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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 3 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 4 | Urban Big Data and the Development of City Intelligence显示文摘 | Yunhe Pan Yun Tian Xiaolong Liu Dedao Gu Gang Hua | 2016 | Engineering2016，2，2： | 14 |
| 5 | Simultaneous removal of SO2 and NO using a spray dryer absorption(SDA) method combined with O3 oxidation for sintering/pelleting flue gas显示文摘Based on the demand of sintering/pelleting flue gas ultra-low emission,a semi-dry method using a spray dryer absorber (SDA) combined with O3 oxidation was proposed for simultaneous removal of SO2 and NO.Effects of O3 injection site,O3/NO molar ratio,and spray tower temperature on the removal efficiencies were investigated.It was revealed that both desulfurization and denitrification efficiencies could reach to 85%under the conditions of setting O3 injection site inside of tower,O3/NO molar ratio 1.8,spray tower temperature 85°C,Ca/(S+2N) molar ratio 2.5 and slurry flow rate 300 m L/hr.CaSO3/Ca(OH)2 mixture slurry was used as absorbent to simulate operating conditions in iron and steel industry.The result shows that the addition of CaSO3 weakens both removal efficiencies.In addition,the reaction mechanism of simultaneous removal of SO2 and NO using SDA combined with O3 oxidation was proposed. | Maoyu Cai Xiaolong Liu Tingyu Zhu Yang Zou Wenliang Tao Mengkui Tian | 2020 | Journal of Environmental Sciences2020，32，10： | 7 |
| 6 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 7 | Enhancing prime editing by Csy4-mediated processing of pegRNA显示文摘Dear Editor,The most advanced prime editor 3(PE3)system comprises the editor,a fusion protein of Cas9 H840A nickase and mutant reverse transcriptase(RTase)(hereafter termed NMRT),a prime editing guide RNA(pegRNA)and an alternative single-guide RNA(sgRNA).1 The pegRNA contains a primer binding site(PBS)and a reverse transcription(RT)template for introducing new genetic information1(Fig.1a;Supplementary information,Fig.S1a).We noted that the PBS,which is generally 10–16 nt at the 3′end of pegRNA,is complementary to part of the spacer at the 5′end of pegRNA,and their annealing is expected to cause pegRNA circularization,which can potentially hamper editing(Fig.1a;Supplementary information,Fig.S1b,c). | Yao Liu Guang Yang Shuhong Huang Xiangyang Li Xin Wang Guanglei Li Tian Chi Yulin Chen Xingxu Huang Xiaolong Wang | 2021 | Cell Research2021，31，10： | 5 |
| 8 | Chemical formation and source apportionment of PM_(2.5) at an urban site at the southern foot of the Taihang mountains显示文摘The region along the Taihang Mountains in the North China Plain(NCP) is characterized by serious fine particle pollution. To clarify the formation mechanism and controlling factors, an observational study was conducted to investigate the physical and chemical properties of the fine particulate matter in Jiaozuo city, China. Mass concentrations of the water-soluble ions(WSIs) in PM_(2.5) and gaseous pollutant precursors were measured on an hourly basis from December 1, 2017, to February 27, 2018. The positive matrix factorization(PMF) method and the FLEXible PARTicle(FLEXPART) model were employed to identify the sources of PM_(2.5). The results showed that the average mass concentration of PM_(2.5) was 111 μg/m^(3) during the observation period. Among the major WSIs, sulfate, nitrate, and ammonium(SNA) constituted 62% of the total PM_(2.5) mass, and NO_(3)^(-) ranked the highest with an average contribution of 24.6%. NH_(4)^(+) was abundant in most cases in Jiaozuo. According to chemical balance analysis, SO_(2)-4, NO_(3)^(-), and Cl^(-) might be present in the form of(NH_4)_(2)SO_4, NH_4NO_3, NH_4Cl, and KCl. The liquid-phase oxidation of SO_(2) and NO_(2) was severe during the haze period. The relative humidity and pH were the key factors influencing SO_(4)^(2-) formation. We found that NO_(3)^(-) mainly stemmed from homogeneous gas-phase reactions in the daytime and originated from the hydrolysis of N_(2)O_5 in the nighttime, which was inconsistent with previous studies. The PMF model identified five sources of PM_(2.5) : secondary origin(37.8%), vehicular emissions(34.7%), biomass burning(11.5%), coal combustion(9.4%), and crustal dust(6.6%). | Xiaoyong Liu Mingshi Wang Xiaole Pan Xiyue Wang Xiaolong Yue Donghui Zhang Zhigang Ma Yu Tian Hang Liu Shandong Lei Yuting Zhang Qi Liao Baozhu Ge Dawei Wang Jie Li Yele Sun Pingqing Fu Zifa Wang Hong He | 2021 | Journal of Environmental Sciences2021，33，5： | 5 |
