|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair显示文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair. | Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai | 2018 | Bone Research2018，6，4： | 12 |
| 2 | Comprehensive Mineral Nutrition Analysis of Watermelon Grafted onto Two Different Rootstocks显示文摘Grafting is a widely used practice in fruit-bearing vegetables. However, why grafting affects plant growth, fruit yield, and quality, especially from the aspect of mineral nutrition, remains unclear. In this study, watermelon cultivar ‘Zaojia 8424' was grafted onto bottle gourd ‘Jingxinzhen1'(Lagenaria siceraria) and pumpkin ‘Qingyanzhen 1'(Cucurbita maxima × C. moschata). Non-grafted plants were used as the control. Results show that rootstock grafting significantly increases plant growth and single fruit weight of watermelon. Watermelon grafted onto rootstocks, especially pumpkin, exhibits significantly higher root volume, root surface area, and number of root tips and forks in comparison with non-grafted plants. Fruit flesh, rind firmness, and rind thickness were enhanced by grafting. However, fruit soluble solids and taste significantly decreased in plants grafted onto pumpkin. The total uptake(mg · plant^(-1)) and concentration(mg · g^(-1)DW) of N, K, Ca, Fe, Mg, and Mn in root, stem, leaf,fruit rind, and flesh were generally higher in grafted plants compared to non-grafted ones, especially for N of pumpkin rootstock-grafted plants.The total uptake of nutrients of plants grafted onto bottle gourd and pumpkin was increased by 30.41% and 49.14% at fruit development stage and by 21.33% and 47.46% at fruit maturation stage, respectively, compared with non-grafted plants. We concluded that watermelon grafting onto suitable rootstocks can increase the uptake of mineral nutrition, especially for N in the pumpkin rootstock grafted plants, thereby affecting plant growth, fruit yield, and quality. | HUANG Yuan ZHAO Liqiang KONG Qiusheng CHENG Fei NIU Mengliang XIE Junjun Muhammad Azher Nawaz BIE Zhilong | 2016 | Horticultural Plant Journal2016，2，2： | 7 |
| 3 | Risk factors for the incidence of apoplexy in pituitary adenoma: a single-center study from southwestern China显示文摘Background:Although the incidence and clinical manifestations of pituitary apoplexy were reported by a few researches,the results are not consistent.This study aimed to explore the risk factors associated with an incidence of apoplexy in pituitary adenomas.Methods:The clinical information of 843 patients with pituitary adenoma from the Department of Neurological Surgery,1st Affiliated Hospital of Kunming Medical University,was reviewed.The incidence,clinical manifestation,and potential risk factors for pituitary apoplexy were analyzed by a case-control study.Results:In total,121 patients(14.4%)with macroadenoma were suffered from pituitary apoplexy.Headache,vomiting,and visual impairment are the top 3 symptoms for the pituitary apoplexy.Logistic regression results showed that the hypertension(hypertension vs non-hypertension OR=2.765,95%CI:1.41~5.416),tumor type(negative staining vs.positive staining,OR=1.501,95%CI:1.248~5.235),and tumor size(diameter>2 cm vs.diameter≤2 cm,OR=3.952,95%CI:2.211~7.053)are independent factors associated with pituitary apoplexy.Conclusion:Our results indicate that the risk factors for the incidence of pituitary apoplexy depend mainly on properties of the tumor itself(tumor size and pathologic type)and the blood pressure of patients. | Yao Li Yuan Qian Yisheng Qiao Xiaoxiang Chen Jiaotian Xu Chao Zhang Wei Wang Junjun Li Xingli Deng | 2020 | Chinese Neurosurgical Journal2020，6，4： | 3 |
| 4 | Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring显示文摘Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions. | Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 5 | ALYREF mediates RNA m^(5)C modification to promote hepatocellular carcinoma progression显示文摘Dear Editor,The incidence of hepatocellular carcinoma(HCC)is increasing in many countries due to hepatic virus infection and unhealthy diet habits,and the unsatisfactory overall survival rate calls for novel treatments with higher efficacy.1 Recent studies have shown that RNA modifications are likely to participate in the progression of HCC,2 suggesting new methods for tumor growth control.Specifically,5-methylcytosine(m5C)is one of the most interesting RNA modification types,as accumulating evidence suggests its role in the promotion of HCC tumorigenesis.3 The RNA methyltransferase Aly/REF export factor(ALYREF)is considered one type of“reader”protein located in the nucleus that recognizes and binds directly with m5C sites in RNA and facilitates the export of RNA from the nucleus to the cytoplasm.4 Notably,ALYREF is considered a promising target for diagnosis and prognosis prediction.5 However,until now,the low number of related studies has limited the understanding of the mechanism of the HCC-promoting effects of ALYREF. | Chen Xue Xinyu Gu Qiuxian Zheng Qingmiao Shi Xin Yuan Yuanshuai Su Junjun Jia Jianwen Jiang Juan Lu Lanjuan Li | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 6 | Two methods of chloral hydrate given drugs for pediatric calming effect observation显示文摘 | Liu Zeng Xiang Yuan Junjun Hu Yuwei | 2010 | Journal of practical medicine in China2010，，27： | 1 |
