|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Conodont Evidence for the Age of the Panxian Fauna,Guizhou,China显示文摘Detailed conodont analysis on the Yangjuan-Chupiwa section,Xinmin,Panxian County,Guizhou Province,revealed a conodont sequence including four Anisian conodont zones,viz.Nicoraella germanica Zone,Nc.kockeli Zone,Paragondolella bifurcata Zone and Neogondolella constricta Zone.These zones indicate that the upper Guanling Formation consists of strata from the Bithynian to the Illyrian of the Anisian.Appearance of Neogondolella constricta suggests that the Anisian/Ladinian boundary might be in the overlying Yangliujing Formation.The Panxian Fauna with well-preserved marine reptile and fish fossils is proved to belong to the lower part of the conodont Nc.kockeli Zone in the studied area.Thus,the age of the Panxian Fauna could be the early Pelsonian of the Anisian. | SUN Zuoyu SUN Yuanlin HAO Weicheng JIANG Dayong | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 19 |
| 2 | Biodiversity and Sequence of the Middle Triassic Panxian Marine Reptile Fauna,Guizhou Province,China显示文摘中间的三叠纪的 Panxian 动物志是一个物理标记和在结束以后跟随早三叠纪的停滞阶段的三叠纪的海洋的生态系统的快速的恢复的代表性的记录 -- 二叠的集体扑灭。十海洋的爬行动物税一在 Guanling 形成的上面的成员从 1.82 2.10 m 厚的含化石的水平被发现了,它能在石块爬行动物的 stratigraphic 分布上通过分析被细分进三张海洋的爬行动物床。更低的爬行动物床产出 sauropterygians Placodus inexpectatus 江等, 2008 并且 Lariosaurus hongguoensis 江等, 2006, ichthyopterygians Xinminosaurus catactes 江等, 2008 并且 Phalarodon cf。Phalarodon fraasi Merriam, 1910,与 Mixosaurus panxianensis 江等联系了, 2006,代表 durophagous 的优势的一个阶段税一。在这张床上,大完全的骨骼可以在长度到达多达 2.3 m,并且岩相和 chemostratigraphic 分析在底部,以及升起的海水平附近与 oxic 水环境显示一个相对深的碳酸盐平台。中间的爬行动物床产出 sauropterygian Nothosaurus yangjuanensis 江等, 2006 并且祖龙 Qianosuchus mixtus 李等, 2006,把等与 Mixosaurus panxianensis 江联系了, 2006。在这张床上的石块被它的大头针 cering 出牙和大全面身体尺寸描绘,与最大可能在长度超过 3 m。这张床可能在底部附近与相对缺氧的状况代表最深的盆的一时间。上面的爬行动物床产出 sauropterygians Wumengosaurus delicatomandibularis 江等, 2008, Keichousaurus sp, protorosaur Dinocephalosaurus 东方人是李, 2003,并且 ichthyopterygian Mixosaurus panxianensis 江等, 2006。在这张床上,爬虫税一由吸喂描绘了出现,并且最长是不到 1 m。这张床对应于减少的水深度的一个时期。 | JIANG Dayong Ryosuke MOTANI HAO Weicheng Olivier RIEPPEL SUN Yuanlin Andrea TINTORI SUN Zuoyu Lars SCHMITZ | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 17 |
| 3 | New primitive ichthyosaurian (Reptilia,Diapsida) from the Middle Triassic of Panxian,Guizhou,southwestern China and its position in the Triassic biotic recovery显示文摘一张新原始 ichthyopterygian Xinminosaurus catactes 情报。et sp。nov。在 Panxian 从 Guanling 形成的中间的三叠纪的上面的成员基于一架完全的骨骼被树立,贵州,西南的中国。它在它的出牙,尺骨,腕骨和 tarsals 有特别地导出的人物的一间套房。它类似于在保留伸长的手足骨头的原始 ichthyopterygians。新税在上和多种水兵在 Panxian 动物志的爬行动物是中间的三叠纪的关於生命的放射的物理标记。这动物志的详细研究将在差异,迁居和中间的三叠纪的 ichthyopterygians 的 paleobiogeographic 亲密关系上供应必要知识。 | Dayong Jiang Ryosuke Motani Weicheng Hao Lars Schmitz Olivier Rieppel Yuanlin Sun Zuoyu Sun | 2008 | Progress in Natural Science:Materials International2008，18，10： | 13 |
| 4 | Guanling Biota: A Marker of Triassic Biotic Recovery from the end-Permian Extinction in the Ancient Guizhou Sea显示文摘After a slow recovery from the end-Permian extinction during the Early Triassic and rapid radiation in the Middle Triassic, evolution of organisms reached a new peak phase in the Late Triassic. The Guanling Biota from the Wayao Member (conodont Paragondolella polygnathiformis Zone), Falang Formation, Xinpu, Guanling County, Guizhou Province, southwestern China corresponds to this peak that marks the full recovery from the end-Permian extinction of marine ecosystems. The biota is of high diversity, containing well preserved and completely articulated skeletons of vertebrates comprising marine reptiles, fishes, and invertebrates including crinoids, ammonites, bivalves, and other fossils, and is one of the best examples of marine ecosystem records in life history. The fossil marine reptiles and crinoids are most significant in this biota, especially the marine reptiles, which