| 9 | Measurement-device-independent quantum secret sharing and quantum conference based on Gaussian cluster state显示文摘Cluster state is the basic resource for one-way quantum computation and a valuable resource for establishing quantum network, because it has a flexible and varied composition form. We present measurement-device-independent quantum secret sharing(QSS) and quantum conference(QC) schemes based on continuous variable(CV) four-mode cluster state with different structures. The users of the protocol prepare their own Einstein-Podolsky-Rosen(EPR) states, respectively. One mode of these EPR states is sent to an untrusted relay where a generalized Bell measurement creates different types of CV cluster states among four users, while the other mode is kept at their own station. We show that a shared secret key for QSS and QC schemes is distilled based on the shared quantum correlation among four users. QC and four users QSS are implemented based on the star shape CV cluster state. QSS with three users are implemented based on the linear or square shape CV cluster states. The results show that the secure transmission distance for an asymmetric network, where the transmission distances between the users and relay are different, is longer than that of a symmetric network, where the transmission distances between the users and relay are the same. The presented schemes provide concrete references for establishing quantum network with the CV cluster state. | Yu WANG Caixing TIAN Qi SU Meihong WANG Xiaolong SU | 2019 | Science China(Information Sciences)2019，62，7： | 4 |
| 10 | Aboveground biomass and its spatial distribution pattern of herbaceous marsh vegetation in China显示文摘Herbaceous marsh is the most widely distributed type of marsh wetland ecosystem,and has important ecological functions such as water conservation,climate regulation,carbon storage and fixation,and sheltering rare species.The carbon sequestration function of herbaceous marsh plays a key role in slowing climate warming and maintaining regional environmental stability.Vegetation biomass is an important index reflecting the carbon sequestration capacity of wetlands.Investigating the biomass of marsh vegetation can provide a scientific basis for estimating the carbon storage and carbon sequestration capacity of marshes.Based on field survey data of aboveground biomass of herbaceous marsh vegetation and the distribution data set of marsh in China,we analyzed the aboveground biomass and its spatial distribution pattern of herbaceous marsh on a national scale for the first time.The results showed that in China the total area of herbaceous marsh was 9.7×10^(4) km^(2),the average density of aboveground biomass of herbaceous marsh vegetation was 227.5±23.0 g C m-2(95%confidence interval,the same below),and the total aboveground biomass was 22.2±2.2 Tg C(1 Tg=1012 g).The aboveground biomass density of herbaceous marsh vegetation is generally low in Northeast China and the Tibetan Plateau,and high in central North China and coastal regions in China.In different marsh distribution regions of China,the average biomass density of herbaceous marsh vegetation from small to large was as follows:temperate humid and semi-humid marsh region(182.3±49.3 g C m^(-2)) | Xiangjin SHEN Ming JIANG Xianguo LU Xingtu LIU Bo LIU Jiaqi ZHANG Xianwei WANG Shouzheng TONG Guangchun LEI Shengzhong WANG Chuan TONG Hangqing FAN Kun TIAN Xiaolong WANG Yuanman HU Yonghong XIE Muyuan MA Shuwen ZHANG Chunxiang CAO Zhichen WANG | 2021 | Science China Earth Sciences2021，64，7： | 4 |
| 11 | Development of high-oil maize haploid inducer with a novel phenotyping strategy显示文摘Doubled haploid(DH) technology is important in modern maize breeding. Haploid inducers determine the efficiency of both haploid induction and identification. It has taken decades to improve the efficiency,haploid induction rate(HIR), from the ~2% of the ancestor haploid inducer, stock6, to the ~10% of modern haploid inducers. Improvement of kernel oil content(KOC) would further enhance haploid identification efficiency. Using molecular marker-assisted selection, in combine with the number of haploids per ear as phenotypic criterion, we developed a new high-oil haploid inducer line, CHOI4, with a mean HIR of 15.8%and mean KOC of 11%. High KOC of CHOI4 can achieve a mean accuracy greater than 90% in identification of haploids of different backgrounds, with reduced false discovery rates and false negative rates in comparison with the previous high-oil haploid inducer line, CHOI3. Comparison of phenotypic selection strategies suggested that the number of haploids per ear can be used as a phenotyping criterion during haploid inducer line development. CHOI4 could further increase the efficiency of large-scale DH breeding programs with lower cost. | Chenxu Liu Jinlong Li Ming Chen Wei Li Yu Zhong Xin Dong Xiaowei Xu Chen Chen Xiaolong Tian Shaojiang Chen | 2022 | The Crop Journal2022，10，2： | 2 |
