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| 1 | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis显示文摘Doxorubicin (纪录影片) ,广泛地使用的反肿瘤药,能由氧化应力和房间 apoptosis 产生严重 cardiotoxicity,它限制它的临床的申请。亚麻酸的酸(翼) 被显示了用作一个有势力 cardioprotective 代理人。这研究的目的是在老鼠为这 cardioprotection 在导致纪录影片的 cardiotoxicity 和内在的分子的机制上探索翼的保护的效果。老鼠随机被划分成四个组并且与正常管理了盐,翼(500 梭织,任何一个 CheRs 都不能维持上述的互补功能,考虑到类似于 E 的接受甲基的趋化性蛋白质,建议他们的关键角色。coli。由 microarray 试金示威了,在 L 的 cheR1 的表示。在 28 点有教养的 | Xiaohua Yu Libao Cui Zizhen Zhang Qihui Zhao Shuangjie Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 4 |
| 2 | Efficiency optimized fuel supply strategy of aircraft engine based on air-fuel ratio control显示文摘Accurate fuel injection control of aircraft engine can optimize the energy efficiency of UAV power system while meeting the propeller speed requirement. Traditional injection control method such as open-loop calibration causes instability of fuel supply which brings the risk of power loss of UAV. Considering that the closed-loop control of AFR can ensure a stable fuel feeding, this paper proposes an AFR control based fuel supply strategy in order to improve the efficiency of fuel-powered UAV while obtaining the required engine speed. According to the optimum fuel injection results, we implement fuzzy-PID method to control the set AFR in different situations. Through simulation and experiment studies, the results indicate that, to begin with, the calibrated mathematical model of the aircraft engine is effective. Next, this fuel supply strategy based on AFR control can normally realize the engine speed regulation, and the applied control algorithm can eliminate the overshoot of AFR throughout all the working progress. What is more,the fuel supply strategy can averagely shorten the response time of the engine speed by about two seconds. In addition, compared with the open-loop calibration, in this work the power efficiency is improved by 9% to 33%. Last but not the least, the endurance can be improved by 30 min with a normal engine speed. This paper can be a reference for the optimization of UAV aircraft engine. | Yixuan WANG Yan SHI Maolin CAI Weiqing XU Qihui YU | 2019 | Chinese Journal of Aeronautics2019，32，2： | 3 |
| 3 | Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro显示文摘Dear Editor,Antibody-dependent enhancement(ADE)has long been recognized for dengue virus(DENV)in vitro and in vivo.It is now clear that antibodies to DENV can also enhance Zika virus(ZIKV)infection in vitro,and vice versa(Dejnirattisai et al.,2016;Stettler et al.,2016).The characteristics of enhancing antibodies,however,remain elusive.Some have suggested that non-neutralizing antibodies or antibodies recognizing specific antigenic sites are | Min Li Xin Wang Qihui Wang Lei Yu Lanfeng Wang Jinghua Yan Fuchun Zhang Linqi Zhang George F.Gao Xia Jin | 2017 | Science China(Life Sciences)2017，60，12： | 2 |
| 4 | Optimization Study on a Single-cylinder Compressed Air Engine显示文摘The current research of compressed air engine(CAE) mainly focused on simulations and system integrations. However, energy efficiency and output torque of the CAE is limited, which restricts its application and popularization. In this paper, the working principles of CAE are briefly introduced. To set a foundation for the study on the optimization of the CAE, the basic mathematical model of working processes is set up. A pressure-compensated valve which can reduce the inertia force of the valve is proposed. To verify the mathematical model, the prototype with the newly designed pressure-compensated intake valve is built and the experiment is carried out, simulation and experimental results of the CAE are conducted, and pressures inside the cylinder and output torque of the CAE are obtained. Orthogonal design and grey relation analysis are utilized to optimize structural parameters. The experimental and optimized results show that, first of all, pressure inside the cylinder has the same changing tendency in both simulation curve and experimental curve. Secondly, the highest average output torque is obtained at the highest intake pressure and the lowest rotate speed. Thirdly, the optimization of the single-cylinder CAE can improve the working efficiency from an original 21.95% to 50.1%, an overall increase of 28.15%, and the average output torque increases also increases from 22.047 5 N · m to 22.439 N · m. This research designs a single-cylinder CAE with pressure-compensated intake valve, and proposes a structural parameters design method which improves the single-cylinder CAE performance. | YU Qihui CAI Maolin SHI Yan XU Qiyue | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 2 |