provide an important link between the Triassic Pacific and Tethys, and between Triassic basal forms and the Jurassic-Cretaceous marine top predators. The most remarkable fossils are the large completely articulated ichthyosaur skeletons up to and more than 10 m, and the first recorded thalattosaurs and placodonts in China. Following our review, of the 17 named reptilian taxa the eight listed here are considered to be valid: three ichthyosaurs (Qianichthyosaurus zhoui Li, 1999; Guizhouichthyosaurus tangae Cao and Luo in Yin et al., 2000, Guanlingsaurus liangae Yin in Yin et al., 2000), three thalattosaurs (Anshunsaurus huangguoshuensis Liu, 1999, Xinpusaurus suni Yin in Yin et al., 2000, Xinpusaurus kohi Jiang et al., 2004), and two placodonts (Sinocyamodus xinpuensis Li, 2000, Psephochelys polyosteoderma Li and Rieppel, 2002). Mixosaurus guanlingensis Cao in Yin et al., 2000 might be a junior synonym of Qianichthyosaurus zhoui Li, 1999, and Cymbospondylus asiaticus Li and You, 2002 and Panjiangsaurus epicharis Chen and Cheng, 2003 might be junior synonyms of Guizhouichthyosaurus tangae Cao and Luo in Yin et al., 2000. It needs to re-describe the holotypes after a complete preparation for clarifying the taxonomic status of Typicusichthyosaurus tsaihuae Yu in Yin et al., 2000, Xinpusaurus bamaolinensis Cheng, 2003, Neosinosaurus hoangi (Zhou in Yin et al., 2000), Wayaosaurus geei Zhou in Yin et al., 2000, Wayaosaurus bellus Zhou in Yin et al., 2000 and Placochelys ? minutus Yin and Luo in Yin et al., 2000. | JIANG Dayong Ryosuke MOTAN LI Chun HAO Weicheng SUN Yuanlin SUN Zuoyu Lars SCHMITZ | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 11 |
| 5 | A New Perleidiform(Actinopterygii,Osteichthyes)from the Middle Anisian(Middle Triassic)of Yunnan,South China显示文摘从 Pelsonian 的二个完全的标本(中间的 Anisian,中间三叠纪) Luoping,云南省,华南被指一个新 actinopterygian 类, Luopingichthys 情报。nov,并且归功于到特别基于古怪 premaxillary 颚的建筑群的典型 synapomorphy 的 perleidiform 家庭 Polzbergidae,即,在 premaxillary 之间的熔化并且沿着 antero 背面的边缘颚颚。新税在上不同于家庭, Felberia 和 Stoppania 的另外的深身体的代表,在它的纺锤形或深的纺锤形的身体形状;有短下文轨道的过程的塑造镰刀的 preopercular;在肛门鳍的底的修改规模的缺乏;短底的背面的鳍;几乎没装饰的规模;并且变瘦前面的牙齿。从中间在 Ctenognathichthys hattichi 上基于对税的完模标本的描述三叠纪( Ladinian ) Prosanto 形成,州 Graub ün 兽穴,东方瑞士,唯一的已知的标本,它显示出在 premaxillary 之间的一样的熔化并且颚,种的系统的位置被澄清并且税在上被建议是家庭 Polzbergidae 的一个进一步的代表,并且被转移到新类。 | SUN Zuoyu Andrea TINTORI JIANG Dayong Cristina LOMBARDO Marco RUSCONI HAO Weicheng SUN Yuanlin | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 9 |
| 6 | Atrypid Brachiopods from the Upper Devonian Wangchengpo Formation(Frasnian)of southern Guizhou,China—Extinction Patterns in the Frasnian of South China显示文摘The Wangchengpo Frasnian section of Dushan County contains two atrypid brachiopod assemblages. The lower is characterized by the Atryparia (Costatrypa) dushanensis fauna that appears at the base of the Hejiazhai Member approximately in the falsiovalis to transitans conodont zones; the upper is characterized by the Radiatrypa yangi fauna, which appears in the Lujiazhai Member approximately correspondent with the hassi to Upper rhenana conodont zones. Atrypid brachiopods, together with other brachiopods from the Dushan section show that the Hejiazhai Member is of Frasnian age. Preliminary analyses of Frasnian atrypid brachiopods from sections of South China indicate that there are nine genera and subgenera including Atryparia (Costatrypa), Kyrtatrypa, Spinatrypa, Isospinatrypa, Spinatrypina, Iowatrypa, Desquamatia (Desquamatia), Desquamatia (Seratrypa), and Radiatrypa. Atrypid species diversity did not change much through the Frasnian. On a regional scale in South China, most atrypid species went extinct prior to the Frasnian/Famennian boundary. At any specific locality or section, these atrypids became extinct about 20–40 m below the Frasnian/Famennian (F/F) boundary, within the linguiformis conodont Zone, marking this as the major extinction level. Three new atrypid species are described: Atryparia (Costatrypa) dushanensis, Iowatrypa pseudobodini, and Radiatrypa yangi. | MA Xueping Paul COPPER SUN Yuanlin LIAO Weihua | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 7 |
