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| 1 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 2 | MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes显示文摘piRNA 机械在调停以它的角色著名 transposons 的 epigenetic silencing。最近的研究建议这功能也包含导出 transposon 的抄本的指导 piRNA 的劈开。同样多 piRNAs 也看起来有能力指向多样的 mRNAs,这提起 piRNAs 可以与 siRNAs 比广泛地扮演降级的吸引人的可能性特定的 mRNAs。直接测试这个假设,我们比较了联系的老鼠 PIWI (MIWI ) 有从老鼠睾丸的试验性地识别的劈开的 mRNA 碎片的 piRNAs,和主要发生在的观察劈开地点从 5 ′ 放 10;通常认为的指向结束 piRNAs。我们也注意了强壮的偏爱因为分别地,在核苷酸的 U 和 A 残余在 piRNAs 和 mRNA 碎片放 1 和 10,由“乒乓球”类似于 piRNA 扩大的模式的特征骑车。通过由介绍的 CLIP-seq 和基因表示 MIWI-RNA 相互作用印射,我们发现许多潜在的指向 piRNA 的 mRNAs 直接与 MIWI 交往,表演在 Miwi 的睾丸提高了表达式层次催化变异的鼠标。基于记者的试金进一步揭示了在调停 piRNA 的目标压抑的为 slicer 活动和 MIWI 的装载 piRNA 能力的在 piRNAs 和 mRNA 目标和要求之间的基础配对的重要性。重要地,我们证明某些关键 piRNA 目标的那合适的周转为精子形成是必要的。一起,这些调查结果为男细菌房间开发和成熟在鼠标睾丸和它的中央要求揭示 piRNA 机械的象 siRNA 一样函数。 | Peng Zhang Jun-Yan Kang Lan-Tao GOU Jiajia Wang Yuanchao Xue Geir Skogerboe Peng Dai Da-Wei Huang Runsheng Chen Xiang-Dong Fu Mo-Fang Liu Shunmin He | 2015 | Cell Research2015，25，2： | 35 |
| 3 | Emerging roles of non-coding RNAs in epigenetic regulation显示文摘Recent deep sequencing surveys of mammalian genomes have unexpectedly revealed pervasive and complex transcription and identified tens of thousands of RNA transcripts that do not code for proteins. These non-coding RNAs(nc RNAs) highlight the central role of RNA in gene regulation. nc RNAs are arbitrarily divided into two main groups: The first includes small RNAs, such as mi RNAs, pi RNAs, and endogenous si RNAs, that usually range from 20 to 30 nt, while the second group includes long non-coding RNAs(lnc RNAs), which are typically more than 200 nt in length. These nc RNAs were initially thought to merely regulate gene expression at the post-transcriptional level, but recent studies have indicated that nc RNAs, especially lnc RNAs, are extensively associated with diverse chromatin remodeling complexes and target them to specific genomic loci to alter DNA methylation or histone status. These findings suggest an emerging theme of nc RNAs in epigenetic regulation. In this review, we discuss the wide spectrum of nc RNAs in the regulation of DNA methylation and chromatin state, as well as the key questions that needs to be investigated and acknowledging the elegant design of these intriguing macromolecules. | Juan Chen Yuanchao Xue | 2016 | Science China(Life Sciences)2016，59，3： | 11 |
| 4 | Noncoding RNA:from dark matter to bright star显示文摘The central dogma states that genes encoded in the DNA should be first transcribed into messenger RNA(mRNA)and then translated into functional proteins(Crick,1970).This dogma has been written in numerous textbooks and learned by myriad students.However,along with the completion of the human genome project in June 2000,an astonishing fact was revealed:only 1.5%of the human genome encodes for proteins(Lander et al.,2001;Venter et al.,2001).This fact raised three fundamental questions:(i)why does the human genome have so few protein-coding genes?(ii)how to explain the apparent differences between humans and other species using the limited coding genes?(iii)what are the roles of the noncoding regions in our genome? | Yuanchao Xue Runsheng Chen Lianghu Qu Xiaofeng Cao | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 5 | PTB/nPTB: master regulators of neuronal fate in mammals显示文摘 | Jing Hu Hao Qian Yuanchao Xue Xiang-Dong Fu | 2018 | Biophysics Reports2018，4，4： | 4 |
| 6 | The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes显示文摘 | Juan Chen Zhaokui Cai Meizhu Bai Xiaohua Yu Chao Zhang Changchang Cao Xihao Hu Lei Wang Ruibao Su Di Wang Yingpeng Yao Rong Ye Baidong Hou Yang Yu Shuyang Yu Jinsong Li Yuanchao xue | 2018 | Cell Research2018，28，10： | 4 |
| 7 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 8 | MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation显示文摘 | Xiaorong Zhang Xinxin Zuo Bo Yang Zongran Li Yuanchao Xue Yu Zhou Jie Huang Xiaolu Zhao Jie Zhou Yun Yan Huiqiong Zhang Peipei Guo Hui Sun Lin Guo Yi Zhang Xiang-Dong Fu | 2014 | Cell2014，，： | 1 |
