthocyanidin B1(PA-B1), proanthocyanidin B2(PA-B2), phloretin 20-O-glucoside(PG), and phloretin 20,40-O-diglucoside(PDG). Principal component analysis showed that PG, PA-B1, and PA-B2 had large,positive factor loading values in the first principal component for each genotype. Increased scavenging activity of2,2-diphenyl-1-picrylhydrazyl(DPPH) radicals was apparent in genotypes ‘Nongda 4', ‘Nongda 3', ‘Nongda 6',‘Wenfenli', and '10-32', suggesting promising applications in the production of nutraceutical products. In summary, our results will aid in breeding, fruit processing, and developing medicinal uses of the Chinese dwarf cherry. | Pengfei Wang Xiaopeng Mu Junjie Du Yu Gary Gao Donghai Bai Luting Jia Jiancheng Zhang Haiyan Ren Xiaofang Xue | 2018 | Journal of Forestry Research2018，29，1： | 8 |
| 13 | Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。 | Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang | 2018 | Molecular Plant2018，11，3： | 8 |
| 14 | Timing of transplantation of autologous bone marrow derived mesenchymal stem cells for treating myocardial infarction显示文摘It is still unclear whether the timing of intracoronary stem cell therapy affects the therapeutic response in patients with myocardial infarction.The natural course of healing the infarction and the presence of putative homing signals within the damaged myocardium appear to favor cell engraftment during the transendothelial passage in the early days after reperfusion.However,the adverse inflammatory environment,with its high oxidative stress,might be deleterious if cells are administered too early after reperfusion.Here we highlight several aspects of the timing of intracoronary stem cell therapy.Our results showed that transplantation of bone marrow mesenchymal stem cells at 2 4 weeks after myocardial infarction is more favorable for reduction of the scar area,inhibition of left ventricular remodeling,and recovery of heart function.Coronary injection of autologous bone marrow mesenchymal stem cells at 2 4 weeks after acute myocardial infarction is safe and does not increase the incidence of complications. | CHEN YiHuan TENG XiaoMei CHEN WeiQian YANG JunJie YANG ZiYing YU YunSheng SHEN ZhenYa | 2014 | Science China(Life Sciences)2014，57，2： | 7 |
| 15 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 16 | Short-term power load forecasting using integrated methods based on long short-term memory显示文摘The development of power system informatization,the massive access of distributed power supply and electric vehicles have increased the complexity of power consumption in the distribution network,which puts forward higher requirements for the accuracy and stability of load forecasting.In this paper,an integrated network architecture which consists of the self-organized mapping,chaotic time series,intelligent optimization algorithm and long short-term memory(LSTM)is proposed to extend the load forecasting length,decrease artificial debugging,and improve the prediction precision for the short-term power load forecasting.Compared with LSTM prediction,the algorithm in this paper improves the prediction accuracy by 61.87%in terms of root mean square error(RMSE),and reduces the prediction error by 50%in the 40-fold forecast window under some circumstances. | ZHANG WenJie QIN Jian MEI Feng FU JunJie DAI Bo YU WenWu | 2020 | Science China(Technological Sciences)2020，63，4： | 7 |
| 17 | Eye movement indices in the study of depressive disorder显示文摘 | YU LI Yangyang XU Mengqing XIA Tianhong ZHANG Junjie WANG Xu LIU Yongguang HE Jijun WANG | 2016 | 上海精神医学2016，28，6： | 6 |
| 18 | A 23 GHz high-temperature superconducting microstrip filter for radio astronomy显示文摘This paper reports a 6-pole high-temperature superconducting (HTS) microstrip bandpass filter for radio astronomy applications. The filter has a center frequency of 23 GHz and a bandwidth the 2 GHz. We have made many efforts, such as adopting 0.25-mm-thick substrate, carefully designing the housing box and filter layout, to solve the problems in realizing a K-band planar filter. A special straight-line half-wavelength resonator (center-widen resonator) was also designed to reduce the insertion loss of the filter. The measured results showed a midband insertion loss of 0.11 dB with a ripple of 0.4 dB, and a return loss better than 11.5 dB. Good agreement was obtained between simulated and measured results. | GAO Lu GUO Jin WANG YueHui YU Tao ZHANG Qiang LI ChunGuang ZHANG XueQiang LI Hong LI JunJie LI WuXia GU ChangZhi MENG JiBao FENG Ji HE YuSheng | 2009 | Chinese Science Bulletin2009，54，19： | 6 |
| 19 | Transcription factor ZmNAC126 plays an important role in transcriptional regulation of maize starch synthesis-related genes显示文摘Maize(Zea mays L.)is one of the most important food crops in the world,and starch is the main component of its endosperm.Transcriptional regulation plays a vital role in starch biosynthesis.However,it is not well understood in maize.We report the identification of the transcription factor ZmNAC126 and its role in regulation of starch synthesis in maize.Transcriptional expression of ZmNAC126 was higher in maize endosperm and kernels than in roots or stems.ZmNAC126 shared a similar expression pattern with starch synthesis genes during seed development,and its expression pattern was also consistent with the accumulation of starch.ZmNAC126 is a typical transcription factor with a transactivation domain between positions 201 and 227 of the amino acid sequence,is located in the nucleus,and binds to CACG repeats in vitro.Yeast one-hybrid assay revealed that ZmNAC126 bound the promoters of ZmGBSSI,ZmSSIIa,ZmSSIV,ZmISA1,and ZmISA2.Transient overexpression of ZmNAC126 in maize endosperm increased the activities of promoters pZmSh2,pZmBt2,pZmGBSSI,pZmSSIIIa,and pZmBT1 but inhibited the activities of pZmISA1 and pZmISA2.ZmNAC126 thus acts in starch synthesis by transcriptionally regulating targeted starch synthesis-related genes in maize kernels. | Qianlin Xiao Yayun Wang Hui Li Chunxia Zhang Bin Wei Yongbin Wang Huanhuan Huang Yangping Li Guowu Yu Hanmei Liu Junjie Zhang Yinghong Liu Yufeng Hu Yubi Huang | 2021 | The Crop Journal2021，9，1： | 5 |
| 20 | Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects显示文摘Early surgical resection and chemotherapy of bone cancer are commonly used in the treatment of bone tumor,but it is still highly challenging to prevent recurrence and fill the bone defect caused by the resection site.In this work,we report a rational integration of photonic-responsive two-dimensional(2D)ultrathin niobium carbide(Nb2C)MXene nanosheets(NSs)into the 3D-printed bone-mimetic scaffolds(NBGS)for osteosarcoma treatment.The integrated 2D Nb2C-MXene NSs feature specific photonic response in the second near-infrared(NIR-II)biowindow with high tissue-penetrating depth,making it highly efficient in killing bone cancer cells.Importantly,Nb-based species released by the biodegradation of Nb2C MXene can obviously promote the neogenesis and migration of blood vessels in the defect site,which can transport more oxygen,vitamins and energy around the bone defect for the reparative process,and gather more immune cells around the defect site to accelerate the degradation of NBGS.The degradation of NBGS provides sufficient space for the bone remodeling.Besides,calcium and phosphate released during the degradation of the scaffold can promote the mineralization of new bone tissue.The intrinsic multifunctionality of killing bone tumor cell and promoting angiogenesis and bone regeneration makes the engineered Nb2C MXeneintegrated composite scaffolds a distinctive implanting biomaterial on the efficient treatment of bone tumor. | Junhui Yin Shanshan Pan Xiang Guo Youshui Gao Daoyu Zhu Qianhao Yang Junjie Gao Changqing Zhang Yu Chen | 2021 | Nano-Micro Letters2021，13，2： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员