| 7 | Is seawater geochemical composition recorded in marine carbonate? Evidence from iron and manganese contents in Late Devonian carbonate rocks显示文摘Iron and manganese are the important redoxsensitive elements in the ocean. Previous studies have established a series of paleo-depositional redox proxies based on the form and content of iron in sedimentary rocks(e.g., degree of pyritization, FeHR/FeT, Fe/Al). These proxies were developed and applied on siliciclastic-rich marine sediments. Although marine carbonate rocks are generally considered to preserve the geochemical signals of ancient seawater, neither Fe nor Mn content in marine carbonate rocks(Fecarb, Mncarb) has been independently used as a proxy to quantify environmental cues in paleo-oceans. Both Fe and Mn are insoluble in oxic conditions(Fe_2O_3, Fe(OH)_3,MnO_2), while their reduced forms(Fe^(2+) and Mn^(2+)) are soluble. Therefore, oxic seawater should have low concentrations of dissolved Fe^(2+)and Mn^(2+), and accordingly carbonate rocks precipitated from oxic seawater should have low Fecarband Mncarb, and vice versa. To evaluate whether Fecarband Mncarbcan be used to quantify oxygen fugacity in seawater, we measured Fecarband Mncarbof Upper Devonian marine carbonate rocks collected from nine sections in South China. Fecarbof intraplatform basin samples wassignificantly higher than that of shelf samples, while shelf and basin samples had comparable Mncarb. The modeling result indicates that the dramatic difference in Fecarbcannot be explained by variation in oxygen fugacity between the shelf and basin seawater. Instead, both Fecarband Mncarb appear to be more sensitive to benthic flux from sediment porewater that is enriched in Fe^(2+)and Mn^(2+). Porewater Fe^(2+)and Mn^(2+)derive from bacterial iron and manganese reduction; flux was controlled by sedimentation rate and the depth of the Fe(Mn) reduction zone in sediments, the latter of which is determined by oxygen fugacity at the water–sediment interface. Thus, high Fecarbof the basin samples might be attributed to low sedimentation rate and/or low oxygen fugacity at the seafloor. However, invariant Mncarbof the shelf and basin samples might be the consequence of complete reduction of Mn in sediments. Our study indicates that marine carbonate rocks may not necessarily record seawater composition, particularly for benthic carbonate rocks. The influence of benthic flux might cause carbonate rocks' geochemical signals to deviate significantly from seawater values. Our study suggests that interpretation of geochemical data from carbonate rocks, including carbonate carbon isotopes, should consider the process of carbonate formation. | Zhe Wang Wen Guo Ting Nie Haoran Ma Tianzheng Huang Yuanlin Sun Bing Shen | 2019 | Acta Geochimica2019，38，2： | 5 |
| 8 | New species of Saurichthys(Actinopterygii:Saurichthyidae)from Middle Triassic(Anisian)of Yunnan Province,China显示文摘Saurichthys dawaziensis sp。nov,从 Gejiu 形成的第三个成员(中间的 Anisian 三叠纪) 在 Luoping 的附近,云南省,一对媒介小 -- 大小的 saurichthyid 鱼。它被与一个分支在楔形的帕拉和上颚上渗透感觉运河在的传出假鳃的动脉描绘尖。新种类是在没有骨化的脊骨,有一个相对狭窄的眼窝后部的区域,短 preopercular,巩膜戒指的单个骨化,在骨盆的鳍之间的小血液的拱门和肛门鳍比更低的三叠纪的种类导出的更多,并且当 quadratojugal 不在时。它是比在在神经拱门在 prae-zygapophyses 和 post-zygapophyses 的奇鳍,和存在有 fringing fulcra 和众多的片断的中间、上面的三叠纪的 Saurichthys 更原始的。与脊椎的列和类的奇鳍有关的一些解剖变化也被讨论。 | WU Feixiang SUN Yuanlin HAO Weicheng JIANG Dayong XU Guanghui SUN Zuoyu Andrea TINTORI | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 5 |