| 5 | Oxidation behavior of TiAl/TiAl-SiC gradient coatings on gamma titanium aluminides 显示文摘 | Gong Shengkai Xu Huibin Yu Qihui | 2000 | Surf Coat Techn2000，130，1： | 1 |
| 6 | Oxidation behavior of TiAl/TiAl–SiC gradient coatings on gamma titanium aluminides显示文摘 | Shengkai Gong Huibin Xu Qihui Yu Chungen Zhou | 2000 | Surface & Coatings Technology2000，，1： | 1 |
| 7 | Studyon Design Criteria and Methods for the Valve Train of theCompressed-air Engine显示文摘 | ZHANG Zhao JIA Ruibin YU Qihui CAI Maolin | 2012 | Applied Mechanics and Materi-als2012，，278： | 1 |
| 8 | Volatiles from the Maillard reaction of L- ascorbic acid and L-alanine at different pHs显示文摘 | Yu Ainong DENG Qihui | 2009 | Food Sci Biotechnol2009，18，6： | 1 |
| 9 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studiesonpattern formation in coculturecell systemscan provide insights intomany physiological and pathologicalprocesses Here,we investigate how theextracellular matrix(ECM)may influence the patterning in coculture systems.Themodel coculture system we use is composed of highly motile invasivebreast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“cllective pulling”effect resultingfrom ECM-mediated transmssion of active contractile forces generated bythe polarized migration of the invasive cells along the vertical direction.Themechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangu Ye Yang Jiao Liyu Liu | 2022 | Research2022，，2： | 0 |
| 10 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes.Here,we investigate how the extracellular matrix(ECM)may influence the patterning in coculture systems.The model coculture system we use is composed of highly motile invasive breast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“collective pulling”effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction.The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangfu Ye Yang Jiao Liyu Liu | 2021 | Research2021，，1： | 0 |
| 11 | Simulation research on dynamic performance of the new type high-pressure solenoid valve显示文摘To improve energy density,the transportation,storage,and operations of hydrogen,methane,and compressed air vehicles currently require high-pressure compression.High-pressure solenoid valve becomes the vital element to above system.In order to reduce leakage and aerodynamic force influence,a new type high-pressure solenoid valve was proposed.The simulation model which included electromagnetic model,aerodynamic force model was established by means of the nonlinear mathematic models.Using the software MATLAB/Simulink for simulation,the dynamic response characteristics of high-pressure pneumatic solenoid valve were obtained under different pulse width modulation(PWM)input control signals.Results show that,first of all,the new type of high-pressure solenoid valve can meet the switch requirement.Secondly,the opening movement and closing movement of the spool lags the PWM rising signal,and the coil current fluctuates significantly during the movement of the spool.Lastly,on/off status of high-pressure valve cannot be represented by the duty cycle.This research can be referred in the design of the high-pressure solenoid valve.. | Qihui YU Qiancheng WANG Kaifei ZHANG Weiwei ZHENG | 2020 | Mechanical Engineering Science2020，2，2： | 0 |
| 12 | Machine Learning Approach Effectively Predicts Binding Between SARS-CoV-2 Spike and ACE2 Across Mammalian Species- Worldwide,2021显示文摘ABSTRACT Introduction:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a recently emergent coronavirus of natural origin and caused the coronavirus disease(COVID-19)pandemic.The study of its natural origin and host range is of particular importance for source tracing,monitoring of this virus,and prevention of recurrent infections.One major approach is to test the binding ability of the viral receptor gene ACE2 from various hosts to SARS-CoV-2 spike protein,but it is time-consuming and laborintensive to cover a large collection of species. | Yue Ma Yu Hu Binbin Xia Pei Du Lili Wu Mifang Liang Qian Chen Huan Yan George F.Gao Qihui Wang Jun Wang | 2021 | China CDC weekly2021，3，46： | 0 |
