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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Changing patterns of strabismus: a decade of experience in Hong Kong显示文摘 | C B O Yu f HongkongD S P Fan V W Y Wong | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 3 | A neural network approach to predict survival/death and growth/no-growth interfaces for Escherichia coli O157:HT显示文摘 | Yu C Davidson V J Yang S X | 2006 | Food microbiology2006，23，7： | 1 |
| 4 | Reliability of a newultrasonic cardiac output monitor in recipients of living donorliver transplantation显示文摘 | Su B C Yu H P Yang M V | 2008 | Liver Transpl2008，14，7： | 1 |
| 5 | A specification and verification method for preventing denial of service 显示文摘 | YU C F GLIGOR V D | 1990 | IEEE Trans on Software Engineering1990，16，6： | 1 |
| 6 | Lipopolysaccharide-induced Leptin release is neurally controlled显示文摘 | Mastronardi C A Yu W H Srivastava V K | 2001 | Proc Natl Acad Sci USA2001，98，14： | 1 |
| 7 | Development and characterization of simple sequence repeat(SSR)markers and their use in determining relationships among Lycopersicon esculentum cultivars显示文摘 | HE C POYSA V YU K | 2003 | Theoretical and Applied Genetics2003，106，2： | 1 |
| 8 | Schema-Free XQuery显示文摘 | Li Y Yu C Jagadish H V | 2004 | Proceedings Vldb Conference2004，3，： | 1 |
| 9 | 显示文摘 | YAM V W W YU K L WONG K M C | 2001 | Organometallics2001，20，： | 1 |
| 10 | Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities 显示文摘 | Chan S L Yu V C | 2004 | Clin Exp Pharrnacol Physiol2004，31，3： | 1 |
| 11 | Systemic delivery of umbilical cord blood cells for stroke therapy:a review显示文摘 | YU G BORLONGAN C V STAHL C E | 2009 | Restor Neurol Neurosci2009，27，1： | 1 |
| 12 | Biodegradation of nonylphenol in river sediment 显示文摘 | YUAN S Y YU C H CHANG B V | 2003 | Environmental Pollution2003，127，2004： | 1 |
| 13 | Aeration experiments for swine waste composting 显示文摘 | Lo K V Liao P H Yu J C | 1992 | Bioresource Techmology1992，41，： | 1 |
| 14 | A new method to support UMTS/WLAN vertical handover using SCTP显示文摘 | Ma Li Yu Fei Leung V C M | 2013 | IEEE Wireless Communications2013，11，4： | 1 |
| 15 | Spatial configuration of transposable element Ac termini affects their ability to induce chro-mosomal breakage in maize显示文摘 | Yu C H Zhang J B Pulletikurti V | 2010 | Plant Cell2010，22，3： | 1 |
| 16 | Degradation of nonylphenol by anaerobic microorganisms from river sediment 显示文摘 | Chang B V Yu C H Yuan S Y | 2004 | Chemoshpere2004，55，4： | 1 |
| 17 | In utero exposure of mice to dibenzo pyrene produces lymphoma in the offspring:role of the aryl hydrocarbon receptor显示文摘 | YU Z LOEHR C V FISCHER K A | 2006 | Cancer Res2006，662，： | 1 |
| 18 | Sequential constraint imposition for dimension-driven solid models显示文摘 | Kumar A V Yu L C | 2001 | Computer-Aided Design2001，33，6： | 1 |
| 19 | Automatic extraction of gene and protein synonyms from MEDLINE and journal articles显示文摘 | Yu H Hatzivassiloglou V Friedman C | 2002 | Proc AMIA Symp2002，，： | 1 |
| 20 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
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