| 9 | Cephalopods of the “Falang Formation” (Triassic) from Guanling and Zhenfeng Counties, Guizhou Province, China显示文摘The 'Falang Formation' of western Guizhou was previously called the 'Halobia Bed' and considered to beLadinian in age. It was subdivided upward into the Zhuganpo, Laishike and Longchang members based on ammonites andthe Trachyceras multitubertulatum Zone of the Longchang Member was put in the Lower Carnian. Here in the presentpaper, 4 genera and 9 species of ammonites and 1 nautiloid genus and species collected from the upper part of the 'FalangFormation' (i.e. the Wayao Formation used in this paper, equivalent to the Laishike Member from Guanling and Zhenfengcounties are described. The geological and geographical distribution of these cephalopods, as well as the co-existingconodonts, put the Wayao Formation to the late early Carnian. | HAO Weicheng, SUN Yuanlin, JIANG Dayong, YANG Shouren and WANG Xinping Geological Museum, Peking University, Beijing 100871 | 2003 | Acta Geologica Sinica(English Edition)2003，77，4： | 5 |
| 10 | Effect of rifampicin pre-and post-treatment on rotenone-induced dopaminergic neuronal apoptosis and alpha-synuclein expression显示文摘BACKGROUND: Rifampicin inhibits the formation of α-synuclein multimer and protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyritine (MPTP)-induced PC12 cell apoptosis.OBJECTIVE: To compare the effect of rifampicin pre-and post-treatment on tyrosine hydroxylase and α-synuclein expression in substantia nigra pars compacta in a rat model of Parkinson’s disease.DESIGN,TIME AND SETTING: A randomized,controlled experiment was performed at the Experimental Animal Center of Sun Yat-sen University North Campus (China) from November 2006 to October 2008.MATERIALS: Rifampicin was purchased from MD,USA;rotenone was purchased from Sigma,USA;mouse anti-rat α-synuclein monoclonal antibody was purchased from B&D,USA;and rabbit anti-rat tyrosine hydroxylase monoclonal antibody was purchased from Chemicon,USA.METHODS: A total of 72 male,Sprague Dawley rats,aged 8 weeks,were randomly assigned to 5 groups: blank control (n = 12),rifampicin (n = 12),rotenone (n = 16),rifampicin pre-treatment (n = 16),and rifampicin post-treatment (n = 16).Parkinson’s disease model rats were established via a subcutaneous injection of rotenone (1.5 mg/kg per day) in the three treatment groups,once a day for 3 successive weeks.Rifampicin (30 mg/kg per day) was intragastrically administered in the rifampicin pre-treatment group 3 days prior to rotenone induction and in the rifampicin post-treatment group 7 days after rotenone induction.Rats were treated with a subcutaneous injection of 1 mL/kg per day sunflower oil in the blank control group and an intragastric injection of 30 mg/kg per day rifampicin in the rifampicin group,once a day for 3 successive weeks in total.MAIN OUTCOME MEASURES: Prior to treatment and in the end of the 3rd week after treatment,the rats were evaluated using the modified neurological severity score.The substantia nigra from the rats was extracted for hematoxylin-eosin staining.Western blot analysis was performed to determine tyrosine hydroxylase and α-synuclein expression.RESULTS: Hematoxylin-eosin staining revealed a significant reduction in the number of substantia nigral neurons in the rotenone group,in addition to neurodegradation,hypopigmentation,and pyknosis.In the rifampicin pre-treatment and post-treatment groups,the number of dopaminergic neurons was significantly increased compared with the rotenone group (P < 0.01),with slight neuronal damage.Compared with the rotenone group,substantia nigral tyrosine hydroxylase expres-sion was significantly increased in the rifampicin pre-treatment and post-treatment groups (P < 0.01),but α-synuclein expression and modified neurological severity scores were significantly decreased (P < 0.01).In addition,the effect of rifampicin in the pre-treatment group was superior to the post-treatment group.There was no significant difference in tyrosine hydroxylase and α-synuclein expression,or in the modified neurological severity scores,between the blank control and rifampicin groups (P > 0.05).CONCLUSION: Rifampicin significantly attenuated neuropathological and behavioral motor deficits induced by rotenone.Moreover,rifampicin enhanced tyrosine hydroxylase expression,but inhibited α-synuclein expression.The effect of rifampicin pre-treatment was superior to rifampicin post-treatment. | Yuanlin Sun Guohua Zhang Jie Xu Shiwen Chen Enxiang Tao Changqing Xu M. Catherine Bennett | 2010 | Neural Regeneration Research2010，5，2： | 4 |