| 7 | Formation and stability of G-quadruplexes self-assembled from Guaninerich strands显示文摘 | Zhou Jiang Yuan Gu Liu Junjun | 2007 | Chem Eur J2007，13，： | 1 |
| 8 | AEG -1 Overexpression: A Novel Indicator for Peritoneal Dissemination and Lymph Node Metastasis in Epithelial Ovarian Cancers显示文摘 | Cong Li Junjun Liu Renbo Lu Ge Yu Xiaochuan Wang Yulan Zhao Hongtao Song Ping Lin Xicai Sun Xiaoguang Yu Yuan Zhang Xiaoming Ning Jingshu Geng | 2011 | International Journal of Gynecological Cancer2011，，4： | 1 |
| 9 | Alkylation of benzene with ethanol over ZSM-5 catalyst with different SiO2/Al2O3 ratios 显示文摘 | Yuan Junjun Borje S G | 2004 | Indian J Chem Technol2004，11，： | 1 |
| 10 | Effect of heavily doping with boron on electronic structures and optical properties of β-SiC 显示文摘 | Feng Guiying Fang Xiaoyong Wang Junjun Zhou Yan Lu Ran Yuan Jie Cao Maosheng | 2010 | Physica B: Condensed Matter2010，405，12： | 1 |
| 11 | Long-term atmospheric visibility trend in Southeast China, 1973–2010显示文摘 | Junjun Deng Ke Du Kai Wang Chung-Shin Yuan Juanjuan Zhao | 2012 | Atmospheric Environment2012，，： | 1 |
| 12 | Alkylation of Benzene with Ethanol over ZSM-5 Catalyst with Different SiOjAIO_3 Ratios 显示文摘 | Yuan Junjun Gevert B S | 2004 | IndianJChem Technol2004，11，5： | 1 |
| 13 | Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α1D-adrenoceptor antagonists显示文摘Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of these two stereochemical NAF isomers to the α1D receptor remained unclear. Herein, we reported the crystallographic structures of optically pure NAF stereoisomers for the first time and unambiguously determined their absolute configurations. The crystal data of R and S enantiomers matched satisfactorily the pharmacophore model for α1D-selective antagonists. Based on the constructed α1D homology model,molecular docking studies shed light on the molecular mechanism of NAF enantiomers binding to α1D-AR. The results indicated that NAF enantiomers exhibited the very similar binding poses and occupied the same binding pocket. | Wei Xu Junjun Huang Renwang Jiang Mu Yuan | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 0 |
| 14 | Relationships between Cloud Droplet Spectral Relative Dispersion and Entrainment Rate and Their Impacting Factors显示文摘Cloud microphysical properties are significantly affected by entrainment and mixing processes.However,it is unclear how the entrainment rate affects the relative dispersion of cloud droplet size distribution.Previously,the relationship between relative dispersion and entrainment rate was found to be positive or negative.To reconcile the contrasting relationships,the Explicit Mixing Parcel Model is used to determine the underlying mechanisms.When evaporation is dominated by small droplets,and the entrained environmental air is further saturated during mixing,the relationship is negative.However,when the evaporation of big droplets is dominant,the relationship is positive.Whether or not the cloud condensation nuclei are considered in the entrained environmental air is a key factor as condensation on the entrained condensation nuclei is the main source of small droplets.However,if cloud condensation nuclei are not entrained,the relationship is positive.If cloud condensation nuclei are entrained,the relationship is dependent on many other factors.High values of vertical velocity,relative humidity of environmental air,and liquid water content,and low values of droplet number concentration,are more likely to cause the negative relationship since new saturation is easier to achieve by evaporation of small droplets.Further,the signs of the relationship are not strongly affected by the turbulence dissipation rate,but the higher dissipation rate causes the positive relationship to be more significant for a larger entrainment rate.A conceptual model is proposed to reconcile the contrasting relationships.This work enhances the understanding of relative dispersion and lays a foundation for the quantification of entrainment-mixing mechanisms. | Shi LUO Chunsong LU Yangang LIU Yaohui LI Wenhua GAO Yujun QIU Xiaoqi XU Junjun LI Lei ZHU Yuan WANG Junjie WU Xinlin YANG | 2022 | Advances in Atmospheric Sciences2022，39，12： | 0 |