| 9 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 10 | RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits显示文摘RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis,but the targets and molecular functions of RBM46 remain unknown.Here,we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRNAs encoding multiple meiotic cohesin subunits and show that RBM46 is required for normal synaptonemal complex formation during meiosis initiation.Using a recently reported,high-resolution technique known as LACE-seq and working with low-input cells,we profiled the targets of RBM46 at single-nucleotide resolution in leptotene and zygotene stage gametes.We found that RBM46 preferentially binds target mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions.In Rbm46 knockout mice,the RBM46-target cohesin subunits displayed unaltered mRNA levels but had reduced translation,resulting in the failed assembly of axial elements,synapsis disruption,and meiotic arrest.Our study thus provides mechanistic insights into the molecular functions of RBM46 in gametogenesis and illustrates the power of LACE-seq for investigations of RNA-binding protein functions when working with low-abundance input materials. | Yue Lv Gang Lu Yuling Cai Ruibao Su Liang Liang Xin Wang Wenyu Mu Xiuqing He Tao Huang Jinlong Ma Yueran Zhao Zi-Jiang Chen Yuanchao Xue Hongbin Liu Wai-Yee Chan | 2023 | Protein & Cell2023，14，1： | 0 |
| 11 | ADAR1:a mast regulator of aging and immunity显示文摘Recently,Nature and Nature Cell Biology published five papers on the function and molecular mechanism of ADAR1(adenosine deaminases acting on RNA)in aging,cancer,and autoimmune diseases.1,2,3,4,5 Among them,four papers published in Nature revealed that ADAR1 regulates autoimmune disease and cancer immunotherapy through canonical adenosine-to-inosine(A-to-I)RNA editing. | Yigan Zhang Jinyue Zhang Yuanchao Xue | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 12 | 拟南芥ARGNAUTE 1在植物响应激素和胁迫过程中结合染色质并促进基因表达显示文摘文章简介经典的RNA干扰是指真核生物中由小RNA诱发的基因沉默。小RNA由Dicer(一种核糖核酸内切酶)从双链或具茎环结构的前体RNA加工而来,随后被RNA干扰的核心效应蛋白ARGONAUTE(AGO)家族蛋白所结合。通过小RNA与靶序列的碱基互补配对. | 刘畅 辛颖 徐乐 Zhaokui Cai Yuanchao Xue Yong Liu Daoxin Xie Yule Liu 戚益军 | 2019 | 科学新闻2019，0，2： | 0 |
| 13 | Ferroic glasses显示文摘Ferroic glasses(strain glass,relaxor and cluster spin glass)refer to frozen disordered states in ferroic systems;they are conjugate states to the long-range ordered ferroic states—the ferroic crystals.Ferroic glasses exhibit unusual properties that are absent in ferroic crystals,such as slim hysteresis and gradual property changes over a wide temperature range.In addition to ferroic glasses and ferroic crystals,a third ferroic state,a glass-ferroic(i.e.,a composite of ferroic glass and ferroic crystal),can be produced by the crystallization transition of ferroic glasses.It can have a superior property not possessed by its two components.These three classes of ferroic materials(ferroic crystal,ferroic glass and glass-ferroic)correspond to three transitions(ferroic phase transition,ferroic glass transition and crystallization transition of ferroic glass,respectively),as demonstrated in a generic temperature vs.defectconcentration phase diagram.Moreover,through constructing a phase field model,the microstructure evolution of three transitions and the phase diagram can be reproduced,which reveals the important role of point defects in the formation of ferroic glass and glass-ferroic.The phase diagram can be used to design various ferroic glasses and glass-ferroics that may exhibit unusual properties. | Yuanchao Ji Dong Wang Yu Wang Yumei Zhou Dezhen Xue Kazuhiro Otsuka Yunzhi Wang Xiaobing Ren | 2017 | npj Computational Materials2017，，1： | 0 |