| 11 | Heterogeneous Mg isotopic composition of the early Carboniferous limestone: implications for carbonate as a seawater archive显示文摘Carbonate precipitation and hydrothermal reaction are the two major processes that remove Mg from seawater.Mg isotopes are significantly(up to 5%)fractionated during carbonate precipitation by preferential incorporation of ^(24)Mg,while hydrothermal reactions are associated with negligible Mg isotope fractionation by preferential sequestration of^( 26)Mg.Thus,the marine Mg cycle could be reflected by seawater Mg isotopic composition(δ^(26)Mg_(sw)),which might be recorded in marine carbonate.However,carbonates are both texturally and compositionally heterogeneous,and it is unclear which carbonate component is the most reliable for reconstructing δ^(26)Mg_(sw).In this study,we measured Mg isotopic compositions of limestone samples collected from the early Carboniferous Huangjin Formation in South China.Based on petrographic studies,four carbonate components were recognized:micrite,marine cement,brachiopod shell,and mixture.The four components had distinct δ^(26)Mg:(1)micrite samples ranged from -2.86% to -2.97%;(2)pure marine cements varied from -3.40% to -3.54%,while impure cement samples containing small amount of Rugosa coral skeletons showed a wider range(-3.27% to-3.75%);(3)values for the mixture component were-3.17% and -3.49%;and (4)brachiopod shells ranged from -2.20% to -3.07%,with the thickened hinge area enriched in ^( 24)Mg.Due to having multiple carbonate sources,neither the micrite nor the mixture component could be used to reconstruct δ^(26)Mg_(sw).In addition,the marine cement was homogenous in Mg isotopes,but lacking the fractionation by inorganic carbonate precipitation that is prerequisite for the accurate determination of δ^(26)Mg_(sw).Furthermore,brachiopod shells had heterogeneous C and Mg isotopes,suggesting a significant vital effect during growth.Overall,the heterogeneous δ^(26)Mg of the Huangjin limestone makes it difficult to reconstruct δ^(26)Mg_(sw)using bulk carbonate/calcareous sediments.Finally,δ^(26)Mg_(sw)was only slightly affected by the faunal composition of carbonate-secreting organisms,even though biogenic carbonate accounts for more than 90% of marine carbonate production in Phanerozoic oceans and there is a wide range(0.2%–4.8%)of fractionation during biogenic carbonate formation. | Haoran Ma Yihe Xu Kangjun Huang Yuanlin Sun Shan Ke Yang Peng Xianguo Lang Zhen Yan Bing Shen | 2018 | Acta Geochimica2018，37，1： | 3 |
| 12 | Validating the deep time carbonate carbon isotope records: effect of benthic flux on seafloor carbonate显示文摘It is a consensus that marine carbonate archives the isotopic composition of seawater dissolved inorganic carbon(DIC,δ13Csw),the largest active C reservoir in the hydrosphere.Carbonate carbon isotope(δ13Ccarb)excursions have been used to reflect perturbations of the global carbon cycle and related environmental change.However,the deep timeδ13Ccarb records indicate faster and more pronounced perturbations of the carbon cycle compared to the present day.Here,we reportδ13Ccarb and elemental compositions of Late Paleozoic carbonate sections from South China,showing negative correlations betweenδ13-Ccarb and Fe^(2+)content of carbonate(Fecarb).We suggest that,because Late Paleozoic carbonate was mainly produced by benthic carbonate-secreting organisms,δ13Ccarbrecorded the isotopic composition near the seafloor,where benthic flux derived from