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| 1 | Genome-Wide Identification of Zn_(2)Cys_(6 ) Class Fungal-Specific Transcription Factors(ZnFTFs)and Functional Analysis of UvZnFTFI in Ustilaginoidea virens显示文摘Transcription factors(TFs)orchestrate the regulation of cellular gene expression and thereby determine cell functionality.In this study,we analyzed the distribution of TFs containing domains,which named as ZnFTFs,both in ascomycete and basidiomycete fungi.We found that ZnFTFs were widely distributed in these fungal species,but there was more expansion of the ZnFTF class in Ascomycota than Basidiomycota.We identified 40 ZnFTFs in Ustilaginoidea virens,and demonstrated the involvement of UvZnFTF1 in vegetative growth,conidiation,pigment biosynthesis and pathogenicity.RNA-Seq analysis suggested that UvZnFTF1 may regulate different nutrient metabolism pathways,the production of secondary metabolites,and the expression of pathogen-host interaction genes and secreted protein-encodi ng genes.Analysis of the distributi on of differe nt fungal TFs in U.virens further dem on strated that UvZnFTFs make up a large TF family and may play essential biological roles in U.virens. | SONG Tianqiao ZHANG Xiong ZHANG You LIANG Dong YAN Jiaoling YU Junjie YU Mina CAO Huijuan YONG Mingli PAN Xiayan QI Zhongqiang DU Yan ZHANG Rongsheng LIU Yongfeng | 2021 | Rice science2021，28，6： | 4 |
| 2 | Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound显示文摘Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation.Electrospun nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner.Herein,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive agents.Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities.Furthermore,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation.The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin��6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW. | Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi Zhao Jinzhong Xiumei Mo | 2021 | Bioactive Materials2021，6，9： | 3 |
| 3 | E- lectrode Materials for Cathodic Corrosion Protection Systems for Ships and Marine Constructions显示文摘 | Kuz'mina Yu L Troschenkoa V N Medyanika T E | 2010 | Russian Journal of General Chemistry2010，80，10： | 1 |
| 4 | A phase lI study of combined VEGF inhibitor (bevacizumab + sorafenib ) in patients with metastatic breast cancer : Hoosier Oncology Group Study BRE06 - 109 显示文摘 | Mina LA Yu M Johnson C | 2013 | Invest New Drugs2013，6，： | 1 |
| 5 | A phase Ⅱ study of combined VEGF inhibitor (bevacizumab+sorafenib) in pa- tients with metastatic breast cancer:Hoosier Oncology Group Study BRE06-109 显示文摘 | Mina LA Yu M Johnson C | 2013 | Invest New Drugs2013，31，5： | 1 |
| 6 | Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse显示文摘 | Tadashi Masuda Mina Maki Koichi Hara Takao Yasuhara Noriyuki Matsukawa SeongJin Yu Eunkyung Cate Bae Naoki Tajiri Sonia H. Chheda Marianna Aurora Solomita Nathan Weinbren Yuji Kaneko Sergei A. Kirov David C. Hess Hideki Hida Cesar V. Borlongan | 2010 | Brain Research2010，，： | 1 |
| 7 | A phase II study of combined VEGF inhibitor ( bevacizumab + sorafenib) in patients with meta- static breast cancer: Hoosier Oncology Group Study BRE06-109 显示文摘 | Mina LA Yu M Johnson C | 2013 | Invest New Drugs2013，31，5： | 1 |
| 8 | UvSMEK1,a Suppressor of MEK Null,Regulates Pathogenicity,Conidiation and Conidial Germination in Rice False Smut Fungus Ustilaginoidea virens显示文摘Rice false smut,which is caused by Ustilaginoidea virens,is an emerging disease of rice spikelets in rice-growing areas worldwide.However,the infection mechanism of U.virens on rice spikelets is still unclear.Here,we characterized a suppressor of mitogen-activated protein kinase kinase or ERK kinase(MEK)null(UvSMEKI)in U.virens that is conserved among filamentous fungi.Compared with wild type U.virens strain P-1,UvSMEKI deletion mutants were defective in pathogenicity and conidial germination.In addition,conidiation of UvSMEKI deletion mutants was significantly reduced on yeast extract tryptone(YT)plates,but inc「eased in YT broth compared with the wild type.Compared with UvSMEKI expression level during the vegetative mycelia and conidiation stages,UvSMEKI dramatically increased during infection of rice florets.Surprisingly,the UvSMEKI deletion mutants exhibited higher tolerance to H_(2)O_(2) and NaCl.In summary,presented evidence suggested that UvSMEKI positively regulated pathogenicity,conidial germination and conidiation in YT broth,and negatively regulated conidiation on YT medium and tolerance to oxidative and osmotic stresses.The results enhanee our understanding of the regulatory mechanism of pathogenicity of U.virens,and present a potential molecular target for blocking rice infection by U.virens. | Yu Junjie Yu Mina SONG Tianqiao CAO Huijuan Yong Mingli Pan Xiayan Qi Zhongqiang Du Yan Zhang Rongsheng Yin Xiaole Liang Dong Liu Yongfeng | 2021 | Rice science2021，28，5： | 0 |
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