| 13 | Investigation on small molecule-aptamer dissociation equilibria based on antisense displacement probe显示文摘Food safety is a major issue to public health and have attracted global attention.Fast,sensitive,and reliable detection methods for food hazardous substances is highly desirable.Aptamers which can bind to the target molecules with high affinity and specificity represent an attractive tool for the recognition of food hazardous substances,which play an important role in the development and application of new food safety detection technology.But current assays for characterizing small molecule-aptamer binding are limited by either the mass sensitivity or the size differentiation ability.Herein,we proposed a comprehensive method for assessing the dissociation equilibria of small molecule-aptamer,which is immobilized-free under ambient conditions.The design employs the Le Chatelier’s principle and could be used to effectively measure small molecule-aptamer interactions.ATP binding aptamer and anti-aflatoxin B1 aptamer were used as the model system to determine their affinity,in which their dissociation equilibria measurements are in excellent close to their previous work.Due to the simplicity and sensitivity of this new method,we believe that it could be recommended as an effective tool for characterizing small molecule-aptamer interactions and promote the further application of small molecular aptamer in food safety. | Lei Wang Lili Yao Qihui Ma Yu Mao Hao Qu Lei Zheng | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 14 | Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine显示文摘Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development. | Xiao Qu Yunfei Jia Na Jia Huahao Fan Anqi Zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao | 2023 | hLife2023，1，1： | 0 |
| 15 | Soybean protein concentrate causes enteritis in juvenile pearl gentian groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂)显示文摘Due to diminishing fish meal(FM)supplies,superb protein(PRO)sources are needed for aquaculture,such as soy-based PRO.However,these can cause enteritis and even intestinal injury in fish when used at high proportions in feed.This research examines the effects of substituting soybean protein concentrate(SPC)for FM on the growth performance and intestinal balance of pearl gentian groupers and investigates the mechanism of SPC-induced enteritis.Experimental fish(n=720)were fed 1 of 3 following diets:(1)a 50%FM diet(control),(2)a diet with 20%of the FM substituted with SPC(group SPC20),and(3)a 40%SPC-substituted diet(SPC40).Fish were fed for 10 wk iso-nitrogenous(50%PRO)and iso-lipidic(10%lipid)diets.Groups SPC20 and SPC40 showed significantly lower developmental performance and intestinal structures than control.Group SPC40 had significantly higher expressions of pro-inflammatory-related genes,such as interleukin 1β(IL1β),IL12,IL17 and tumor necrosis factorαand significantly lower expressions of anti-inflammatory-related genes,such as IL5,IL10 and transforming growth factorβ1.Biochemical and 16S high-throughput sequencing showed that the abundance and functions of intestinal flora in group SPC40 were significantly affected(P<0.05),and there were significant correlations between operational taxonomic unit abundance variations and inflammatory gene expressions at genus level(P<0.05).The second-and third-generation full-length transcriptome sequence was used to analyze the mechanism of SPC-induced enteritis in pearl gentian groupers,which showed that enteritis induced by SPC may be caused by disturbances to intestinal immune function induced by an imbalance in intestinal nutrition and metabolism,such as the intestinal immunity network for IgA production pathway.However,it remains unclear as to which intestinal immune or nutritional imbalance is most important in enteritis development.This study provides a basis for further research into soy PRO-related enteritis in fish. | Wei Zhang Beiping Tan Junming Deng Qihui Yang Shuyan Chi Aobo Pang Yu Xin Yu Liu Haitao Zhang | 2023 | Animal Nutrition2023，，1： | 0 |
| 16 | Preparation of CdTe Nanocrystals Doped Fluorescent Silica Spheres by Sol-gel Method and Their Surface Modification via Thiol-ene Chemistry显示文摘 | LIU Yan YU Dongdong ZHU Wei BAI Xiao SHEN Qihui LIU Xiaoyang ZHOU Jianguang | 2017 | Chemical Research in Chinese Universities2017，33，3： | 0 |