| 15 | In Situ Iodide Passivation Toward Efficient CsPbI_(3) Perovskite Quantum Dot Solar Cells显示文摘All-inorganic CsPbI_3 quantum dots(QDs) have demonstrated promising potential in photovoltaic(PV) applications. However, these colloidal perovskites are vulnerable to the deterioration of surface trap states, leading to a degradation in efficiency and stability. To address these issues, a facile yet effective strategy of introducing hydroiodic acid(HI) into the synthesis procedure is established to achieve high-quality QDs and devices. Through an in-depth experimental analysis, the introduction of HI was found to convert PbI_2 into highly coordinated [PbI_m]~(2-m), enabling control of the nucleation numbers and growth kinetics. Combined optical and structural investigations illustrate that such a synthesis technique is beneficial for achieving enhanced crystallinity and a reduced density of crystallographic defects. Finally, the effect of HI is further reflected on the PV performance. The optimal device demonstrated a significantly improved power conversion efficiency of 15.72% along with enhanced storage stability. This technique illuminates a novel and simple methodology to regulate the formed species during synthesis, shedding light on ofurther understanding solar cell performance, and aiding the design of future novel synthesis protocols for high-performance optoelectronic devices. | Junwei Shi Ben Cohen‑Kleinstein Xuliang Zhang Chenyu Zhao Yong Zhang Xufeng Ling Junjun Guo Doo‑Hyun Ko Baomin Xu Jianyu Yuan Wanli Ma | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 16 | The Probability Density Function Related to Shallow Cumulus Entrainment Rate and Its Influencing Factors in a Large-Eddy Simulation显示文摘The process of entrainment-mixing between cumulus clouds and the ambient air is important for the development of cumulus clouds.Accurately obtaining the entrainment rate(λ)is particularly important for its parameterization within the overall cumulus parameterization scheme.In this study,an improved bulk-plume method is proposed by solving the equations of two conserved variables simultaneously to calculateλof cumulus clouds in a large-eddy simulation.The results demonstrate that the improved bulk-plume method is more reliable than the traditional bulk-plume method,becauseλ,as calculated from the improved method,falls within the range ofλvalues obtained from the traditional method using different conserved variables.The probability density functions ofλfor all data,different times,and different heights can be well-fitted by a log-normal distribution,which supports the assumed stochastic entrainment process in previous studies.Further analysis demonstrate that the relationship betweenλand the vertical velocity is better than other thermodynamic/dynamical properties;thus,the vertical velocity is recommended as the primary influencing factor for the parameterization ofλin the future.The results of this study enhance the theoretical understanding ofλand its influencing factors and shed new light on the development ofλparameterization. | Lei ZHU Chunsong LU Xiaoqi XU Xin HE Junjun LI Shi LUO Yuan WANG Fan WANG | 2024 | Advances in Atmospheric Sciences2024，41，1： | 0 |
| 17 | Facile Modification on Buried Interface for Highly Efficient and Stable FASn_(0.5)Pb_(0.5)I_(3) Perovskite Solar Cells with NiOx Hole-Transport layers显示文摘Formamidinium(FA)-based Sn-Pb perovskite solar cells(FAPb_(0.5)Sn_(0.5)I_(3) PSCs)with ideal bandgap and impressive thermal stability have caught enormous attention recently.However,it still suffers from the challenge of realizing high efficiency due to the surface imperfections of the transport materials and the energy-level mismatch between functional contacts.Herein,it is demonstrated that the modification on buried interface with alkali metal salts is a viable strategy to alleviate these issues.We systematically investigate the role of three alkali metal bromide salts(NaBr,KBr,CsBr)by burying them between the NiOx hole transport layer(HTL)and the perovskite light-absorbing layer,which can effectively passivate interface defects,improve energy-level matching and release the internal residual strain in perovskite layers.The device with CsBr buffer layer exhibits the best power conversion efficiency(PCE)approaching 20%,which is one of the highest efficiencies for FA-based Sn-Pb PSCs employing NiO_(x) HTLs.Impressively,the long-term storage stability of the unencapsulated device is also greatly boosted.Our work provides an efficient strategy to prepare desired FA-based ideal-bandgap Sn-Pb PSCs which could be applied in tandem solar cells. | Hui Zhang Yuan Zhou Tonghui Guo Xiang Zhang Zhenkun Zhu Junjun Jin Xiaxia Cui Dan Zhang Zhen Wang Lin Li Nai Wang Guanqi Tang Qidong Tai | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员