| 14 | RNA biology and therapeutics显示文摘Eukaryotic genomes undergo pervasive transcription,generating vast amounts of noncoding RNAs alongside protein-coding mRNAs[1].These noncoding RNAs,including small noncoding RNAs,long noncoding RNAs(lncRNAs),and circular RNAs,have been shown to play critical roles in gene regulation,chromatin remodeling,assembly of membraneless organelles,and other essential biological processes.They function through a diverse range of mechanisms[2],[3],[4],[5].Dysregulation of noncoding RNAs contributes to human disease pathogenesis and affects plant development and stress response[6],[7],[8].Over the past decade,significant progress has been made in unraveling the functions of noncoding RNAs and elucidating the molecular mechanisms by which they operate.The involvement of noncoding RNAs in human disease pathogenesis and agronomic trait regulation has garnered increasing attention. | Puyue Wang Yuanchao Xue Yijun Qi Runsheng Chen | 2023 | Fundamental Research2023，3，5： | 0 |
| 15 | New Method Reveals How Protein-Mediated RNA Loops Orchestrate Gene Splicing显示文摘A research team led by Prof.XUE Yuanchao from the Institute of Biophysics of the Chinese Academy of Sciences has developed a new method for global profiling of in-situ RNA–RNA contacts associated with a specific RNA-binding protein(RBP)and revealed positional mechanisms by which PTBP1-associated RNA loops regulate cassette exon splicing.This study was published online in Molecular Cell on March 22.In eukaryotes,the same pre-mRNA can produce multiple protein isoforms to execute similar or different biological functions through alternative splicing.Several longstanding models proposed that RBPs may regulate alternative splicing by modulating long-range RNA–RNA interactions(RRI).However,direct experimental evidence was lacking. | XUE Yuanchao | 2023 | Bulletin of the Chinese Academy of Sciences2023，37，2： | 0 |
| 16 | Connection of the prefabricated updeck of road tunnels by a short lap-spliced joint using ultra-high-performance fiber-reinforced concrete显示文摘Prefabricated internal structures of road tunnels,consisting of precast elements and the connections between them,provide advantages in terms of quality control and manufacturing costs.However,the limited construction space in tunnels creates challenges for on-site assembly.To identify feasible connecting joints,flexural tests of precast straight beams connected by welding-spliced or lap-spliced reinforcements embedded in normal concrete or ultra-high-performance fiber-reinforced concrete(UHPFRC)are first performed and analyzed.With an improvement in the strength grade of the closure concrete for the lap-spliced joint,the failure of the beam transforms from a brittle splitting mode to a ductile flexural mode.The beam connected by UHPFRC100 with short lap-spliced reinforcements can achieve almost equivalent mechanical performance in terms of the bearing capacity,ductility,and stiffness as the beam connected by normal concrete with welding-spliced reinforcements.This favorable solution is then applied to the connection of neighboring updeck slabs resting on columns in a double-deck tunnel.The applicability is validated by flexural tests of T-shaped joints,which,fail in a ductile fashion dominated by the ultimate bearing capacity of the precast elements,similar to the corresponding straight beam.The utilization of UHPFRC significantly reduces the required lap-splice length of reinforcements owing to its strong bonding strength. | Hui WANG Yong YUAN Junnan QIU Yuan XUE Guangzhou XIE Qian CHENG Yuanchao DING Qing AI | 2023 | Frontiers of Structural and Civil Engineering2023，17，6： | 0 |
| 17 | Temperature-field history dependence of the elastocaloric effect for a strain glass alloy显示文摘The singular change of the order parameter at the first order martensitic transformation(MT)temperature restricts the caloric response to a narrow temperature range.Here the MT is tuned into a sluggish strain glass transition by defect doping and a large elastocaloric effect appears in a wide temperature range.Moreover,an inverse elastocaloric effect is observed in the strain glass alloy with history of zerofield cooling and is attributed to the slow dynamics of the nanodomains in response to the external stress.This study offers a design recipe to expand the temperature range for good elastocaloric effect. | Deqing Xue Ruihao Yuan Yuanchao Yang Jianbo Pang Yumei Zhou Xiangdong Ding Turab Lookman Xiaobing Ren Jun Sun Dezhen Xue | 2022 | Journal of Materials Science & Technology2022，，8： | 0 |
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