| 12 | Selective growth and characterization of ZnO nanorods assembled a hexagonal pattern on H2-decomposed GaN epilayer显示文摘这份报纸报导为高度制作和 patterning 的一个简单、有效的方法订了 ZnO nanorod 数组在上分解 H2 经由热水的线路轧了 epilayer。模式的边,被 H2 流动分解了,提供适当成核地点为排列 ZnO nanorods 选择生长。ZnO nanorod 数组的密度装配了六角形的模式能被改变解决方案集中,生长时间和反应调节温度。结果证明了 ZnO nanorods 与完美的排列在直径和高度是高度一致的并且取向附生地被种[0001 ] 方向。这个工作提供一篇小说和可存取的线路准备面向、排列的 ZnO nanorod 数组模式。并且排列 ZnO nanorods 形式可能在 ZnO nanomaterials 的许多潜在的应用被使用的一个理想的六角形的模式。 | Yu TIAN Huiquan CHEN Xiaolong ZHU Guang ZHENG Jiangnan DAI | 2013 | Frontiers of Optoelectronics2013，6，4： | 2 |
| 13 | Research Progress on the Effect of Aflatoxin on Poultry Immunization显示文摘Aflatoxins( AFs) are a major pollution source of grain pollution and are secondary metabolites produced by Aspergillus flavus and A.parasiticus,which are one of the most toxic and carcinogenic substances.Feeding animals with aflatoxin-contaminated food can cause toxicosis,acute liver injury or liver cancer in animals,and also can cause multiple organ damage,decline in production performance and disease resistance,even death,which brings great economic losses to animal husbandry.In addition,AFs can do great harm to the human body.When the body ingests large amounts of AFs,it may suffer from acute poisoning and acute liver damage; and AFs can cause chronic poisoning of the body with continuous intake of trace AFs.This paper briefly analyzed the effect of AFs on the structure and function of poultry immune organs,immune gene expression,immunosuppression and so on. | Xiaolong YU Xinmiao HE Wentao WANG Yanzhong FENG Heshu CHEN Ming TIAN Di LIU | 2018 | Agricultural Biotechnology2018，7，6： | 2 |
| 14 | Study on mechanism of low-temperature oxidation of n-hexanal catalysed by 2D ultrathin Co_(3)O_(4) nanosheets显示文摘Achieving high catalytic performance with lower possible cost and higher energetic efficiency is critical for catalytic oxidation of volatile organic compounds(VOCs).However,traditional thermocatalysts generally undergo low catalytic activity and fewer active sites.Herein,this paper synthesizes nearly all-surface-atomic,ultrathin two-dimensional(2D)Co_(3)O_(4) nanosheets to address these problems through offering a numerous active sites and high electron mobility.The 2D Co_(3)O_(4) nanosheets(1.70 nm)exhibit catalyzation to the total oxidation of n-hexanal at the lower temperature of r90%=202℃,and at the space velocity of 5.0×10^(4) h^(-1).It is over 1.2 and 6 times higher catalytic activity than that of 2D CoO nanosheets(1.71 nm)and bulk Co_(3)O_(4) counterpart,respectively.Transient absorption spectroscopy analysis shows that the oxygen vacancy defect traps electrons,thereby preventing the recombination with holes,increasing the lifetime of electrons,and making electron-holes reach a nondynamic equilibrium.The longer the electron lifetime is,the easier the oxygen vacancy defects capture electrons.Furthermore,the defects combine with oxygen to form active oxygen components.Compared with the lattice oxygen involved in the reaction of bulk Co_(3)O_(4),the nanosheets change the catalytic reaction path,which effectively reduces the activation energy barrier from 34.07 to 27.15 kJ/mol.The changed surface disorder,the numerous coordinatively-unsaturated Co atoms and the high ratio of O_(ads)/O_(lat) on the surface of 2D Co_(3)O_(4) nanosheets are responsible for the catalytic performance. | Leilei Miao Xiaolong Tang Shunzheng Zhao Xizhou Xie Chengcheng Du Tian Tang Honghong Yi | 2022 | Nano Research2022，15，2： | 2 |
| 15 | Geochemistry and Geochronology of Diorite in Pengshan Area of Jiangxi Province:Implications for Magmatic Source and Tectonic Evolution of Jiangnan Orogenic Belt显示文摘Magmatic activities associated with tectonic events play a significant role in understanding the evolution of an orogenic belt.The Jiangnan orogenic belt has been regarded as the collisional suture zone between the Yangtze Block and the Cathaysia Block.Although the magmatic activities during the period of intra-plate extension after the collision have been well studied in recent years,some remaining issues,including source nature and geodynamic mechanism,need to be further addressed.In this paper,based on a detailed field geological,petrological,geochemical and geochronological study,we focus our work on diorites in the Pengshan area located at the northwestern margin of the Jiangnan orogenic belt.The mineral assemblages are mainly composed of plagioclase(55 vol.