anaerobic organic matter degradation delivers both Fe2+and 13C-depleted DIC from porewater.The binary mixing between seawater and benthic flux would result in the deviation ofδ13Ccarb fromδ13Csw.The negative correlation implies thatδ13Ccarb is influenced by benthic flux and is affected by the seafloor redox and sedimentation rate.The deep time spatially heterogeneous and temporally oscillatoryδ13Ccarb records in the basin-scale could be alternatively attributed to the variations of local environmental factors rather than aδ13Csw depth-gradient.Thus,the seafloor carbonate precipitation is continuously affected by diagenetic reactions in sediments,suggesting thatδ13Ccarb recording the seawater DIC composition is conditional.Our study urges that the interpretation ofδ13Ccarb should also consider the sedimentary process and depositional environment of marine carbonate. | Weiming Ding Ting Nie Yongbo Peng Yuanlin Sun Jinzhuang Xue Bing Shen | 2021 | Acta Geochimica2021，40，3： | 2 |
| 13 | Is the PhyloCode better than Linnaean system?—— New development and debate on biologi-cal nomenclatural issues显示文摘The Linnaean system provides ultimate means governing biological nomenclature and classification. With series of modification, this system has admirably served bio-logical sciences for some 250 years. The new PhyloCode, however, advocates the phylogenetic nomenclature that radically alternates the current nomenclatural rules. The new proposals upset many systematic biologists and have provoked hot debate on nomenclatural issues. Binomial no-menclature and hierarchical classification are the key com-ponents of the Linnaean system. Proposed abandonment of these in the PhyloCode is widely criticized for it would not help to promote systematics but create chaos. It is not the Linnaean system but the phylogenetic nomenclature that should be abandoned. | GAO Keqin & SUN Yuanlin School of Earth and Space Sciences, Peking University, Beijing 100871, China | 2003 | Chinese Science Bulletin2003，48，3： | 2 |
| 14 | National guidelines for diagnosis and treatment of thyroid cancer 2022 in China(English version)显示文摘Contents 1. Overview 2. Diagnosis and management 2.1 Screening for high-risk group 2.2 Clinical manifestations 2.2.1 Symptoms 2.2.2 Signs 2.2.3 Invasion and metastasis 2.3 Laboratory examination 2.3.1 Routine examination 2.3.2 Special examination 2.4 Imaging 2.4.1 Ultrasonography 2.4.2 Computed tomography (CT)2.4.3 Magnetic resonance imaging (MRI)2.4.4 Positron emission tomography (PET)-CT。 | 无 Shaoyan Liu Yansong Lin Yiming Zhu Lin Gui Xiaorong Hou Ziren Kong Yuanlin Piao Yuqing Sun Hao Wang Jian Wang Bo Zhang Ye Zhang Kun Zheng | 2022 | Chinese Journal of Cancer Research2022，34，3： | 2 |
| 15 | Rifampicin inhibits apoptosis in rotenone-induced differentiated PC12 cells by ameliorating mitochondrial oxidative stress显示文摘BACKGROUND:Previous studies have shown that rifampicin exhibits neuroprotective effects,but the precise mechanisms remain unclear.Rifampicin is thought to exert the neuroprotective effect as a hydroxyl free radical scavenger.OBJECTIVE:To investigate the protective effects of rifampicin pretreatment on rotenone-induced mitochondrial oxidative stress in differentiated PC12 cells.DESIGN,TIME AND SETTING:A repeated measure,cell-based study was performed at the Department of Neurology,Second Affiliated Hospital,Sun Yat-sen University,China between December 2007 and November 2008.MATERIALS:PC12 cells were a kind gift from the Physiology Laboratory of Zhongshan Medical School,Sun Yat-sen University,China.Rotenone and rifampicin were purchased from Sigma,USA.METHODS:PC12 cells were differentiated by culturing with 100 ng/mL 7S nerve growth factor for 9 days in Dulbecco's modified Eagle's medium/Nutrient Mix F12(DMEM/F12) supplemented with 10% fetal bovine serum.The cells were assigned to six groups according to various treatment conditions:control,cultured with