| 17 | A Rhodamine-Based Sensor for Chromogenic Detection of Cu^(2+) and Fluorescent Detection of Fe^(3+)显示文摘A rhodamine-benzimidazole conjugate(RB) as a probe was investigated.UV-Vis analysis showed that a strong absorption band at 552 nm was formed with the addition of Cu^(2+),while other transition metal ions induced a little more absorption.The absorption value of RB solution at 552 nm has a linear correlation with Cu^(2+) concentration between 35-70 μmol/L;the detection limit reached 6.82×10^(-2) μmol/L,which is lower than the settled limitation for copper in the drinking water(~30 μmol/L) standardized by World Health Organization(WHO).Moreover,FL analysis showed that only Fe^(3+) could induce large fluorescence intensity enhancement at 582 nm;other common metal ions including Cu^(2+) cannot induce the enhancement.There was a good linear correlation between relative fluorescence intensity and Fe^(3+) concentration ranging from 2 μmol/L to 20 μmol/L,and the detection limit reached1.70×10^(-2) μmol/L.The results showed that RB could detect Cu^(2+)and Fe^(3+) simultaneously,with the UV-Vis and fluorescence spectroscopy,respectively. | YU Xianglin QU Hao HU Qihui HOU Kun YAN Yushi WU Dan ZHANG Pian LI Junbo | 2014 | Wuhan University Journal of Natural Sciences2014，19，2： | 0 |
| 18 | A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery显示文摘Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple variants.These variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory activity.We previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral infections.Here,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal administration.These results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases. | Lili Wu Anqi Zheng Yangming Tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen Wu Shaogui Zeng Hang Yang Qihui Wang George Fu Gao | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 19 | Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has an extremely broad host range that includes hippopotami,which are phylogenetically closely related to whales.The cellular ACE2 receptor is one of the key determinants of the host range.Here,we found that from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain(RBD)of both SARS-C oV and SARS-C oV-2 and facilitate the trans duction of SARS-C oV and SARS-C oV-2 pseudo viruses into ACE2-expressing cells.We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2,respectively,bound to the RBDs,revealing that they have similar binding modes to human ACE2 when it comes to the SARS-C oV-2 RBD and SARS-C oV RBD.Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-C oV-2,which deserves further careful investigation and study.It will provide an early warning for the prospective monitoring of marine mammals. | Shihua Li Ruirui Yang Di Zhang Pu Han Zepeng Xu Qian Chen Runchu Zhao Xin Zhao Xiao Qu Anqi Zheng Liang Wang Linjie Li Yu Hu Rong Zhang Chao Su Sheng Niu Yanfang Zhang Jianxun Qi Kefang Liu Qihui Wang George F.Gao | 2022 | National Science Review2022，9，9： | 0 |
| 20 | Genomic Perspectives on the Emerging SARS-CoV-2 Omicron Variant显示文摘A new variant of concern for SARS-CoV-2,Omicron(B.1.1.529),was designated by the World Health Organization on November 26,2021.This study analyzed the viral genome sequencing data of 108 samples collected from patients infected with Omicron.First,we found that the enrichment efficiency of viral nucleic acids was reduced due to mutations in the region where the primers anneal to.Second,the Omicron variant possesses an excessive number of mutations compared to other variants circulating at the same time(median:62 vs.45),especially in the Spike gene.Mutations in the Spike gene confer alterations in 32 amino acid residues,more than those observed in other SARS-CoV-2 variants.Moreover,a large number of nonsynonymous mutations occur in the codons for the amino acid residues located on the surface of the Spike protein,which could potentially affect the replication,infectivity,and antigenicity of SARS-CoV-2.Third,there are 53 mutations between the Omicron variant and its closest sequences available in public databases.Many of these mutations were rarely observed in public databases and had a low mutation rate.In addition,the linkage disequilibrium between these mutations was low,with a limited number of mutations concurrently observed in the same genome,suggesting that the Omicron variant would be in a different evolutionary branch from the currently prevalent variants.To improve our ability to detect and track the source of new variants rapidly,it is imperative to further strengthen genomic surveillance and data sharing globally in a timely manner. | Wentai Ma Jing Yang Haoyi Fu Chao Su Caixia Yu Qihui Wang Ana Tereza Ribeiro de Vasconcelos Georgii A.Bazykin Yiming Bao Mingkun Li | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
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