%-65 vol.%)and hornblende(35 vol.%-45 vol.%).One diorite sample yields zircon^(206)Pb/^(238)U mean age of 768±8 Ma(MSWD=0.29).The diorites have enriched large ion lithophile elements(Ba,K and Rb)and incompatible elements(Th and U),and are depleted in high field-strength elements including Ta,Ti and Nb.Diorites in this study have relatively high MgO content(6.56 wt.%-7.58 wt.%,7.07 wt.%on average)and Mg number values(65-67,65.8 on average).The diorites are metaluminous,high K calc-alkaline series rocks with high contents of K_2O(1.59 wt.%-1.97 wt.%)and total alkali(Na_2O+K_2O=5.56 wt.%-6.05 wt.%).The Nd/Th ratio(4.34-5.27)is higher than that of crust-derived rocks and lower than mantle-derived rocks.The Rb/Sr ratio(0.19-0.22)is slightly lower than crust,but significantly higher than upper mantle.Based on the above geochemical and geochronological analyses,we suggest that the diorites in the Pengshan area were mainly derived from crustal materials with a small amount of mantleoriginated materials involved,and possibly produced from an extensional tectonic setting after the collision between the Yangtze Block and Cathaysia Block. | Hongfeng Shi Junpeng Wang Yuan Yao Jing Zhang Song Jin Yingxin Zhu Kang Jiang Xiaolong Tian Deng Xiao Wenbin Ning | 2020 | Journal of Earth Science2020，31，1： | 2 |
| 16 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 17 | High-energy laser pulse with a submegahertz repetition rate from a passively mode-locked fiber la- ser显示文摘 | Tian Xiaolong Tang Ming Perryping S | 2009 | Opt Lett2009，34，： | 1 |
| 18 | High-energy wave-breaking free pulse from all-fiber mode-locked laser system显示文摘 | Tian Xiaolong Tang Ming Cheng Xueping | 2009 | Opt Ex- press2009，17，： | 1 |
| 19 | Cell-free synthesis system-assisted pathway bottleneck diagnosis and engineering in Bacillus subtilis显示文摘Metabolic engineering is a key technology for cell factories construction by rewiring cellular resources to achieve efficient production of target chemicals.However,the existence of bottlenecks in synthetic pathway can seriously affect production efficiency,which is also one of the core issues for metabolic engineers to solve.Therefore,developing an approach for diagnosing potential metabolic bottlenecks in a faster and simpler manner is of great significance to accelerate cell factories construction.The cell-free reaction system based on cell lysates can transfer metabolic reactions from in vivo to in vitro,providing a flexible access to directly change protein and metabolite variables,thus provides a potential solution for rapid identification of bottlenecks.Here,bottleneck diagnosis of the N-acetylneuraminic acid(NeuAc)biosynthesis pathway in industrially important chassis microorganism Bacillus subtilis was performed using cell-free synthesis system.Specifically,a highly efficient B.subtilis cell-free system for NeuAc de novo synthesis was firstly constructed,which had a 305-fold NeuAc synthesis rate than that in vivo and enabled fast pathway dynamics analysis.Next,through the addition of all potential key intermediates in combination with substrate glucose respectively,it was found that insufficient phosphoenolpyruvate supply was one of the NeuAc pathway bottlenecks.Rational in vivo metabolic engineering of NeuAc-producing B.subtilis was further performed to eliminate the bottleneck.By down-regulating the expression level of pyruvate kinase throughout the growth phase or only in the stationary phase using inhibitory Nterminal coding sequences(NCSs)and growth-dependent regulatory NCSs respectively,the maximal NeuAc titer increased 2.0-fold.Our study provides a rapid method for bottleneck diagnosis,which may help to accelerate the cycle of design,build,test and learn cycle for metabolic engineering. | Rongzhen Tian Minghu Wang Jintian Shi Xiaolong Qin Haoyu Guo Xuanjie Jia Jianghua Li Long Liu Guocheng Du Jian Chen Yanfeng Liu | 2020 | Synthetic and Systems Biotechnology2020，5，3： | 1 |
| 20 | Phase relations of R-T-M temary system, crystal structure and magnetic properties of R(T,M)13 compounds (R = Light rare earth; T = Co, Fe; M = Al, Si) ( Ⅰ ) 显示文摘 | Liang Jingkui Rao Guanghui Tang Weihua Zhao Yanming Guo Yongquan Yan Xiaohua Zhang Yuling Cheng Xiangrong Xie Sishen Yu Yude Tian Jinghua Cheng Xiaolong Liang Jingmei | 1996 | Progress in Natural Science1996，6，6： | 1 |
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