normal media;rifampicin group,treated with 300 μmol/L rotenone for 26 hours;rotenone group,treated with 2.5 μmol/L rotenone for 24 hours;rifampicin pretreatment groups,pretreated with 100,200,and 300 μmol/L rifampicin for 2 hours,respectively,followed by 2.5 μmol/L rotenone for 24 hours.MAIN OUTCOME MEASURES:Mitochondrial membrane potential was measured by fluorescence microscopy and flow cytometry,respectively,using rhodamine123 staining.Intracellular reactive oxygen species formation was analyzed by flow cytometry using 2',7'-dichlorofluorescin-diacetate staining,and intracellular reduced glutathione was measured with a microplate reader.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Cell apoptosis was detected by Hoechst 33342 staining and flow cytometry.RESULTS:Increased apoptosis in rotenone-induced,differentiated,PC12 cells was accompanied by the loss of mitochondrial transmembrane potential,the formation of reactive oxygen species,and reduced glutathione depletion(P<0.01).Rotenone-induced mitochondrial dysfunction was blocked in a dose-dependent manner by rifampicin(P<0.05 or P<0.01).CONCLUSION:Pretreatment of differentiated PC12 cells with rifampicin blocked rotenone-induced apoptosis by ameliorating mitochondrial dysfunction and oxidative stress. | Shiwen Chen Yuanlin Sun Zhifeng Zeng Enxiang Tao | 2010 | Neural Regeneration Research2010，5，4： | 2 |
| 16 | Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta?显示文摘Dear Editor,A series of studies had focused on the ecological stability of human microbiome(Lozupone et al.,2012;Faith et al.,2013;Moya and Ferrer,2016).Despite the continuous perturbation and the highly personalized composition within the human microbiome(Human Microbiome Project,2012),healthy adults stably maintain their microbial communities in terms of space and time(Faith et al.,2013;Moya and Ferrer,2016;Oh et al.,2016).This stability is proved to be critical for the well-being of human body(Lozupone et al.,2012).On the contrary,major shifts in microbial community composition are often related to diseases(Lynch and Pedersen,2016). | Fangqiao Wei Xiangyu Sun Yufeng Gao Haoyu Dou Yang Liu Lili Su Haofei Luo Ce Zhu Qian Zhang Peiyuan Tong Wen Ren Zhe Xun Ruochun Guo Yuanlin Guan Shenghui Li Yijun Qi Junjie Qin Feng Chen Shuguo Zheng | 2021 | Protein & Cell2021，12，6： | 1 |
| 17 | Three- dimensional reconstruction of cranial defect using active contour model and image registration 显示文摘 | Liao Yuanlin Lu Chia Feng Sun Yung Nien | 2011 | Med Biol Eng2011，49，： | 1 |
| 18 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 19 | COVID-19-associated gastrointestinal and liver injury:clinical features and potential mechanisms显示文摘Coronavirus disease-2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The infection is spreading globally and poses a huge threat to human health.Besides common respiratory symptoms,some patients with COVID-19 experience gastrointestinal symptoms,such as diarrhea,nausea,vomiting,and loss of appetite.SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2(ACE2)and there is increasing evidence of a possible fecal–oral transmission route.In addition,there exist multiple abnormalities in liver enzymes.COVID-19-related liver injury may be due to drug-induced liver injury,systemic inflammatory reaction,and hypoxia–ischemia reperfusion injury.The direct toxic attack of SARS-CoV-2 on the liver is still questionable.This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19. | Peijie Zhong Jing Xu Dong Yang Yue Shen Lu Wang Yun Feng Chunling Du Yuanlin Song Chaomin Wu Xianglin Hu Yangbai Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 20 | Glucose May Attenuate Isoflurane-Induced Caspase-3 Activation in H4 Human Neuroglioma Cells显示文摘 | Yongxing Sun Yiying Zhang Baiqi Cheng Yuanlin Dong Chuxiong Pan Tianzuo Li Zhongcong Xie | 2014 | Anesthesia & Analgesia2014，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员